Hsp70 and Its Molecular Role in Nervous System Diseases by Giuseppina Turturici, Gabriella Sconzo, Fabiana Geraci

“…Hsp70 functions as a chaperone and protects neurons from protein aggregation and toxicity (Parkinson disease, Alzheimer disease, polyglutamine diseases, and amyotrophic lateral sclerosis), protects cells from apoptosis (Parkinson disease), is a stress marker (temporal lobe epilepsy), protects cells from inflammation (cerebral ischemic injury), has an adjuvant role in antigen presentation and is involved in the immune response in autoimmune disease (multiple sclerosis). …”
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Multiple small bowel GIST as GI manifestation of neurofibromatosis type I: A case report by Habtamu Tsegaye, Adamu Tigabu

“…Histopathology shows Grade I GIST with score 4+ immune reactivity for CD117. It is typically difficult to make a conclusive preoperative diagnosis of GISTs. …”
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Kimura disease: A rare cause of cervical lymphadenopathy and a diagnostic challenge by Virendra Kumar Goyal, Jagdish Vishnoi, Ruhi Dak, Shokat Ali Bohra, Gunjan Sharma

“…An allergic reaction and an alteration of the immune system remains one of the pathophysiological bases. …”
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Propionibacterium acnes: A Treatable Cause of Constrictive Pericarditis by Daniel Cruz, Haitham Ahmed, Yousuf Gandapur, M. Roselle Abraham

“…In this case report we share a case of infective Pericarditis caused by Propionibacterium acnes (P. acnes) in an immune-competent, nonsurgical patient. This case and review will illustrate the importance of considering P. acnes as a cause of idiopathic pericardial effusion and effusive constrictive disease. …”
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Covariation Between Microbiome Composition and Host Transcriptome in the Gut of Wild Drosophila melanogaster: A Re‐Analysis by Frances Llanwarne, Adam J. Dobson

“…The differentially expressed gene sets were enriched in functions including protein translation, mitochondrial respiration, immunity and reproduction. Each gene set had a distinct functional signature, suggesting that wild flies exhibit a range of distinct axes of functional variation, which correspond to orthogonal axes of microbiome variation. …”
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Comparative Evaluation of Salivary Ferritin Levels as a Predictor Inflammatory Biomarker Before and After Non Surgical Periodontal Therapy- An Interventional Study by Saurabh Tembhurne, Sachin K. Malagi, Dennis V. Abraham, Kshitibhushan S. Pandaw, Arundhuti Mahato, Priyal Agrawal

“…Background: Ferritin plays a crucial role in the host immune response, with elevated serum ferritin levels established in various chronic inflammation-related diseases, including periodontitis. …”
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Treatment with the CCR5 antagonist OB-002 reduces lung pathology, but does not prevent disease in a Syrian hamster model of SARS-CoV-2 infection. by Bryce M Warner, Robert Vendramelli, Amrit S Boese, Jonathan Audet, Nikesh Tailor, Courtney Meilleur, Nathan Glowach, Marnie Willman, Thang Truong, Estella Moffat, Kevin Tierney, Beata Kosak, Irfan Dhanidina, Jarret Engstrom, Bozena Korczak, Ian McGowan, Carissa Embury-Hyatt, Darwyn Kobasa

“…Daily treatment with OB-002 altered immune gene transcription in the lungs, and reduced pathology following infection, but did not prevent weight loss or viral replication in the lungs of infected animals, even in combination with the antiviral drug remdesivir. …”
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Chain Gangs: New Aspects of Hyaluronan Metabolism by Michael Erickson, Robert Stern

“…., the ability to modulate immune responses through effects on T regulatory cells and, in its fragmented forms, by being able to engage several toll-like receptors. …”
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Serum IL-18 Is Increased at Early Postburn Period in Moderately Burned Patients by Y. Kenan Coban, Murat Aral

“…IL-18 enhances the Th1 immune responses in bacterial andviral infections. …”
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Regulation of pyroptosis by NF-κB signaling by Ling Yang, Yan Zhang, Zhuodong Chai, Yuqi Zhou, Zhenyu Li, Yinan Wei

“…Nuclear factor-κB (NF-κB), a prototypical pro-inflammatory transcription factor, plays a critical role in immune system regulation. Recent research highlights the multifaceted roles of NF-κB signaling in pyroptosis. …”
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Microbes, macrophages, and melanin: a unifying theory of disease as exemplified by cancer by Stacie Z. Berg, Jonathan Berg

