Spontaneous base flipping helps drive Nsp15’s preferences in double stranded RNA substrates by Zoe M. Wright, Kevin John Butay, Juno M. Krahn, Isha M. Wilson, Scott A. Gabel, Eugene F. DeRose, Israa S. Hissein, Jason G. Williams, Mario J. Borgnia, Meredith N. Frazier, Geoffrey A. Mueller, Robin E. Stanley

“…Abstract Coronaviruses evade detection by the host immune system with the help of the endoribonuclease Nsp15, which regulates levels of viral double stranded RNA by cleaving 3′ of uridine (U). …”
Get full text

New Potential Weapons for Refractory Scleritis in the Era of Targeted Therapy by Claudia Fabiani, Jurgen Sota, Maite Sainz-de-la-Maza, Laura Pelegrín, Giacomo Emmi, Giuseppe Lopalco, Florenzo Iannone, Lorenzo Vannozzi, Silvana Guerriero, Maria Chiara Gelmi, Donato Rigante, Gian Marco Tosi, José Hernández-Rodríguez, Luca Cantarini

“…To assess the efficacy of biologic drugs, beyond tumor necrosis factor- (TNF-) α inhibitors, in the management of noninfectious refractory scleritis, either idiopathic or associated with systemic immune-mediated disorders. Patients and Methods. This is a retrospective study assessing the efficacy of several biologic agents (rituximab, anakinra, tocilizumab, and abatacept) and the small molecule tofacitinib in the treatment of scleritis through assessment of scleral inflammation and relapses, as well as treatment impact on best-corrected visual acuity (BCVA) and safety profile. …”
Get full text

Hib Vaccines: Past, Present, and Future Perspectives by Adi Essam Zarei, Hussein A. Almehdar, Elrashdy M. Redwan

“…While earlier developments of adjuvants created effective products, there is still a need to create new generations, rationally designed based on recent discoveries in immunology, mainly in innate immunity. Many factors may play a role in the immunogenicity of Hib conjugate vaccines, such as the polysaccharides and proteins carrier used in vaccine construction, as well as the method of conjugation. …”
Get full text

Adding glucose combined with microalgae to water improves the benefits of the fungal community on the whiteleg shrimp (Litopenaeus vannamei) culture by Bilal Raza, Jiangdong Ke, Lin Chen, Yikai Shi, Jinyong Zhu, Zeyu Shao, Zhongming Zheng, Kaihong Lu, Wen Yang

“…Moreover, Aspergillus was indentified as both the biomarkers and modular nodes in co-occurrence network, domonstrating its strong association with non-specific immune enzyme activities of shrimp. Network topology analysis showed that the N. oculata and glucose combined promoted the complexity and amplified the proportion of negative edges in the fungal network, thereby enhacing the stability of the fungal community. …”
Get full text

Extraction, Purification, Structural Characteristics, Biological Activities, and Applications of Polysaccharides from <i>Gastrodia elata</i>: A Review by Yan Yang, Yonglin Hai, Yongcheng Yang, Rouyuan Wen, Le Wang, Yan Qian, Jiaxian Zhang, Yongguo Li, Zhilong Shi, Haizhu Zhang

“…Recent studies have revealed various biological activities associated with <i>G. elata</i> polysaccharides, including antioxidant, anti-tumor, anti-inflammatory, antibacterial, anti-aging, immune regulation, and neuroprotective properties. …”
Get full text

Population-Level SARS-CoV-2 RT–PCR Cycle Threshold Values and Their Relationships with COVID-19 Transmission and Outcome Metrics: A Time Series Analysis Across Pandemic Years by Judith Carolina De Arcos-Jiménez, Ernestina Quintero-Salgado, Pedro Martínez-Ayala, Gustavo Rosales-Chávez, Roberto Miguel Damian-Negrete, Oscar Francisco Fernández-Diaz, Mariana del Rocio Ruiz-Briseño, Rosendo López-Romo, Patricia Noemi Vargas-Becerra, Ruth Rodríguez-Montaño, Ana María López-Yáñez, Jaime Briseno-Ramirez

