Climate change, air pollution and chronic respiratory diseases: understanding risk factors and the need for adaptive strategies by Jiayu Xu, Zekang Su, Chenchen Liu, Yuxuan Nie, Liangliang Cui

“…Potential pathophysiological mechanisms linking climate change and increased risk of CRD involved pulmonary inflammation, immune disorders, oxidative stress. Notably, the elderly, children, impoverished groups and people in regions with limited adaptability are more sensitive to respiratory health risks caused by climate change. …”
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Heme alters biofilm formation in Mycobacterium abscessus by Hadia Aftab, Jessica Samudio, Grace Wang, Lily Le, Rajesh K. Soni, Rebecca K. Donegan

“…During infection, Mabs can form biofilms in the lung which reduce both the ability of the immune response to clear infection and the effectiveness of antibiotic therapy. …”
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Investigation of polarization transformations performed with a refractive bi-conical axicon using the FDTD method by P.A. Khorin, A.M. Algubili, S.A. Degtyarev, S.K. Sergunin, S.V. Karpeev, S.N. Khonina

“…The proposed element is shown to be immune to chromatic aberrations in a significant range of changes in the refractive index of the element material and incident wavelengths (1.5 ≤ n ≤ 1.7; 1 μm ≤ λ ≤ 1.5 μm).…”
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Comparison of Immunological Characteristics of Mesenchymal Stem Cells from the Periodontal Ligament, Umbilical Cord, and Adipose Tissue by Jin-Hee Kim, Chris H. Jo, Hang-Rae Kim, Young-il Hwang

“…Unlike the other two types of MSCs, UC-MSCs showed minimal expression of HLA-DR after activation, suggesting that they pose minimal risk of initiating an allogeneic immune response when administered in vivo. These characteristics, the ease of collection, and the minimal ethical concerns regarding their use suggest UC-MSCs to be suitable MSC therapeutic candidates.…”
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Analysis of Gene Expression in an Inbred Line of Soft-Shell Clams (Mya arenaria) Displaying Growth Heterosis: Regulation of Structural Genes and the NOD2 Pathway by John J. Wilson, Janelle Grendler, Azaline Dunlap-Smith, Brian F. Beal, Shallee T. Page

“…Also differentially expressed was the nucleotide-binding oligomerization domain 2 (NOD2) receptor pathway that contributes to determination of growth, immunity, apoptosis, and proliferation. NOD2 pathway members that were upregulated included a subset of isoforms of RIPK2 (mean 3.3-fold increase in expression), ERK/MAPK14 (3.8-fold), JNK/MAPK8 (4.1-fold), and NFκB (4.08-fold). …”
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Evaluation of a Rapid Kit for Detection of IgM against Leptospira in Human by Mohan Rao, Fairuz Amran, Nadia Aqilla

“…This study measures efficiency of an immune-chromatographic assay, Leptocheck WB, in detecting acute leptospirosis. …”
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Balancing Inflammation: The Link between Th17 and Regulatory T Cells by Maggie L. Diller, Ragini R. Kudchadkar, Keith A. Delman, David H. Lawson, Mandy L. Ford

“…The balance between these two cell populations is essential for immune homeostasis and dysregulation of this balance has been implicated in a variety of inflammatory conditions including autoimmunity, allograft rejection, and tumorigenesis. …”
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Contribution of long-lived plasma cells to antibody-mediated allograft rejection by Eunkyeong Jang, Jeehee Youn

“…Persistent alloantigens derived from allograft tissues can be recognized by the host’s alloreactive immune system. This process enables cognate B cells to differentiate into plasma cells, which secrete donor-specific antibodies that are key drivers of antibody-mediated allograft rejection. …”
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Effects of POPs-induced SIRT6 alteration on intestinal mucosal barrier function: A comprehensive review by Guangcan Chen, Tengyang Huang, Yifeng Dai, Xia Huo, Xijin Xu

“…The intestinal mucosal barrier, a sophisticated defense mechanism comprising the epithelial layer, mucosal chemistry, and cellular immunity, shields the host from external threats and fosters a symbiotic relationship with intestinal bacteria. …”
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Efficacy of Nivolumab in a Patient with Metastatic Renal Cell Carcinoma and End-Stage Renal Disease on Dialysis: Case Report and Literature Review by Jawaher Ansari, Muhammad Ali, Ashraf Farrag, Arwa M. Ali, Abdulaziz Alhamad

