Alterations of the Murine Gut Microbiome with Age and Allergic Airway Disease by Marius Vital, Jack R. Harkema, Mike Rizzo, James Tiedje, Christina Brandenberger

“…With advanced age the microbiome and the immune system are changing and, currently, little is known about how these two factors contribute to the development of allergic asthma in the elderly. …”
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A deep multiple instance learning framework improves microsatellite instability detection from tumor next generation sequencing by John Ziegler, Jaclyn F. Hechtman, Satshil Rana, Ryan N. Ptashkin, Gowtham Jayakumaran, Sumit Middha, Shweta S. Chavan, Chad Vanderbilt, Deborah DeLair, Jacklyn Casanova, Jinru Shia, Nicole DeGroat, Ryma Benayed, Marc Ladanyi, Michael F. Berger, Thomas J. Fuchs, A. Rose Brannon, Ahmet Zehir

“…Abstract Microsatellite instability (MSI) is a critical phenotype of cancer genomes and an FDA-recognized biomarker that can guide treatment with immune checkpoint inhibitors. Previous work has demonstrated that next-generation sequencing data can be used to identify samples with MSI-high phenotype. …”
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Osteopontin at the Crossroads of Inflammation and Tumor Progression by Luigi Mario Castello, Davide Raineri, Livia Salmi, Nausicaa Clemente, Rosanna Vaschetto, Marco Quaglia, Massimiliano Garzaro, Sergio Gentilli, Paolo Navalesi, Vincenzo Cantaluppi, Umberto Dianzani, Anna Aspesi, Annalisa Chiocchetti

“…In this context, osteopontin (OPN) appears to be a key determinant of the crosstalk between cancer cells and the host microenvironment, which in turn modulates immune evasion. OPN is overexpressed in several human carcinomas and has been implicated in inflammation, tumor progression, and metastasis. …”
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Nosocomial Infections in Burned Patients in Motahari Hospital, Tehran, Iran by Leila Azimi, Abbas Motevallian, Amirmorteza Ebrahimzadeh Namvar, Babak Asghari, Abdolaziz Rastegar Lari

“…Burn patients are at high risk of developing nosocomial infection because of their destroyed skin barrier and suppressed immune system, compounded by prolonged hospitalization and invasive therapeutic and diagnostic procedures. …”
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Advancing Coherent Power Grid Partitioning: A Review Embracing Machine and Deep Learning by Mohamed Massaoudi, Maymouna Ez Eddin, Ali Ghrayeb, Haitham Abu-Rub, Shady S. Refaat

“…There is an increased emphasis on immunizing renewable-dominated power systems from large-scale cascading failures and cyberattacks through optimal power grid partitioning (PGP). …”
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Integrating transcriptomics, metabolomics, and network pharmacology to investigate multi-target effects of sporoderm-broken spores of Ganoderma lucidum on improving HFD-induced dia... by Lidan Hu, Lili Yu, Zhongkai Cao, Yue Wang, Caifeng Zhu, Yayu Li, Jiazhen Yin, Zhichao Ma, Xuelin He, Ying Zhang, Wunan Huang, Yuelin Guan, Yue Chen, Xue Li, Xiangjun Chen

“…In addition, NP analysis further indicated that GLP may efficiently alleviate DN via immune-related pathways. In conclusion, this study provides supportive evidence of the anti-inflammatory effects of GLP supplements, highlighting their potential for promising clinical applications in treating DN.…”
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Price fluctuations of quail eggs at the farm level and their contributing factors in The Jabodetabek and East Java by Ratu Reni Budiyanti, Vony Armelia, Magfira, Akbar Satria Bahari

“…Quail eggs offer numerous health benefits, including enhancing the immune system, supporting brain growth and development, and repairing damaged cells. …”
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СONSTRUCTION AND THE ALGORITHM OPERATION OF THE LASER COMBINED FIRE DETECTOR by A. I. Kitsak, A. P. Lushchyk, D. L. Esipovich, V. N. Konon, I. V. Kavalchyk, O. A. Protasevich, I. B. Tretyak

“…The urgent task for this type of detector is to increase its sensitivity to «black» smoke and ensure resilience to the effects of electromagnetic interference and particle smoke origin.The objective of this work is to develop a structure and algorithm of point combined fire detector that provides high sensitivity to various types of fumes, detection rate and high noise immunity. The decision of the current objective is carried out using the proposed optical scheme of the dual-channel devices of smoke detection (for control of the radiation intensities scattered by smoke particles and passed through the smoke).The design and algorithm of the combined fire detector comprising a dual-channel laser device of smoke detection and carbon monoxide detector is developed.The results of the made detector tests indicate about its increased in comparison with the conventional single-channel point smoke fire detector sensitivity to various types of fumes and detection rate of fires. …”
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Understanding secondary hypogammaglobulinemia and its implications for cancer prognosis in children: A retrospective cohort study by Ana Lucía Guzmán, Isabella Villamil, Sofía Martínez-Betancur, Oriana Arias-Valderrama, Jacobo Triviño-Arias, Jessica Largo, Viviana Lotero, Alexis Franco, Ximena Castro, Pamela Rodríguez, Luz Angela Urcuqui, Diego Medina, Manuela Olaya

“…Immunodeficiencies are disturbances in the immune system that can affect cell function, quantity, or both. …”
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Immunotherapy in colorectal cancer: Statuses and strategies by Yuan Li, Zewei Cheng, Shengli Li, Jiwei Zhang