“…The study further observed a weakening association in later pandemic stages, likely influenced by the emergence of new variants, hybrid immunity, changes in human behavior, and diagnostic shifts. …”
Get full text

Current landscape and future prospects of interleukin-2 receptor (IL-2R) agonists in cancer immunotherapy by Kengo Tanigawa, William L. Redmond

“…Immune checkpoint blockade (ICB) has significantly improved the survival for many patients with advanced malignancy. …”
Get full text

Advances in the treatment of glioma-related signaling pathways and mechanisms by metformin by Xingyuan Ma, Xingyuan Ma, Chao Sun, Xiao Ding, Yuhang Zhang, Yuhang Zhang, Tingzhen Deng, Tingzhen Deng, Yatao Wang, Yatao Wang, Haijun Yang, Haijun Yang, Ruiwen Ding, Ruiwen Ding, Haotian Li, Haotian Li, Dawen Wang, Dawen Wang, Maohua Zheng, Maohua Zheng

“…Metformin’s inhibition of glioma proliferation involves complex cellular processes, including mitochondrial dysfunction, increased reactive oxygen species (ROS) production, and modulation of immune responses. Additionally, metformin affects glioma stem cells by inhibiting key pathways, including STAT3, mTOR, and AKT, and altering the tumor microenvironment. …”
Get full text

Advancing risk stratification in kidney transplantation: integrating HLA-derived T-cell epitope and B-cell epitope matching algorithms for enhanced predictive accuracy of HLA compa... by Matthias Niemann, Matthias Niemann, Benedict M. Matern, Benedict M. Matern, Gaurav Gupta, Bekir Tanriover, Fabian Halleck, Klemens Budde, Eric Spierings, Eric Spierings

“…IntroductionThe immune-mediated rejection of transplanted organs is a complex interplay between T cells and B cells, where the recognition of HLA-derived epitopes plays a crucial role. …”
Get full text

Clinical Features and Genetic Analysis of 20 Chinese Patients with X-Linked Hyper-IgM Syndrome by Lin-Lin Wang, Wei Zhou, Wei Zhao, Zhi-Qing Tian, Wei-Fan Wang, Xiao-Fang Wang, Tong-Xin Chen

“…Six patients received hematopoietic stem cell transplantations and four of them had immune reconstructions and clinical remissions. Eighteen unique mutations in CD40L gene were identified in these 20 patients from 19 unrelated families, with 12 novel mutations. …”
Get full text

Cell deconvolution-based integrated time-series network of whole blood transcriptome reveals systemic antiviral activities and cell-specific immunological changes against PRRSV inf... by Byeonghwi Lim, Chiwoong Lim, Min-Jae Jang, Young-Jun Seo, Do-Young Kim, Christopher K. Tuggle, Kyu-Sang Lim, Jun-Mo Kim

“…This study highlights the time-series antiviral activities associated with viremia and the transcriptomic changes associated with immune responses in specific cell types. The findings provide comprehensive insights into host responses to PRRSV infection, including diagnostic biomarkers.…”
Get full text

Altered Phenotype of Circulating Dendritic Cells and Regulatory T Cells from Patients with Acute Myocarditis by Paola del Carmen Guerra-de-Blas, Daniela Cruz-González, Elena B. Martínez-Shio, Roberto González-Amaro, Héctor González-Pacheco, Esther Layseca-Espinosa, Carlos D. Escobedo-Uribe, Adriana E. Monsiváis-Urenda

“…This proinflammatory status may contribute to the pathogenesis and immune deregulation in acute myocarditis.…”
Get full text

Mesenchymal Stromal Cells Are More Immunosuppressive In Vitro If They Are Derived from Endometriotic Lesions than from Eutopic Endometrium by Fawaz Abomaray, Sebastian Gidlöf, Cecilia Götherström

