Poly ADP-Ribosylation in a Plant Pathogenic Oomycete <i>Phytophthora infestans</i>: A Key Controller of Growth and Host Plant Colonisation by Viktoriya O. Samarskaya, Sofya Koblova, Tatiana Suprunova, Eugene A. Rogozhin, Nadezhda Spechenkova, Sofiya Yakunina, Andrew J. Love, Natalia O. Kalinina, Michael Taliansky

“…ADP-ribosylation is a reversible modification of proteins and nucleic acids, which controls major cellular processes, including DNA damage repair, cell proliferation and differentiation, metabolism, stress, and immunity in plants and animals. The involvement of ADP-ribosylation in the life cycle of <i>Dictyostelium</i> and some filamentous fungi has also been demonstrated. …”
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Activated Circulating T Follicular Helper Cells Are Associated with Disease Severity in Patients with Psoriasis by Ying Wang, Lili Wang, Haoyu Yang, Weichang Yuan, Jingyi Ren, Yanping Bai

“…Circulating T follicular helper (cTfh) cells are known to be involved in numerous immune-mediated diseases, but their pathological role in psoriasis is less fully investigated. …”
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ANGPTL4 induces Kupffer cell M2 polarization to mitigate acute rejection in liver transplantation by Weifeng Huang, Liqing Jiang, Yingsong Jiang, Shanshan Li, Wanqi Liu, Kezhen Zong, Dadi Peng, Zhongjun Wu, Zuotian Huang

“…Using a rat orthotopic liver transplantation model, we observed reduced ANGPTL4 expression during AR, whereas increased ANGPTL4 levels were linked to immune tolerance. Administration of ANGPTL4 recombinant protein improved liver function, suppressed inflammation, and promoted M2 polarization of KCs. …”
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The IVIG treatment response in autoimmune polyendocrine syndromes type 2 with anti-GAD65 antibody-associated stiff person syndrome: a case report and literature review by Yulong Yang, Hailin Jiang, Wenming Yang, Wenming Yang, Wenming Yang, Han Wang, Han Wang, Meixia Wang, Meixia Wang, Xiang Li, Peng Huang, Shuzhen Fang, Wenjie Hao, Yue Yang, Furong Zhao, Wei He

“…Autoimmune polyendocrine syndromes (APS) is a rare group of disorders caused by impaired function of multiple endocrine glands due to disruption of immune tolerance. Of which, type 2 (APS-2) is the most common. …”
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Food nutrition and toxicology targeting on specific organs in the era of single-cell sequencing by Xiaofei Wang, Xiaowen Cheng, Huiling Liu, Xiaohuan Mu, Hao Zheng

“…ScRNA-seq applications has been summarized on three typical organs (brain, liver, kidney), and two representative immune- and tumor related health problems. The ever-increasing role of scRNA-seq in dietary food research with further improvement can provide sub-cellular information and the coupling between other cellular modalities. …”
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Impact of Chlorella sorokiniana feed additive on poultry growth health and oxidative stress in erythrocytes by Ioannis Tsamesidis, Anastasia Pappa, Aggelos Charisis, Zoi Prentza, Konstantinos Theocharis, Apostolos Patsias, Dimitrios Foukas, Christos Chatzidoukas, Eleni P. Kalogianni

“…Growth performance parameters (weight, feed conversion ratio (FCR), mortality, European Production Efficiency Index (EPEF)) and the immune system response are examined. In addition, it examines well-being gut health and nutrient absorption related variables via macroscopical and histological analysis. …”
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Suppression of Th17 Cell Response in the Alleviation of Dextran Sulfate Sodium-Induced Colitis by Ganoderma lucidum Polysaccharides by Bing Wei, Ran Zhang, Jingbo Zhai, Junfeng Zhu, Fangli Yang, Dan Yue, Xiaoyi Liu, Changlong Lu, Xun Sun

“…Ganoderma lucidum polysaccharides (GLP) has anti-inflammatory and immunomodulatory effects. Dysregulated immune responses are involved in the pathogenesis of dextran sulfate sodium (DSS)-induced colitis. …”
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Rejection of the Covid-19 Vaccination in Community Sidourip Village-Beringin District by Nanda Novziransyah, Budi Kurniawan, Mayasari Rahmadhani, Ira Aini Dania, Dewi Pangestuti, Maimunah R.

“…The aim of Covid-19 vaccination is to reduce spread, morbidity and mortality, achieve immunity and protect the public. However, there are still many groups of people who refuse to be vaccinated. …”
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Transcriptomic Analysis Reveals Molecular Mechanisms Underpinning Mycovirus-Mediated Hypervirulence in <i>Beauveria bassiana</i> Infecting <i>Tenebrio molitor</i> by Charalampos Filippou, Robert H. A. Coutts, Ioly Kotta-Loizou, Sam El-Kamand, Alexie Papanicolaou

“…These observations suggest that detoxification of immune-related (oxidative) defenses and nutrient scouting, as mediated by these genes, occurs in mid-infection during the internal growth phase. …”
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Roles of fermented plant-, dairy- and meat-based foods in the modulation of allergic responses by Muhamad Hafiz Abd Rahim, Nur Hazlin Hazrin-Chong, Hanis Hazeera Harith, Wan Abd Al Qadr Imad Wan-Mohtar, Rashidah Sukor

