Editorial: Activation of the cGAS-STING pathway by extra-nuclear DNA and its pharmacognostic modulation in human disease by Preston M. McCourt, Charles A. Day, Souren Paul, Souren Paul

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Editorial: Viral infection pathogenesis and pathology in nervous system by A. Alwin Prem Anand

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Infectious bursal disease virus affecting interferon regulatory factor 7 signaling through VP3 protein to facilitate viral replication by Zhiyuan Wang, Yang Chen, Yanyan Chen, Rui Chen, Weiwei Wang, Shichen Hu, Yihai Li, Hongjun Chen, Ping Wei, Xiumiao He

Subjects: “…interferon regulatory factor 7 (IRF7)…”
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IFN Regulatory Factor 1 Mediates Macrophage Pyroptosis Induced by Oxidized Low-Density Lipoprotein in Patients with Acute Coronary Syndrome by Min Guo, Rui Yan, Hongmei Yao, Liqin Duan, Meng Sun, Zheng Xue, Yongping Jia

“…Then, overexpression and inhibition of IRF-1 was performed in macrophages from patients with ACS to explore the possible role and mechanism of IRF-1 involvement in macrophage pyroptosis. …”
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Functional performance of patients with stroke during inpatient rehabilitation: a cross-sectional study of home and access visits by Melissa J. Krauss, Emily Somerville, Callista Poiter, Rebecca M. Bollinger, Brianna M. Holden, Gabrielle Blenden, Danielle Kretzer, Susan L. Stark

“…ICF scores were compared between predischarge home visits and IRF discharge and between access visits and IRF discharge using Wilcoxon signed-rank tests. …”
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Statistical Estimation and Hypothesis Testing on Impulse Response Function by Iryna Rozora, Anastasiia Melnyk

“…A rate of convergence of IRF estimator in the space L2([0,Λ]) is obtained that gives a possibility to propose a nonparametric goodness-of-fit testing on IRF. …”
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Outcomes and predictive factors for fluid resolution following three loading injections of faricimab for treatment-naïve neovascular age-related macular degeneration by Hee Yong Han, Sang Min Park, Ji Hyun Lee, Chul Gu Kim, Jong Woo Kim, Han Joo Cho, Jae Hui Kim

“…At baseline, SRF was observed in 55 eyes (79.7%), IRF in 39 eyes(56.5%), and serous PED in 57 eyes(82.6%). …”
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Malate initiates a proton-sensing pathway essential for pH regulation of inflammation by Yu-jia-nan Chen, Rong-chen Shi, Yuan-cai Xiang, Li Fan, Hong Tang, Gang He, Mei Zhou, Xin-zhe Feng, Jin-dong Tan, Pan Huang, Xiao Ye, Kun Zhao, Wen-yu Fu, Liu-li Li, Xu-ting Bian, Huan Chen, Feng Wang, Teng Wang, Chen-ke Zhang, Bing-hua Zhou, Wan Chen, Tao-tao Liang, Jing-tong Lv, Xia Kang, You-xing Shi, Ellen Kim, Yin-hua Qin, Aubryanna Hettinghouse, Kai-di Wang, Xiang-li Zhao, Ming-yu Yang, Yu-zhen Tang, Hai-long Piao, Lin Guo, Chuan-ju Liu, Hong-ming Miao, Kang-lai Tang

“…Both L-malate and acidification inhibit BiP-IRF2BP2 interaction, and protect IRF2BP2 from BiP-driven degradation in macrophages. …”
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CAPTCHA as a Visual Performance Metric in Active Macular Disease by Gautam Vangipuram, Aaron Y. Lee, Kasra A. Rezaei, Lisa C. Olmos De Koo, Yewlin E. Chee, Jennifer R. Chao, Catherine Egan, Cecilia S. Lee

“…Distance VA and contrast sensitivity are positively correlated with the presence of IRF and SRF in active macular disease. CAPTCHA performance did not appear to be a significant predictor of either IRF or SRF in our pilot study.…”
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Modified vaccinia virus Ankara triggers type I IFN production in murine conventional dendritic cells via a cGAS/STING-mediated cytosolic DNA-sensing pathway. by Peihong Dai, Weiyi Wang, Hua Cao, Francesca Avogadri, Lianpan Dai, Ingo Drexler, Johanna A Joyce, Xiao-Dong Li, Zhijian Chen, Taha Merghoub, Stewart Shuman, Liang Deng

“…We report that MVA infection elicits the production of type I IFN in murine conventional dendritic cells (cDCs), but not in plasmacytoid dendritic cells (pDCs). Transcription factors IRF3 (IFN regulatory factor 3) and IRF7, and the positive feedback loop mediated by IFNAR1 (IFN alpha/beta receptor 1), are required for the induction. …”
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干扰素调节因子5下调PARP-1抑制鼻咽癌细胞的侵袭力 by 李民英, 何秀芳, 郑斯明, 周嘉雄

