New frontiers in CRISPR: Addressing antimicrobial resistance with Cas9, Cas12, Cas13, and Cas14 by Ahmed S.A. Ali Agha, Ali Al-Samydai, Talal Aburjai

“…It originated from bacterial adaptive immune mechanisms and has gained significant recognition in the scientific community. …”
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Monocyte Subsets in Schistosomiasis Patients with Periportal Fibrosis by Jamille Souza Fernandes, Maria Ilma Araujo, Diego Mota Lopes, Robson da Paixão de Souza, Edgar M. Carvalho, Luciana Santos Cardoso

“…A major issue with Schistosoma mansoni infection is the development of periportal fibrosis, which is predominantly caused by the host immune response to egg antigens. Experimental studies have pointed to the participation of monocytes in the pathogenesis of liver fibrosis. …”
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Regenerative properties of bone marrow mesenchymal stem cell derived exosomes in rotator cuff tears by Junjie Chen, Zihe Wang, Ming Yi, Yi Yang, Mengzhao Tian, Yinqi Liu, Guoyou Wang, Huarui Shen

“…As a result, the healing process of rotator cuff injuries faces significant challenges.Bone marrow-derived mesenchymal stem cell exosomes (BMSC-exos) have emerged as a prominent focus of research within the field of bioengineering, owing to their remarkable potential to regulate cellular proliferation and differentiation, modulate immune responses, and facilitate tissue repair and regeneration following cellular damage. …”
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An Injectable IPN Nanocomposite Hydrogel Embedding Nano Silica for Tissue Engineering Application by Ali Kakapour, Saied Nouri Khorasani, Shahla Khalili, Mahshid Hafezi, Mehdi Sattari‐Najafabadi, Mahsa Najarzadegan, Samin Saleki, Shadab Bagheri‐Khoulenjani

“…Besides, for cross‐linking, visible light is used as an alternative to UV light to prevent disruptions in cellular metabolism and immune system reactions. Four GM/SA/SNP hydrogels different in SNPs concentration (0, 0.5, 1, and 2 w/w%) are studied. …”
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Global Autorecognition and Activation of Complement by Mannan-Binding Lectin in a Mouse Model of Type 1 Diabetes by Esben Axelgaard, Jakob Appel Østergaard, Saranda Haxha, Steffen Thiel, Troels Krarup Hansen

“…MBL is a complement-activating pattern recognition molecule of the innate immune system that can mediate an inflammation response through activation of the lectin pathway. …”
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Integrated Bioinformatics and Experimental Approaches Identified the Role of NPPA in the Proliferation and the Malignant Behavior of Breast Cancer by Aijun Sun, Xiaonan Sheng, Jinhai Tang, Zhenfeng Yu, Jian Zhang

“…The NPPA expression is downregulated in breast cancer patients, independent of the ER status, PR status, stemness score, and immune infiltrating condition. And we observed the enhanced proliferation, migration, and invasion potential of breast cancer cells after NPPA depletion. …”
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DNA mismatch repair (MMR) genes expression in lung cancer and its correlation with different clinicopathologic parameters by Mayada Saad Farrag, Heba Wagih Abdelwahab, Amr Abdellateef, Nahla Anber, Mohamed Adel Ellayeh, Dalia Tawfeek Hussein, Ahmed Ramadan Eldesoky, Heba Sheta

“…This will advance management strategies and even guide immune checkpoint inhibitor therapy for LC.…”
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circ-1584 selectively promotes the antitumor activity of the oncolytic virus M1 on pancreatic cancer by Taofang Hao, Yuanyuan Li, Qianyao Ren, Ying Zeng, Leyi Gao, Wenbo Zhu, Jiankai Liang, Yuan Lin, Jun Hu, Guangmei Yan, Shuxin Sun, Jing Cai

“…Pancreatic cancer is among the most challenging tumors to treat, and due to its immune tolerance characteristics, existing immunotherapy methods are not effective in alleviating the disease. …”
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Benefits of the use of porcine skin for the management of toxic epidermal necrolysis injuries: Review of the literature by Juan Ludeña, Diana Rojas, Pedro Ciudad, Walter Navarro, Rafael Rossi, Annelisse Travi

“…Toxic epidermal necrolysis (TEN) is a rare immune-mediated adverse skin reaction; secondary in most cases to the administration of a drug. …”
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Pollen–Food Allergy Syndrome: Allergens, Clinical Insights, Diagnostic and Therapeutic Challenges by Laura Haidar, Camelia Felicia Bănărescu, Cristina Uța, Sandra Iulia Moldovan, Elena-Larisa Zimbru, Răzvan-Ionuț Zimbru, Elena Ciurariu, Marius Georgescu, Carmen Panaitescu

“…However, novel approaches such as allergen immunotherapy and biologics targeting key immune pathways are gaining traction as potential interventions for more severe or refractory cases. …”
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Managing pediatric psoriasis: update on treatments and challenges—a review by A. A. Hebert, J. Browning, P. C. Kwong, A. M. Duarte, H. N. Price, E. Siegfried