“…Nivolumab, an anti-programmed death-1 immune checkpoint inhibitor antibody, is indicated for the treatment of patients with mRCC who have received prior antiangiogenic therapy. …”
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Mechanisms and roles of membrane-anchored ATG8s by Soo-Kyeong Lee, Sang-Won Park, Deok-Jin Jang, Jin-A. Lee

“…These pathways expand ATG8’s functional repertoire in immune regulation, membrane repair, and pathogen clearance, as ATG8 becomes conjugated to single-membrane structures (e.g., phagosomes and lysosomes). …”
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Defective removal of invariant chain peptides from MHC class II suppresses tumor antigen presentation and promotes tumor growth by Joanna Bandola-Simon, Yoshinaga Ito, Kai W. Wucherpfennig, Paul A. Roche

“…Our data reveal a previously unknown mechanism of immune evasion in which enhanced expression of MHC-II-CLIP complexes on tumor-draining lymph node DCs limits MHC-II availability for tumor peptides.…”
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Thirty years from FDA approval of pegylated liposomal doxorubicin (Doxil/Caelyx): an updated analysis and future perspective by Alberto A Gabizon, Shira Gabizon-Peretz, Shadan Modaresahmadi, Ninh M La-Beck

“…PLD is a complex product and we are still in a learning curve regarding a number of factors such as its interaction with the complement system and its immune modulatory properties, as well as its integration in multimodality therapy that may potentiate its value and role in cancer therapy.…”
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Neuroinflammation as Fuel for Axonal Regeneration in the Injured Vertebrate Central Nervous System by Ilse Bollaerts, Jessie Van houcke, Lien Andries, Lies De Groef, Lieve Moons

“…As aging not only affects the CNS, but also the immune system, the regeneration potential is expected to further decline in aged individuals, an element that should definitely be considered in the search for novel therapeutic strategies.…”
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The Impact of PPARγ Genetic Variants on IBD Susceptibility and IBD Disease Course by Jessica Mwinyi, Christa Grete-Wenger, Jyrki J. Eloranta, Gerd A. Kullak-Ublick

“…PPARγ is a nuclear receptor that regulates numerous pathways including cytokine expression and immune responses and plays an important role in controlling colon inflammation. …”
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Purification and identification of anti-inflammatory peptides from sturgeon (Acipenser schrenckii) cartilage by Li Yuan, Qian Chu, Bei Yang, Wei Zhang, Quancai Sun, Ruichang Gao

“…However, previous studies have proposed the possibility of producing peptides from cartilage with immune function modulation potential. The current study aimed to investigate the potential anti-inflammatory activity of peptides derived from sturgeon (Acipenser schrenckii) cartilage in lipopolysaccharide (LPS)-stimulated RAW264.7 macrophages. …”
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Claudin-11 regulates immunological barrier formation and spermatogonial proliferation through stem cell factor by Taichi Sugawara, Kayoko Sonoda, Nattapran Chompusri, Kazuhiro Noguchi, Seiji Okada, Mikio Furuse, Tomohiko Wakayama

“…This suggests that adaptive immune responses to spermatogenic cells are not a cause of defective spermatogenesis in Cldn11-deficient mice. …”
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A Case of Long-Term Survival after Checkpoint Inhibitor Pneumonitis in a Patient with Squamous Cell Lung Cancer by Hironori Ashinuma, Satoko Mizuno, Yasushi Yoshida, Masato Shingyoji

“…The management of grade 1 checkpoint inhibitor pneumonitis (CIP) is to withhold immune checkpoint inhibitors; however, the natural history of this condition is unknown. …”
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Transforming Growth Factor-Beta and Matrix Metalloproteinases: Functional Interactions in Tumor Stroma-Infiltrating Myeloid Cells by Jelena Krstic, Juan F. Santibanez

“…In tumorigenesis, it may act as a protumorigenic factor and have a profound impact on the regulation of the immune system response. Matrix metalloproteinases (MMPs) are a family that comprises more than 25 members, which have recently been proposed as important regulators acting in tumor stroma by regulating the response of noncellular and cellular microenvironment. …”
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Identifying vital spreaders in large-scale networks based on neighbor multilayer contributions by Weiwei Zhu, Xuchen Meng, Jiaye Sheng, Dayong Zhang

“…IntroductionIdentifying influential spreaders in complex networks is crucial for understanding information propagation and disease immunity. The spreading ability of a node has been commonly assessed through its neighbor information. …”
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