Interventional real-time molecular MRI for targeting early myocardial injury in a pig model by Timo Heidt, Simon Reiss, Julien Thielmann, Christian Weber, Alexander Maier, Thomas Lottner, Heidi R. Cristina-Schmitz, Timon Bühler, Diana Chiang, Claus Jülicher, Carolin Wadle, Ingo Hilgendorf, Dennis Wolf, Gavin Tumlinson, Luis Hortells, Dirk Westermann, Michael Bock, Constantin von zur Mühlen

“…Abstract Myocardial ischemia induces tissue injury with subsequent inflammation and recruitment of immune cells. Besides myocardial tissue characterization, magnetic resonance imaging (MRI) allows for functional assessment using molecular imaging contrast agents. …”
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The Use of Antisense-Mediated Inhibition to Delineate The Role of Inflammatory Agents in The Pathophysiology of Spinal Cord Injury by Damien D. Pearse, Francisco C. Pereira, Katina Chatzipanteli, Francisco W. Dalton Dietrich, Mary Bartlett Bunge

“…During this period, glia and immune cells respond to chemical cues associated with the debris of lysed neurons, disrupted axons, and a broken blood-brain-barrier by releasing a battery of cytokines including tumor necrosis factor-α (TNF-α) and, interleukin-β (IL-1β) as well as reactive oxygen species such as nitric oxide (NO-)[2]. …”
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Uncovering Molecular Mechanisms of Feed Efficiency in Pigs Through Multi-Omics Analysis of the Jejunum by Saixian Zhang, Yue Xiang, Yaobang Jian, Qiulin Zhao, Jiahui Sun, Yi Huang, Jing Xu, Xiaolong Qi, Jingjin Li, Zhuqing Zheng, Liangliang Fu, Yuwen Liu, Xinyun Li

“…By comparing gene expression and chromatin accessibility profiles in the jejunum, we identified key differentially expressed genes (DEGs) and differentially accessible regions (DARs) associated with lipid metabolism and immune function, both of which are critical pathways for efficient growth. …”
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Identification and Characterization of the <i>LecRLKs</i> Gene Family in Maize, and Its Role Under Biotic and Abiotic Stress by Xiangbo Yang, Ziqi Chen, Jianyu Lu, Xuancheng Wei, Yanying Yao, Wendi Lv, Jiarui Han, Jianbo Fei

“…It can rapidly respond to both biotic and abiotic stresses while mediating mechanisms of plant immune responses. This study represents the first identification of the LecRLK family genes in maize. …”
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Recent advances in adipose-derived mesenchymal stem cell-derived exosomes for regulating macrophage polarization by Zhewei Dong, Yingli Fu, Zhongming Cai, Hao Dai, Yucang He

“…This review summarizes the contents and functions of ADSC-EXOs, outlines their properties and the characteristics of macrophage phenotypes, and emphasizes their impact on macrophage polarization and their contribution to immune-related diseases.…”
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Conjugation of LasR Quorum-Sensing Inhibitors with Ciprofloxacin Decreases the Antibiotic Tolerance of P. aeruginosa Clinical Strains by Daria Bortolotti, Claudio Trapella, Alessandra Bragonzi, Paolo Marchetti, Vinicio Zanirato, Andrea Alogna, Valentina Gentili, Carlo Cervellati, Giuseppe Valacchi, Mariangela Sicolo, Giulia Turrin, Anna Fantinati, Dario Di Luca, Roberta Rizzo

“…Pseudomonas aeruginosa is a Gram-negative bacterium that commonly infects subjects with weakened immune system causing deadly infections above all at pulmonary level. …”
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Mesenchymal Stem Cells from Patients with Rheumatoid Arthritis Display Impaired Function in Inhibiting Th17 Cells by Yue Sun, Wei Deng, Linyu Geng, Lu Zhang, Rui Liu, Weiwei Chen, Genhong Yao, Huayong Zhang, Xuebing Feng, Xiang Gao, Lingyun Sun

“…Mesenchymal stem cells (MSCs) possess multipotent and immunomodulatory properties and are suggested to be involved in the pathogenesis of immune-related diseases. This study explored the function of bone marrow MSCs from rheumatoid arthritis (RA) patients, focusing on immunomodulatory effects. …”
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Challenges in Treating Statin-Associated Necrotizing Myopathy by Patrick Webster, Nicholas Wiemer, Abdalhamid Al Harash, Cody Marshall, Nazia Khatoon, Michael Lucke

“…While these symptoms are generally self-limited, in rare cases, statin use is associated with an immune-mediated necrotizing myopathy caused by development of autoantibodies against HMG-CoA reductase. …”
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Harnessing macrophage-drug conjugates for allogeneic cell-based therapy of solid tumors via the TRAIN mechanism by Bartlomiej Taciak, Maciej Bialasek, Malgorzata Kubiak, Ilona Marszalek, Malgorzata Gorczak, Olha Osadchuk, Daria Kurpiel, Damian Strzemecki, Karolina Barwik, Marcin Skorzynski, Julia Nowakowska, Waldemar Lipiński, Łukasz Kiraga, Jan Brancewicz, Robert Klopfleisch, Łukasz Krzemiński, Emilia Gorka, Anna Smolarska, Irena Padzinska-Pruszynska, Małgorzata Siemińska, Jakub Guzek, Jan Kutner, Marlena Kisiala, Krzysztof Wozniak, Giacomo Parisi, Roberta Piacentini, Luca Cassetta, Lesley M. Forrester, Lubomir Bodnar, Tobias Weiss, Alberto Boffi, Paulina Kucharzewska, Tomasz P. Rygiel, Magdalena Krol

