PD-L1/TLR7 dual-targeting nanobody-drug conjugate mediates potent tumor regression via elevating tumor immunogenicity in a host-expressed PD-L1 bias-dependent way by Wei Huang, Ji Zhou, Jia Li, Yakun Wan, Chao Hu, Meng Liu, Pan Xu, Feng Tang, Jianhua Sun, Xiaolu Yu, Yiru Long, Binfan Chen, Yongliang Tong, Mengwen Shan, Xiaomin Jia, Henglei Lu, Runqiu Chen, Jin Ren, Guangyi Jin, Likun Gong

“…Here, we aimed to improve efficacy for anti-programmed death ligand 1 (PD-L1) therapy by developing a PD-L1/TLR7 dual-targeting nanobody-drug conjugate (NDC), based on the PD-L1 nanobodies and TLR7 agonist we developed.Methods PD-L1 nanobodies were obtained by phage display screening and identified through T-cell activation bioassay, in vivo imaging and quantitative biodistribution study. Immune activation and PD-L1-inducing of TLR7 agonists were evaluated in diverse innate cell models. …”
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Whole lung radiomic features are associated with overall survival in patients with locally advanced non-small cell lung cancer treated with definitive radiotherapy by Meng Yan, Zhen Zhang, Jia Tian, Jiaqi Yu, Andre Dekker, Dirk de Ruysscher, Leonard Wee, Lujun Zhao

“…Tumor-based radiomic features and whole lung-based radiomic features were extracted from primary tumor and whole lungs (excluding the primary tumor) delineations in planning CT images. Feature selection of radiomic features was done by the least absolute shrinkage (LASSO) method embedded with a Cox proportional hazards (CPH) model with 5-fold cross-internal validation, with 1000 bootstrap samples. …”
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Reservoir water level decline accelerates ground subsidence: InSAR monitoring and machine learning prediction of surface deformation in the Three Gorges Reservoir area by Jiaer Yang, Jiaer Yang, Pinglang Kou, Pinglang Kou, Xu Dong, Xu Dong, Ying Xia, Qinchuan Gu, Yuxiang Tao, Jiangfan Feng, Qin Ji, Weizao Wang, Ram Avtar

“…This study combines SBAS-InSAR technology and machine learning to analyze and predict surface deformation in Fengjie County, Chongqing, China, between 2020 and 2022, focusing on riverside urban ground, riverside road slopes, and ancient landslides in the reservoir area.MethodsSBAS-InSAR technology was applied to 36 Sentinel-1A images to monitor surface deformation, complemented by hydrological and meteorological data. …”
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Deep-Reticular Pseudodrusen-Net: A 3-Dimensional Deep Network for Detection of Reticular Pseudodrusen on OCT Scans by Amr Elsawy, PhD, Tiarnan D.L. Keenan, PhD, MD, Alisa T. Thavikulwat, MD, Amy Lu, MD, Sunil Bellur, MD, Souvick Mukherjee, PhD, Elvira Agron, MS, Qingyu Chen, PhD, Emily Y. Chew, MD, Zhiyong Lu, PhD

“…The AREDS2 RPD labels were transferred from fundus autofluorescence images, which were captured at the same visit for OCT scans, and DAAMD RPD labels were obtained from the Wisconsin reading center. …”
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Clinical and molecular outcomes from the 5-Year natural history study of SSADH Deficiency, a model metabolic neurodevelopmental disorder by Itay Tokatly Latzer, Jean-Baptiste Roullet, Wardiya Afshar-Saber, Henry H. C. Lee, Mariarita Bertoldi, Gabrielle E. McGinty, Melissa L. DiBacco, Erland Arning, Melissa Tsuboyama, Alexander Rotenberg, Thomas Opladen, Kathrin Jeltsch, Àngels García-Cazorla, Natalia Juliá-Palacios, K. Michael Gibson, Mustafa Sahin, Phillip L. Pearl

“…Methods SSADHD subjects underwent clinical evaluations, neuropsychological assessments, biochemical quantification of γ-aminobutyrate (GABA) and related metabolites, electroencephalography (standard and high density), magnetoencephalography, transcranial magnetic stimulation, magnetic resonance imaging and spectroscopy, and genetic tests. This was parallel to laboratory molecular investigations of in vitro GABAergic neurons derived from induced human pluripotent stem cells (hiPSCs) of SSADHD subjects and biochemical analyses performed on a versatile murine model that uses an inducible and reversible rescue strategy allowing on-demand and cell-specific gene therapy. …”
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Establishing a radiomics model using contrast-enhanced ultrasound for preoperative prediction of neoplastic gallbladder polyps exceeding 10 mm by Dong Jiang, Yi Qian, Yijun Gu, Ru Wang, Hua Yu, Zhenmeng Wang, Hui Dong, Dongyu Chen, Yan Chen, Haozheng Jiang, Yiran Li

