Anti-HSV-1 agents: an update by Wenwen Lv, Lei Zhou, Jia Wu, Jishuai Cheng, Yongzhong Duan, Wen Qian

Subjects: “…HSV-1…”
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HSV-1 miR-H6 Inhibits HSV-1 Replication and IL-6 Expression in Human Corneal Epithelial Cells In Vitro by Fang Duan, Jingyu Liao, Qiang Huang, Yuhong Nie, Kaili Wu

“…HSV-1 infection in the cornea could lead to blindness. …”
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Advanced progress in the genetic modification of the oncolytic HSV-1 virus by Mi Zhou, Mi Zhou, Mi Zhou, Zhenyu Shen, Zhenyu Shen, Zhenyu Shen

“…Certain genetic alterations have shown efficacy in improving clinical outcomes for HSV-1-based therapies. These modifications include silencing specific genes and inserting exogenous genes into the HSV-1 genome. …”
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Antiviral activity of Ferula assa-feotida on HSV-1, 2 in vitro by Javad Charostad, Tahere Navidfar, Masoumeh Kiani, Paul Schinitzler, Akram Astani

“…No HSV-1 or HSV-2 activity was detected in cells treated prior to and following viral infection. …”
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The Role of Cyclooxygenase in Multiplication and Reactivation of HSV-1 in Vestibular Ganglion Neurons by Yuehong Liu, Shufeng Li, Zhengmin Wang

“…Nonsteroidal anti-inflammatory drugs (NSAIDs) have been reported to suppress reactivation of HSV-1 in trigeminal ganglions. However, whether this drug can affect reactivation of HSV-1 in vestibular ganglions is unclear. …”
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HSV-1 Encephalitis in an Elderly Man Receiving Ibrutinib for Waldenstrom’s Macroglobulinemia by Mark R. Wallace

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Gene Therapy with HSV1-sr39TK/GCV Exhibits a Stronger Therapeutic Efficacy Than HSV1-TK/GCV in Rat C6 Glioma Cells by Lei-qing Li, Fang Shen, Xiao-yan Xu, Hong Zhang, Xiao-feng Yang, Wei-guo Liu

“…Therefore, In order to reduce the GCV dose required, we aim to compare the therapeutic efficacy of HSV1-sr39TK, an HSV1-TK mutant with increased GCV prodrug catalytic activity, with wildtype TK in C6 glioma cells. …”
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Effects of Acyclovir and IVIG on Behavioral Outcomes after HSV1 CNS Infection by Chandran Ramakrishna, Mari S. Golub, Abby Chiang, Teresa Hong, Markus Kalkum, Edouard M. Cantin

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Prolonged Intractable Hiccups Associated with HSV (I&II) Esophagitis and H. pylori Gastritis by Christina Hopkins, Asha Bansari, Michael Ladna, Bahram Dideban

“…EGD revealed circumferential ulceration of middistal esophagus and biopsies confirmed HSV (I&II) esophagitis and H. pylori gastritis. He was prescribed triple therapy for H. pylori and acyclovir for HSV esophagitis. …”
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Design of the Inhibitors for Pseudorabies Virus Replication by Reinforcement Learning from HSV‑1 DNA Polymerase Inhibitors by Lin Wei, Yang Hu, Licheng Bai, Chenxu Xiao, Zhang Liu, Yun You, Keke Wang, Yunyuan Huang, Junfei Zhu, Jun Weng, Wenling Zhou, Han Li, Honghe Zhao, Zhiyong Wu, Meng Mei, Zigong Wei

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Next-generation sequencing and immuno-informatics for designing a multi-epitope vaccine against HSV-1-induced uveitis by He Cao, Zhi Cao, Yue Han, Jing Shan

