The Antimicrobial Peptide Lysozyme Is Induced after Multiple Trauma by Tim Klüter, Stefanie Fitschen-Oestern, Sebastian Lippross, Matthias Weuster, Rolf Mentlein, Nadine Steubesand, Claudia Neunaber, Frank Hildebrand, Thomas Pufe, Mersedeh Tohidnezhad, Andreas Beyer, Andreas Seekamp, Deike Varoga

“…The antimicrobial peptide lysozyme is an important factor of innate immunity and exerts high potential of antibacterial activity. …”
Get full text

Aspirin Modulates Innate Inflammatory Response and Inhibits the Entry of Trypanosoma cruzi in Mouse Peritoneal Macrophages by Aparecida Donizette Malvezi, Rosiane Valeriano da Silva, Carolina Panis, Lucy Megumi Yamauchi, Maria Isabel Lovo-Martins, Nagela Ghabdan Zanluqui, Vera Lúcia Hideko Tatakihara, Luiz Vicente Rizzo, Waldiceu A. Verri, Marli Cardoso Martins-Pinge, Sueli Fumie Yamada-Ogatta, Phileno Pinge-Filho

“…Our results indicate that PGE2, NO∙, and lipoxins are involved in the regulation of anti-T. cruzi activity by macrophages, providing a better understanding of the role of prostaglandins in innate inflammatory response to T. cruzi infection as well as adding a new perspective to specific immune interventions.…”
Get full text

Biochemistry of Bacterial Biofilm: Insights into Antibiotic Resistance Mechanisms and Therapeutic Intervention by Kashish Azeem, Sadaf Fatima, Asghar Ali, Ayesha Ubaid, Fohad Mabood Husain, Mohammad Abid

“…Biofilms, composed of structured communities of bacteria embedded in a self-produced extracellular matrix, pose a significant challenge due to their heightened resistance to antibiotics and immune responses. This review highlights the mechanisms underpinning antibiotic resistance within bacterial biofilms, elucidating the adaptive strategies employed by microorganisms to withstand conventional antimicrobial agents. …”
Get full text

Chick Early Amniotic Fluid Alleviates Dextran-Sulfate-Sodium-Induced Colitis in Mice via T-Cell Receptor Pathway by Fan Chen, Yining Zhao, Yanfa Dai, Ning Sun, Xuezheng Gao, Jiajun Yin, Zhenhe Zhou, Ke-jia Wu

“…Ulcerative colitis (UC) is a chronic immune disease that is difficult to cure. We recently found that chick early amniotic fluid (ceAF) has notable anti-inflammatory and antioxidative properties, through its active components. …”
Get full text

CRISPR/Cas Enzyme Catalysis in Liquid–Liquid Phase‐Separated Systems by Yaqin Zhang, Jianai Chen, Zhina Wu, Chenfei Zhao, Rui Wang, Zhiping Li, Jiasi Wang, Di Wang

“…Abstract The clustered regularly interspaced palindromic repeats (CRISPR) /CRISPR‐associated proteins (Cas) system is the immune system in bacteria and archaea and has been extensively applied as a critical tool in bioengineering. …”
Get full text

DYNAMICS OF IL12 CYTOKINE EXPRESSION IN HUMAN MACROPHAGES AFTER TREATMENT WITH DIOXIN by D. Y. Oshchepkov, E. V. Kashina, E. V. Antontseva, E. A. Oshchepkova, V. A. Mordvinov, D. P. Furman

“…Thus, the well-known dioxin influence on the immune system can be associated with the difference in the dioxin effect on the expression dynamics of the genes encoding IL-12 subunits.…”
Get full text

Improved protection scheme for shipboard microgrids based on high frequency impedance method with experimental validation by Asmaa M. Aboelezz, Magdi M. El-Saadawi, Abdelfattah A. Eladl, Magda I. El-Afifi, Vladimír Bureš, Bishoy E. Sedhom

“…Results demonstrate the method’s effectiveness in detecting faults under diverse conditions, including variations in fault resistance, dynamic load behavior, changes in photovoltaic irradiation, system configuration alterations, noise immunity, and multi-fault scenarios. The method achieves fault clearance times ranging from 0.17 ms in MATLAB/Simulink simulations to 33–45 ms in experimental tests, showing its capability to enhance fault detection in complex DC microgrid environments.…”
Get full text

Disease Stage-Associated Alterations in Learning and Memory through the Electroacupuncture Modulation of the Cortical Microglial M1/M2 Polarization in Mice with Alzheimer’s Disease... by Long Li, Le Li, Jiayong Zhang, Sheng Huang, Weilin Liu, Zhifu Wang, Shengxiang Liang, Jing Tao, Lidian Chen

“…Microglia are the primary cells that exert immune function in the central nervous system, and accumulating evidence suggests that microglia act as critical players in the initiation of neurodegenerative disorders, such as Alzheimer’s disease (AD). …”
Get full text

Perioperative Nutrition in Abdominal Surgery: Recommendations and Reality by Yannick Cerantola, Fabian Grass, Alessandra Cristaudi, Nicolas Demartines, Markus Schäfer, Martin Hübner

“…Preoperative oral supplementation of a minimum of five days is preferable; depending on the patient and the type of surgery, immune-enhancing formulas are recommended. However, surgeons' compliance with evidence-based guidelines remains poor and efforts are necessary to implement routine nutritional screening and nutritional support.…”
Get full text

