NF-κB Inhibitory Activity of the Di-Hydroxy Derivative of Piperlongumine (PL-18) by Yael Schlichter Kadosh, Subramani Muthuraman, Ariel Kushmaro, Rajendran Saravana Kumar, Jacob Gopas

“…Inflammation is a critical response of the immune system to infection or injury, serving to repair and restore tissue homeostasis. …”
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A Rare Extraskeletal Osteosarcoma Appearing After 55 Years on a Large Stage 3 Burn Scar by O. Vanhooteghem, I. Theate

“…Deep tissues are probably less subject to severe insult than is the epithelial layer during physical insult, suggesting that soft tissues transform to a lesser extent during the late stages of tumoral development as in an immunocompromised district with altered local immune defense with both cellular and humoral defense affected. …”
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Monkeypox and other orthopoxvirus zoonoses by K. N. Gruzdev

“…Their role is currently increasing while the number of persons not immune to smallpox grows. Along with this, there is a genetic transformation of pathogens. …”
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Small-Animal X-ray Dose from Micro-CT by John M. Boone, Orlando Velazquez, Simon R. Cherry

“…Although the radiation levels used for micro-CT are generally not lethal to the animal, they are high enough where changes in the immune response and other biological pathways may alter the experimental outcomes. …”
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Ferritin in Adult-Onset Still’s Disease: Just a Useful Innocent Bystander? by Bella Mehta, Petros Efthimiou

“…Adult-Onset Still’s Disease (AOSD) is an immune-mediated systemic disease with quotidian-spiking fever, rash, and inflammatory arthritis. …”
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Allogeneic Antigen Composition for Preparing Universal Cancer Vaccines by Petr G. Lokhov, Elena E. Balashova

“…The present report extends these studies in vitro by investigating the efficacy of allogeneic antigens with regard to their ability to target immune responses against the tumor vasculature since alloantigens simplify vaccine development and implementation in clinical practice. …”
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Coinfections increase the risk of HIV acquisition, AIDS progression, and therapy and prophylaxis failure: a review by Robert Root-Bernstein

“…Repeated predispository infections also degrade immune competence independent of HIV and undermine ART and pre-exposure prophylaxis effectiveness. …”
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Mechanisms of liver disease in patients infected with HIV by Matthew B Kaspar, Richard K Sterling

“…A thorough understanding of the mechanisms driving the development of liver disease in these patients is essential when evaluating and caring for these patients.Methods The literature regarding mechanisms of liver disease by which different disease entities may cause hepatic injury and fibrosis was reviewed and synthesised.Results A number of discrete mechanisms of injury were identified, to include: oxidative stress, mitochondrial injury, lipotoxicity, immune-mediated injury, cytotoxicity, toxic metabolite accumulation, gut microbial translocation, systemic inflammation, senescence and nodular regenerative hyperplasia. …”
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Cardiac Dedifferentiated Liposarcoma Requiring a Mitral Valve Replacement Complicated by Severe Paravalvular Leak: A Rare Case Report with Literature Review by Anju Adhikari, Adam Hafeez, Alexandra Halalau

“…MVR was later complicated by paravalvular leak leading to acute congestive heart failure. Tissue immune histology was consistent with dedifferentiated liposarcoma. …”
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Sarcoid-like reaction at the patient with chronic hepatitis C on a background of antiviral therapy by A. V. Lapshin, N. I. Kokina, M. V. Mayevskaya, I. A. Sokolina, V. T. Ivashkin

“…Cessation of antiviral therapy did not result in improvement of patient’s state within 2 months. Immune-suppressive therapy by methylprednisolon and phosphogliv was prescribed, that resulted in complete regression of clinical symptoms and radiological changes in the lungs. …”
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Influenza A virus infection of human primary dendritic cells impairs their ability to cross-present antigen to CD8 T cells. by Anna Smed-Sörensen, Cécile Chalouni, Bithi Chatterjee, Lillian Cohn, Peter Blattmann, Norihiro Nakamura, Lélia Delamarre, Ira Mellman

“…Influenza A virus (IAV) infection is normally controlled by adaptive immune responses initiated by dendritic cells (DCs). …”
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Putative Key Role of Inositol Messengers in Endothelial Cells in Preeclampsia by Sirilaksana Kunjara, Patricia McLean, Laurens Rademacher, Thomas W. Rademacher, Fabiana Fascilla, Stefano Bettocchi, Marco Scioscia