“…In this article, we provide evidence that tumors are actually complex microbial communities composed of various microorganisms living within biofilms encapsulated by a hard matrix; that these microorganisms are what cause the genetic mutations seen in cancer and control angiogenesis; that these pathogens spread by hiding in tumor cells and M2 or M2-like macrophages and other phagocytic immune cells and traveling inside them to distant sites camouflaged by platelets, which they also reprogram, and prepare the distant site for metastasis; that risk factors for cancer are sources of energy that pathogens are able to utilize; and that, in accordance with our previous unifying theory of disease, pathogens utilize melanin for energy for building and sustaining tumors and metastasis. …”
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The Four Pillars for Successful Regenerative Therapy in Endodontics: Stem Cells, Biomaterials, Growth Factors, and Their Synergistic Interactions by C. Brizuela, George T.-J. Huang, A. Diogenes, T. Botero, M. Khoury

“…The regenerated dental pulp will recover the protective mechanisms including innate immunity, tertiary dentin formation, and pain sensitivity. …”
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Predictors associated with time to default for HIV/AIDS patients under HAART at Debre Tabor Referral Hospital: a Cox regression model by Koyachew Bitew Abebe

“…Abstract The human immunodeficiency virus systematically undermines the immune system, which serves as our body’s inherent safeguard against diseases. …”
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COVID-19-Induced Fatal Thrombotic Thrombocytopenic Purpura in a Healthy Young Patient by Mariana Codevila Buere Pereira, Bruna Ruschel, Bruna Schneider, Vitor Salomão Gonçalves Melo de Melgar, Tatiana Helena Rech

“…TTP can be an unusual presentation of COVID-19 disease mediated by the virus-induced immune response. We report a case of a healthy young patient presenting with the classic TTP pentad a few days after a diagnosis of COVID-19 confirmed by a positive SARS-CoV-2 RT-PCR test. …”
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Modulation of cytokine production by carnitine by Nicola M. Kouttab, Claudio De Simone

“…These preliminary studies provide evidence that carnitine may modulate immune functions through the production of selected cytokines.…”
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Discovering the interactome, functions, and clinical relevance of enhancer RNAs in kidney renal clear cell carcinoma by Zhaohui Sun, Haojie Du, Xudong Zheng, Hepeng Zhang, Huajie Hu

“…Our findings revealed that up-regulated eRNAs in KIRC potentially regulate immune response and hypoxia pathways, while down-regulated eRNAs may impact ion transport, cell cycle, and metabolism. …”
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HIV-Associated Neurotoxicity: The Interplay of Host and Viral Proteins by Sushama Jadhav, Vijay Nema

“…The mechanisms associated with such immune activation can disrupt neuronal and glial functions. …”
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Advances in adjuvant therapy for operable N2 non-small cell lung cancer: a narrative review by Lei Liu, Yilong Mao, Leilei Guo, Chencong Li, Yiqian Wang

“…Meanwhile, the booming development of adjuvant targeted therapy and adjuvant immunotherapy also provides newer therapeutic options for the prognosis of postoperative pN2 stage NSCLC, and some new markers will guide the adaptive application of immune drugs in the future. This article analyzes the current stage of therapeutic advances in operable stage N2 non-small cell lung cancer, and discusses in detail in this article the therapeutic controversy of postoperative adjuvant radiotherapy in pN2 stage non-small cell lung cancer, so as to explore a more reasonable treatment mode for future patients with stage N2 non-small cell lung cancer.…”
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Increased Vitamin B12 Levels in Patients with Oral Cancer by Prashant Gupta, Subhash Chandra, Awanindra Kumar Jha, Tanya Khaitan, Anjani Kumar Shukla, Shantala R Naik

“…Serum vitamin B12 is important in maintaining the immune system and also repairing the damaged deoxyribonucleic acid (DNA) of cells. …”
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Computational design of multi-epitope vaccine against Hepatitis C Virus infection using immunoinformatics techniques. by Sara Zubair, Fahed Parvaiz, Turki Abualait, Khalid Al-Regaiey, Tasneem Anwar, Mahnoor Zafar, Imdad Kaleem, Shahid Bashir

“…Hepatitis C Virus (HCV) is a blood borne pathogen that affects around 200 million individuals worldwide. Immunizations against the Hepatitis C Virus are intended to enhance T-cell responses and have been identified as a crucial component of successful antiviral therapy. …”
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