A Program for Postgraduate Diploma in Human Resource Management by Kabale University

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From non-human to human primates: a translational approach to enhancing resection, safety, and indications in glioma surgery while preserving sensorimotor abilities by Matteo Gambaretti, Matteo Gambaretti, Luca Viganò, Luca Viganò, Matteo Gallo, Giovanni Pratelli, Tommaso Sciortino, Lorenzo Gay, Marco Conti Nibali, Alberto Luigi Gallotti, Alberto Luigi Gallotti, Leonardo Tariciotti, Luca Mattioli, Lorenzo Bello, Lorenzo Bello, Gabriella Cerri, Gabriella Cerri, Marco Rossi, Marco Rossi, Marco Rossi

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Human versus Analogue Insulin for Youth with Type 1 Diabetes in Low-Resource Settings (HumAn-1): protocol for a randomised controlled trial by Éimhín Ansbro, Jing Luo, Chung-Chou H Chang, Kaushik Ramaiya, Bruce L Rollman, Sylvia Kehlenbrink, Sae-Rom Chae, Abigail Foulds, Claire Josey, Christina Lalama, Margaret L Prust, Bedowra Zabeen, Graham Ogle

“…To determine whether insulin glargine, a long-acting insulin analogue, reduces the risk of serious hypoglycaemia and/or improves glycaemic time-in-range (TIR) versus human insulin regimens in this population, we are conducting the Human vs Analogue Insulin for Youth with Type 1 Diabetes in Low-Resource Settings randomised controlled trial.Methods and analysis This is a 1:1 randomised, parallel-group clinical trial comparing biosimilar insulin glargine with human insulin (Neutral Protamine Hagedorn (NPH) or premixed 70/30 insulin) in 400 youth with type 1 diabetes (T1D) recruiting in Dhaka, Bangladesh (n=250) and Mwanza, Tanzania (n=150). …”
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Therapeutic Potential of Synthetic Human β-Defensin 1 Short Motif Pep-B on Lipopolysaccharide-Stimulated Human Dental Pulp Stem Cells by Jue Shi, Zihe Hu, Yanyan Zhou, Minghao Zuo, Haiyan Wu, Wenjing Jin, Zhijian Xie

“…Alleviating inflammation is critical to inflamed pulp repair. Human β-defensin 1 short motif Pep-B is a cationic peptide that has anti-inflammatory, antibacterial, and immunoregulation properties, but its repair effect on human dental pulp stem cells (hDPSCs) under inflammation remains unclear. …”
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A Summary: Portraying the Legal Culture and the European Human Rights Culture of the European Court of Human Rights and the European Court of Justice through Interviews by Nina-Louisa Arold Lorenz

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Inhibition of CFTR-mediated intestinal chloride secretion by nornidulin: Cellular mechanisms and anti-secretory efficacy in human intestinal epithelial cells and human colonoids. by Chamnan Yibcharoenporn, Thidarat Kongkaew, Nichakorn Worakajit, Rungtiwa Khumjiang, Praphatsorn Saetang, Saravut Satitsri, Vatcharin Rukachaisirikul, Chatchai Muanprasat

“…Nornidulin, a fungus-derived natural product from Aspergillus unguis, has previously been shown to inhibit cAMP-induced Cl- secretion in T84 cells (human intestinal cell lines). However, the cellular mechanism of nornidulin in inhibiting cAMP-induced Cl- secretion and its anti-secretory efficacy is still unknown especially in a human colonoid model, a preclinical model recapitulating intestinal physiology in humans. …”
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Human Immune System Increases Breast Cancer-Induced Osteoblastic Bone Growth in a Humanized Mouse Model without Affecting Normal Bone by Tiina E. Kähkönen, Mari I. Suominen, Jenni H. E. Mäki-Jouppila, Jussi M. Halleen, Azusa Tanaka, Michael Seiler, Jenni Bernoulli

“…The study was performed using CIEA NOG (NOG) mice engrafted with human CD34+ hematopoietic stem cells (huNOG) and age-matched immunodeficient NOG mice. …”
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The Effect of Exosomes Derived from Human Umbilical Cord Mesenchymal Stromal/Stem Cells on the Regeneration of Human Pulpectomized Tooth: A Case Report by Nazanin Jafari, Mina Seyed Habashi, Alireza Afshar, Mohammad Ghasemi, Madina A. Kurmanalina, Nadiar M. Mussin, Asset A. Kaliyev, Shahrokh Zare, Zahra Khodabandeh, Nader Tanideh, Amin Tamadon

