12-month outcomes of ziv-aflibercept for neovascular age-related macular degeneration in eyes previously treated with aflibercept by Wajiha J Kheir, Mahdi Hassoun, Rola N Hamam, Ziad Fayez Bashshur

“…Data on best corrected visual acuity (BCVA), intraocular pressure, injection intervals, central retinal thickness (CRT), volume cube presence of subretinal fluid (SRF), and intraretinal fluid (IRF) were obtained. Main outcome measures included changes in BCVA, injection intervals, CRT, SRF, and IRF before and after 12 months of ziv-aflibercept treatment. …”
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Advancing CO2++ Modeling in the Martian Dayside Ionosphere: Insights from Natural Lifetime Analysis by Long Cheng, Erik Vigren, Moa Persson, Hao Gu, Jun Cui

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Development an Inflammation-Related Factor-Based Model for Predicting Organ Failure in Acute Pancreatitis: A Retrospective Cohort Study by Yunpeng Peng, Xiaole Zhu, Chaoqun Hou, Chenyuan Shi, Dongya Huang, Zipeng Lu, Yi Miao, Qiang Li

“…Several inflammation-related factors (IRFs) have been reported to predict organ failure of acute pancreatitis (AP) in previous clinical studies. …”
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A case of familial systemic sclerosis by Shreeja Jha, Mohammed Fahad Khan, Aditi Ravindra

“…Given the strong family history, full exome sequencing carried out using the next-generation sequencing method showed an interferon regulatory factor 5 (IRF5) IRF5 rs2004640 GT substitution. The case intends to draw attention to the genetic and familial basis of systemic sclerosis.…”
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Oral S2-Ag85 DNA Vaccine Activated Intestinal Cell dsDNA and RNA Sensors to Promote the Presentation of Intestinal Antigen by Dang Sheng, Sui Xin, Wu Dongxing, Wen Shubo, Song Yang, Chen Zeliang, Zhai Jingbo

“…The molecular mechanisms of in vitro detection sensor molecules RIG-1, Pol III, and related conductor transductor molecules DAI, STING, AIM2, IRF3, and IRF7 were determined by separating intestinal IEC, DC, and IELC cells. …”
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Observational Study of Pediatric Cochlear Implant Recipients: Two-year Follow-up Outcomes by Sidika CESUR, Ayca CIPRUT, Sengul TERLEMEZ

“…A moderate negative relationship was found between the age of implantation and SSQ-P and family satisfaction scores of IRF (p<0.05). Conclusions: Family expectations, overall well-being, quality of life, auditory, and verbal skills increase positively with earlier CI intervention. …”
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Effect of Berberine on the Inflammatory Response of ANA-1 Cells Induced by Angiotensin Ⅱ Based on TLR4 Signaling Pathway by GAO Dexing, JIA Peizhi, PENG Jun, LIN Wei

“…Compared with the control group, the phosphorylation expression of ERK, p38 protein of the model group after intervention for 15 minutes was significantly increased, the phosphorylation expression of JNK protein of the model group after intervention for 30 minutes was significantly increased, the phosphorylation expression of p65, IRF-3 protein of the model group after intervention for 45 minutes was significantly increased, the phosphorylation of p65, IRF-3, ERK, p38 and JNK proteins of the model + the high dose BBR group and the model + the inhibition group were significantly decreased. …”
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Targeting BRD4 ameliorates experimental emphysema by disrupting super-enhancer in polarized alveolar macrophage by Difei Li, Xing Shi, Yuqiong Yang, Yao Deng, Dandan Chen, Shuyu Chen, Jinyong Wang, Guanxi Wen, Zhenyu Liang, Fengyan Wang, Jiaqi Gao, Yuanyuan Liu, Danna Wang, Ruifang Liang, Haizhao Xu, Rongchang Chen, Shanze Chen, Lingwei Wang

“…A diagram of the mechanism by which BRD4 mediated super-enhancer of IRF4 in M2 AMs. Graphic illustration showed targeting BRD4 in M2 polarized AMs lead to the downregulation of MMP12 expression, resulting in the amelioration of experimental emphysema by disrupting the super-enhancer of IRF4. …”
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Mitochondrial DNA from endothelial cells activated the cGAS-STING pathway and regulated pyroptosis in lung ischaemia reperfusion injury after lung transplantation by Ying-nan Ju, Hu Li, Zi-peng Zhuo, Qing Yang, Wei Gao

“…The expression of cGAS-STING-TBK1-IRF3, histological injury, pulmonary permeability, and the levels of cytokines and pyroptotic proteins in transplanted lungs were tested. …”
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Clinical Evaluation of Faricimab in Real-World Diabetic Macular Edema in India- A Multicenter Observational Study by Chakraborty D, Das S, Maiti A, Sinha TK, Das A, Sheth J, Boral SK, Mondal S, Nandi K

“…The overall CMT reduction was statistically significant at 6 months (P< 0.001). Resolution of IRF and SRF was achieved in both groups, with SRF reducing from 82.1% to 20.5% (P< 0.001) and IRF from 87.2% to 17.9% (P< 0.001). …”
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Integrative Bioinformatics Analysis of Pyroptosis-Related Genes and Analysis of Immune Cell Infiltration in Infantile Hemangioma Regression by Liu L, Lin S, Bai J, Zhang B

“…IL-6 was significantly positively correlated with Th17 cell infiltration and significantly negatively correlated with Tgd cell infiltration; EGFR was negatively correlated with Tgd cell infiltration; and IRF1 and IL32 were significantly negatively correlated with Th17 cell infiltration.Conclusion: Four PRGs, namely, IL6, EGFR, IRF1 and IL32, may play a significant role in IH regression. …”
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Multivendor Spectral-Domain Optical Coherence Tomography Dataset, Observer Annotation Performance Evaluation, and Standardized Evaluation Framework for Intraretinal Cystoid Fluid S... by Jing Wu, Ana-Maria Philip, Dominika Podkowinski, Bianca S. Gerendas, Georg Langs, Christian Simader, Sebastian M. Waldstein, Ursula M. Schmidt-Erfurth