“…【方法】本研究使用的临床标本是经病理确诊的鼻咽癌患者组织标本46例和正常组织51例。免疫组化 检测鼻咽癌组织和正常组织中IRF5和PARP-1的表达。构建IFR5过表达质粒，上调鼻咽癌细胞CNE-2中IFR5 表达，荧光定量PCR（QPCR）和免疫印迹确定建立IRF5过表达细胞。…”
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Lipoma of the Ischiorectal Fossa: A Rare Case Report by Djavan Khubanov, Kamala Gasimova

“…Ischiorectal fossa (IRF) masses are uncommon and pose significant diagnostic challenges because of their varied etiologies. …”
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Renal impairment and in-hospital adverse renal events in critically ill patients assessed by age-adapted estimated glomerular filtration rate criteria by Chong Zhang, Weiru Liang, Meng Ning, Bin Su, Tingting Guo, Kun Hu, Wei Su, Yi Chen, Wenjin Peng, Yingwu Liu

“…Background Impaired renal function (IRF) is associated with an elevated risk of major adverse renal events (MARE). …”
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Ataxin-10 Inhibits TNF-α-Induced Endothelial Inflammation via Suppressing Interferon Regulatory Factor-1 by Yong Li, Qi Zhang, Na Li, Liting Ding, Jinping Yi, Yue Xiao, Shibiao Chen, Xuan Huang

“…Using the yeast two-hybrid assay, we found that Ataxin-10 can directly bind to interferon regulatory factor-1 (IRF-1). Upon TNF-α stimulation, Ataxin-10 promoted the cytoplasmic localization of IRF-1, which inhibited the transcription of VCAM-1. …”
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Intracardiac Fibrinolysis and Endothelium Activation Related to Atrial Fibrillation Ablation with Different Techniques by Orsolya Hajas, Zsuzsa Bagoly, Noémi K Tóth, Réka Urbancsek, Alexandra Kiss, Kitti B Kovács, Ferenc Sarkady, Attila Nagy, Anna V. Oláh, László Nagy, Marcell Clemens, László Csiba, Zoltán Csanádi

“…We measured markers of fibrinolysis and endothelium activation before and after PVI with the second-generation cryoballoon (Cryo), pulmonary vein ablation catheter (PVAC-Gold), and irrigated radiofrequency (IRF). Methods. Markers of fibrinolysis and endothelium activation in left atrial (LA) blood samples were measured in 31 patients before and after PVI (Cryo:10, PVAC-Gold: 7, IRF: 14). …”
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Inconspicuous taxa in citizen science-based botanical research: actual contribution, limitations, and new opportunities for non-vascular cryptogams by Carlos Cerrejón, Carlos Cerrejón, Marion Noualhaguet, Nicole J. Fenton, Marc-Frédéric Indorf, Mariano J. Feldman, Mariano J. Feldman

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Predictive value of different baseline optical coherence tomography biomarkers for visual acuity changes in neovascular age-related macular degeneration by Hamid Riazi-Esfahani, Hooshang Faghihi, Fatemeh Bazvand, Mohammadreza Mehrabi Bahar, Hassan Khojasteh, Ahmed Husein Ahmed, Shahin Faghihi, Ali Fakhraie, Mohammad Hossein Zamani, Samin Ghasemi, Esmaeil Asadi Khameneh, Elias Khalili Pour

“…Results Among 89 eyes with nAMD, mean best-corrected visual acuity (BCVA) improved by 6 Early Treatment Diabetic Retinopathy Study (ETDRS) letters from baseline to month 3, with sustained improvement through month 12. Baseline IRF was associated with poorer visual acuity improvement at month 12, with patients showing a mean improvement of 1.6 ± 18.2 ETDRS letters versus 11.1 ± 10 ETDRS letters in those without IRF (P = 0.002). …”
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TBK1 在抗病毒固有免疫中的作用及其调控机制 by 赵伟

“…一方面，TBK1可接受来自于多种模式识别受体（PRR）的活化信号；另一方面，活化的TBK1作为激酶，可对转录因子IRF3/IRF7等底物进行磷酸化修饰，开启抗病毒固有免疫反应。本文综述了TBK1参与的抗病毒固有免疫信号通路，及其表达与活化的调节机制。…”
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Mapping integral cell-type-specific interferon-induced gene regulatory networks (GRNs) involved in systemic lupus erythematosus using systems and computational analysis by Blessy Kiruba, Akshayata Naidu, Vino Sundararajan, Sajitha Lulu S

“…These findings indicate that IRF3, IRF7, STAT1, MYB, and FOXO1 are promising targets for therapeutic interventions for SLE.…”
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Exploring Local People’s Perception of Ecosystem Services in Djoumouna Periurban Forest, Brazzaville, Congo by V. Kimpouni, J. D. D. Nzila, N. Watha-Ndoudy, M. I. Madzella-Mbiemo, S. Yallo Mouhamed, J.-P. Kampe

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