Loss of Notch dimerization perturbs intestinal homeostasis by a mechanism involving HDAC activity. by Quanhui Dai, Kristina Preusse, Danni Yu, Rhett A Kovall, Konrad Thorner, Xinhua Lin, Raphael Kopan

“…Transcriptomic analysis of colonic spheroids uncovered no evidence of dimer-dependent target gene miss-regulation, confirmed impaired stem cell maintenance in-vitro, and discovered an elevated signature of epithelial innate immune response to symbionts, a likely underlying cause for heightened sensitivity in NDD mice. …”
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A case series of sinonasal mucormycosis and actinomycosis infection: a clinicopathological approach by Arushi Gupta, Shaan Khetrapal, Safia Rana, Zeeba Shamim Jairajpuri, Sabina Khan, Sujata Jetley, Seema Monga

“…It primarily affects individuals with weakened immune systems or diabetes mellitus (DM). Case Reports: This study includes eight patients aged from 24 to 68 years (six males and two females), all of whom presented to the ear, nose, and throat department with primary complaints of nasal obstruction. …”
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Aging impairs CD8 T cell responses in adoptive T-cell therapy against solid tumors by Gulfiya Kadyrzhanova, Miho Tamai, Shukla Sarkar, Rajkumar Singh Kalra, Hiroki Ishikawa

“…Age-associated defects in T cell-mediated immunity can increase the risk of cancers, but how aging influences adoptive T-cell therapy (ACT) for cancers remains unclear. …”
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Sexual Transmission of Hepatitis B virus: Epidemiological Considerations and Implications for Control with Vaccine by Franklyn N Judson

“…Prior to the acquired immune deficiency syndrome (AIDS) epidemic, more than 50% of the new hepatitis B virus infections in the United States and Canada were sexually transmitted, approximately one-quarter by heterosexual men and women and one-third by homosexual men. …”
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A rapid change in virulence gene expression during the transition from the intestinal lumen into tissue promotes systemic dissemination of Salmonella. by Sebastian E Winter, Maria G Winter, Ivan Godinez, Hee-Jeong Yang, Holger Rüssmann, Helene L Andrews-Polymenis, Andreas J Bäumler

“…Collectively, our data point to PAMP repression as a novel pathogenic mechanism to overcome the mucosal barrier through innate immune evasion.…”
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FAULT DIAGNOSIS OF ROLLING BEARINGS BASED ON CHANNEL AND SPATIAL RECONSTRUCTION NETWORKS by ZHOU Tao, YAO DeChen, YANG JianWei

“…Since the fault vibration data collected in real engineering may be accompanied by noise，traditional diagnostic models are difficult to identify fault categories，to address this problem，a rolling bearing fault diagnosis research method based on channel and spatial reconstruction and progressive convolutional neural networks （CSRP-CNN） was proposed.The model utilizes channel and spatial reconstruction convolution （CSConv） to reduce the redundant information of channels and space in fault features，and reduces the complexity and computation to improve the performance； using convolutional block attention module （CBAM），attention enhancement operation was carried out in the channel and spatial dimensions to make the model pay attention to important fault feature information； and progressive convolutional network structure was used in the shallow layer of the network，which will fuse the previous fault feature information fused with the current input to obtain richer feature information.The performance of CSRP-CNN was evaluated by two different datasets of Case Western Reserve University（CWRU）and machinery fault simulator magnum（MFS-MG）.After the noise and ablation tests，it is verified that CSRP-CNN has strong robustness and the effects of CSConv，CBAM and progressive convolutional neural network（PCNN） on the model noise immunity performance.…”
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In Vivo Demonstration of Cancer Molecular Imaging with Ultrasound Radiation Force and Buried-Ligand Microbubbles by Mark A. Borden, Jason E. Streeter, Shashank R. Sirsi, Paul A. Dayton

“…In designing targeted contrast agent materials for imaging, the need to present a targeting ligand for recognition and binding by the target is counterbalanced by the need to minimize interactions with plasma components and to avoid recognition by the immune system. We have previously reported on a microbubble imaging probe for ultrasound molecular imaging that uses a buried-ligand surface architecture to minimize unwanted interactions and immunogenicity. …”
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Hepatitis C Virus, Cryoglobulinemia, and Kidney: Novel Evidence by Fabrizio Fabrizi

“…Mixed cyoglobulinemia is a systemic vasculitis primarily mediated by immune complexes; it is characterized by variable organ involvement including skin lesions, chronic hepatitis, glomerulonephritis, peripheral neuropathy, and arthralgias. …”
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Imaging of CD47 Expression in Xenograft and Allograft Tumor Models by Alexander Zheleznyak, Oluwatayo F. Ikotun, Julie Dimitry, William A. Frazier, Suzanne E. Lapi