“…The TRAIN process requires direct cell-to-cell contact and an immune synapse-like structure. At last, MDCs with various anti-cancer drugs are formulated with their safety and anti-tumor efficacy validated in multiple syngeneic mice and orthotopic human tumor models via different routes of administration. …”
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Towards designing improved cancer immunotherapy targets with a peptide-MHC-I presentation model, HLApollo by William John Thrift, Nicolas W. Lounsbury, Quade Broadwell, Amy Heidersbach, Emily Freund, Yassan Abdolazimi, Qui T. Phung, Jieming Chen, Aude-Hélène Capietto, Ann-Jay Tong, Christopher M. Rose, Craig Blanchette, Jennie R. Lill, Benjamin Haley, Lélia Delamarre, Richard Bourgon, Kai Liu, Suchit Jhunjhunwala

“…Antigen presentation on MHC class I (MHC-I) is crucial for the adaptive immune response to cancer cells, necessitating highly predictive computational methods to model this phenomenon. …”
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Primary Biliary Cholangitis Associated with Ulcerative Colitis: Case Series and Literature Review by Qi Li, Ye Zong

“…Shared susceptibility genes, certain bacterial infections, and common immune-mediated mechanisms may be involved in the pathogenesis of UC patients with PBC. …”
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Probiotics in the Modern World by Y. P. Uspenskiy, Y. A. Fominykh, K. N. Nadzhafova, S. V. Polyushkin

“…Alike normal microflora, probiotic strains incorporate into general metabolism by mediating a spectrum of functions, e.g. maintaining colonisation resistance, nutrient metabolism, supplying the host with vital metabolites, regulation of local and adaptive immune responses, enhancing the intestinal barrier. …”
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The Fetal Allograft Revisited: Does the Study of an Ancient Invertebrate Species Shed Light on the Role of Natural Killer Cells at the Maternal-Fetal Interface? by Amy Lightner, Danny J. Schust, Yi-Bin A. Chen, Breton F. Barrier

“…Since human uterine NK cells appear to de-emphasize primary immunological function, it is proposed that they may share the same evolutionary roots as the B. schlosseri allorecognition system rather than a primary origin in immunity.…”
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Secretory Products of Trichinella spiralis Muscle Larvae and Immunomodulation: Implication for Autoimmune Diseases, Allergies, and Malignancies by Ljiljana Sofronic-Milosavljevic, Natasa Ilic, Elena Pinelli, Alisa Gruden-Movsesijan

“…Those products can successfully modulate parasite-specific immune responses as well as responses to unrelated antigens (either self or nonself in origin), providing an anti-inflammatory milieu and maintaining homeostasis. …”
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The Pivotal Role of TBK1 in Inflammatory Responses Mediated by Macrophages by Tao Yu, Young-Su Yi, Yanyan Yang, Jueun Oh, Deok Jeong, Jae Youl Cho

“…TBK1 is a serine/threonine-protein kinase which regulates antiviral defense, host-virus interaction, and immunity. It is ubiquitously expressed in mouse stomach, colon, thymus, and liver. …”
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Transport and inhibition of the sphingosine-1-phosphate exporter SPNS2 by Huanyu Z. Li, Ashley C. W. Pike, Yung-Ning Chang, Dheeraj Prakaash, Zuzana Gelova, Josefina Stanka, Christophe Moreau, Hannah C. Scott, Frank Wunder, Gernot Wolf, Andreea Scacioc, Gavin McKinley, Helena Batoulis, Shubhashish Mukhopadhyay, Andrea Garofoli, Adán Pinto-Fernández, Benedikt M. Kessler, Nicola A. Burgess-Brown, Saša Štefanić, Tabea Wiedmer, Katharina L. Dürr, Vera Puetter, Alexander Ehrmann, Syma Khalid, Alvaro Ingles-Prieto, Giulio Superti-Furga, David B. Sauer

“…Abstract Sphingosine-1-phosphate (S1P) is a signaling lysolipid critical to heart development, immunity, and hearing. Accordingly, mutations in the S1P transporter SPNS2 are associated with reduced white cell count and hearing defects. …”
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ECM29/proteasome-mediated self-antigen generation by CNS-resident neuroglia promotes regulatory T cell activation by Sheng-Wen Chen, Ying Chu, Chien-Hsin Chu, Xuan-Dieu Thi Pham, Hang Pong Ng, Chin-Lin Guo, Pei-Lin Cheng

“…Thus, Ecm29/proteasome-controlled, neuroglia-derived self-antigens modulate CNS immune tolerance.…”
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Research Progress in Diseases Caused by STAT1 Gain-of-Function Mutations by LI Linpeng, MA Jing, GU Hao, SHU Zhou, MAO Huawei

“…For the treatment of STAT1-GOF, such as targeted therapy with ruxolitinib for STAT1 hyperphosphorylation, immunomodulatory therapy and hematopoietic stem cell transplantation for different self-immune systems, certain curative effects can be obtained. …”
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The Effect of Age and Occupation on the Seroprevalence of Helicobacter pylori Infection by GI Perez-Perez, T Marrie, H Inouye, T Shimoyama, G Marshall, G Meiklejohn, MJ Blaser

“…The seroprevalence did not decrease in elderly persons (60 to 99 years), indicating a persistent immune response. More detailed analysis was perfom1ed on the Canadian population. …”
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Exploring the Crosstalk between Inflammation and Epithelial-Mesenchymal Transition in Cancer by Indranil Chattopadhyay, Rangarao Ambati, Rohit Gundamaraju

“…The current review elucidates the interaction between EMT tumor cells and immune cells under the microenvironment. Such complex interactions provide a better understanding of tumor angiogenesis and metastasis and in defining the aggressiveness of the primary tumors. …”
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