Multifunctional biosynthesized magnetosome for multimodal imaging and combined therapy of tumor by Xiaoqing Han, Xingbo Wang, Jiao Yan, Panpan Song, Yanjing Wang, Yaqing Kang, Abdur Rauf, Haiyuan Zhang

“…Moreover, photothermal and photodynamic effect of IR780 could kill tumor cells and elicit immunogenic cell death to mediate anti-tumor immunity, promoting dendritic cells (DCs) maturation and then activating specific effector T cells to further eliminate tumor cells. …”
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Bioinformatics approaches to multi-omics analysis of the potential of CDKN2A as a biomarker and therapeutic target for uterine corpus endometrial carcinoma by Liang Ma, Yuling Li, Jingxian Wu, Yanfei Gao

“…The expression levels, signaling pathways, and copy number variations of CDKN2A in UCEC were explored, along with its immune cell subset associations. CDKN2A expression was found to be elevated in UCEC, particularly in the signaling pathways involved in cell proliferation and inflammation. …”
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Synthetic peptides as valuable and versatile tools for research: our 20 year journey in Chile by Constanza Cárdenas, Paula Santana, Claudio Álvarez, Luis Mercado, Sergio Marshall, Fernando Albericio, Fanny Guzmán

“…They are ubiquitous across the evolutionary scale, fulfilling a wide variety of functions, from immune system effectors in simple organisms to signaling or neuromodulating agents in high vertebrates. …”
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Apaf-1 is an evolutionarily conserved DNA sensor that switches the cell fate between apoptosis and inflammation by Jie Ruan, Xuxia Wei, Suizhi Li, Zijian Ye, Linyi Hu, Ru Zhuang, Yange Cao, Shaozhou Wang, Shengpeng Wu, Dezhi Peng, Shangwu Chen, Shaochun Yuan, Anlong Xu

“…Although Apaf-1 structurally resembles animal NOD-like receptor (NLR) and plant resistance (R) proteins, whether it is directly involved in innate immunity is still largely unknown. Here, we found that Apaf-1-like molecules from lancelets, fruit flies, mice, and humans have conserved DNA sensing functionality. …”
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Revolution of blood cancer treatment in the oral cavity: Breakthroughs in nanotherapy by Pavithra Bharathy, Elizabeth Rani E, Punniyakoti V. Thanikachalam

“…However, challenges exist in addressing the heterogeneity of blood cancers in the oral cavity, navigating the tumor microenvironment, overcoming drug resistance, and modulating immune evasion. Future directions include individualized treatment plans, multifunctional nanoparticles, combination therapies, and improved nanoparticle design. …”
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Failure of colonization following gut microbiota transfer exacerbates DSS-induced colitis by Kevin L. Gustafson, Trevor R. Rodriguez, Zachary L. McAdams, Lyndon M. Coghill, Aaron C. Ericsson, Craig L. Franklin

“…Mice receiving a low richness GM via CH and gastric gavage exhibited greater disease severity and higher expression of pro-inflammatory immune mediators compared to those receiving a high richness GM. …”
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A Framework to Examine the Role of Epigenetics in Health Disparities among Native Americans by Teresa N. Brockie, Morgan Heinzelmann, Jessica Gill

“…Psychiatric disorders are also associated with methylation differences in endocrine, immune, and neurotransmitter genes that serve to regulate the stress response and are linked to psychiatric symptoms and medical morbidity. …”
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L-arabinose alleviates constipation through gastrointestinal peptide，gut microbiota，and Phlpp2 of gastrointestinal rhythms in rats by Ting Gong, Linzheng Liao, Yong Tang, Weiwei Liu, Ling Yao, Zhen Wu, Jianmei Li, Fulai Bai, Qian Zhang, Liling Tang

“…These results indicate that L-arabinose not only alleviates constipation but also enhances immune function and regulates signaling pathways, restoring gastrointestinal peptides to near-normal levels.…”
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The unseen perils of oral-care products generated micro/nanoplastics on human health by Utsa Saha, Snehasmita Jena, Faizan Zarreen Simnani, Dibyangshee Singh, Anmol Choudhury, Shaikh Sheeran Naser, Sudakshya S. Lenka, Apoorv Kirti, Aditya Nandi, Adrija Sinha, Swadheena Patro, Małgorzata Kujawska, Mrutyunjay Suar, Nagendra Kumar Kaushik, Aishee Ghosh, Suresh K. Verma

“…MPs/NPs released during dental procedures can be ingested, leading to immune suppression, tissue fibrosis, and systemic toxicities. …”
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Pulmonary Histoplasmosis in a Referral Hospital in Mexico City by Alejandro Hernández Solís, Javier Araiza Santibáñez, Jazmín Guadalupe Tejeda Olán, Andrea Quintana Martínez, Alejandro Hernández de la Torriente, Rocio de la Torriente Mata

“…The signs and symptoms of the disease are mediated by the immune status of the host. The clinical picture is often confused with systemic diseases. …”
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Hepatitis E rORF2p Stimulated and Unstimulated Peripheral Expression Profiling in Patients with Self-Limiting Hepatitis E Infection by Sanjay B. Rathod, Anuradha S. Tripathy