“…Purpose This study aims to establish an imaging radiomics model using clinical data and contrast-enhanced ultrasound (CEUS) to predict neoplastic GBP exceeding 10 mm in diameter preoperatively. …”
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Estimation des rendements fourragers des pâturages dans les espaces climatiques du Burkina Faso à partir de données satellitaires by Wièmè Some, Antoine Denis, Amani Louis Kouadio, Bakary Djaby, Hassan Bismark Nacro, Adrien Marie Gaston Belem, Bernard Tychon

“…Conclusions: Une série de recommandations a été identifiée pour améliorer le couplage entre données de biomasse végétale fourragère collectées sur le terrain et variables extraites des images satellitaires, et ainsi améliorer la performance des modèles. …”
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ELABELA promotes the migration and homing of bone marrow mesenchymal stem cells to myocardial injury sites through the ERK1/2/miR-299a-5p/Exo70 pathway by Jing-Yu Hou, Hao Wu, Shuang-Mei Li, Xiao-Jing Li, Shu-Jun Yang, Xu-Xiang Chen, Chang-Qing Zhou, Hui-Bao Long, Hai-Dong Wu, Jia-Ying Fu, Ya-Jie Guo, Tong Wang

“…Cardiac repair was evaluated through fluorescence imaging, echocardiography, and histological analysis. …”
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Development and interpretation of a pathomics-driven ensemble model for predicting the response to immunotherapy in gastric cancer by Jing Wang, Zhe Li, Wei Wang, Md Tauhidul Islam, Xiaoyan Wang, Zhen Han, Zihan Li, Guoxin Li, Yuming Jiang, Taojun Zhang, Wenjun Xiong, Zepang Sun, Lequan Yu, Zhicheng Zhang, Xianqi Yang, Shengtian Sang, Alyssa A Guo

“…The aim of this study was to develop and validate a pathomics-driven ensemble model for predicting the response to ICIs in gastric cancer, using H&E-stained whole slide images (WSI).Methods This multicenter study retrospectively collected and analyzed H&E-stained WSIs and clinical data from 584 patients with gastric cancer. …”
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Botulinum Toxin Injection with Conjunctival Microincision for the Treatment of Acute Acquired Comitant Esotropia and Its Effectiveness by Hongjia Xu, Weifeng Sun, Shuying Dai, Yanyan Cheng, Jing Zhao, Yuan Liu, Juan Wang, Ya’nan Wang, Yu Gao, Huifang Han, Aijun Han

“…Neurological evaluation and brain magnetic resonance imaging (MRI) were unremarkable in all patients. The mean spherical equivalent refraction was −1.22 ± 2.85D and −0.97 ± 2.80D in the right and left eyes, respectively. …”
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PENGEMBANGAN INSTRUMEN PENILAIAN HASIL BELAJAR FISIKA BERORIENTASI HOTS (Higher Order Thinking Skills) PADA MATERI ELASTISITAS DAN HUKUM HOOKE by Dona Desilva, Indra Sakti, Rosane Medriati

“…The results of the research and the development showed that 1) The HOTS instrument design had the form of the question in multiple choice and essay, presentation of the questions in paper test, context of the question as outside the classroom (contextual), subject matter in Elasticity and Hooke's Law and indicators of the question in HOTS, 2) Validity test results by expert judgment and practitioners which was in the very valid category with a percentage of 97.14% for the material aspect, 98.33% for the construction aspect and 100% for the language aspect, and 3) The characteristics of HOTS instruments was referred to the HOTS indicator (at the cognitive level C4 or C5 or C6), used the Operational Verb (KKO) level C4 or C5 or C6, contextual and used stimulus (texts, images, tables).   Keywords: HOTS, assessment instruments, learning outcomes, research and development, Elasticity and Hooke's Law …”
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Inflammatory markers predict efficacy of immunotherapy in advanced non-small cell lung cancer: a preliminary exploratory study by Yingqing Zhang, Na Yan, Yan Feng, Yonglei Wu, Yuejiao Sun, Xixi Gao, Chao Gu, Xiaolong Ma, Feng Gao, Hui Zhang, Jiaqi Zhou

