Immunomodulatory Effect of Bisphosphonate Risedronate Sodium on CD163+ Arginase 1+ M2 Macrophages: The Development of a Possible Supportive Therapy for Angiosarcoma by Taku Fujimura, Yumi Kambayashi, Sadanori Furudate, Aya Kakizaki, Setsuya Aiba

“…An imbalance of immunosuppressive cells and cytotoxic cells plays an important role in inhibiting the antitumor immune response of the tumor-bearing host. We previously reported the profiles of tumor infiltrating leukocytes in cutaneous angiosarcoma (AS) and suggested that a combination of docetaxel (DTX) with bisphosphonate risedronate sodium (RS) might be effective for MMP9-expressing AS by targeting immunosuppressive cells such as M2 macrophages. …”
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Small Intestinal Bacterial Overgrowth in Patients with Irritable Bowel Syndrome: Clinical Characteristics, Psychological Factors, and Peripheral Cytokines by Hua Chu, Mark Fox, Xia Zheng, Yanyong Deng, Yanqin Long, Zhihui Huang, Lijun Du, Fei Xu, Ning Dai

“…Psychosocial factors and low-grade colonic mucosal immune activation have been suggested to play important roles in the pathophysiology of IBS. …”
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Influence of nano-polystyrene on cyfluthrin toxicity in honeybee Apis cerana cerana Fabricius by Yunfei Xue, Xueyang Gong, Linfu Yang, Dandan Zhi, Qingxin Meng, Yulong Guo, Kun Dong, Yakai Tian

“…Concerning the detoxification-related genes, the two toxins alone and in combination significantly promoted the expression of P450 9E2 and Cyp9Q3 genes, and the upregulation trend was found more significant for the combination. Regarding immune gene expression, exposure to a single toxin or both toxins significantly down-regulated the abaecin gene, but only exposure to nanoPS significantly decreased apidaecin expression. …”
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Utilizing Cytokines to Function-Enable Human NK Cells for the Immunotherapy of Cancer by Rizwan Romee, Jeffrey W. Leong, Todd A. Fehniger

“…Natural killer (NK) cells are innate lymphoid cells important for host defense against pathogens and mediate antitumor immunity. Cytokine receptors transduce important signals that regulate proliferation, survival, activation status, and trigger effector functions. …”
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SPOP Inhibition of Endometrial Carcinoma and Its Clinicopathological Relationship by Qing Zhu, Guanghui Zhang, Mingyang Tang, Rumin Zheng, Huaiyong Gan

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Repurposing Lesogaberan to Promote Human Islet Cell Survival and β-Cell Replication by Jide Tian, Hoa Dang, Angela Hu, Willem Xu, Daniel L. Kaufman

“…Immunohistochemical analysis of human islets that were grafted into immune-deficient mice revealed that oral treatment with lesogaberan promoted human β-cell replication and islet cell survival in vivo as effectively as GABA (which activates both GABAA-Rs and GABAB-Rs), perhaps because of its more favorable pharmacokinetics. …”
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Gene Therapy Approaches by Ahmed Jumaa Ahmed, Hogir Saadi

“…Non-viral vectors are much less successful than viral vectors, but because of their low immune responses and their broad therapeutic DNA ability, they have advantages. …”
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SAMHD1 shapes deoxynucleotide triphosphate homeostasis by interconnecting the depletion and biosynthesis of different dNTPs by Claudia McCown, Corey H. Yu, Dmitri N. Ivanov

“…The regulatory relationship between the biosynthesis and depletion of different dNTPs sheds light on the emerging role of SAMHD1 in the biology of dNTP homeostasis with implications for HIV/AIDS, innate antiviral immunity, T cell disorders, telomere maintenance and therapeutic efficacy of nucleoside analogs.…”
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Mechanisms of Action of Mesenchymal Stem Cells in Metabolic-Associated Fatty Liver Disease by Sitong Yi, Qingwei Cong, Ying Zhu, Qiumin Xu

“…They can also reduce liver tissue injury and reverse the development of MAFLD by regulating immune response, antifibrotic activities, and lipid metabolism. …”
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Hepatitis B and C seroprevalence in patients with diabetes mellitus and its relationship with microvascular complications by Kadir Gisi, Ali Cetinkaya, Mesut Ozkaya, Bulent Kantarceken, Gokce Gisi, Sedat Koroglu