“…Positive outcomes on AR through fermented foods could be linked to microbial hydrolysis of food allergens, improvement in gut microbiota robustness, and modulation of the immune system that promotes a balance between T helper 1 (Th1) and Th2 cells. …”
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Congenital T-cell activation impairs transitional-to-follicular B-cell maturation in humans by Hugues Allard-Chamard, Kirsty Hillier, Michelle L. Ramseier, Alice Bertocchi, Naoki Kaneko, Katherine Premo, Grace Yuen, Marshall Karpel, Vinay S. Mahajan, Christina Tsekeri, Joseph S. Hong, Jean Vencic, Rory Crotty, Anish V. Sharda, Sara Barmettler, Emma Westermann-Clark, Jolan E. Walter, Musie Ghebremichael, Alex K. Shalek, Jocelyn R. Farmer, Shiv Pillai

“…Abstract: Patients with cytotoxic T-lymphocyte–associated protein 4 (CTLA4) deficiency exhibit profound humoral immune dysfunction, yet the basis for the B-cell defect is not known. …”
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Unravelling the TCRβ repertoire: a key to unlocking the immunopathogenesis and precision medicine in SLE by Qiao Zhou, Li Zeng, Zhixin Zhang, Jian Liu, Yichen Zhang, Yang An, Lijing Yang, Tianzuo Lan, Pengming He, Xueping Wen, Shaoping Deng

“…Objectives SLE is a multifaceted autoimmune disorder with a complex pathogenesis involving genetic, environmental and hormonal factors, which converge on immune dysregulation. The T cell receptor (TCR) repertoire’s role in SLE has garnered significant interest due to its potential in both diagnostics and therapeutics. …”
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Interaction of Herbal Compounds with Biological Targets: A Case Study with Berberine by Xiao-Wu Chen, Yuan Ming Di, Jian Zhang, Zhi-Wei Zhou, Chun Guang Li, Shu-Feng Zhou

“…Based on the biological process classification of in vitro berberine targets, those targets related to signal transduction, intracellular signalling cascade, cell surface receptor-linked signal transduction, cell motion, cell cycle control, immunity system process, and protein metabolic process are most frequently involved. …”
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Autologous CIK Cell Immunotherapy in Patients with Renal Cell Carcinoma after Radical Nephrectomy by Yajing Zhang, Jin Wang, Yao Wang, Xue-Chun Lu, Hui Fan, Yang Liu, Yan Zhang, Kai-Chao Feng, Wen-Ying Zhang, Mei-Xia Chen, Xiaobing Fu, Wei-Dong Han

“…CIK cells treatment could prolong survival in patients with RCC after radical nephrectomy and showed acceptable curative effect with potential enhancement of cellular immune function. This trial is registered with Clinicaltrials.gov NCT01799083.…”
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Benzylthiouracil-Induced Glomerulonephritis by Sihem Trimeche Ajmi, Rim Braham, Sarra Toumi, Molka Chadli Chaieb, Amel Maaroufi, Koussay Ach, Larbi Chaieb

“…A renal biopsy was performed and revealed pauci-immune extracapillary glomerular nephropathy and necrotic vasculitis lesions. …”
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Virally-initiated pain states: phenotypes, mechanisms, and future directions by Sara A. Dochnal, Steven P. Cohen, Mark R. Hutchinson, Mark R. Hutchinson, Mark R. Hutchinson, Yury I. Miller, Tony L. Yaksh

“…These virally induced pain states can arise through direct viral replication within neurons, or indirectly, via immune responses to infection in both the contexts of afferent signaling in the dorsal root ganglion (DRG) or subsequent higher order integration in intracranial systems. …”
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Microbiome interplays in the gut-liver axis: implications for liver cancer pathogenesis and therapeutic insights by Xuran Wang, Bin Zhang, Runqiu Jiang

“…In this review, we present the concept of Gut-Liver Axis and its function in the mutual influence between gut microbiota and PLC from several aspects in which we will focus on the structure of gut barrier and the functional influences the gut microbiota have on the immune response and metabolic changes on human liver. …”
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Preclinical assessment of splicing modulation therapy for ABCA4 variant c.768G>T in Stargardt disease by Dyah W. Karjosukarso, Femke Bukkems, Lonneke Duijkers, Tomasz Z. Tomkiewicz, Julia Kiefmann, Andrei Sarlea, Sander Bervoets, Irene Vázquez-Domínguez, Laurie L. Molday, Robert S. Molday, Mihai G. Netea, Carel B. Hoyng, Alejandro Garanto, Rob W. J. Collin

“…No major safety concerns regarding off-targets, immunostimulation and toxicity are observed in transcriptomics analysis, cytokine stimulation assays in human primary immune cells, and cytotoxicity assays. Conclusions Additional optimization and in vivo studies will be performed to further investigate the lead candidate. …”
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Maternal–Foetal Effects of Exposure to Bisphenol A: Outcomes and Long-Term Consequences by Henrique Eloi Costa, Ines Medeiros, Melissa Mariana, Elisa Cairrao

“…Specifically, BPA exposure affects the immune system of the offspring and promotes the development of respiratory diseases, including asthma and wheezing. …”
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Sustainable Immunomodulatory via Macrophage P2Y12 Inhibition Mediated Bioactive Patche for Peritendinous Antiadhesion by Zaijin Tao, Shuo Wang, Jingwen Liu, Tonghe Zhu, Jia Jiang, Shen Liu, Xin Ma

“…Although modified anti‐adhesion barriers have been studied extensively, the immune response induced by the implants and the unclear mechanism limits their application. …”
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