Decreased Interleukin-4 Release from the Neurons of the Locus Coeruleus in Response to Immobilization Stress by Hyun-ju Lee, Hyun-Jung Park, Angela Starkweather, Kyungeh An, Insop Shim

“…Interleukin-4 (IL-4), an anti-inflammatory cytokine, is known to regulate inflammation caused by immune challenge but the effect of IMO on modulation of IL-4 expression in the brain has not been assessed yet. …”
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Adaptive evolution of SARS-CoV-2 during a persistent infection for 521 days in an immunocompromised patient by Hanno Schmidt, Lea Schick, Jürgen Podlech, Angélique Renzaho, Bettina Lieb, Stefan Diederich, Thomas Hankeln, Bodo Plachter, Oliver Kriege

“…Abstract Immunocompromised patients struggle to adequately clear viral infections, offering the virus the opportunity to adapt to the immune system in the host. Here we present a case study of a patient undergoing allogeneic hematopoietic stem cell transplantation with a 521-day follow-up of a SARS-CoV-2 infection with the BF.7.21 variant. …”
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Central nervous system B-cell lymphoma in a patient diagnosed with chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids: A case report by Evangelos Koumasopoulos, Evangelia-Anna Spiteri, Aigli G Vakrakou, Panagiotis Toulas, Georgios Velonakis, George Stranjalis, Leonidas Stefanis, Maria-Eleptheria Evangelopoulos, Maria Anagnostouli

“…In our opinion, the presented case supports the putative neoplastic nature of the disease, at least in the long term, and/or along with Epstein–Barr virus involvement, which is known that have been related to other immune-mediated diseases such as multiple sclerosis and malignancies, especially with specific human leukocyte antigen haplotypes. …”
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Intrathyroidal Clear Cell Tumor of Parathyroid Origin with Review of Literature by Daniela Pirela, Daniela Treitl, Siba El Hussein, Robert Poppiti, Thomas Mesko, Alex Manzano

“…The histologic appearance together with the immune profile was diagnostic of WCCA, with diffuse positivity for GATA3, focal weak positivity for parathyroid hormone, and negativity for PAX8, thyroglobulin, TTF1, synaptophysin, chromogranin, and S100p. …”
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Ring Defects Associated with Boron–Oxygen‐Related Degradation in p‐Type Silicon Heterojunction Solar Cells by Bruno Vicari Stefani, Moonyong Kim, Matthew Wright, Anastasia Soeriyadi, Ilya Nyapshaev, Konstantin Emtsev, Brett Hallam

“…Therefore, it is typically assumed that SHJ cells are immune to such defects. This contrasts with the high‐temperature passivated emitter and rear cell (PERC) and tunneling oxide passivating contact (TOPCon) architectures, which can suffer from oxygen precipitates that are recombination active and difficult to predict. …”
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Novel target and cofactor repertoire for the transcriptional regulator JTY_0672 from Mycobacterium bovis BCG by Hui Wang, Xiaotian Li, Shuxian Wang, Ren Fang, Jiayin Xing, Ruiying Wu, Chunhui Zhang, Zhaoli Li, Ningning Song

“…Besides, this protein either promoted recalcitrance to the host immune response and induced pathological injury and inflammation. …”
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Clinical Characteristics of Three Cases with SAMD9/SAMD9L Gene Mutations by ZHU Ke, SUN Bijun, WANG Wenjie, ZHOU Qinhua, LIU Luyao, HOU Jia, WANG Xiaochuan, SUN Jinqiao

“…All patients presented with recurrent infections, growth retardation, and myelodys-plasia, with varying degrees of involvement of multiple systems, including respiratory, gastrointestinal, immune, endocrine, neurological, and reproductive systems. …”
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Multiple sclerosis diagnosis with brain MRI retrieval: A deep learning approach by R.M. Haggag, Eman M. Ali, M.E. Khalifa, Mohamed Taha

“…Multiple Sclerosis (MS) is an auto-immune disorder affecting the central nervous system, affecting 2.8 million people worldwide. …”
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Proteomic Analysis of Exudates from Chronic Ulcer of Diabetic Foot Treated with Scorpion Antimicrobial Peptide by Zhixiang Tan, Zhiguo Yu, Xiaobo Xu, Lanxia Meng, Mosheng Yu, Rui Tao, Yingliang Wu, Zhanyong Zhu

“…Inhibited biological functions such as cell death, inflammatory response, immune diseases, and bacterial growth were also involved. …”
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B7-H4 Pathway in Islet Transplantation and β-Cell Replacement Therapies by Xiaojie Wang, Jianqiang Hao, Daniel L. Metzger, Ziliang Ao, Mark Meloche, C. Bruce Verchere, Lieping Chen, Dawei Ou, Alice Mui, Garth L. Warnock

“…More importantly, B7-H4 plays an indispensable role in alloimmunity in the absence of the classic CD28/CTLA-4 : B7 pathway, suggesting a synergistic/additive effect with other agents such as CTLA-4 on inhibition of unwanted immune responses.…”
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Data Mining Mycobacterium tuberculosis Pathogenic Gene Transcription Factors and Their Regulatory Network Nodes by Guangxin Yuan, Yu Bai, Yuhang Zhang, Guangyu Xu