“…The observed upregulations of inhibitory, integrin, activatory, and Treg-associated cytokine genes on the PBMCs of acute HEV patients complemented by their frequency data suggest them as the major players in the fine-tuning of immune response in self-limiting hepatitis E infection.…”
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Oral Verruciform Xanthoma within Lichen Planus: A Case Report and Literature Review by Vasileios I. Theofilou, Alexandra Sklavounou, Prokopios P. Argyris, Evanthia Chrysomali

“…The occurrence of the lesion in patients with immune-mediated mucocutaneous diseases may suggest a role of localized epithelial cell damage and chronic inflammation in its pathogenesis. …”
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PBC: Animal Models of Cholangiopathies and Possible Endogenous Viral Infections by Masashi Ninomiya, Yoshiyuki Ueno, Tooru Shimosegawa

“…Primary Biliary Cirrhosis (PBC) is considered an autoimmune disease characterized by immune-mediated destruction of the intrahepatic bile ducts and its characteristic serologic marker, the anti-mitochondrial antibody (AMA). …”
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Clade 2.3.4.4b but not historical clade 1 HA replicating RNA vaccine protects against bovine H5N1 challenge in mice by David W. Hawman, Thomas Tipih, Eddie Hodge, E. Taylor Stone, Nikole Warner, Natalie McCarthy, Brian Granger, Kimberly Meade-White, Shanna Leventhal, Kiara Hatzakis, Stephanie Park, Karen Gaffney, Kyle Rosenke, Jesse H. Erasmus, Heinz Feldmann

“…Our data highlight the utility of nucleic acid vaccines to be rapidly updated to match emergent viruses of concern while demonstrating that contemporary bovine H5N1 viruses can evade immunity elicited by historical HA antigens.…”
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Effects of <i>Echinacea purpurea</i> and Alkylamides on Respiratory Virus Replication and IL-8 Expression In Vitro by Keely Puchalski, Johanne A. Gerstel, Abiola Jimoh, Yalda Shokoohinia, Jeffrey Langland

“…Although previous research suggests that the alkylamides present in <i>Echinacea</i> may be responsible for reducing the symptoms associated with the common cold or flu through their immunomodulatory activity, the roles of specific alkylamides and their targets (i.e., immune and/or antiviral) have not been well-elucidated or established. …”
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Efficacy of melatonin treatment in a cystic fibrosis mouse model of airway infection by Kristen R. Schaefer, Sara Rogers, Zachary Faber, Thomas J. Kelley

“…Abstract Approaches to mitigate the severity of infections and of immune responses are still needed for the treatment of cystic fibrosis (CF) even with the success of highly effective modulator therapies. …”
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Siltuximab for chimeric antigen receptor T-cell therapy–related CRS and ICANS: a multicenter retrospective analysis by Amneet Bajwa, Qiuhong Zhao, Marcus Geer, Chenyu Lin, James Westholder, Joseph Maakaron, Monalisa Ghosh, David Frame, Ahmed Galal, Justin Tossey, Nausheen Ahmed, Evandro Bezerra, Nathan Denlinger, Marcos de Lima, Narendranath Epperla, Paolo Caimi, Timothy Voorhees

“…Abstract: Chimeric antigen receptor T-cell (CAR-T) therapies are effective in many hematologic malignancies; however, adverse events including cytokine release syndrome (CRS) and immune effector cell–associated neurotoxicity syndrome (ICANS) can affect a significant number of patients. …”
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Therapeutic implications and comprehensive insights into cellular senescence and aging in the tumor microenvironment of sarcoma by Pengfei Zan, Yi Zhang, Yidong Zhu, Qingjing Chen, Zhengwei Duan, Yonghao Guan, Kaiyuan Liu, Anquan Shang, Zihua Li

“…In this study, we revealed that senescence level and age were associated with TME, immune treatment indicators, and prognosis in SARC. …”
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Erythropoietin, Forkhead Proteins, and Oxidative Injury: Biomarkers and Biology by Kenneth Maiese, Jinling Hou, Zhao Zhong Chong, Yan Chen Shang

“…In particular, both the growth factor and cytokine erythropoietin (EPO), and members of the mammalian forkhead transcription factors of the O class (FoxOs), may offer the greatest promise for new treatment regimens, since these agents and the cellular pathways they oversee cover a range of critical functions that directly influence progenitor cell development, cell survival and degeneration, metabolism, immune function, and cancer cell invasion. Furthermore, both EPO and FoxOs function not only as therapeutic targets, but also as biomarkers of disease onset and progression, since their cellular pathways are closely linked and overlap with several unique signal transduction pathways. …”
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A high-quality chromosome-scale genome assembly of the Cherokee rose (Rosa laevigata) by Yi Wang, Huijun Yan, Xianqin Qiu, Hao Zhang, Yonghong Zhang, Hongying Jian

“…Abstract Rosa laevigata is an excellent rose germplasm, highly resistant to aphid, and immune to both rose black spot and powdery mildew disease. …”
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