“…Regenerative endodontic procedures (REPs) aim to regenerate pulp tissue while preserving tooth vitality. Exosomes from human umbilical cord mesenchymal stromal/stem cells (hUCMSCs) demonstrated potential for tissue regeneration. …”
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St. John Paul II’s Natural Law Legacy and International Human Rights Culture of Human Dignity – A Road to Universal Brotherhood and Peace by Ján Figel

Subjects: “…Universal Declaration of Human Rights…”
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Research of the Technological Future’s Uncertainty by J. Kovalchuk, I. Stepnov

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The First European Maps of Muscovy (1525) by O. F. Kudryavtsev

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Molluscum contagiosum in a severely immunocompromised human immunodeficiency virus patient: Dermatological manifestation being a diagnostic clue for human immunodeficiency virus infection by Darshankumar Manubhai Raval, Vaishnavi M Rathod

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Theoretical modeling of hepatitis C acute infection in liver-humanized mice support pre-clinical assessment of candidate viruses for controlled-human-infection studies by Zhenzhen Shi, Adquate Mhlanga, Yuji Ishida, Ari Josephson, Nicholson T. Collier, Hiromi Abe-Chayama, Chise Tateno-Mukaidani, Scott J. Cotler, Jonathan Ozik, Marian Major, Jordan J. Feld, Kazuaki Chayama, Harel Dahari

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Human-Prosthetic Interaction (HumanIT): A study protocol for a clinical trial evaluating brain neuroplasticity and functional performance after lower limb loss. by Elke Lathouwers, Bruno Tassignon, Alexandre Maricot, Ahmed Radwan, Maarten Naeyaert, Hubert Raeymaekers, Peter Van Schuerbeek, Stefan Sunaert, Johan De Mey, Kevin De Pauw, Kevin De Pauw

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Analysis of early effects of human APOE isoforms on Alzheimer’s disease and type III hyperlipoproteinemia pathways using knock-in rat models with humanized APP and APOE by Metin Yesiltepe, Tao Yin, Marc Tambini, Hanmei Bao, Meixia Pan, Cristina d’Abramo, Luca Giliberto, Xianlin Han, Luciano D’Adamio

“…These rats were crossed with those carrying a humanized App allele to express human Aβ, which is more aggregation-prone than rodent Aβ, enabling the study of human APOE-human Aβ interactions. …”
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Titin fragment is a sensitive biomarker in Duchenne muscular dystrophy model mice carrying full-length human dystrophin gene on human artificial chromosome by Yosuke Hiramuki, Miwa Hosokawa, Kayo Osawa, Taku Shirakawa, Yasuhiro Watanabe, Ritsuko Hanajima, Hiroyuki Kugoh, Hiroyuki Awano, Masafumi Matsuo, Yasuhiro Kazuki

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Effects of Macromolecular Crowding on Human Adipose Stem Cell Culture in Fetal Bovine Serum, Human Serum, and Defined Xeno-Free/Serum-Free Conditions by Mimmi Patrikoski, Michelle Hui Ching Lee, Laura Mäkinen, Xiu Min Ang, Bettina Mannerström, Michael Raghunath, Susanna Miettinen

“…The ability of MMC to support adipose stem cell (ASC) proliferation, metabolism, and multilineage differentiation was studied under different conditions: fetal bovine serum- (FBS-) and human serum- (HS-) based media and xeno- and serum-free (XF/SF) media. …”
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Milk Products Containing Bioactive Tripeptides Have an Antihypertensive Effect in Double Transgenic Rats (dTGR) Harbouring Human Renin and Human Angiotensinogen Genes by Tiina Jauhiainen, Taru Pilvi, Zhong Jian Cheng, Hannu Kautiainen, Dominik N. Müller, Heikki Vapaatalo, Riitta Korpela, Eero Mervaala

“…Double transgenic rats (dTGR) harbouring human renin and human angiotensinogen genes develop malignant hypertension due to increased angiotensin II formation. …”
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The Protection of the Right to Life at the Intersection between Reproductive Rights and Scientific Progress in the Jurisprudence of the Inter-American Court of Human Rights and the European Court of Human Rights by Simona Fanni

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