Development of a differentiating of infected from vaccinated animal (DIVA) ELISA to detect antibodies against Senecavirus A in pigs using two expression systems of non-structural p... by Parin Watcharavongtip, Patumporn Jermsutjarit, Angkana Tantituvanont, Dachrit Nilubol

“…They can be valuable tools for sero-surveillance and for evaluating immunity status tests to support and approve vaccination programs for pig herds in the future.…”
Get full text

Targeting gut microbiota in osteoporosis: impact of the microbial-based functional food ingredients by Pauline Duffuler, Khushwant S. Bhullar, Jianping Wu

“…Additional reports demonstrate that gut microbiota regulates bone metabolism through the modulation of the gut function (mineral availability and absorption, gut integrity), the immune system, and the endocrine system. Thus, based on the vital role of gut microbiota on bone health, it has emerged as a novel therapeutic target for the prevention of bone loss and the treatment of osteoporosis. …”
Get full text

Deranged Bioenergetics and Defective Redox Capacity in T Lymphocytes and Neutrophils Are Related to Cellular Dysfunction and Increased Oxidative Stress in Patients with Active Syst... by Ko-Jen Li, Cheng-Han Wu, Song-Chou Hsieh, Ming-Chi Lu, Chang-Youh Tsai, Chia-Li Yu

“…We conclude that deranged cellular bioenergetics and defective redox capacity in T and PMN are responsible for cellular immune dysfunction and are related to increased oxidative stress in active SLE patients.…”
Get full text

The chemokine CX3CL1 promotes intraperitoneal tumour growth despite enhanced T-cell recruitment in ovarian cancer by Stefanie Seitz, Tobias F. Dreyer, Christoph Stange, Katja Steiger, Dirk Wohlleber, Martina Anton, Thuý An Pham, Dominique Sauter-Peschke, Ute Reuning, Gabriele Multhoff, Wilko Weichert, Marion Kiechle, Viktor Magdolen, Holger Bronger

“…T-cell recruiting chemokines are required for a successful immune intervention in ovarian cancer, and also for the efficacy of modern anticancer agents such as PARP inhibitors. …”
Get full text

Comparative Analysis of Hemagglutination Inhibition and Plaque Reduction Neutralization Tests for Japanese Encephalitis Virus Antibody Detection by Cui Li, Jianqing Wan, Deli Wang, Lu Xiao, Xuni Li, Cunshuai Zhang, Zhao Wang

“…We conducted a comparative analysis of the outcomes obtained from the PRNT and HI using 240 serum samples collected from 30 JEV-immunized avian subjects at various time points. Comparative analysis revealed a significant correlation between the HI and PRNT (R² = 0.9321, <i>p</i> ≤ 0.0001). …”
Get full text

Resolution of Inflammation in Neurodegenerative Diseases: The Role of Resolvins by Sajad Chamani, Vanessa Bianconi, Aida Tasbandi, Matteo Pirro, George E. Barreto, Tannaz Jamialahmadi, Amirhossein Sahebkar

“…Among PUFA-derived proresolving mediators, different eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) derivatives have been described, namely, resolvins (resolution phase interaction products), which exert their anti-inflammatory and immune-regulatory activities through specific G-protein-coupled receptors. …”
Get full text

Microglial Lyzl4 Facilitates β‐Amyloid Clearance in Alzheimer's Disease by Jie Pan, Jie Zhong, Ji Geng, Jane Oberhauser, Shihua Shi, Jun Wan

“…However, microglia, the primary immune cells of the central nervous system, are known to maintain homeostasis through the phagocytic clearance of protein aggregates and cellular debris. …”
Get full text

Fetal Programming of Body Composition, Obesity, and Metabolic Function: The Role of Intrauterine Stress and Stress Biology by Sonja Entringer, Claudia Buss, James M. Swanson, Dan M. Cooper, Deborah A. Wing, Feizal Waffarn, Pathik D. Wadhwa

“…We discuss putative maternal-placental-fetal endocrine and immune/inflammatory candidate mechanisms that may underlie the long-term effects of intrauterine stress. …”
Get full text

From Multimorbidity to Network Medicine in Patients with Rheumatic Diseases by Winston Gilcrease, Luca Manfredi, Savino Sciascia, Fulvio Ricceri

“…For instance, rheumatic diseases such as rheumatoid arthritis and systemic lupus erythematosus are not just a collection of symptoms affecting various organs but are also interconnected through underlying systemic inflammatory processes, immune system dysregulation, and genetic predispositions.…”
Get full text

A Case of Thyroid Storm Associated with Cardiomyopathy and Poststreptococcal Glomerulonephritis by Lisa J. Underland, Gerson A. Vallencia Villeda, Abhijeet Pal, Leslie Lam

“…PSGN is due to glomerular immune complexes and can complicate group A strep infection. …”
Get full text

Microfluidic organ-on-chip systems for periodontal research: advances and future directions by Gopu Sriram, Gopu Sriram, Hardik Makkar, Hardik Makkar

“…The pathogenesis of periodontal disease involves a complex interplay between microbial dysbiosis and host immune responses, which can lead to a loss of dental support structures and contribute to systemic conditions such as cardiovascular disease, diabetes, and inflammatory bowel disease. …”
Get full text