Dyslipidemia rather than Type 2 Diabetes Mellitus or Chronic Periodontitis Affects the Systemic Expression of Pro- and Anti-Inflammatory Genes by Rafael Nepomuceno, Bárbara Scoralick Villela, Sâmia Cruz Tfaile Corbi, Alliny De Souza Bastos, Raquel Alves Dos Santos, Catarina Satie Takahashi, Silvana Regina Perez Orrico, Raquel Mantuaneli Scarel-Caminaga

“…The expression of genes, including IL10, JAK1, STAT3, SOCS3, IP10, ICAM1, IFNA, IFNG, STAT1, and IRF1, was investigated by RT-qPCR. Patients with dyslipidemia demonstrated statistically higher expression of the IL10 and IFNA genes, while IFNG, IP10, IRF1, JAK1, and STAT3 were lower in comparison with nondyslipidemic patients. …”
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Feedback loop centered on MAF1 reduces blood–brain barrier damage in sepsis-associated encephalopathy by Xuebiao Wei, Wenqiang Jiang, Zhonghua Wang, Yichen Li, Yuanwen Jing, Yongli Han, Linqiang Huang, Shenglong Chen

“…Knockdown of Cullin 2 (CUL2) stimulated the accumulation of MAF1 protein, attenuated the RNA sensor RIG-I/interferon regulatory factor 3 (IRF3) signaling pathway, and reduced cell apoptosis. …”
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Research on E-Commerce Platform-Based Personalized Recommendation Algorithm by Zhijun Zhang, Gongwen Xu, Pengfei Zhang

“…Aiming at data sparsity and timeliness in traditional E-commerce collaborative filtering recommendation algorithms, when constructing user-item rating matrix, this paper utilizes the feature that commodities in E-commerce system belong to different levels to fill in nonrated items by calculating RF/IRF of the commodity’s corresponding level. In the recommendation prediction stage, considering timeliness of the recommendation system, time weighted based recommendation prediction formula is adopted to design a personalized recommendation model by integrating level filling method and rating time. …”
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AN ANALYSIS OF INTERACTIONAL PATTERN BETWEEN TEACHER AND STUDENT IN SMAN 1 CURUP KOTA by Hendi Afriyanto, Alamsyah Harahap, Azwandi Azwandi

“…The data analysis shows that (a) the dominant pattern used in the classroom is complete pattern (IRF) and there are also semi-complete pattern (IR) and incomplete pattern (IF); (b) In the type of acts section, the elicitation is the highest followed by informative and starter in the initiation move,  reply as the highest act in the response move, and in the follow up accept as the highest followed by comment. …”
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AN ANALYSIS OF INTERACTIONAL PATTERN BETWEEN TEACHER AND STUDENT IN SMAN 1 CURUP KOTA by Hendi Afriyanto, Alamsyah Harahap, Azwandi Azwandi

“…The data analysis shows that (a) the dominant pattern used in the classroom is complete pattern (IRF) and there are also semi-complete pattern (IR) and incomplete pattern (IF); (b) In the type of acts section, the elicitation is the highest followed by informative and starter in the initiation move,  reply as the highest act in the response move, and in the follow up accept as the highest followed by comment. …”
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Characterization of the First Marine Pestivirus, Phocoena Pestivirus (PhoPeV) by Lars Söder, Denise Meyer, Olaf Isken, Norbert Tautz, Matthias König, Alexander Postel, Paul Becher

“…Pestiviruses generally counteract the cellular innate immune response by degradation of interferon regulatory factor 3 (IRF3) mediated by the viral N-terminal protease (N^pro). …”
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Nucleotide sequence variants, gene expression and serum profile of immune and antioxidant markers associated with brucellosis resistance/susceptibility in Shami goat by Ahmed A. Elsayed, Ahmed M. Sallam

“…Levels of gene expression of SLC11A1, TLR1, TLR9, SP110, ADORA3, CARD15, IRF3, HMOX1, TKT, RPIA and AMPD were significantly (P < 0.05) up regulated in the infected compared to the non-infected ones. …”
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A Rare Case of ALK-Positive Large B-Cell Lymphoma with CD33 Expression by Jessica Corean, K. David Li

“…Immunophenotypically, the tumor cells are typically negative for common B-cell markers, T-cell markers, and CD30; however, they express markers of terminally differentiated B cells/plasma cells such as CD38, CD138, and MUM-1/IRF4. The diagnosis of ALK+ LBCL can be challenging, and often a large panel of immunostains is required to exclude other hematopoietic and nonhematopoietic neoplasms. …”
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EFFECT OF SHOCKS OF AGRICULTURAL TERMS OF TRADE (TOT) ON SOME AGRICULTURAL INDICATORS IN IRAQ FOR THE PERIOD (1990 - 2019) by AlAttabi, H. A., B. H. AlBadri

“…The research uses VAR, Variance decomposition and IRF approaches. The research is due to the almost monolithic exports and the multiplicity of imports, and the results of the agricultural product response to the shock of the agricultural gross terms of trade (GBTT) indicated that it had a negative impact, due to the shocks that the last variable was subjected to, which was reflected on an agricultural product, but they are not permanent as they returned to the normal situation within the sixth year. …”
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From bench to bedside: elucidating VEGF(R) inhibitor-related heart failure in cancer treatment by Shengkun Peng, MinHong Cai, Hongyu Kuang, Anqi Lin, Qinghua Ma, Xiaoqin Dai, Peng Luo, Yijun Liu, Guo Zhang, Yifeng Bai