“…Introduction: Diabetic patients are susceptible to bacterial, viral and fungal infections because of various deficiencies in the immune system. Aim: To investigate a possible link between hepatitis B/C prevalence and microvascular complications as well as duration of diabetes. …”
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Hubungan Antara Nilai Neutrophil-to-Lymphocyte Ratio (NLR) dengan Kadar Procalcitonin (PCT) pada Pasien COVID-19 di Kabupaten Jember by Sofia Yusnur Rafida, Hairrudin Hairrudin, Muhammad Hasan

“…The neutrophil-to-lymphocyte ratio (NLR) and Procalcitonin (PCT) are biomarkers that represent inflammatory activity and immune status as predictors for the prognosis of COVID-19 patients. …”
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Retraction Note: Extracorporeal membrane oxygenation support for SARS-CoV-2: a multi-centered, prospective, observational study in critically ill 92 patients in Saudi Arabia by Saad Alhumaid, Abbas Al Mutair, Header A. Alghazal, Ali J. Alhaddad, Hassan Al-Helal, Sadiq A. Al Salman, Jalal Alali, Sana Almahmoud, Zulfa M. Alhejy, Ahmad A. Albagshi, Javed Muhammad, Amjad Khan, Tarek Sulaiman, Maha Al-Mozaini, Kuldeep Dhama, Jaffar A. Al-Tawfiq, Ali A. Rabaan

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Sustained and Efficient Delivery of Antivascular Endothelial Growth Factor by the Adeno-associated Virus for the Treatment of Corneal Neovascularization: An Outlook for Its Clinica... by Mengzhen Xie, Lixiang Wang, Yingping Deng, Ke Ma, Hongbo Yin, Xiaolan Zhang, Xingye Xiang, Jing Tang

“…Corneal neovascularization can arise from all conditions of chronic irritation or hypoxia, which disrupts the immune-privileged state of the healthy cornea, increases the risk of rejection after keratoplasty, and leads to opacity. …”
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Small fiber neuropathy: clinical presentation, diagnostic methods, possibly causes and treatment by E. Paulėkas, D. Garšvienė, K. Petrikonis

“…There is a plethora of possible SFN causes, such as metabolic, immune system mediated or neurotoxic factors, although in about 50% of cases, the precise etiology remains unknown. …”
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Elucidating genetic intersections: Co-differentially expressed genes in myasthenia gravis and idiopathic inflammatory myopathies and their role in comorbid pathogenesis by Wenqu Yang, Feng Liang

“…The nomogram model, incorporating three of these co-DEGs, showed high predictive accuracy for MG with IIM complications, with an area under the ROC curve of 0.94. Immune infiltration analysis revealed distinct patterns in MG and IIM, particularly involving gamma delta T cells and activated mast cells. …”
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A case of acute brucellosis associated with HIV infection in Turkey by Fatma Yekta Urkmez, Sevil Alkan

“…Human immunodeficiency virus (HIV)-positive patients are vulnerable to co-infections and super-infections due to targeting the immune system. Because opportunistic infections are considered primarily, it is very difficult to detect co-infections, especially Brucella spp., in this patient group. …”
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Functional Analysis of Monkeypox and Interrelationship between Monkeypox and COVID-19 by Bioinformatic Analysis by Eun Jung Sohn

“…By comparing our data with published transcriptome of severe acute respiratory syndrome coronavirus 2 infections in other cell lines, the common function of monkeypox and COVID-19 includes cytokine signaling in the immune system, TNF signaling, and MAPK cascade regulation. …”
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Cytokines and Cytokine Profiles in Human Autoimmune Diseases and Animal Models of Autoimmunity by Manfred Kunz, Saleh M. Ibrahim

“…In psoriasis, researchers found a particular immune signalling cluster. Moreover the identification of a new subset of inflammatory T cells, so-called Th17 T cells, secreting interleukin (IL)-17 as one of their major cytokines and the identification of the IL-23/IL-17 axis of inflammation regulation, have significantly improved our understanding of autoimmune diseases. …”
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The Effect of Taraxacum officinale Hydroalcoholic Extract on Blood Cells in Mice by Mehrdad Modaresi, Narges Resalatpour

“…Dandelion has been used as a remedy for anemia, purifing the blood, and providing immune modulation. Therefore, the aim of this study was to investigate the effect of hydro alcoholic extract on blood cells in mice. …”
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One-year surveillance of Chlamydia spp. infection in stray cats from northeastern Italy by Laura Bellinati, Letizia Ceglie, Elisa Mazzotta, Mery Campalto, Laura Lucchese, Alda Natale

“…Infection is more frequent in conditions of overcrowding, stress, poor hygiene and impairment of the immune system. For this reason, stray cats appear to be particularly susceptible to this pathogen. …”
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