Molecular Imaging of IGF-1R in Cancer by Yingying Sun PhD, Xilin Sun PhD, Baozhong Shen MD, PhD

“…However, while IGF-1R has become a promising target for cancer therapy, IGF-1R-targeted therapy is ineffective in unselected patients. …”
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Gene Expression of IGF1, IGF1R, and IGFBP3 in Epiretinal Membranes of Patients with Proliferative Diabetic Retinopathy: Preliminary Study by Dorota Romaniuk, Malgorzata W. Kimsa, Barbara Strzalka-Mrozik, Magdalena C. Kimsa, Adam Kabiesz, Wanda Romaniuk, Urszula Mazurek

“…Therefore, the present study focused on the assessment of IGF1, IGF1R, and IGFBP3 mRNA levels in ERMs and PBMCs from patients with PDR. …”
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Lactoferrin Induces Osteoblast Growth through IGF-1R by Jian-Ming Hou, En-Yu Chen, Fan Lin, Qing-Ming Lin, Ying Xue, Xu-Hua Lan, Man Wu

“…Conclusion. Lactoferrin induced IGF-1/IGF-1R in a concentration-dependent manner. …”
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Mechanical Stress-Induced IGF-1 Facilitates col-I and col-III Synthesis via the IGF-1R/AKT/mTORC1 Signaling Pathway by Bin Yan, Canjun Zeng, Yuhui Chen, Minjun Huang, Na Yao, Jie Zhang, Bo Yan, Jiajun Tang, Liang Wang, Zhongmin Zhang

“…Interestingly, col-I protein, col-I mRNA, col-III protein, col-III mRNA, and IGF-1 protein, but not IGF-1 mRNA, were inhibited by IGF-1 neutralizing antibody. …”
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Expression of Concern: Role of Ubiquitination in IGF-1 Receptor Signaling and Degradation. by PLOS One Editors

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Expression of Concern: Role of Ubiquitination in IGF-1 Receptor Signaling and Degradation

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IGF-1 impacts neocortical interneuron connectivity in epileptic spasm generation and resolution by Carlos J. Ballester-Rosado, John T. Le, Trang T. Lam, Anne E. Anderson, James D. Frost, Jr., John W. Swann

“…To evaluate the impact of IGF-1 deficiencies on interneuron development, IGF-1R levels were reduced in the neocortex of neonatal conditional IGF-1R knock out mice by viral injections. …”
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GH, IGF-1, and Age Are Important Contributors to Thyroid Abnormalities in Patients with Acromegaly by Xia Wu, Lu Gao, Xiaopeng Guo, Qiang Wang, Zihao Wang, Wei Lian, Wei Liu, Jian Sun, Bing Xing

“…The thyroid gland volume was significantly increased in patients with higher random GH (p=0.01), higher nadir GH (p=0.008), and higher IGF-1 level (p=0.018). Age (p=0.002) was an independent risk factor for thyroid morphological abnormalities in acromegaly. …”
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Impact of strict IGF1 control on quality-of-life scores in patients with acromegaly by Chaitanya Gandhi, Marie-Claire Denis, Daniel Holmes, Juan Rivera, Stan van Uum, Shereen Ezzat, Constance Chik

“…ObjectiveExamine, in a real-world setting, whether strict normalization of modestly elevated insulin-like growth factor 1 (IGF1) results in clinical and health-related quality of life benefits in patients with acromegaly using an open-label, non-randomized, 6-month prospective interventional study.MethodsIn patients with acromegaly and modest IGF1 elevation, strict IGF1 control was achieved by addition or dose escalation of pegvisomant. …”
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PPAR-γ Agonists and Their Effects on IGF-I Receptor Signaling: Implications for Cancer by A. Belfiore, M. Genua, R. Malaguarnera

“…In this regard, promising drugs have been developed to target the IGF-I receptor or its ligands. These therapies are limited by the development of insulin resistance and compensatory hyperinsulinemia, which in turn, may stimulate cancer growth. …”
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Stress-Activated Protein Kinases (SAPKs) in IGF-I Mediated Cell Survival by Darren Krause, Anthony Lyons, Patrick Walsh, Rosemary O’Connor

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Efficacy of cartilage-targeted IGF-1 in a mouse model of growth hormone insensitivity by Krishma Tailor, Krishma Tailor, Janine van Ree, Timothy Stowe, Brit Ventura, Connor Sisk, Joanna Courtis, Anna Camp, Fatima Elzamzami, Jan van Deursen, Robert O’Brien, Jeffrey Baron, Julian C. Lui

