Phase II trial of nab-paclitaxel plus ramucirumab in combination with nivolumab for unresectable advanced or recurrent gastric cancer after progression on first-line treatment incl... by Hidekazu Hirano, Naoki Takahashi, Yusuke Amanuma, Nobumi Suzuki, Daisuke Takahari, Takeshi Kawakami, Chie Kudo-Saito, Kengo Nagashima, Narikazu Boku, Ken Kato, Hirokazu Shoji

“…Accumulating evidence suggests rationales for continuing immunotherapy beyond progression, synergistic effects between immune checkpoint inhibitors and angiogenesis inhibitors, and a preferable combination of steroid-free chemotherapy with immunotherapy. …”
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Serum and Salivary IgE, IgA, and IgG4 Antibodies to Dermatophagoides pteronyssinus and Its Major Allergens, Der p1 and Der p2, in Allergic and Nonallergic Children by Diego O. Miranda, Deise A. O. Silva, Jorge F. C. Fernandes, Meimei G. J. Queirós, Hamilton F. Chiba, Leandro H. Ynoue, Rafael O. Resende, Janethe D. O. Pena, Sun-Sang J. Sung, Gesmar R. S. Segundo, Ernesto A. Taketomi

“…The presence of specific IgA appears to have a key role for the healthy immune response to mucosal allergens. Also, specific IgA measurements in serum and/or saliva may be useful for monitoring activation of tolerance-inducing mechanisms during allergen specific immunotherapeutic procedures, especially sublingual immunotherapy.…”
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Incipient and subclinical tuberculosis: a narrative review by Malay Sarkar

“…However, recently, the concept of a dynamic spectrum of infection has emerged, wherein the pathogen is initially eradicated by the innate or adaptive immune system, either in conjunction with or independently of T cell priming. …”
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The Fractured Self: Exploring Selfhood in the Neuronovel The Echo Maker and the Neuromemoir Brain on Fire by Bonnie Cross

“…This paper will focus on two works: the neuronovel The Echo Maker (2006) by Richard Powers, a fictional account of Mark Schluter who suffers from Capgras Syndrome, that is, a rare neurological condition that results in the patient’s belief that their loved ones have been replaced with exact copies; and the neuromemoir Brain on Fire: My Month of Madness (2012) by Susannah Cahalan, which describes Cahalan’s experiences as she is diagnosed with anti-NMDA receptor encephalitis, a rare auto-immune disease. Both works have protagonists that suffer from a serious brain illness and must rely on their own perceptions, those of family and friends, and neuroscientific research in order to heal and create a more cohesive sense of self again. …”
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Pandemic Fictions: Covid-19 and the Cultures of Dystopia by Sean Mark

“…Contextualising the British government’s handling of the crisis in the political culture of neoliberalism, the essay uses the concept of dystopia to underline the continuity of this response with the politics of the decade that preceded it – in the aborted pursuit of “herd immunity”, for example; the non-transparent conferment to private-sector companies, with little or no public health expertise, of contracts worth billions; and the authoritarian use of Covid legislation. …”
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Shikonin Induces Glioma Necroptosis, Stemness Decline, and Impedes (Immuno)Proteasome Activity by Xianyun Qin, Lu Zhang, Jilan Liu, Yan Lu, Fuyao Zhou, Feng Jin

“…Our findings indicate that Shikonin-induced programed necrosis leads to a downregulation of proteasome activity and a decrease in the expression of immune proteasome subunits PSMB8/9/10 and PSME1/2/3, contributing to the attenuation of stemness in gliomas. …”
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Folic Acid: Sources, Chemistry, Absorption, Metabolism, Beneficial Effects on Poultry Performance and Health by Herinda Pertiwi, Mohamad Yusril Nur Mahendra, Juriah Kamaludeen

“…At the same time, the effect on poultry health influences antioxidant activities, thyroid hormones, blood biochemicals, anti-inflammatory gene expressions, and immune responses. The present review deals with FA sources, chemistry, absorption, metabolism, effects on performance, and poultry health, which are based on valid basic information.…”
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Autologous Hematopoietic Cell Transplant as an Effective Treatment Modality for Systemic Sclerosis and Multiple Myeloma by Memon H, Parrondo R, Schreurs J, Ayala E, Iqbal M

“…Hamda Memon,1 Ricardo Parrondo,2 Julianna Schreurs,2 Ernesto Ayala,2 Madiha Iqbal2 1Department of Family Medicine, Geisinger Health in Wilkes Barre, Wilkes Barre, Pennsylvania, USA; 2Division of Hematology and Oncology, Mayo Clinic, Jacksonville, Florida, USACorrespondence: Madiha Iqbal, Department of Medicine,Division of Hematology-Oncology and Blood and Marrow Transplantation Program, Mayo Clinic, 4500 San Pablo road, Jacksonville, FL, 32224, USA, Email Iqbal.madiha@mayo.eduAbstract: Systemic sclerosis (SSc) is a multi-system disease characterized by a dysregulated immune system. Autologous hematopoietic cell transplantation (AHCT) is the only treatment that has been shown to confer significant benefit in controlling disease and improving survival for patients with SSc. …”
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Regulation of Glial Cell Functions by PPAR-𝜸 Natural and Synthetic Agonists by Antonietta Bernardo, Luisa Minghetti