“…Immunotherapy, an emerging frontier in oncology, represents a novel therapeutic approach that leverages the body's immune system to target cancer cells. The principal advantage of immunotherapy is its capacity to selectively target cancer cells while minimizing damage to healthy cells. …”
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Inferring causal protein signalling networks from single‐cell data based on parallel discrete artificial bee colony algorithm by Jinduo Liu, Jihao Zhai, Junzhong Ji

“…Abstract Inferring causal protein signalling networks from human immune system cell data is a promising approach to unravel the underlying tissue signalling biology and dysfunction in diseased cells, which has attracted considerable attention within the bioinformatics field. …”
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A multifunctional mesoporous silica drug delivery nanosystem that ameliorates tumor hypoxia and increases radiotherapy efficacy by Yanhong Chu, LiFeng Wang, Yaohua Ke, Xiaoyu Feng, Wenmei Rao, Wei Ren, Kai Xin, Yan Wang, Lixia Yu, Baorui Liu, Qin Liu

“…Abstract Radiotherapy (RT) is a widely used treatment with strong therapeutic effects, but overcoming challenges related to hypoxia-induced tumor resistance and ineffective antitumor immune responses is crucial for optimal outcomes. …”
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The Change of Skeletal Muscle Caused by Inflammation in Obesity as the Key Path to Fibrosis: Thoughts on Mechanisms and Intervention Strategies by Yixuan Li, Wenwen Guo, Han Li, Yuhao Wang, Xinwei Liu, Wen Kong

“…Obesity leads to a chronic inflammatory state throughout the body, with increased infiltration of immune cells and inflammatory factors in skeletal muscle tissue, and, at the same time, the level of intracellular mitochondrial oxidative stress rises. …”
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Mechanistic PKPD modeling to describe cytokine release associated with CD3 T-cell engager therapies by Apolline Lefèvre, Apolline Lefèvre, Zinnia P. Parra-Guillen, Zinnia P. Parra-Guillen, Iñaki F. Trocóniz, Iñaki F. Trocóniz, Iñaki F. Trocóniz, Christophe Boetsch, Nicolas Frances

“…IntroductionT-cell engagers (TCE), a therapeutic class of cancer immunotherapy (CIT), offer a novel approach to cancer treatment by harnessing and reactivating the patient’s immune system to eradicate tumor cells. However, the use of TCE in the clinic can lead to severe side effects, including cytokine release syndrome (CRS). …”
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Predicting the tumor microenvironment composition and immunotherapy response in non-small cell lung cancer from digital histopathology images by Sushant Patkar, Alex Chen, Alina Basnet, Amber Bixby, Rahul Rajendran, Rachel Chernet, Susan Faso, Prashanth Ashok Kumar, Devashish Desai, Ola El-Zammar, Christopher Curtiss, Saverio J. Carello, Michel R. Nasr, Peter Choyke, Stephanie Harmon, Baris Turkbey, Tamara Jamaspishvili

“…Abstract Immune checkpoint inhibitors (ICI) have become integral to treatment of non-small cell lung cancer (NSCLC). …”
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Coexistence of immunoglobulin G4-related kidney disease and acute hematogenous disseminated pulmonary tuberculosis: a case report by Fangfang Zhou, Hanqing Chu, Youjun Xu, Yena Zhang, Kuibi Tan, Jinxia Ge, Ningjun Shao, Qun Luo

“…BackgroundImmunoglobulin G4-related disease (IgG4-RD) is an immune-mediated fibrous inflammatory disease. Recently, an association between IgG4-RD and tuberculosis (TB) has been reported.Case summaryWe report a 56-year-old man complaining of a cough and poor appetite for 2 months and oliguria for 1 day. …”
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Evaluation of Oxidative Stress and Mitophagy during Adipogenic Differentiation of Adipose-Derived Stem Cells Isolated from Equine Metabolic Syndrome (EMS) Horses by Krzysztof Marycz, Christine Weiss, Agnieszka Śmieszek, Katarzyna Kornicka

“…Mesenchymal stem cells (MSCs) are frequently used in both human and veterinary medicine because their unique properties, such as modulating the immune response and differentiating into multiple lineages, make them a valuable tool in cell-based therapies. …”
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Klebsiella pneumoniae Biofilms and Their Role in Disease Pathogenesis by Maria Eduarda Souza Guerra, Giulia Destro, Brenda Vieira, Alice S. Lima, Lucio Fabio Caldas Ferraz, Anders P. Hakansson, Michelle Darrieux, Thiago Rojas Converso

“…Bacteria in the biofilm are shielded from immune responses and antibiotics. The present review discusses the characteristics of K. pneumoniae biofilms, factors affecting biofilm development, and their contribution to infections. …”
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Hopf Bifurcation in an SEIDQV Worm Propagation Model with Quarantine Strategy by Yu Yao, Wenlong Xiang, Andong Qu, Ge Yu, Fuxiang Gao

“…In general, users may immunize their computers with countermeasures in exposed and infectious state, which may take a period of time. …”
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The Role of Limbal Epithelial Stem Cells in Regulating Corneal (Lymph)angiogenic Privilege and the Micromilieu of the Limbal Niche following UV Exposure by M. Notara, A. Lentzsch, M. Coroneo, C. Cursiefen

“…This review focuses on the role of corneal and limbal epithelial cells and the stem cell niche in maintaining corneal avascularity and corneal immune privilege and how this may be deregulated following UV exposure. …”
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