“…Recombinant human IGF-1 is used to treat severe primary IGF-1 deficiency, but this treatment requires twice-daily injection, often does not fully correct the growth deficit, and has important off-target effects. …”
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IGF-1 Restores Visual Cortex Plasticity in Adult Life by Reducing Local GABA Levels by José Fernando Maya-Vetencourt, Laura Baroncelli, Alessandro Viegi, Ettore Tiraboschi, Eero Castren, Antonino Cattaneo, Lamberto Maffei

“…Moreover, we show that a transitory increase of IGF-1 expression is associated to the plasticity reinstatement induced by environmental enrichment (EE) and that blocking IGF-1 action by means of the IGF-1 receptor antagonist JB1 prevents EE effects on plasticity processes.…”
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IGF-1R Inhibition Suppresses Cell Proliferation and Increases Radiosensitivity in Nasopharyngeal Carcinoma Cells by Zhe Wang, Guangyan Liu, Jiwei Mao, Min Xie, Ming Zhao, Xuefen Guo, Shanshan Liang, Heming Li, Xuefeng Li, Ruoyu Wang

“…Thus, IGF-1R may be a potential therapeutic target for patients with different malignancies. …”
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Interpreting IGF-1 in children treated with recombinant growth hormone: challenges during early puberty by Helena-Jamin Ly, Helena-Jamin Ly, Carina Ankarberg-Lindgren, Hans Fors, Hans Fors, Staffan Nilsson, Jovanna Dahlgren, Jovanna Dahlgren

“…Insulin-like growth factor-1 (IGF-1) is a tool for monitoring GH treatment and dosing. …”
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IGF-1 Increases with Hyperbaric Oxygen Therapy and Promotes Wound Healing in Diabetic Foot Ulcers by Figen Aydin, Ahmet Kaya, Levent Karapinar, Mert Kumbaraci, Ahmet Imerci, Hasan Karapinar, Cengiz Karakuzu, Mustafa Incesu

“…There was no significant difference in initial IGF-1 levels between the two groups (P=0.399). The mean IGF-1 level increased with HBOT (P<0.05). …”
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Insulin-Like Growth Factor (IGF)-I and Insulin in Normal and Growth-Restricted Mother/Infant Pairs by Ariadne Malamitsi-Puchner, Despina D. Briana, Dimitrios Gourgiotis, Maria Boutsikou, Karl-Philipp Puchner, Stavroula Baka, Antonios Marmarinos, Dimitrios Hassiakos

“…Insulin-like growth factor (IGF)-I and insulin are essential for fetal growth. …”
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The Role of the Multiple Hormonal Dysregulation in the Onset of “Anemia of Aging”: Focus on Testosterone, IGF-1, and Thyroid Hormones by Marcello Maggio, Francesca De Vita, Alberto Fisichella, Fulvio Lauretani, Andrea Ticinesi, Graziano Ceresini, Anne Cappola, Luigi Ferrucci, Gian Paolo Ceda

“…Epidemiological data more consistently support an association between lower testosterone and anemia in adult-older individuals. Low IGF-1 has been especially associated with anemia in the pediatric population and in a wide range of disorders. …”
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Effects of linsitinib on M22 and IGF:1-treated 3D spheroids of human orbital fibroblasts by Fumihito Hikage, Megumi Suzuki, Tatsuya Sato, Araya Umetsu, Toshifumi Ogawa, Nami Nishikiori, Masato Furuhashi, Hiroshi Ohguro, Megumi Watanabe

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Paracrine role of endothelial IGF-1 receptor in depot-specific adipose tissue adaptation in male mice by Cheukyau Luk, Katherine I. Bridge, Nele Warmke, Katie J. Simmons, Michael Drozd, Amy Moran, Amanda D. V. MacCannell, Chew W. Cheng, Sam Straw, Jason L. Scragg, Jessica Smith, Claire H. Ozber, Chloe G. Wilkinson, Anna Skromna, Natallia Makava, Hiran A. Prag, T. Simon Futers, Oliver I. Brown, Alexander-Francisco Bruns, Andrew MN Walker, Nicole T. Watt, Romana Mughal, Kathryn J. Griffin, Nadira Y. Yuldasheva, Sunti Limumpornpetch, Hema Viswambharan, Piruthivi Sukumar, David J. Beech, Antonio Vidal-Puig, Klaus K. Witte, Michael P. Murphy, Richard C. Hartley, Stephen B. Wheatcroft, Richard M. Cubbon, Lee D. Roberts, Mark T. Kearney, Natalie J. Haywood

“…We explore the role of endothelial insulin-like growth factor-1 receptor (IGF-1R), as a paracrine modulator of white adipose phenotype. …”
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