Reactivity in cell culture medium and in vitro anticancer activity of 3,5-di-tert-butylcatechol: link to metal-catechol interactions by Aviva Levina, Debbie C. Crans, Peter A. Lay

“…Electrospray mass spectrometry and UV/Vis spectroscopy were used to study the reactivities of the molecules in buffer solutions and cell culture medium, in the presence and absence of glutathione and imidazole.Results and DiscussionThe dtbH2 and dtbQ molecules showed high anti-proliferative activity (IC50 < 10 μM in 72 h assays) in T98G and A549 cell lines in the absence of added metal ions. …”
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Comparison of human-induced pluripotent stem cell-derived macrophages with peripheral blood-derived macrophages using single-cell genomics by ZHANG Yutong, HOU Guojun, SHEN Nan

“…A reference dataset was constructed with highly variable genes from PBDMs, and the highly variable genes of IPSDMs were projected onto the PBDM dataset using the scmap package to infer IPSDMs cell identities based on variable gene similarity. …”
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Carboxylesterase 4A Inhibits the Malignant Biological Behavior of Nasopharyngeal Carcinoma via the PI3K/AKT Pathway by Qiaoli Chen MS, Quanxiang Hao MBBS, Yanping Yang MBBS, Limei Li PhD, Danping Li MS, Ran Zhao MS, Wanqi Wei MBBS, Lixian Deng MBBS, Jiaming Su MBBS, Ziyuan Liang MBBS, Shiyue Tang MS, Yaomin Lu MBBS, Yushan Liang PhD, Zhe Zhang PhD, Xiaoying Zhou PhD, Xue Xiao PhD, Ping Li PhD, Yi Huang PhD, Weilin Zhao PhD

“…Additionally, KEGG analysis based on GEO data and high-throughput transcriptome sequencing of cell lines all strongly suggested that CES4A was involved in regulating phosphoinositide 3-kinase (PI3K)/protein kinase B (AKT) signaling pathway. …”
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Exploring the impact and mechanisms of behavioral activation on sleep disorders in colorectal cancer: a randomized controlled trial by Anlong Li, Runze Huang, Han Ge, Dajie Liu, Shaochun Liu, Yingxue Jia, Jiaying Chai, Xinyi Zheng, Lijun Liu, Chen Gan, Jian Xu, Ling Cheng, Mingjun Zhang, Huaidong Cheng

“…Cognitive behavioral therapy for insomnia (CBT-I) is considered the first-line treatment but is often complex, costly, and requires highly trained therapists. …”
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A perinatal psychiatry access program to address rural and medically underserved populations using telemedicine by Courtney King, Marie Hayes, Lizmarie Maldonado, Elizabeth Monter, Rubin Aujla, Erin Phlegar, Claire Smith, Liz Parker, Kerry Blome, Amanda Sandford, Edie Douglas, Constance Guille

“…Abstract Background Although highly prevalent, most perinatal mental health and substance use disorders often go unrecognized, undiagnosed, and untreated. …”
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Optimum Design of Corona Ring of Composite Insulators Considering the Effect of Mutual Phases by Monte Carlo and Coordinate Search Intelligente Algorithms by Mostafa Khajavi, Sajad Bagheri, Asaad Shemshadi

“…Today, composite insulators are used in high-voltage power transmission lines, especially in polluted and humid areas. …”
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Research Progress of Methods of Initial Water Rights Allocation in River Basins by WU Dan, LIU Mengyao

“…The development of a robust and highly feasible method of initial water rights allocation in a river basin can provide important support for promoting high-quality economic development of the river basin and optimizing the layout of its industrial structure.This paper systematically reviews the methods of initial water rights allocation in river basins from four aspects:multi-objective coupling allocation methods,multi-stage coupling allocation methods with stakeholder participation,allocation methods oriented towards industrial structure optimization,and adaptive allocation methods.The results show that multi-objective coupling allocation methods focus on the coordinated reflection of multi-dimensional objectives,such as social equity,economic benefits,ecological protection,and risk control.The multi-stage coupling allocation methods with stakeholder participation concentrate on strengthening the interest interaction among water resource stakeholders and fully reflecting their interest demands.The allocation methods oriented towards industrial structure optimization center on promoting the optimization and upgrading of the industrial structures in river basins.The adaptive allocation methods highlight the improvement of the adaptability of the water resources in river basins to economic and social development.Initial water rights allocation in river basins has gradually developed from "multi-objective coupling allocation methods based on allocation principles" to "adaptive allocation methods based on allocation principles and the negotiation game mechanism".Solving the problem of adapting initial water rights to industrial structure optimization and promoting the optimization and upgrading of industrial structures and high-quality economic development will become the main lines of research on initial water rights allocation in river basins in the future.…”
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Differential Susceptibility to Propofol and Ketamine in Primary Cultures of Young and Senesced Astrocytes by Liang Huang, Ferit Tuzer, Abigail Murtha, Michael Green, Claudio Torres, Henry Liu, Shadi Malaeb