“…The pleiotropic effects of PPAR-𝛾 agonists are likely to be mediated by several mechanisms involving anti-inflammatory activities on peripheral immune cells (macrophages and lymphocytes), as well as direct effects on neural cells including cerebral vascular endothelial cells, neurons, and glia. …”
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The effect of bovine colostrum usage on serum immunoglobulins and protein levels in basketball players by Ali Kıvrak, Gurkan Ucar

“…In conclusion, it has been suggested that future researches on colostrum will be suitable for various sports branches and different age groups considering especially sportsmen' criteria such as immunity, regeneration, performance. Thus, the sportsmen will benefit from the outstanding characteristics of colostrum at a maximum level; the success will be achieved more in this way.…”
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A review on the microbiology of Ethiopian traditional fermented beverage products by Guesh Mulaw, Trhas Gebregziabher, Teklemichael Tesfay

“…The fermented foods and beverages are important in preventing non-communicable diseases such as cardiovascular diseases, gastrointestinal tissues, immune disorders, and cancer. Overall, the paper provides a comprehensive overview of the current knowledge and tradition on Ethiopian fermented beverages.…”
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Oxidative stress in viral hepatitis by Huseyin Erdal, Hacer Ozlem Kalayci

“…In viral hepatitis, viral proteins and immune-mediated inflammatory responses contribute to excessive ROS generation, resulting in oxidative damage to hepatocytes. …”
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Mycotoxins and Antifungal Drug Interactions: Implications in the Treatment of Illnesses Due to Indoor Chronic Toxigenic Mold Exposures by Ebere C. Anyanwu, Andrew W. Campbell, John E. Ehiri

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Fractional-Order Active Disturbance Rejection Controller Design for Large Radio Telescope Antenna by Jian-Yu Jiang, Bin Wu, Ting Zhou

“…Afterwards, the relationship between the parameters of fractional-order extended state observer and the performance of disturbance suppression and noise immunity is revealed. The stability of fractional-order extended state observer is proved under similar assumptions as an integer order extended state observer. …”
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THE INFLUENCE OF DIABETES IN PEDIATRIC DENTISTRY by Oleg Solomon, Irina Adriana Beuran, Iulian Constantin, Razvan Leata, Grosu Robert Marius, Petrea Marius, Alina Calin, Kamel Earar

“…Rigorous oral hygiene should be encouraged to prevent infections and complications associated with compromised immune response. Interdisciplinary collaboration between dentists, diabetologists and other health professionals is essential for developing a coordinated and effective treatment plan.…”
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Natural Compounds as Regulators of NLRP3 Inflammasome-Mediated IL-1β Production by József Tőzsér, Szilvia Benkő

“…IL-1β is one of the main proinflammatory cytokines that regulates a broad range of immune responses and also participates in several physiological processes. …”
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Advances and Challenges in Cancer Stem Cells for Onco-Therapeutics by Sulaiman Mohammed Alnasser

“…The strategy of targeting cancer stem cells is beset with challenges, including immune rejection and disease relapse. Additionally, the capacity to inadvertently generate cancer stem cells upon transplantation underscores the critical need to eliminate these cells to ensure the efficacy of cell-based therapies. …”
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Variant Guillain-Barré Syndrome in a Patient with Non-Hodgkin’s Lymphoma by R. H. Bishay, J. Paton, V. Abraham

“…Clinicians should also be mindful of direct neoplastic invasion or, less commonly, paraneoplastic phenomenon, as alternative mechanisms, the latter possibly reflecting immune dysregulation in particularly aggressive lymphomas. …”
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Consensus Clustering and Survival-Related Genes of Cuproptosis in Cutaneous Melanoma by Wentao Qin, Fu Gan, Yiji Jike, Mingyang Jiang, Ang Li

“…Secondly, we used differential analysis and Cox regression analysis to find the differential genes related to prognosis, constructed the CRG score, found the critical score for dividing high and low CRG score groups, and then analyzed the prognosis and immune infiltration of high and low CRG score groups. …”
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DETERMINATION OF GLYCOGEN IN BEE ORGAN TISSUES AS AN ENERGY METABOLISM PARAMETER by I. V. Serduchenko, N. N. Gugushvili

“…Consequently, honeybees of Oka breeds have higher resistance to unfavorable weather conditions and can produce progeny with a higher level of immunity. So, the specified method of glycogen determination in bee organ tissues increases the accuracy of diagnosis and plays a very important role in determining the level of energy metabolism in insects and will be useful for apiculture.…”
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