Physiological Roles of DNA Double-Strand Breaks by Farhaan A. Khan, Syed O. Ali

“…Under tight spatiotemporal regulation, DSBs serve as a tool for genetic modification, widely used across cellular biology to generate diverse functionalities, ranging from the fundamental upkeep of DNA replication, transcription, and the chromatin landscape to the diversification of immunity and the germline. Growing evidence points to a role of aberrant DSB physiology in human disease and an understanding of these processes may both inform the design of new therapeutic strategies and reduce off-target effects of existing drugs. …”
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Regulated Spatial Distribution of Cyclooxygenases and Lipoxygenases in Crohn's Ulcer

“…The regulated distribution indicated coordinated interplay between inflammatory cells and parenchymal cells, between arachidonic acid pathways, and between innate and adaptive immunity; and the barrier-like structures indicated protective roles for cyclooxygenase 2 and 15-Lipoxygenase-1 in Crohn's disease.…”
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New-Onset Lichen Planus Induced by the Pfizer COVID-19 Vaccine by Fadi A. Alghamdi, Shahad T. Khayyat, Mohammed M. Alshareef, Wala’a Felemban

“…Lichen planus is a chronic, immune-mediated, inflammatory dermatological illness with an unclear etiology. …”
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Microglia and Synapse: Interactions in Health and Neurodegeneration by Zuzana Šišková, Marie-Ève Tremblay

“…A series of discoveries spanning for the last few years has challenged our view of microglial function, the main form of immune defense in the brain. The surveillance of neuronal circuits executed by each microglial cell overseeing its territory occurs in the form of regular, dynamic interactions. …”
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Emerging therapeutics in idiopathic inflammatory myopathy by Shinji Sato

“…Thus, the new disease entities of amyopathic DM (ADM) or clinically ADM and immune-mediated necrotizing myopathy have been recognized recently. …”
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Predictive potential of the bankruptcy global models in the tourism industry by Agustín Del Castillo García, Sergio Manuel Fernández Miguélez

“…The tourism industry is not immune to this concern and in the previous literature there are certain bankruptcy prediction models, generally focused on hotels or restaurants. …”
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Modelling the strategies for age specific vaccination scheduling during influenza pandemic outbreaks by Diána H. Knipl, Gergely Röst

“…Taking into account the delay between developing immunity and vaccination is a key factor in evaluating the impact of vaccination campaigns. …”
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Food science and COVID-19 by Klaus W. Lange

“…While no foods, single nutrients or dietary supplements are capable of preventing infection with COVID-19, a balanced diet containing sufficient amounts of macronutrients and diverse micronutrients is a prerequisite of an optimally functioning immune system. High-energy diets and obesity are major risk factors for a more severe course of COVID-19.Therefore, population-wide body weight control and weight reduction in overweight people are important preventive measures. …”
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The Role of Oxidative Stress in the Aging Process by Barbara F. Oliveira, José Augusto Nogueira-Machado, Míriam M. Chaves

“…An appropriate theory must explain four main characteristics of aging: it is progressive, endogenous, irreversible, and deleterious for the individual. The aging of the immune system, or immunosenescence, is manifested by an increased susceptibility to infections with increased morbidity and mortality. …”
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Microevolution during Chronic Infection May Lead T. asahii to Coexist with the Host by Gen Ba, Xuelian Lv, Xin Yang, Wenling Wang, Junhong Ao, Rongya Yang

“…Two T. asahii strains were isolated from a chronic trichosporonosis patient between a 15-year interval, and the microevolutionary changes were compared by the immune response of dendritic cell (DC), mice survival model, and transcriptome sequencing analysis. …”
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Bioartificial Liver Support by Vincent G Bain, Jose Luis Montero, Manuel de la Mata

“…Serious side effects such as hemodynamic instability and immune reactions have been infrequent. Much controversy, however, surrounds the issue of possible transmission of pig endogenous retrovirus to humans, and current trials are being carefully monitored. …”
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Mechanism and Therapeutic Prospect of miRNAs in Neurodegenerative Diseases by Ya-Min Ma, Lan Zhao

“…They can also increase or reduce neuronal damage by regulating the body’s signaling pathways, immune system, stem cells, gut microbiota, etc. They can not only affect the occurrence of diseases and exacerbate disease progression but also promote neuronal repair and reduce apoptosis, to prevent and slow down the development of diseases. …”
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Correction: Ethnoracial disparities in childhood growth trajectories in Brazil: a longitudinal nationwide study of four million children by Helena Benes Matos da Silva, Rita de Cássia Ribeiro‑Silva, Juliana Freitas de Mello e Silva, Irina Chis Ster, Poliana Rebouças, Emanuelle Goes, Maria Yury Ichihara, Andrêa Ferreira, Julia M. Pescarini, Rosemeire Leovigildo Fiaccone, Enny S. Paixão, Maurício L. Barreto

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Production and development of vaccines for ornithobacterium rhinotracheale infection in turkeys by Osman Erganis, Hasan Hüseyin Hadimli, Kursat Kav, Zafer Sayin, Zeki Aras

“…The vaccine containing mineral oil and ginseng as adjuvant induced significantly greater humoral immune response than others. Also, vaccine containing mineral oil and ginseng as adjuvant was determined to be more effective in the field trials in a company privately producing turkeys.…”
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The Impact of Farnesoid X Receptor Activation on Intestinal Permeability in Inflammatory Bowel Disease by Maja Stojancevic, Karmen Stankov, Momir Mikov

“…The development and investigation of FXR agonists provide strong support for the regulatory role of FXR in mucosal innate immunity. Activation of FXR in the intestinal tract decreases the production of proinflammatory cytokines such as interleukin (IL) 1-beta, IL-2, IL-6, tumour necrosis factor-alpha and interferon-gamma, thus contributing to a reduction in inflammation and epithelial permeability. …”
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Human-Specific Endogenous Retroviruses by Anton Buzdin

“…Although modest in terms of its copy number, this group appeared to modify the human genome activity by endogenizing ~50 functional copies of viral genes that may have important implications in the immune response, cancer progression, and antiretroviral host defense. …”
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Retinal Toxicity after Initial Administration of Nivolumab and Ipilimumab by Adnan Kilani, Efstathios Vounotrypidis, Susanna F. König, Armin Wolf

“…To present a rare case of a bilateral immune checkpoint inhibitor- (ICI-) induced photoreceptor injury with a bacillary layer detachment (BALAD) and a dissection of the photoreceptor inner and outer segment, accompanied by ICI-induced Vogt-Koyanagi-Harada- (VKH-) like uveitis after initial administration of nivolumab and ipilimumab. …”
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Advances in nucleic acid-based cancer vaccines by Hung-Chun Liao, Shih-Jen Liu

“…In oncology, the combination of mRNA vaccine encoding neoantigens and immune checkpoint inhibitors (ICIs) has shown remarkable efficacy in eliciting protective responses against diseases like melanoma and pancreatic cancer. …”
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Lipopeptide adjuvants for antibiotics and vaccines: the future step in the fight against multidrug-resistant and extensively drug-resistant pathogens by Chloé O. Sebilleau, Steven J. Sucheck

“…In the case of vaccines, they allow for modulation and increase of the immune response. Lipopeptides are molecules of choice because of their ability to activate specific cell surface receptors, penetrate the outer membrane of GNB, safety and ease of synthesis. …”
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Efficacy of Sodium Valproate in the Treatment of Photosensitive Epilepsy (PSE) and the Probable Reasons for the Persistence of Occipital Spikes by Ebere C. Anyanwu, John E. Ehiri, Andrew W. Campbell

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