“…Background Psoriasis is a chronic, immune-mediated inflammatory disease with prominent cutaneous features, although the limited number of medications approved for pediatric psoriasis makes treating this population difficult. …”
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Low Grade Islet but Marked Exocrine Pancreas Inflammation in an Adult with Autoimmune Pre-Diabetes by Hiroshi Nomoto, Tatyana Gurlo, Madeline Rosenberger, Mark D. Girgis, Sarah Dry, Peter C. Butler

“…There was patchy low grade immune infiltration in some, but not all, islets that met criteria for autoimmune insulitis. …”
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Antigen-Specific Tissue-Resident Memory T Cells in the Respiratory System Were Generated following Intranasal Vaccination of Mice with BCG by Qiongli Wu, Shuangpeng Kang, Jun Huang, Shunqiao Wan, Binyan Yang, Changyou Wu

“…Tissue-resident memory T cells (TRM) are different from effector memory T cells (TEM) and central memory T cells (TCM) and contribute to the protective immunity against local challenges. Currently, we found that CD4+ and CD8+ TRM cells in the nasal mucosa, trachea, lungs, and lavage fluids were heterogeneous on the expression of CD69 and CD103 as well as the production of cytokines including IFN-γ, IL-2, and TNF-α. …”
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Emerging Role and Therapeutic Implication of Wnt Signaling Pathways in Autoimmune Diseases by Juan Shi, Shuhong Chi, Jing Xue, Jiali Yang, Feng Li, Xiaoming Liu

“…This review summarizes currently our understanding of the pathogenic roles of Wnt signaling in several major autoimmune disorders and miRNAs, those targeting Wnt signaling in autoimmune diseases, with a focus on the implication of the Wnt signaling as potential biomarkers and therapeutic targets in immune diseases, as well as miRNA-mediated regulation of Wnt signaling activation in the development of autoimmune diseases.…”
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Activated Platelets Induce an Anti-Inflammatory Response of Monocytes/Macrophages through Cross-Regulation of PGE2 and Cytokines by Bona Linke, Yannick Schreiber, Bettina Picard-Willems, Patrick Slattery, Rolf M. Nüsing, Sebastian Harder, Gerd Geisslinger, Klaus Scholich

“…Platelets are well known for their role in hemostasis and are also increasingly recognized for their roles in the innate immune system during inflammation and their regulation of macrophage activation. …”
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A conformational change of C-reactive protein drives neutrophil extracellular trap formation in inflammation by Ebru Karasu, Rebecca Halbgebauer, Lena Schütte, Johannes Greven, Felix M. Bläsius, Johannes Zeller, Oscar Winninger, David Braig, David Alexander Christian Messerer, Bettina Berger, Hendrik Feuerstein, Anke Schultze, Karlheinz Peter, Uwe Knippschild, Klemens Horst, Frank Hildebrand, Steffen U. Eisenhardt, Markus Huber-Lang

“…Dissociation of native pentameric CRP (pCRP) into the monomeric structure (mCRP) liberates proinflammatory features, presumably contributing to excessive immune cell activation via unknown molecular mechanisms. …”
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The Beneficial Effect of IL-12 and IL-18 Transduced Dendritic Cells Stimulated with Tumor Antigens on Generation of an Antitumor Response in a Mouse Colon Carcinoma Model by Jagoda Mierzejewska, Katarzyna Węgierek-Ciura, Joanna Rossowska, Agnieszka Szczygieł, Natalia Anger-Góra, Bożena Szermer-Olearnik, Magdalena Geneja, Elżbieta Pajtasz-Piasecka

“…Application of the developed DC-based vaccines may exert a favorable impact on stimulation of an antitumor immune response, especially if these DC vaccines are administered repeatedly.…”
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Noise‐based logic locking scheme against signal probability skew analysis by Ahmad Rezaei, Ali Mahani

“…Also, more crucially, our locking blocks are immune to SPS attack solely. After executing various attacks, retrieved circuits indicate improved overall resiliency against automatic test pattern generation based and approximate guided removal attacks as well.…”
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Changes in the Microbiome During Chronic Rhinosinusitis by Mateusz de Mezer, Nina Chalama, Cheyanna Bratt, Melanie Kiebalo, Natalia Dolata, Jan Rogaliński, Małgorzata Leszczyńska

“…Viral culprits may induce an unhindered local immune response that contributes to the recurrence and chronicity of inverted papillomas—benign mucosal lesions with the propensity for local destruction and malignant transformation that can be found in patients with a history of nasal infection. …”
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EBV-associated lymphoadenopathy in a child by H.B. Mateiko, U.A. Hlushko, T.V. Nesterova, L.V. Antoniuk, N.B. Horbal

“…Immunohistochemical study of the lymph node biopsy revealed reactive hyperplasia with expressed immune blast transformation, the presence of CD30-positive cells while excluding Hodgkin lymphoma. …”
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