Large Granular Lymphocytic Leukemia: A Report of Response to Rituximab by Uroosa Ibrahim, Sara Parylo, Shiksha Kedia, Shafinaz Hussein, Jean Paul Atallah

“…A response to rituximab in refractory cases such as ours has been reported and may guide us towards exploring other immune-based therapeutics in this rare disease.…”
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Molecular characterization of mixed-histology endometrial carcinoma provides prognostic and therapeutic value over morphologic findings by Paulina J. Haight, Ashwini Esnakula, Courtney J. Riedinger, Adrian A. Suarez, Jessica Gillespie, Ashley Patton, Alexis Chassen, David E. Cohn, Casey M. Cosgrove

“…Transcriptional analysis demonstrated 93 differentially expressed genes between p53abnl and NSMP tumors, including many associated with the innate immune response and DNA damage repair. While p53abnl and NSMP tumors have similarly poor outcomes, transcriptome analysis revealed biologic differences that could impact targeted therapeutics in this high-risk group.…”
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Comprehensive Insights into Monkeypox (mpox): Recent Advances in Epidemiology, Diagnostic Approaches and Therapeutic Strategies by Suresh Kumar, Dhanyashri Guruparan, Kalimuthu Karuppanan, K. J. Senthil Kumar

“…Over the past two decades, the incidence of mpox has surged, possibly linked to a declining immunity against the smallpox vaccine worldwide. Recent outbreaks of mpox in multiple countries have sparked concerns regarding altered transmission patterns and the potential for a global menace. …”
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Nursing of a patient with type 2 diabetes mellitus complicated with invasive pulmonary aspergillosis resulting in the formation of a cavity in the upper lobe of the right lung caus... by TIAN Haitong (田海彤), YU Xiaojie (于潇杰), LIU Zhenmei (刘振梅), DU Chunmei (杜春梅), XING Yuejiao (邢月娇), LIN Xiaomeng (林晓萌), JIANG Wenjie (姜文杰), WANG Cong (王琮), ZHANG Mengjie (张梦婕), LU Kexin (陆可欣), ZHAO Yanan (赵亚楠)

“…Efforts were made to reduce the risk of hemoptysis, control the blood glucose, improve immunity and quality of life of the patient. (本文总结1例2型糖尿病合并侵袭性肺曲霉菌病导致右肺上叶空洞形成致大咯血患者的护理的经验。…”
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Fetal Bradyarrhythmias: A Comprehensive Update on Current Knowledge by Maria Elisa Martini Albrecht, Larissa Keren de Azevedo Teixeira, Edward Araujo Júnior, Nathalie Jeanne Bravo-Valenzuela, Roberta Granese

“…In contrast, isolated or immune-mediated complete atrioventricular block may progress rapidly to hydrops, requiring close monitoring, medical intervention, and, in some cases, early delivery. …”
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CDC20‐Mediated Selective Autophagy Degradation of PBRM1 Affects Immunotherapy for Renal Cell Carcinoma by Yizeng Fan, Weichao Dan, Taotao Que, Yi Wei, Bo Liu, Zixi Wang, Yulin Zhang, Yuzhao Wang, Tianjie Liu, Yanxin Zhuang, Mengxing Li, Chendong Guo, Jin Zeng, Bohan Ma, Lei Li

“…Abstract Polybromo 1 (PBRM1) inactivating mutations are associated with clinical benefit from immune checkpoint inhibitor treatments in clear cell renal cell carcinoma (ccRCC). …”
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BA inhibits LPS-stimulated inflammatory response and apoptosis in human middle ear epithelial cells by regulating the Nf-Kb/Iκbα axis by He Qian, Cai Yanzhi, Kong Meihua

“…The pathogenesis of OM is multifaceted, encompassing a variety of factors including bacterial or viral infections, host immune responses, and the function of middle ear epithelial cells. …”
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Phenotyping of Leukocytes and Leukocyte-Derived Extracellular Vesicles by Lotte Hatting Pugholm, Rikke Bæk, Evo Kristina Lindersson Søndergaard, Anne Louise Schacht Revenfeld, Malene Møller Jørgensen, Kim Varming

“…Extracellular vesicles (EVs) have a demonstrated involvement in modulating the immune system. It has been proposed that EVs could be used as biomarkers for detection of inflammatory and immunological disorders. …”
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Personalising glioblastoma medicine: explant organoid applications, challenges and future perspectives by Niclas Skarne, Rochelle C. J. D’Souza, Helen M. Palethorpe, Kylah A. Bradbrook, Guillermo A. Gomez, Bryan W. Day

“…GBOs represent a translational leap forward and are currently the state-of-the-art in 3D in vitro culture system, retaining brain cancer heterogeneity, and transiently maintaining the immune infiltrate and tumour microenvironment (TME). …”
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Radix Codonopsis: a review of anticancer pharmacological activities by Cai-Yue Liu, Zheng Li, Fan-E. Cheng, Yi Nan, Yi Nan, Wei-Qiang Li, Wei-Qiang Li