“…Herpes Simplex Virus type 1 (HSV-1) is a major cause of virus-induced uveitis. …”
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HIV-1 Replication in HIV-Infected Individuals Is Significantly Reduced When Peripheral Blood Mononuclear Cells Are Superinfected with HSV-1 by Taneth Yamsuwan, Chintana Chirathaworn, Pokrath Hansasuta, Parvapan Bhattarakosol

“…This study investigated HSV-1 replication in PBMCs from 25 HIV-infected individuals and 15 healthy donors and the effects of HSV-1 superinfection on HIV-1 production. …”
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Editorial: Oncolytic virotherapy, volume II by Ahmed Majeed Al-Shammari, Pier Paolo Piccaluga, Pier Paolo Piccaluga

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Repetitive Noninvasive Monitoring of HSV1-tk-Expressing T Cells Intravenously Infused into Nonhuman Primates Using Positron Emission Tomography and Computed Tomography with F-FEAU by Gianpietro Dotti, Mei Tian, Barbara Savoldo, Amer Najjar, Laurence J.N. Cooper, James Jackson, Amanda Smith, Osama Mawlawi, Rajesh Uthamanthil, Agatha Borne, David Brammer, Vincenzo Paolillo, Mian Alauddin, Carlos Gonzalez, David Steiner, William K. Decker, Frank Marini, Steven Kornblau, Catherine M. Bollard, Elizabeth J. Shpall, Juri G. Gelovani

“…This study represents a proof of principle and supports the application of 18 F-FEAU PET-CT imaging for monitoring the distribution of intravenously administered sr39HSV1-tk gene-transduced CTLs in humans.…”
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HSV-1 Encephalitis: High Index of Clinical Suspicion, Prompt Diagnosis, and Early Therapeutic Intervention Are the Triptych of Success—Report of Two Cases and Comprehensive Review of the Literature by Dimitrios Patoulias, Georgios Gavriiloglou, Konstantinos Kontotasios, Mairi Tzakri, Petros Keryttopoulos, Christos Koutras

“…Through the presentation of two cases of HSV-1 encephalitis that we managed in our department over the last 1 year and after systematic and comprehensive research of the relevant literature, we aim at showing the crucial role of medical history and physical examination, along with the high index of clinical suspicion, in order to make promptly the diagnosis and administer timely intravenous acyclovir, limiting the possibility of complications during the disease’s course.…”
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Efficacy of traditional herb aqua extract of Teucrium stocksianum and its fractions against HSV-1 virus expression levels of genes (UL46 and US6) by Emad Asgari, Zohreh Sharifi, Farahnaz Bineshian, Mahsa Zamanian

“…Conclusion: T. stocksianum, has an anti-viral property and may be considered as a remedy for anti-HSV-1 agents. …”
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Investigation of the effıciency of pomegranate (punica granatum l.) peel extract on herpes simplex virus-1 by Irmak Dik, Hatice Pelin Aslım

Subjects: “…hsv-1…”
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Clinical Activity of Behcet’s Disease Associated with SARS-CoV-2 and Herpes Simplex Virus: Insights from Three Case Reports by Bakti FU, Sufiawati I

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Rational strategies for designing next-generation oncolytic viruses based on transcriptome analysis of tumor cells infected with oncolytic herpes simplex virus-1 by Naeme Javid, Shahriyar Abdoli, Majid Shahbazi, Majid Shahbazi

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In Vitro and In Vivo Characterization of a Dual-Function Green Fluorescent Protein–HSV1-Thymidine Kinase Reporter Gene Driven by the Human Elongation Factor 1α Promoter by Gary D. Luker, Kathryn E. Luker, Vijay Sharma, Christina M. Pica, Julie L. Dahlheimer, Joe A. Ocheskey, Timothy J. Fahrner, Jeffrey Milbrandt, David Piwnica-Worms

“…Using this model system, expression of EGFP was quantified by flow cytometry and fluorescence microscopy, while the HSV1-TK component of the reporter was quantified with 8-[ 3 H]ganciclovir (8-[ 3 H]GCV). …”
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