The Role of TLR2, TLR4, and TLR9 in the Pathogenesis of Atherosclerosis by Mohsin H. K. Roshan, Amos Tambo, Nikolai P. Pace

“…They are expressed by a variety of immune cells where they recognize pathogen-associated molecular patterns (PAMPs). …”
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Comparison of Myeloid Cells in Circulation and in the Tumor Microenvironment of Patients with Colorectal and Breast Cancers by Salman M. Toor, Eyad Elkord

“…Taken together, this work suggests that CRC patients may benefit more from the development of therapeutic agents to promote myeloid cell differentiation or inhibition for the reversal of immune suppression.…”
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Update on Primary Biliary Cirrhosis by Jenny Heathcote

“…The etiology of PBC remains elusive; studies suggest that the interlobular bile duct destruction is immune based, and associated autoimmune diseases are common. …”
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The Neurobiological Pathogenesis of Poststroke Depression by Chao Feng, Min Fang, Xue-Yuan Liu

“…Abundant studies suggested that large lesions in critical areas such as left frontal lobe and basal ganglia or accumulation of silent cerebral lesions might interrupt the pathways of monoamines or relevant pathways of mood control, thus leading to depression. Activation of immune system after stroke produces more cytokines which increase glutamate excitotoxicity, results in more cell deaths of critical areas and enlargement of infarctions, and, together with hypercortisolism induced by stress or inflammation after stroke which could decrease intracellular serotonin transporters, might be the key biochemical change of PSD. …”
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Key characteristics in designing HIV interventions at a glance by Mona Larki, Elham Manouchehri

“…Acquired immune deficiency syndrome (AIDS) is one of the most serious problems confronting human society, with significant healthcare costs, societal concerns, and focus on the youth. …”
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Novel anti-inflammatory properties of mannose oligosaccharides in the treatment of inflammatory bowel disease via LGALS3 modulation by Yaqi Du, Yan Fan, Xin Li, Fenqin Chen

“…Detailed molecular analyses further demonstrated that these changes in microbiota were associated with modifications in the host’s immune response, particularly through the suppression of key inflammatory pathways and cytokines involved in IBD progression. …”
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Role of microglia in the pathogenesis of multiple sclerosis and links to immunomodulatory therapy by P. Valiukevičius, R. Liutkevičienė, R. Balnytė

“…Microglial cells phagocytose harmful myelin remnants, promote remyelination, and control the proper response of peripheral immune cells, but disruption of these functions can lead to demyelination and neurodegeneration. …”
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Antibody dynamics in dogs submitted to different canine visceral leishmaniasis treatment protocols by Eliesse Pereira Costa, Gisele Vaz Aguirre Samoel, Gilneia da Rosa, Vanessa Osmari, Michelli Lopes de Souza, Luís Felipe Dias Lopes, Fernanda Silveira Flôres Vogel, Sônia de Avila Botton, Luís Antônio Sangioni

“…All animals submitted to the evaluated treatment protocols showed relative improvement in clinical signs. Furthermore, the immune response of animals must be considered, given the challenges of parasitic loads in infections. …”
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Targeting glycolysis: exploring a new frontier in glioblastoma therapy by Lu Yang, Sijia Li, Lei Yu, Jiao Leng, Na Li

“…Lactate has been implicated in promoting tumor cell proliferation, invasion, and immune evasion. Additionally, this review systematically analyzes potential therapeutic strategies targeting key molecules within the glycolytic pathway, such as Glucose Transporters (GLUTs), Monocarboxylate Transporters(MCTs), Hexokinase 2 (HK2), 6-Phosphofructo-2-Kinase/Fructose-2,6-Biphosphatase 3 (PFKFB3), Pyruvate Kinase Isozyme Type M2 (PKM2), and the Lactate Dehydrogenase A (LDHA). …”
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Evaluation of Nutritional Supplements on Periodontal Fibroblast in Systemic Disease Conditions: An In Vitro Study by Saleh A. Alsanie