“…Integral to this work is the dataset used which must be fit for purpose for IRF segmentation algorithm training and testing. …”
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Genetics of Myasthenia Gravis: A Case-Control Association Study in the Hellenic Population by Zoi Zagoriti, Marianthi Georgitsi, Olga Giannakopoulou, Fotios Ntellos, Socrates J. Tzartos, George P. Patrinos, Konstantinos Poulas

“…These are interferon regulatory factor 5 (IRF-5), TNFα-induced protein 3 (TNFAIP3), also known as A20, and interleukin-10 (IL-10), key molecules in the regulation of immune function. …”
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Differentiation status determines the effects of IFNγ on the expression of PD-L1 and immunomodulatory genes in melanoma by Teitur Sævarsson, Adrián López García de Lomana, Ólafur Sánchez, Veerle van Esch, Gunnar Bjarni Ragnarsson, Siggeir Fannar Brynjólfsson, Eiríkur Steingrímsson, Berglind Ósk Einarsdóttir

“…Furthermore, the intensified PD-L1 protein expression occurs through the JAK-STAT1-IRF1 axis. Lastly, dedifferentiated patient derived melanoma cell lines showed enhanced inflammatory signaling in response to IFNγ compared to differentiated cells, and tended to have higher PD-L1 expression, associated with increased IRF1 expression and activity. …”
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RNA N6‐Methyladenosine‐Binding Protein YTHDFs Redundantly Attenuate Cancer Immunity by Downregulating IFN‐γ Signaling in Gastric Cancer by Dongjun Jang, Chanwoong Hwa, Seoyeon Kim, Jaeik Oh, Seungjae Shin, Soo‐Jin Lee, Jiwon Kim, Sang Eun Lee, Yoojin Yang, Dohee Kim, Seoho Lee, Hae Rim Jung, Yumi Oh, Kyunggon Kim, Hye Seung Lee, Joon‐Yong An, Sung‐Yup Cho

“…Collectively, these findings highlight how YTHDFs modulate cancer immunity by influencing IFN‐γ signaling through IRF1 regulation, suggesting their viability as therapeutic targets in cancer immunotherapy.…”
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Comparison of optical coherence tomography vs. fluorescein angiography-based macular neovascularization classifications in age-related macular degeneration by Gábor G. Deák, Klaudia Birner, Bianca S. Gerendas, Georgios Mylonas, Günther Weigert, Martin Michl, Irene Steiner, Ursula M. Schmidt-Erfurth

“…Significant differences in the volumes of intraretinal fluid (IRF), subretinal fluid (SRF), and pigment epithelial detachment (PED) were noted among MNV types (p < 0.0001). …”
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Impact of modulating leptin sensitivity on the transcriptomic profile of adult-derived hypothalamic mouse neurons by Ewa Ocłoń, Artur Gurgul, Tomasz Szmatoła, Igor Jasielczuk, Miroslaw Kucharski, Joanna Zubel-Łojek, Dorota Anna Zieba

“…To this end, 3’ mRNA-Seq transcriptome analysis was employed, unexpectedly revealing downregulation of key genes associated with the NOD-like receptor signaling pathway (Irf9, Mapk3, Stat2, Nfkbia, Ikbkg, Rela, Cxcl1, and Traf5), the C-type lectin receptor signaling pathway (Nfkb2, Irf9, Mapk3, Stat2, Nfkbia, Ikbkg, Rela, and Ptgs2), the NF kappa B signaling pathway (Nfkbia, Ikbkg, Nfkb2, Rela, Traf5, Cxcl1, and Ptgs2), and the IL 17 signaling pathway (Nfkbia, Ikbkg, Mapk3, Rela, Traf5, Cxcl1, and Ptgs2). …”
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Integrative single-cell and bulk RNA-seq analyses identify CD4+ T-cell subpopulation infiltration and biomarkers of regulatory T cells involved in mediating the progression of athe... by Yifeng Zhang, Yifeng Zhang, Shuxian Lu, Shuxian Lu, Liang Qiu, Liang Qiu, Manman Qin, Manman Qin, Dan Shan, Lianhua Xie, Yao Yi, Yao Yi, Jun Yu

“…Interestingly, we found that IRF8 and ZNF267 as potential biomarkers were upregulated in circulating CD4+ T cells in patients with atherosclerotic coronary artery disease. …”
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曲古抑菌素A下调人肺腺癌细胞A549内IDO表达的分子机制

“…双荧光素酶报告基因分析和Western blot结果表明：TSA能显著抑制GAS、ISRE和IRF-1 的激活却不能抑制NF-κB的激活。【结论】TSA能下调IFN-γ诱导的A549细胞中IDO的表达，其机制可能是与其抑制STAT1的磷酸化和核转位，以及抑制STAT1与GAS的结合有关。…”
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The Central Role and Possible Mechanisms of Bacterial DNAs in Sepsis Development by Zhenxing Cheng, Simon T. Abrams, James Austin, Julien Toh, Susan Siyu Wang, Zhi Wang, Qian Yu, Weiping Yu, Cheng Hock Toh, Guozheng Wang

“…The major downstream signalling pathways includeTLR-9-MyD88-IKKa-IRF-7/NF-κB pathways to increase IFN/proinflammatory cytokine production, STING-TBK1-IRF3 pathway to increase IFN-beta, and AIM2-ASC-caspas-1 pathway to release IL-1beta. …”
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