“…Moreover, significant upregulation was observed in inflammatory pathways, specifically those involving IL-1, IL-6, TNF-α, and IRF3/IRF7-mediated immune responses. Clinical cohort analyses demonstrated significant elevations in both cardiac injury biomarkers (NT-proBNP, CK-MB, cTnT) and inflammatory mediators (CRP) following VEGF(R)i administration. …”
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Faricimab efficacy in type 1 macular neovascularization: AI-assisted quantification of pigment epithelium detachment (PED) volume reduction over 12 months in Naïve and switch eyes by Jennifer Cattaneo, Paolo Forte, Giovanni Forte, Chiara M. Eandi

“…Significant reduction in SRF and IRF volumes were noted in both groups. A significant reduction in PED volume was observed over the follow-up period in both groups (mean slope = -206 nL, 95%CL = -273/-138; p-value < 0.001). …”
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Evaluation Model and Decision Analysis of Digital Firms Ranked in Forbes’ Top Companies by Fang Chen Kao, Thanh Nhan Dinh, Anh Thi Truc Nguyen

“…This study evaluates the profitability and marketability efficiencies of digital firms ranked in Forbes’ list of top companies by using a two-stage network data envelopment analysis (DEA) model with multiplicative efficiency aggregation under the second-order cone programming (SOCP) and examines the respective impacts of the 1995–2001 dot-com bubble and the 2007–2009 global financial crisis on the companies’ efficiencies by applying impulse response function (IRF) analysis. The data of our 49 sampled companies are derived from the Compustat database. …”
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Fiscal policy on Peru’s gross domestic product through fiscal multipliers, 2000 – 2022 by Jhunniors Puscan Visalot, Omer Cruz Caro, Alex Javier Sánchez Pantaleón, Einstein Sánchez Bardales, Angelica María Carrasco Rituay, River Chavez Santos

“…Using an SVAR methodology and impulse response analysis (IRF), it was possible to obtain that, after an increase in current spending, GDP initially decreases; and as time passes, it fluctuates and recovers. …”
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Gegen Qinlian Decoction Attenuates Colitis-Associated Colorectal Cancer via Suppressing TLR4 Signaling Pathway Based on Network Pharmacology and In Vivo/In Vitro Experimental Valid... by Yaoyao Xu, Qiaoyan Cai, Chunyu Zhao, Weixiang Zhang, Xinting Xu, Haowei Lin, Yuxing Lin, Daxin Chen, Shan Lin, Peizhi Jia, Meiling Wang, Ling Zhang, Wei Lin

“…GQD reduced IL-1β, IL-6, and TNF-α levels in the serum and downregulated TLR4, MyD88, and phosphorylation of IκBα, P65, and IRF3 in the colon tissue from AOM/DSS-induced mice. …”
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Analysis of the influence internal and external factors on the performance of IDXV30 by Tumpal Samosir, Pardomuan Sihombing

“…The analysis phase is through the Stationarity Test, Optimal Lag Test, VAR Stability Test, Granger Causality Test, Cointegration Test, Impulse Response Function (IRF), and Forecast Error Variance Decomposition (FEVD). …”
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Expression of Proinflammatory and Regulatory Cytokines via NF-κB and MAPK-Dependent and IFN Regulatory Factor-3-Independent Mechanisms in Human Primary Monocytes Infected by Mycob... by Elena Giacomini, Maria Elena Remoli, Marta Scandurra, Valérie Gafa, Manuela Pardini, Lanfranco Fattorini, Eliana M. Coccia

“…The analysis of the signalling pathways leading to this selective cytokine expression showed that in monocytes Mtb activates MAPK and NF-κB but is unable to stimulate IRF-3 phosphorylation, a transcription factor required for IL-12p35 and IFN-β gene expression. …”
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The Identification of Immune-Related Biomarkers for Osteoarthritis Immunotherapy Based on Single-Cell RNA Sequencing Analysis by Zhe Tan, Rong Chen, Hanyu Lin, Hong Wang

“…The single-cell RNA sequencing analysis was used to evaluate the expression distribution of the MMP, VEGFA, SPI1, and IRF8 in synovial tissues of patients with osteoarthritis. …”
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IFN-β production induced by PRRSV is affected by GP3 quantity control and CLND4 interaction by Dexin Li, Xinyu Cui, Yingchao Li, Qin Zhang, Hongyan Gao, Youbo Li, Yanmeng Hou, Hongjie Yuan, Yihong Xiao

“…GP3 also downregulated IFN-β by decreasing the phosphorylation of TBK1 and IRF3. These findings highlight functional differences in GP3 under quantity control, which account for the variations in IFN-β induction during the early and late stages of infection. …”
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Distinct plasmablast developmental intermediates produce graded expression of IgM secretory transcripts by Evelyn P. Sievert, Marissa C. Franke, Kayla B. Thomas, Yoseop Yoon, Yongsheng Shi, Roger Sciammas

“…We observed (1) graded μS-PAS usage during PC differentiation, (2) IRF4 and Blimp-1 functioned hierarchically to increase μ abundance as well as μS-PAS usage, and (3) graded μS populations did or did not express Blimp-1. …”
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CD5-Positive Primary Cutaneous Diffuse Large B-Cell Lymphoma-Leg Type by Alexandra Papoudou-Bai, Leonidas Marinos, Amalia Vassou, Eleni Kapsali, Panagiotis Kanavaros

“…Immunohistochemistry revealed that these large cells were positive for CD5, CD20, CD79a, MUM1/IRF4, Bcl6, Bcl2, and cytoplasmic IgM/λ, whereas CD3, CD56, CD23, CD21, CD10, CD30, cyclin D1, CD68, lysozyme, myeloperoxidase, and CD34 were not detected. …”
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