Neoadjuvant anti-PD1 immunotherapy for surgically accessible recurrent glioblastoma: clinical and molecular outcomes of a stage 2 single-arm expansion cohort by J. Ricardo McFaline-Figueroa, Lu Sun, Gilbert C. Youssef, Raymond Huang, Gang Li, Jiyoon Kim, Eudocia Q. Lee, Lakshmi Nayak, Ugonma Chukwueke, Rameen Beroukhim, Tracy T. Batchelor, E. Antonio Chiocca, Richard G. Everson, Lisa Doherty, Jennifer Stefanik, Kathryn Partridge, Amanda Spearman, Alexa Myers, Catharina Westergaard, Alyssa Russ, Maria Lavallee, Anna Smokovich, Corey LaForest-Roys, Rachel Garcia Fox, Christine McCluskey, Wenya Linda Bi, Omar Arnaout, PierPaolo Peruzzi, G. Rees Cosgrove, Keith L. Ligon, Isabel Arrillaga-Romany, Jennifer L. Clarke, David A. Reardon, Timothy F. Cloughesy, Robert M. Prins, Patrick Y. Wen

“…Abstract Glioblastoma is immunologically “cold” and resistant to single-agent immune-checkpoint inhibitors (ICI). Our previous study of neoadjuvant pembrolizumab in surgically-accessible recurrent glioblastoma identified a molecular signature of response to ICI and suggested that neoadjuvant pembrolizumab may improve survival. …”
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A two-strain HIV-1 mathematical model to assess the effects of chemotherapy on disease parameters by Tinevimbo Shiri, Winston Garira, Senelani D. Musekwa

“…We present a two-strain HIV mathematical model that captures the dynamics of the immune system and two HIV-1 variants under antiretroviral therapy. …”
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Hubungan antara Rasio Neutrofil Terhadap Limfosit Preterapi dengan Angka Harapan Hidup Pasien Karsinoma Nasofaring di RSUD Abdoel Wahab Sjahranie Tahun 2018 by Nabiella Hasti Aulia, Hadi Irawiraman, Eva Susanti

“…Neutrophils and lymphocytes are the first lines to provide body immunity against foreign substances. Neutrophil-to-Lymphocyte Ratio (NLR) is a prognostic factor in various malignancies. …”
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Mechanisms Underlying the Osteo- and Adipo-Differentiation of Human Mesenchymal Stem Cells by Yu Zhang, Dilaware Khan, Julia Delling, Edda Tobiasch

“…In addition, even in allogenic origin-derived donor cells, hMSCs generate a local immunosuppressive microenvironment, causing only a weak immune reaction. There is an increasing need for bone replacement in patients from all ages, due to a variety of reasons such as a new recreational behavior in young adults or age-related diseases. …”
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Inhibins Tune the Thymocyte Selection Process by Regulating Thymic Stromal Cell Differentiation by Ebzadrel Carbajal-Franco, Marisol de la Fuente-Granada, Germán R. Alemán-Muench, Eduardo A. García-Zepeda, Gloria Soldevila

“…These ligands were initially identified as hormones that regulate the hypothalamus-pituitary-gonadal axis; however, increasing evidence has demonstrated that they are key regulators in the immune system. We have previously demonstrated that Inhibins are the main Activin ligands expressed in the murine thymus and that they regulate thymocyte differentiation, promoting the DN3-DN4 transition and the selection of SP thymocytes. …”
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High-Performance Optical Fiber Displacement Sensor with Extended Linear Range and Sensitivity by Gorka Zubia, Joseba Zubia, Josu Amorebieta, Gotzon Aldabaldetreku, Asier Zubia, Gaizka Durana