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Metabolomic analysis of murine tissues infected with Brucella melitensis. by Bárbara Ponzilacqua-Silva, Alexis S Dadelahi, Charles R Moley, Mostafa F N Abushahba, Jerod A Skyberg

“…Brucella can replicate in a variety of tissues and can induce immune responses that alter host metabolite availability. …”
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Triplet Therapy with PD-1 Blockade, Histone Deacetylase Inhibitor, and DNA Methyltransferase Inhibitor Achieves Radiological Response in Refractory Double-Expressor Diffuse Large B... by Runhui Zheng, Xiaobo Chen, Chunyan Wang, Pengfei Qin, Huo Tan, Xiaodan Luo

“…Double-expressor diffuse large B-cell lymphoma (DLBCL) with 17p deletion is an aggressive and refractory disease. Immune checkpoint blockade and epigenetic drugs have been widely used, but the efficacy of different combined applications varied. …”
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An Unusual Case of Cystic Fibrosis Associated Pneumocystis jiroveci Pneumonia in an Infant by Ravinder Kaur, Priyanka Katariya, Megh Singh Dhakad, Bhanu Mehra, Urmila Jhamb, A. P. Dubey

“…Pneumocystis jiroveci pneumonia (PJP) is one of the major infections in patients with impaired immunity. The entity is common in HIV-seropositive individuals but quite very rare in HIV-seronegative individuals especially children. …”
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Total synthesis and target identification of marine cyclopiane diterpenes by Tian Li, Shan Jiang, Yuanhao Dai, Xia Wu, Huihui Guo, Liang Shi, Xueli Sang, Li Ren, Jie Wang, Lili Shi, Wenming Zhou, Houhua Li, Hong-Dong Hao

“…Herein, we report our synthetic and chemical proteomics studies of cyclopiane diterpenes which culminate in the asymmetric total synthesis of conidiogenones C, K and 12β-hydroxy conidiogenone C, and identification of Immunity-related GTPase family M protein 1 (IRGM1) as a cellular target. …”
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Peroxisome Proliferator-Activated Receptor-γ in Thyroid Autoimmunity by Silvia Martina Ferrari, Poupak Fallahi, Roberto Vita, Alessandro Antonelli, Salvatore Benvenga

“…An increasing body of evidence shows the importance of the (C-X-C motif) receptor 3 (CXCR3) and cognate chemokines (C-X-C motif) ligand (CXCL)9, CXCL10, and CXCL11, in the T helper 1 immune response and in inflammatory diseases such as thyroid autoimmune disorders. …”
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Crosstalk between the Gut and Brain in Ischemic Stroke: Mechanistic Insights and Therapeutic Options by Wenjing Huang, Luwen Zhu, Wenjing Song, Mei Zhang, Lili Teng, Minmin Wu

“…There is mounting evidence that maintaining gut microbiota homeostasis can frequently enhance the effectiveness of ischemic stroke treatment by modulating immune, metabolic, and inflammatory responses through MGBA. …”
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Th17 Cells in Autoimmune and Infectious Diseases by José Francisco Zambrano-Zaragoza, Enrique Jhonatan Romo-Martínez, Ma. de Jesús Durán-Avelar, Noemí García-Magallanes, Norberto Vibanco-Pérez

“…The view of CD4 T-cell-mediated immunity as a balance between distinct lineages of Th1 and Th2 cells has changed dramatically. …”
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Ways to promote the efficiency of herpetic stomatitis treatment by R.V. Lutsenko, N.V. Moisieieva, A.H. Sydorenko, H.Yu. Ostrovska, A.A. Kapustianska

“…The drug suppresses the synthesis of the virus due to the structure of inosinic acid in the polyribosomes of the cell affected by the virus, and also helps to eliminate the deficiency or dysfunction of immunity that occurred in the case of herpetic stomatitis, it affects the activity of T-cytotoxic lymphocytes and natural killers, enhances the action of neutrophil granulocytes, chemotaxis and phagocytosis of monocytes and macrophages, increases the synthesis of interleukins IL-1 and IL-2, affects the number of Ig G immunoglobulins. …”
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