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    Expression and delivery of HA1-M2e antigen using an innovative attenuated Salmonella–mediated delivery system confers promising protection against H9N2 avian influenza challenge by Ram Prasad Aganja, In-Shik Kim, Hyun-Jin Tae, John Hwa Lee

    Published 2025-01-01
    “…Bioinformatics tools predicted that the HA1 and M2e sequences, which were designed as consensus sequences of South Korean strains (2000–2021), would have high antigenicity and favorable structures. …”
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    Implementasi Permenkes Nomor 72 Tahun 2016 tentang Standar Pelayanan Kefarmasian di Rumah Sakit Terhadap Tatakelola SDM Instalasi Farmasi Rsu Mayjen H.A Thalib Kerinci Tahun 2018 by Trianengsih AT, Hardisman Hardisman, Dedy Almasdy

    Published 2019-05-01
    “…Tujuan penelitian ini adalah mengetahui bagaimana implementasi Permenkes No.72 Tahun 2016 tentang standar pelayanan kefarmasian terhadap tata kelola SDM Instalasi farmasi RSU Mayjen H.A Thalib Kerinci Tahun 2018 dengan menganalisis kualifikasi, persyaratan serta Beban kerja dan kebutuhan SDM di IFRS MHAT. …”
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    Delivery of dendritic cells targeting 3M2e-HA2 nanoparticles with a CpG adjuvant via lysosomal escape of Salmonella enhances protection against H9N2 avian influenza virus by Futing Jia, Wenfeng Wang, Yawen Tian, Ainul Zahra, Yingkai He, Chongbo Ge, Tongyu Zhang, Mingyue Wang, Jingshuo Gong, Gerui Zhang, Guilian Yang, Wentao Yang, Chunwei Shi, Jianzhong Wang, Haibin Huang, Xin Cao, Yang Zeng, Nan Wang, Zhannan Wang, Chunfeng Wang, Yanlong Jiang

    Published 2025-01-01
    “…Avian influenza virus (AIV) subtype H9N2 still poses a great threat to the poultry farming industry and public health worldwide, and the development of a new influenza vaccine that is safe and conservative and able to address influenza virus mutations is highly promising for application. HA2, the neck of the HA protein, and M2e, the extracellular N-terminal structural domain of the M2 protein, are conserved and effective protective antigens.In this study, the HA2 sequences were fused with three M2e copies (H9N2, H1N1 and H5N1) to the norovirus VP1 protein via the SpyTag-SpyCatcher platform to form self-assembled nanoparticles and display antigenic proteins on its surface, yielding pYL262. …”
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    HA2为基础的流感病毒候选疫苗同时与H5N1、H1N1和H3N2亚型毒株产生交叉反应

    Published 2014-01-01
    “…摘 要: 【目的】 探讨以流感病毒(IAV)血凝素蛋白茎部(HA2)保守表位为免疫原来诱导针对不同血清型流感病毒的广谱体液免疫应答。【方法】 我们构建了一个重组的IAV疫苗IR30-Fd,由A/VietNam/1203/2004(H5N1)病毒株HA2的30个保守的氨基酸残基(IR30)和一个连在碳端的三聚体基序(foldon, Fd)组成。…”
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