“…Optical Fiber Displacement Sensors (OFDSs) provide several advantages over conventional sensors, including their compact size, flexibility, and immunity to electromagnetic interference. These features make OFDSs ideal for use in confined spaces, such as turbines, where direct laser access is impossible. …”
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A Comprehensive Review on the Beneficial Roles of Vitamin D in Skin Health as a Bio-Functional Ingredient in Nutricosmetic, Cosmeceutical, and Cosmetic Applications by Sofia Neonilli A. Papadopoulou, Elena A. Anastasiou, Theodora Adamantidi, Anna Ofrydopoulou, Sophia Letsiou, Alexandros Tsoupras

“…Nevertheless, recent research has shown its importance for the brain, heart, muscles, immune system, and skin health, due to its distinct bio-functionality in almost every tissue in the human body. …”
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E3 ubiquitin ligase SYVN1 as a promising therapeutic target for diverse human diseases by Li Zhu, Yong-Ping Liu, Yuan-Wang, Bo-Xuan Sun, Yu-Ting Huang, Ji-Kai Zhao, Jian-Feng Liu, Li-Ming Yu, Hui-Shan Wang

“…Consequently, SYVN1 plays a crucial role in both normal human physiology and the pathogenesis of various diseases, such as oncogenesis, cardiovascular disorders, immune regulation, skeletal anomalies, and neurological diseases. …”
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Cytokine Profile of Patients with Allergic Rhinitis Caused by Pollen, Mite, and Microbial Allergen Sensitization by Yury A. Tyurin, Svetlana A. Lissovskaya, Rustem S. Fassahov, Ilshat G. Mustafin, Anton F. Shamsutdinov, Marina A. Shilova, Albert A. Rizvanov

“…These cells actively express a group of receptors of the innate immune system. A specific cytokine profile is its representation. …”
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Dendritic Cells from Aged Subjects Display Enhanced Inflammatory Responses to Chlamydophila pneumoniae by Sangeetha Prakash, Sudhanshu Agrawal, Dandan Ma, Sudhir Gupta, Ellena M. Peterson, Anshu Agrawal

“…Dendritic cells (DCs) are the initiators and regulators of immune responses. Therefore, we investigated the role of DCs in the age-associated increased CPn infection in vitro in humans. …”
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Smartphone based non invasive real time white blood cell counter leveraging blue light and static magnetic field by Nafi Us Sabbir Sabith, Masud Rabbani, Kazi Shafiul Alam, Sheikh Iqbal Ahamed

“…Abstract White blood cells (WBCs), also known as leukocytes, are one of the most significant parts of the immune system. They generate antibodies, protect the body from illnesses, and heal wounds. …”
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Mycobacterium avium subsp. paratuberculosis in an Italian Cohort of Type 1 Diabetes Pediatric Patients by Maria Luisa Manca Bitti, Speranza Masala, Francesca Capasso, Novella Rapini, Simona Piccinini, Federica Angelini, Andrea Pierantozzi, Roberta Lidano, Silvia Pietrosanti, Daniela Paccagnini, Leonardo A. Sechi

“…We demonstrated a higher MAP DNA prevalence in plasma samples from T1D patients and a stronger immune response towards MAP HBHA, compared with healthy control subjects. …”
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Lemon-derived nanoparticle-functionalized hydrogels regulate macrophage reprogramming to promote diabetic wound healing by Enyou Jin, Yusheng Yang, Shengjie Cong, Dengke Chen, Ruixiong Chen, Jun Zhang, Yanjun Hu, Weini Chen

“…Abstract The orderly regulation of immune inflammation and promotion of the regeneration of skin vessels and fibers are key to the treatment of diabetic skin injury (DSI). …”
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Follicular Helper CD4+ T Cells in Human Neuroautoimmune Diseases and Their Animal Models by Xueli Fan, Chenhong Lin, Jinming Han, Xinmei Jiang, Jie Zhu, Tao Jin