“…All patients were collected for clinical information, including baseline blood indicator (NLR, PLR, LMR, SII, CRP, RDW, PCV and PCT) levels before PD-1/PD-L1 inhibitor therapy and blood indicator levels and imaging evaluation results every two cycles after PD-1/PD-L1 inhibitor therapy. …”
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START—the Swiss tele-assisted rehabilitation and training program to support transition from inpatient to outpatient care in the subacute phase after a stroke: feasibility, safety... by Szabina Gäumann, Carina Ziller, Carina Ziller, Nele Paulissen, Nele Paulissen, Frank Behrendt, Frank Behrendt, Zorica Suica, Zorica Suica, Björn Crüts, Luana Gammerschlag, Katrin Parmar, Katrin Parmar, Hans Ulrich Gerth, Hans Ulrich Gerth, Leo H. Bonati, Leo H. Bonati, Leo H. Bonati, Corina Schuster-Amft, Corina Schuster-Amft, Corina Schuster-Amft

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Effectiveness of ICS/LABA and LAMA/LABA in COPD due to biomass by Alejandra Ramírez-Venegas, Francisco Montiel-Lopez, Robinson E. Robles-Hernández, Bartolome R. Celli, Raúl H. Sansores, Maricruz Cassou-Martínez, José L. Pérez Lara-Albisua, Claudia González-González, María E. Mayar-Maya, Aloisa P. Hernández-Morales, Rafael J. Hernández-Zenteno, Ramcés Falfán-Valencia, Ireri Thirión-Romero, Oliver Pérez-Bautista, Rogelio Pérez-Padilla

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Emotion dysregulation in youths with obsessive-compulsive disorder and its implication for treatment - An exploratory study from the TECTO trial: A protocol and statistical analysi... by Christine Lykke Thoustrup, Camilla Uhre, Valdemar Uhre, Melanie Ritter, Signe Vangkilde, Janus Engstrøm, Jane Lindschou, Christian Gluud, Anne Katrine Pagsberg, Markus Harboe Olsen

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The interaction of tPA with NMDAR1 drives neuroinflammation and neurodegeneration in α-synuclein-mediated neurotoxicity by Daniel Torrente, Enming J. Su, Alí Francisco Citalán-Madrid, Gerald P. Schielke, Daniel Magaoay, Mark Warnock, Tamara Stevenson, Kris Mann, Flavie Lesept, Nathalie Delétage, Manuel Blanc, Erin H. Norris, Denis Vivien, Daniel A. Lawrence

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Financial Toxicity and Kidney Disease in Children and Adults: A Scoping Review by Siligato R, Gembillo G, De Giorgi A, Di Maria A, Scichilone LM, Capone M, Vinci FM, Nicoletti S, Bondanelli M, Malaventura C, Storari A, Santoro D, Dionisi S, Fabbian F

“…Rossella Siligato,1,2 Guido Gembillo,2,3 Alfredo De Giorgi,4 Alessio Di Maria,1 Laura Maria Scichilone,1 Matteo Capone,1,5 Francesca Maria Vinci,1,5 Simone Nicoletti,1 Marta Bondanelli,5 Cristina Malaventura,5 Alda Storari,1,5 Domenico Santoro,3 Sara Dionisi,6 Fabio Fabbian1,5 1Nephrology Unit, University Hospital of Ferrara, Ferrara, Italy; 2Department of Biomedical, Dental, Morphological and Functional Imaging Sciences, University of Messina, Messina, Italy; 3Unit of Nephrology and Dialysis, Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy; 4Internal Medicine, University Hospital of Ferrara, Ferrara, Italy; 5Department of Medical Sciences, University of Ferrara, Ferrara, Italy; 6Nursing, Technical and Rehabilitation, Department DATeR Azienda Unità Sanitaria Locale Di Bologna, Bologna, ItalyCorrespondence: Fabio Fabbian, Department of Medical Sciences, via Luigi Borsari, 46, Ferrara, Italy, I-44124, Tel +39 0532 239385, Email f.fabbian@ospfe.itPurpose: Social determinants of health have been related with kidney diseases and their outcomes. …”
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Cantelli’s Bounds for Generalized Tail Inequalities by Nicola Apollonio

“…Three diverse applications to random matrices, tails of linear images of random vectors, and network homophily are also given.…”
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Effect of Acupotomy Intervention on Fibrosis of Rectus Femoris in Rabbits with Knee Osteoarthritis by LIU Jing, ZENG Weiquan, LIN Qiaoxuan, LU Liming, GUO Zexing, LIU Hong, ZHANG Liangzhi, XIU Zhongbiao

“…Lequesne MG knee joint grade score, X-ray and MRI imaging examination of knee joint and pathological morphology of rectus femoris were confirmed after successful modeling. …”
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Comparative analysis of morphologival parameters in isolated and fused L5 spondylolysis patients on the basis of CT features by Rui Ma, Xiaoxia Huang, Luyao Li, Ye Kai, Jun Liu, Gao Leilei, Xiangning Sun, Yong Teng

“…Differences in the morphological imaging parameters of the L5 vertebrae and pedicles among the three groups were compared. …”
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