“…It is renowned for its pharmacological effects, including tonifying the middle qi, invigorating the spleen, benefiting the lungs, enhancing immunity, and nourishing the blood. Codonopsis extract is frequently incorporated into health products such as tablets and capsules, making it accessible for daily health maintenance. …”
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Analysis of five cases showing false-high Hemoglobin A1c due to reduced catalase activity by Kenji Hara, Atsushi Ujiie, Shiori Suzuki, Takenori Okumura, Mio Kubo, Hiroyuki Shinozaki, Mototaka Yamauchi, Takafumi Tsuchiya, Kohzo Takebayashi, Nobuyuki Shimozawa, Masafumi Koga, Koshi Hashimoto

“…HbA1c levels were higher than those obtained using other methods, such as HPLC, immune-based methods, and other enzyme-based kits. …”
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Assessing spacer acquisition rates in E. coli type I-E CRISPR arrays by Luke J. Peach, Haoyun Zhang, Brian P. Weaver, James Q. Boedicker, James Q. Boedicker

“…Through an adaptation process, short “spacer” sequences, captured from these elements and incorporated into a CRISPR array, provide target specificity for the immune response. CRISPR arrays and array expansion are also central to many emerging biotechnologies. …”
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Substantiation of application and estimation of efficacy of probiotics at inflammatory bowel diseases by Ye. A. Poluektova, Yu. O. Sidorina, S. Yu. Kuchumova, A. V. Korolev, O. S. Shifrin

“…Microbiome changes result in initiation of cascade of pathological immune reactions of the host in related to presence of genetical defects, that, in turn, promotes development of clinical symptoms and morphological changes in intestinal wall. …”
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Taste Preference and Metabolic Rate of Trehalose in Chickens by Fuminori Kawabata, Misako Sakai, Hiroki Murasawa, Yu Komine, Kazuhisa Mukai, Yuko Kawabata

“…Because Tre is utilized by the gut microbiome and enhances gut immunity in chickens, it is used as a feed ingredient. …”
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The Role of Connexin-43 in the Inflammatory Process: A New Potential Therapy to Influence Keratitis by Chu-Yang Xu, Wen-Song Zhang, Hong Zhang, Yan Cao, Hong-Yan Zhou

“…We analyzed the effects of signaling molecules, such as innate immunity messengers, transcription factors, LPS, cytokine, inflammatory chemokines, and MMPs, on Cx43 expression during the inflammatory process. …”
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CD8+ T-Cell Responses before and after Structured Treatment Interruption in Ugandan Adults Who Initiated ART with CD4+ T Cells <200 Cell/μL: The DART Trial STI Substudy by Jennifer Serwanga, Susan Mugaba, Auma Betty, Edward Pimego, Sarah Walker, Paula Munderi, Charles Gilks, Frances Gotch, Heiner Grosskurth, Pontiano Kaleebu

“…These data add to others that found no evidence to support STI as a strategy to improve HIV-specific immunity during ART.…”
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Manganese-pyrochloric acid photosensitizer nanocomplexes against osteosarcoma: achieving both high activatability and high effectiveness by Xuran Zhang, Xuran Zhang, Jian Wang, Qun Feng, Li Lei, Zhiyong Zhu

“…Additionally, Mn2+ ions activated the cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) pathway, promoting maturation of dendritic cells (DCs) and augmenting CD8+-mediated antitumor immune responses.DiscussionThis study advances the on-demand activation of photosensitive drugs and photodynamic immunotherapy toward clinical applicability by exploiting Mn2+–PPa nanocomplexes with high activatability and effectiveness for targeted PDT and immunotherapy.…”
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Differential Gene Expression Profile of Human Neutrophils Cultured with Plasmodium falciparum-Parasitized Erythrocytes by Mohamad Alaa Terkawi, Ryo Takano, Kentaro Kato

“…Neutrophils (PMNs) are the most abundant cellular component of our innate immune system, where they play central roles in the pathogenesis of and resistance to a broad range of diseases. …”
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The spatially informed mFISHseq assay resolves biomarker discordance and predicts treatment response in breast cancer by Evan D. Paul, Barbora Huraiová, Natália Valková, Natalia Matyasovska, Daniela Gábrišová, Soňa Gubová, Helena Ignačáková, Tomáš Ondris, Michal Gala, Liliane Barroso, Silvia Bendíková, Jarmila Bíla, Katarína Buranovská, Diana Drobná, Zuzana Krchňáková, Maryna Kryvokhyzha, Daniel Lovíšek, Viktoriia Mamoilyk, Veronika Mancikova, Nina Vojtaššáková, Michaela Ristová, Iñaki Comino-Méndez, Igor Andrašina, Pavel Morozov, Thomas Tuschl, Fresia Pareja, Jakob N. Kather, Pavol Čekan

“…Our consensus subtyping and risk groups mitigate single sample discordance, provide early and late prognostic information, and identify high risk patients with enriched immune signatures, which predict response to neoadjuvant immunotherapy in the multicenter, phase II, prospective I-SPY2 trial. …”
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RAGE is a Potential Cause of Onset and Progression of Nonalcoholic Fatty Liver Disease by Kamyar Asadipooya, Kamran B. Lankarani, Rishi Raj, Mohammadreza Kalantarhormozi

“…AGE-RAGE interaction contributes to fat accumulation in the liver leading to inflammation, fibrosis, insulin resistance, and other complications of the fatty liver disease. The immune system, especially macrophages, has an important defense mechanism against RAGE pathway activities. …”
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