“…Specifically, vitamin C and omega-3 fatty acids demonstrated significant protective effects against inflammation-induced cell damage, while probiotics promoted a balanced immune response. Conclusion: Nutritional supplements, including vitamin C, vitamin D, omega-3 fatty acids, and probiotics, exhibit promising effects on periodontal health in systemic disease conditions. …”
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Effectiveness of Polyclonal Antibody Immunoconjugate Treatment with Propamidine Isethionate for Amoebic Keratitis in Golden Hamsters by Manuel Enrique Ávila-Blanco, Sandra Lizbeth Aguilera-Martínez, Javier Ventura-Juarez, Jorge Pérez-Serrano, Elizabeth Casillas-Casillas, Luis Fernando Barba-Gallardo

“…We proposed an immunoconjugate treatment obtained from Acanthamoeba immunized rabbit serum combined with propamidine isethionate; the corneas of hamsters inoculated with A. griffini (MYP2004) were treated with the combined, at 1, 2, and 3 weeks. …”
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Cell-Type-Specific Differentiation and Molecular Profiles in Skin Transplantation: Implication of Medical Approach for Genetic Skin Diseases by Noritaka Oyama, Fumio Kaneko

“…These local events are more unlikely to be regulated by the host immunity, because human skin transplantation has accomplished the donor skin engraftment onto the immunocompromised or immunosuppressive animals. …”
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Biological characterization and clinical significance of cuproptosis-related genes in lung adenocarcinoma by Meilin Li, Yu Tan, Zhixin Li, Lingfeng Min

“…Results CDKN2A and MTF1 were cuproptosis-associated LUAD differential genes and were differentially expressed in immune subtypes. The expression of CDKN2A and MTF1 showed correlation with multiple functional states of LUAD.CDKN2A was negatively correlated with LUAD survival prognosis. …”
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Comparative transcriptome analysis in two contrasting genotypes for Sclerotinia sclerotiorum resistance in sunflower. by Mingzhu Zhao, Bing Yi, Xiaohong Liu, Dexing Wang, Dianxiu Song, Enyu Sun, Liangji Cui, Jingang Liu, Liangshan Feng

“…Most of DEGs were enriched in cell wall organisation, protein kinase activity, hormone, transcription factor activities, redox homeostasis, immune response, and secondary metabolism. Differential expression of genes involved in expansins, pectate lyase activities, ethylene biosynthesis and signaling and antioxidant activity after S. sclerotiorum infection could potentially be responsible for the differential resistance among two genotypes. …”
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The Expression of PPAR Pathway-Related Genes Can Better Predict the Prognosis of Patients with Colon Adenocarcinoma by Xiao-Yu Zhou, Jian-Qi Wang, Jin-Xu Chen, Jing-Song Chen

“…Furthermore, PPAR-Riskscore was able to evaluate the immune cell infiltration and chemotherapy sensitivity of each tumor sample. …”
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Relapsed childhood T-cell acute lymphoblastic leukemia and lymphoblastic lymphoma by Andrew D. Hughes, Petri Pölönen, David T. Teachey

“…Given these insights into disease biology and the development of targeted and immune-based treatments, it is reasonable to hope for improved patient outcomes, although challenges still exist. …”
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The Role of Glial Cells in the Pathophysiology of Epilepsy by Filiz Onat, My Andersson, Nihan Çarçak

“…Microglia, the innate immune cells of the CNS, contribute to neuroinflammation, glutamate excitotoxicity, and the balance between excitatory and inhibitory neurotransmission, underscoring their dual role in seizure promotion and protection. …”
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Une bactérie multirésistante avant l’ère des antibiotiques : l’agent de la mélioïdose by Buisson, Yves

“…B. pseudomallei is a facultative intracellular bacterium that can overcome host immune defences, induce acute, subacute, or chronic invasive infection, or remain latent for years. …”
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Acquired Myelodysplasia or Myelodysplastic Syndrome: Clearing the Fog by Ethan A. Natelson, David Pyatt

“…Moreover, the term MDS is occasionally inappropriately applied to hematologic disorders associated with acquired morphologic myelodysplastic features which may rather represent potentially reversible hematological responses to immune-mediated factors, nutritional deficiency states, and disordered myelopoietic responses to various pharmaceutical, herbal, or other potentially myelotoxic compounds. …”
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Corrosion Behavior of Work Hardened SnPb-Solder Affected Copper in the Bay of Bengal Water Environment by M. Muzibur Rahman, S. Reaz Ahmed, M. Salim Kaiser

“…Copper and its alloys are extensively used in marine applications due to high corrosion resistant behavior. But the corrosion immunity of copper varies with the environmental factors especially the sea water ingredients. …”
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