“…Follicular helper CD4+ T (TFH) cells play a fundamental role in humoral immunity deriving from their ability to provide help for germinal center (GC) formation, B cell differentiation into plasma cells and memory cells, and antibody production in secondary lymphoid tissues. …”
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Phytogenic feed additives as alternatives to antibiotics in poultry production: A review by Noor Aminullah, Allauddin Mostamand, Ahmadullah Zahir, Obaidullah Mahaq, Mohammad Naeem Azizi

“…PFAs, derived from plant-based compounds, exhibit multiple beneficial properties, including antimicrobial, antioxidative, anti-inflammatory, and immune-modulatory effects. Moreover, they offer the potential to produce high-quality organic poultry products while reducing the likelihood of microbial resistance. …”
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Oral administration of egg white ovotransferrin prevents osteoporosis in ovariectomized rats by Nan Shang, Xiaoyu Bao, Michael Doschak, Jianping Wu

“…In addition to its direct regulatory role on bone turnover, ovotransferrin supplementation might benefit osteoporosis prevention by inhibiting adipogenesis, and regulating immune response. Our results suggested the potential application of ovotransferrin as a functional food ingredient on the prevention of osteoporosis.…”
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Histopathological, Immunohistochemical and Biochemical Studies of Murine Hepatosplenic Tissues Affected by Chronic Toxoplasmosis by Samah Hassan Yahia, Samia Elsayed Etewa, Nesreen Saeed Saleh, Samira Metwally Mohammad, Nora Ibrahim Aboulfotouh, Ahmad Mansour Kandil, Mohamed Hassan Sarhan

“…Many molecules like caspase-3, CD3, and CD138 are implicated in the tissue immune response in a trial to alleviate hazardous toxoplasmosis impact. …”
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Serum Magnesium and Vitamin D Levels as Indicators of Asthma Severity by Mohammed Nadeem Shaikh, Brahma Reddy Malapati, Ruchi Gokani, Bhavita Patel, Mitul Chatriwala

“…Serum magnesium levels affect the concentration of circulating vitamin D in blood and subsequently it affects the immunity; thus it plays significant role in the pathogenesis of asthma. …”
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ORCHAMP: an observation network for monitoring biodiversity and ecosystem functioning across space and time in mountainous regions by Thuiller, Wilfried, Saillard, Amélie, Abdulhak, Sylvain, Augé, Vincent,  Birck, Carole, Bonet, Richard, Choler, Philippe, Delestrade, Anne,  Kunstler, Georges, Leccia, Marie-France, Lienard, Bertrand, Poulenard, Jérome, Valay, Jean-Gabriel, Bayle, Arthur, Bonfanti, Nicolas, Brousset, Lenka,  Bizard, Léa,  Calderón-Sanou, Irene, Dentant, Cédric, Desjonquères, Camille, Gielly, Ludovic, Guéguen, Maya, Guiter, Frédéric, Hedde, Mickael,  Hustache, Eric, Kedhim, Norine, Lapenu, Pierre, Le Guillarme, Nicolas,  Marchal, Lise, Mahieu, Chloé, Martin, Gabrielle, Martinez-Almoyna, Camille,  Miele, Vincent, Murienne, Jérôme, Paillet, Yoan, Rome, Maxime,  Renaud, Julien, The Orchamp Consortium

“…Mountainous regions are not immune to these threats, experiencing the impacts of global warming, increased recreational activities, and changes in agricultural practices. …”
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Untargeted metabolomic and proteomic analysis implicates SIRT2 as a novel therapeutic target for diabetic nephropathy by Ruijing Zhang, Runze Chang, Heng Wang, Jinshan Chen, Chuanlong Lu, Keyi Fan, Yuhang Zhang, Lizheng Li, Sheng Yan, Honglin Dong

“…Correlation analysis of major differentially abundant metabolites and differentially expressed proteins revealed that SIRT2 might be a key hub linking energy metabolism and innate immune responses. KEGG enrichment analysis showed that HIF-1 signaling pathway and renal cell carcinoma pathway were co-enriched pathways in energy metabolism and inflammatory response. …”
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