UCP2 inhibition eliminates pancreatic β cell autoinflammation in T2DM with islet-mitochondrial sequential targeting nanomedicines by Zerun Liu, Wensheng Chen, Jinping Zhang, Ting Huang, Ying Hong, Tianjiao Zhao, Min Liu, Qiaohui Chen, Yongqi Yang, Shuya Wang, Jue Wang, Xiaohong Ying, Yiming Li, Qiong Huang, Kelong Ai

“…Mito-G is a negatively charged ultra-small nanomedicine synthesized by polymerization of genipin (a potent UCP2 inhibitor) and glycine. It can specifically reach β cells and have a natural mitochondrial targeting. …”
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Advancements and Perspectives in the Bioprosthetic Heart Valve: A Comprehensive Review on Biomaterial Processing and Emerging Polymeric Materials by Hanluo Li, Shenghua Li, Yalan Lei, Ming Sun, Chunlin Wu, Xueli Wang, Shiwen Xiong, Qing Wang, Sini Kang, Song Chen, Xiaoke Shang

“…The effectiveness and limitations of various decellularization agents, including nonionic, ionic, and amphoteric detergents, are critically evaluated, alongside novel cross‐linking reagents such as ribose, genipin, and polyphenols. Furthermore, the development of polymeric heart valves and nanocomposite materials is also explored as a means to address the limitations of conventional mechanical and bioprosthetic valves. …”
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