“…It was predicted that IL-6, JUN, and TP53, along with transcription factors SRC, TNF, and MAPK14, could regulate the immune response, with their function being extracellular region activity and protein binding during infection with M. tuberculosis.…”
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Alloreactive-free CAR-VST therapy: a step forward in long-term tumor control in viral context by Valentine Wang, Barbara Savoldo, José-Arthur Guimaraes, Gianpietro Dotti, Loïc Reppel, Loïc Reppel, Danièle Bensoussan, Danièle Bensoussan

“…This review provides a comprehensive overview of CAR-VST development, emphasizing strategies to mitigate immunogenicity, such as using a specialized TCR, and approaches to improve therapeutic persistence against host immune responses. In this review, we discuss the production methods of CAR-VSTs and explore optimization strategies to enhance their functionality, activation profiles, memory persistence, and exhaustion resistance. …”
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Mechanisms and Emerging Regulators of Neuroinflammation: Exploring New Therapeutic Strategies for Neurological Disorders by Mi Eun Kim, Jun Sik Lee

“…This review explores the cellular and molecular mechanisms underlying neuroinflammation, focusing on the roles of microglia, astrocytes, and peripheral immune cells. Key signaling pathways, including NF-κB, JAK-STAT, and the NLRP3 inflammasome, are discussed alongside emerging regulators such as non-coding RNAs, epigenetic modifications, and the gut–brain axis. …”
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Intraperitoneal Injection of Multiplacentas Pooled Cells Treatment on a Mouse Model with Aplastic Anemia by Jun Li, Hong Chen, Yan-Bo Lv, Qiang Wang, Zheng-Jun Xie, Li-Hua Ma, Jie He, Wei Xue, Shan Yu, Jun Guo, Ting-Hua Wang, Tian-Xi Wu, Xing-Hua Pan

“…Multiplacentas pooled cells were intraperitoneally injected into a radiation- and immunity-induced mouse aplastic anemia model with single time. …”
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Cellular and Molecular Mediators of Neuroinflammation in the Pathogenesis of Parkinson’s Disease by Sandeep Vasant More, Hemant Kumar, In Su Kim, Soo-Yeol Song, Dong-Kug Choi

“…Microglia, the resident innate immune cells, may play a major role in the inflammatory process of the diseased brain of patients with PD. …”
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Robust Band-Pass Filter-Based PLL-Less Approach for Three-Phase Nonsinusoidal Grid Conditions by Manish Kumar, Anant Kumar Verma, Claudio Burgos-Mellado, Raj Kumar Jarial, Ravinder Nath, Bhumaiah Jula, Diego Munoz-Carpintero, Catalina Gonzalez-Castano, Pedro Roncero-Sanchez

“…This work presents a PLL-less grid synchronization solution for three-phase applications to counter the slower dynamic response and demonstrate better immunity against the nonideality of a three-phase grid. …”
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Naltriben promotes tumor growth by activating the TRPM7-mediated development of the anti-inflammatory M2 phenotype by Viviane Nascimento Da Conceicao, Yuyang Sun, Manigandan Venkatesan, Jorge De La Chapa Chapa, Karthik Ramachandran, Rahul S. Jasrotia, Victor Drel, Xiufang Chai, Bibhuti B. Mishra, Muniswamy Madesh, Brij B. Singh

“…Abstract Macrophage plasticity is critical for maintaining immune function and developing solid tumors; however, the macrophage polarization mechanism remains incompletely understood. …”
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Emerging roles of circular RNAs on the regulation of production traits in chicken by Guishuang You, Hong Long, Xiaoxu Shen, Huadong Yin, Shibin Zhang

“…Recent studies have demonstrated that circRNAs are extensively engaged in numerous production traits, which include skeletal muscle formation, fat deposition, ovarian follicle development, liver function, bone development, immunity, and resistance to environmental stress. These processes play crucial roles in determining the overall productivity of chickens. …”
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Physical Activity Protects the Human Brain against Metabolic Stress Induced by a Postprandial and Chronic Inflammation by Leo Pruimboom, Charles L. Raison, Frits A. J. Muskiet

“…We review evidence that lack of physical activity induces chronic low-grade inflammation and, consequently, an energy conflict between the selfish immune system and the selfish brain. Although the notion that increased physical activity would improve health in the modern world is widespread, here we provide a novel perspective on this truism by providing evidence that recovery of normal human behaviour, such as spontaneous physical activity, would calm proinflammatory activity, thereby allocating more energy to the brain and other organs, and by doing so would improve human health.…”
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F4/80+ Host Macrophages Are a Barrier to Murine Embryonic Stem Cell-Derived Hematopoietic Progenitor Engraftment In Vivo by Heather L. Thompson, Nico van Rooijen, Bryce T. McLelland, Jennifer O. Manilay

“…Understanding how embryonic stem cells and their derivatives interact with the adult host immune system is critical to developing their therapeutic potential. …”
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