“…Endometriosis is an inflammatory disease with predominance of immunosuppressive M2 macrophages in the pelvic cavity that could be involved in the pathology through support and immune escape of ectopic lesions. Mesenchymal stromal cells (MSC) are found in ectopic lesions, and MSC from nonendometriosis sources are known to induce M2 macrophages. …”
Get full text

Nutritional supplementation, combined with a balanced diet and environmental health education, improved the conversion of LTBI and daily nutrient intake by Samsidi Suparman, Fahri Sukmal, Nur Fauziyah Roro, Dewi Maryati, Khairat Fakhrida, Sunanda Putra Egy, Juliastuti Aditya

“…This study evaluates the efficacy of an integrated intervention model in improving specific immune responses and nutrient intake among subjects. …”
Get full text

Cloning and Characterization of Immunological Properties of Haemophilus influenzae Enolase by Yesenia Osorio-Aguilar, Maria Cristina Gonzalez-Vazquez, Patricia Lozano-Zarain, Ygnacio Martinez-Laguna, Alejandro Carabarin-Lima, Rosa del Carmen Rocha-Gracia

“…Both in silico and experimental results showed that recombinant enolase from H. influenzae is immunogenic that could induce a humoral immune response; this was observed mediating the generation of specific polyclonal antibodies anti-rNTHiENO that recognize typeable and nontypeable H. influenzae strains. …”
Get full text

qDATA - an R application implementing a practical framework for analyzing quantitative real-time PCR data by Adrian Ionascu, Alexandru Al. Ecovoiu, Mariana Carmen Chifiriuc, Attila Cristian Ratiu

“…The efficiency of our computing approach was tested using input Ct values corresponding to immune related gene expression evaluated in experimental infection of Drosophila melanogaster and Apis mellifera workers. …”
Get full text

Efficacy and Safety of the Combination of Transarterial Chemoembolization with Camrelizumab plus Apatinib for Advanced Hepatocellular Carcinoma: A Retrospective Study of 38 Patient... by Jin-Xing Zhang, Yu-Xing Chen, Chun-Gao Zhou, Jin Liu, Sheng Liu, Hai-Bin Shi, Qing-Quan Zu

“…To evaluate the effectiveness and safety of transarterial chemoembolization (TACE) combined with immune checkpoint inhibition (camrelizumab) plus an antiangiogenic agent (apatinib) for advanced hepatocellular carcinoma (HCC). …”
Get full text

Effect of plasma free fatty acids on lung function in male COPD patients by Rostam Yazdani, Hossein Fallah, Shirin Yazdani, Beydolah Shahouzehi, Behnaz Danesh

“…Free fatty acids (FFA) as signaling molecules through a series of G-proteins coupled receptors, play an important role in regulation of the immune system and oxidative stress. For this reason, we decided to investigate the profile of FFA in the plasma in the COPD patients. …”
Get full text

Improving ferroptosis-mediated immunotherapy for colorectal cancer through lysosome-targeted photodynamic therapy by Zhian Chen, Yutong Wang, Zhenhao Li, Meijuan Chen, Yingshi Li, Chuyue Lu, Zhenyu Lin, Hua Zheng, Lujia Chen, Qianbing Zhang

“…Notably, combined with PD-L1 antibody and TLA could greatly potentiate the immune response and exhibit highest anti-tumor effects. …”
Get full text

The association of gut microbiota, immunocyte dynamics, and protein–protein ratios with tuberculosis susceptibility: a Mendelian randomization analysis by Hanxin Wu, Weijie Ma, Liangyu Zhu, Li Peng, Xun Huang, Lei Zhong, Rui Yang, Bingxue Li, Weijiang Ma, Li Gao, Xinya Wu, Jieqin Song, Suyi Luo, Fukai Bao, Aihua Liu

“…An7 indirectly affected tuberculosis through immunocyte (CD4 on CM CD4+), with a masking effect ratio of 0.008, demonstrating immune cells’ mediating role in the association between gut microbiota and tuberculosis. …”
Get full text