“…CD47 has been shown to be overexpressed by various tumor types as a means of escaping the antitumor immune response. The goal of this research was to investigate the utility of CD47 imaging using positron emission tomography (PET) in both human xenograft and murine allograft tumor models. …”
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Sleep quality and hemoglobin levels in adolescents by Akhiyan Hadi Susanto, Jihan Salsabila, Yulian Wiji Utami

“…Low hemoglobin levels in the blood can interfere with the growth process, decrease fitness levels, memory and immunity, and concentration levels. It can affect learning ability and academic achievement in adolescents. …”
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Balancing mitigation strategies for viral outbreaks by Hamed Karami, Pejman Sanaei, Alexandra Smirnova

“…This paper examined biological models for the post-vaccination stage of a viral outbreak that integrate two important mitigation tools: social distancing, aimed at reducing the disease transmission rate, and vaccination, which boosts the immune system. Five different scenarios of epidemic progression were considered: (ⅰ) the 'no control' scenario, reflecting the natural evolution of a disease without any safety measures in place, (ⅱ) the 'reconstructed' scenario, representing real-world data and interventions, (ⅲ) the 'social distancing control' scenario covering a broad set of behavioral changes, (ⅳ) the 'vaccine control' scenario demonstrating the impact of vaccination on epidemic spread, and (ⅴ) the 'both controls concurrently' scenario incorporating social distancing and vaccine controls simultaneously. …”
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Peroxisome Proliferator-Activated Receptor γ and PGC-1α in Cancer: Dual Actions as Tumor Promoter and Suppressor by Seong-Hoon Yun, Sang-Heum Han, Joo-In Park

“…Peroxisome proliferator-activated receptor γ (PPARγ) is part of a nuclear receptor superfamily that regulates gene expression involved in cell differentiation, proliferation, immune/inflammation response, and lipid metabolism. …”
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On the imbalance of international communications by H. J. Hsia

“…Further attempts are also made to examine the in-herent, natural immunity of cultures against alien concepts and practices. …”
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Blood serum IgE and muscle element levels in Cyprinus carpio infested by Argulus foliaceus in Lake Çavuşçu (Konya/Turkey): Assessment of their impact on human health by Gümüş Numan Emre

“…IgE is considered part of the parasite-specific immune defense system called allergic antibody. The results were compared with serum IgE levels in non-parasitized carp. …”
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Point-of-Care Based Electrochemical Immunoassay for Epstein-Barr Virus Detection by Miao Yu, Ming Liu, Yuan Li

“…When antigen specifically binds to antibody, the formation of immune complexes blocks electron transfer of [Fe(CN)6]4-/3- and is reflected in the detection of cyclic voltammetry/electrochemical impedance spectroscopy. …”
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In Vivo Exposure of Deltamethrin Dysregulates the NFAT Signalling Pathway and Induces Lung Damage by Prakriti Sharma, R. S. Sethi

“…Overall, the present study showed that deltamethrin exposure induces lung damage and immune dysregulation via dysregulating the NFAT signalling pathway.…”
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Galectin-3: A Novel Marker for the Prediction of Stroke Incidence and Clinical Prognosis by Ahmed Sayed, Malak Munir, Mohamed S. Attia, Badrah S. Alghamdi, Ghulam Md Ashraf, Eshak I. Bahbah, Mohamed Elfil

“…Galectins are a group of proteins expressed by many types of cells and tissues including vasculature, certain immune cells, fibroblasts, and gastrointestinal epithelial cells. …”
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Why women or why not men? sex and autoimmune diseases by Gilberto Cincinelli, Elena Generali, Rajkiran Dudam, Vinod Ravindran, Carlo Selmi

“…In a parallel fashion, the immune system shows sex-dependent differences in number and functions of both its innate and its adaptive arms, with women capable to mount a more vigorous response compared to men. …”
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How Neutrophil Extracellular Traps Become Visible by Nicole de Buhr, Maren von Köckritz-Blickwede

“…Neutrophil extracellular traps (NETs) have been identified as a fundamental innate immune defense mechanism against different pathogens. …”
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Role of Macrophages in the Pathogenesis of Atopic Dermatitis by Sadaf Kasraie, Thomas Werfel

“…Several cofactors, such as an impaired skin barrier function, modifications of the immune system, and a complex genetic background, direct the course of AD. …”
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