“…These effects were seen in comparisons of total cell count and at both high and low dose concentrations. High doses of propofol also significantly reduced cell viability compared to those exposed to baseline controls and ketamine. …”
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Enhancing Fault Detection and Classification in MMC-HVDC Systems: Integrating Harris Hawks Optimization Algorithm with Machine Learning Methods by Omar Hazim Hameed Hameed, Uğurhan Kutbay, Javad Rahebi, Fırat Hardalaç, Ibrahim Mahariq

“…Accurate fault detection in high-voltage direct current (HVDC) transmission lines plays a pivotal role in enhancing operational efficiency, reducing costs, and ensuring grid reliability. …”
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Exploration of ANKRD27 as an immune-related prognostic factor in pan-cancer and hepatocellular carcinoma by Ningzhe Shen, Congcong Fan, Haosun Ying, Xinmiao Li, Weizhi Zhang, Jinglu Yu, Jianjian Zheng, Yifei Li

“…Elevated expression of ANKRD27 was found in TCGA-HCC and GSE14520 cohorts and was confirmed in HCC cell lines. HCC patients with high ANKRD27 expression had poorer prognosis. …”
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Identification and validation of prognostic biomarkers in ccRCC: immune-stromal score and survival prediction by Fang Lyu, Yuxin Zhong, Qingliu He, Wen Xiao, Xiaoping Zhang

“…The risk score model exhibited a high degree of predictive accuracy for survival outcomes in ccRCC. …”
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Inhibiting H3K27 Demethylases Downregulates CREB‐CREBBP, Overcoming Resistance in Relapsed Acute Lymphoblastic Leukemia by Juan Lazaro‐Navarro, Clara Alcon, Mathurin Dorel, Lina Alasfar, Lorenz Bastian, Claudia Baldus, Kathy Astrahantseff, Marie‐Laure Yaspo, Joan Montero, Cornelia Eckert

“…High CREBBP expression in BCP‐ALL cell lines correlated with high GSK‐J4 sensitivity and low dexamethasone sensitivity. …”
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miR-149-3p Is a Potential Prognosis Biomarker and Correlated with Immune Infiltrates in Uterine Corpus Endometrial Carcinoma by Xiaoyuan Lu, Li Jing, Sicong Liu, Haihong Wang, Buze Chen

“…QRT-PCR was used to validate the expression of miR-149-3p in UCEC cell lines. Results. High expression of miR-149-3p in UCEC was significantly associated with age (P<0.001), histological type (P<0.001), histological grade (P<0.001), tumor invasion (P=0.014), and radiation therapy (P=0.011). …”
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Mechanism Analysis of the Influence of Freeze-Thaw on the Damage and Debonding Evolution of Sandstone-Concrete Interface by Yanjun Shen, Tao Luo, Xin Wei, Xueting Li, Long Jin, Liangdong Wen, Hui Peng, Yanjun Ji

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Method for Identifying Abnormal Hot Spots on the Surface of Composite Insulators by LIU Yao

“…【Objective】To avoid the operational risk of high-voltage transmission lines caused by thermal faults of composite insulators, a method for identifying abnormal hot spots on the surface of composite insulators is studied.…”
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Current trends, methods and results of brown mustard (Brassica juncea) and black mustard (Brassica nígra) breeding by V. S. Trubina

“…Individual selection based on self-pollination in the seed production of brown mustard population cultivars was found to facilitate identification of high-yielding lines, promptly increase the yield of cultivars, isolate lines exceeding the initial population in oil yield, and obtain biotypes with unusual fatty acid composition. …”
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Insights into mungbean defense response to Cercospora leaf spot based on transcriptome analysis by Sukanya Inthaisong, Pakpoom Boonchuen, Tana Jaichopsanthia, Pongpan Songwattana, Apinya Khairum, Witsarut Chueakhunthod, Akkawat Tharapreuksapong, Panlada Tittabutr, Neung Teaumroong, Piyada Alisha Tantasawat

“…In this study, RNA sequencing (RNA-seq) analysis was used to unravel the mechanisms of resistance to CLS in a resistant line (SUPER5) and a susceptible variety (CN84-1) upon CLS infection. …”
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A novel nanocarrier based on natural polyphenols enhancing gemcitabine sensitization ability for improved pancreatic cancer therapy efficiency by Yuman Dong, Jieru Li, Yiwei Dai, Xinyu Zhang, Xiangyan Jiang, Tao Wang, Bin Zhao, Wenbo Liu, Haonan Sun, Pengcheng Du, Long Qin, Zuoyi Jiao

“…Pancreatic cancer (PC) is a highly lethal malignancy with rapid progression and poor prognosis. …”
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Fodder qualities of heterotic hybrids from intergeneric crosses between maize and eastern gamagrass by P. A. Panikhin, V. A. Sokolov

“…Eastern gamagrass is a C4 plant as well, characterized by high yield and high feed value of hay. We decided to combine in our research economically valuable qualities of this plant by developing apomictic intergeneric hybrids. …”
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Radiographic Measurements and Diagnosis of Hip Dysplasia in Infants Using Computer Vision and a Rule-Based System by Ernesto Pérez Pérez, Roberto Díaz Amador, Karina Leonor Fernández Sánchez, José Julio Requeiro Molina, José Julio Requeiro Morejón

“…The correspondence between the diagnosis predicted by the system and that issued by specialist doctors was also high.</p>…”
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