Does semaglutide reduce alcohol intake in Danish patients with alcohol use disorder and comorbid obesity? Trial protocol of a randomised, double-blinded, placebo-controlled clinica... by Jens Juul Holst, Tina Vilsbøll, Claus Thorn Ekstrøm, Helene Benveniste, Nora D Volkow, Anders Fink-Jensen, Gitte M Knudsen, Mette Kruse Klausen, Tugba Kuzey, Julie Niemann Pedersen, Signe Keller Justesen, Line Rasmussen, Ulla B Knorr, Graeme Mason, George Koob

“…Secondary endpoints include changes from baseline to week 26 in alcohol consumption, smoking status, quality of life, fibrosis-4 score, plasma concentration of phosphatidylethanol, brain gamma-aminobutyric acid (GABA) levels, alcohol cue reactivity, functional connectivity and white matter tract integrity.Status Recruitment started in June 2023.Ethics and dissemination The study is approved by the Ethics Committee of the Capital Region of Denmark, the Danish Board of Health and the Danish Data Protection Agency. …”
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Enhanced myofibroblast differentiation of eMSCs in intrauterine adhesions by Jun Song, Meiqi Li, Yuan Tao, Yumeng Li, Canrong Mai, Jingting Zhang, Lan Yao, Shaoquan Shi, Jianyong Xu

“…Methods Endometrium biopsies were collected from IUA patients and controls. The fibrosis features and eMSC distributions were investigated with IHC (immunohistochemistry). …”
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Impact of shear wave elastography and attenuation imaging for predicting life-threatening event in patients with metabolic dysfunction-associated steatotic liver disease by Yudai Fujiwara, Hidekatsu Kuroda, Tamami Abe, Tomoaki Nagasawa, Ippeki Nakaya, Asami Ito, Takuya Watanabe, Kenji Yusa, Hiroki Sato, Akiko Suzuki, Kei Endo, Yuichi Yoshida, Takayoshi Oikawa, Keisuke Kakisaka, Kei Sawara, Toshifumi Tada, Akio Miyasaka, Takuma Oguri, Naohisa Kamiyama, Takayuki Matsumoto

“…An area under the curve analysis was performed to determine the cutoff values of liver stiffness measurements (LSM) by 2D-SWE and attenuation coefficient (AC) by UGAP for a moderate fibrosis and a moderate steatosis. We then classified the cohort into Groups A (low LSM and low AC), B (low LSM and high AC), C (high LSM and high AC), and D (high LSM and low AC). …”
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Automated AI-based image analysis for quantification and prediction of interstitial lung disease in systemic sclerosis patients by Julien Guiot, Monique Henket, Fanny Gester, Béatrice André, Benoit Ernst, Anne-Noelle Frix, Dirk Smeets, Simon Van Eyndhoven, Katerina Antoniou, Lennart Conemans, Janine Gote-Schniering, Hans Slabbynck, Michael Kreuter, Jacobo Sellares, Ioannis Tomos, Guang Yang, Clio Ribbens, Renaud Louis, Vincent Cottin, Sara Tomassetti, Vanessa Smith, Simon L. F. Walsh

“…Results We evaluated a group of 75 patients suffering from SSc-ILD, either limited or diffuse, of whom 30 presented progressive pulmonary fibrosis (PPF). The patients presenting PPF exhibited more extensive lesions (in % of total lung volume (TLV)) based on image analysis than those without PPF: 3.93 (0.36–8.12)* vs. 0.59 (0.09–3.53) respectively, whereas pulmonary functional test showed a reduction in Force Vital Capacity (FVC)(pred%) in patients with PPF compared to the others : 77 ± 20% vs. 87 ± 19% (p < 0.05). …”
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Dietary caloric input and tumor growth accelerate senescence and modulate liver and adipose tissue crosstalk by José Xavier do Nascimento Júnior, Júlia da Conceição Gomes, Ricardo Imbroisi Filho, Helber de Maia Valença, Jéssica Ristow Branco, Amanda Bandeira Araújo, Amanda de Oliveira Esteves Moreira, Letícia Diniz Crepaldi, Larissa Pereira Paixão, Alan C. Ochioni, Thainá M. Demaria, João Gabriel Bernardo Leandro, Livia Marques Casanova, Mauro Sola-Penna, Patricia Zancan

“…In the liver, the induced tumor increases fibrosis and accelerates the senescence process, despite the lower systemic pro-inflammatory state. …”
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Anti-PD-1 exacerbates bleomycin-induced lung injury in mice via Caspase-3/GSDME-mediated pyroptosis by Fei Wang, Haiyi Deng, Maolin Zhou, Yilin Yang, Jiankui Zhou, Yansheng Wang, Xiaohong Xie, Xinqing Lin, Ming Liu, Gengyun Sun, Chengzhi Zhou

“…Compared with the BLM group, the aPD-1 + BLM group presented more significant weight loss, greater levels of lung inflammation and fibrosis, and decreased lung function. In this ICI-LI model, high levels of caspase-3/gasdermin E (GSDME) were detected in the lung tissue of mice, and the JNK inhibitor SP600125 mitigated lung damage by inhibiting GSDME-mediated pyroptosis. …”
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Cardiac Gene Therapy With Phosphodiesterase 2A Limits Remodeling and Arrhythmias in Mouse Models of Heart Failure by Rima Kamel, Aurélia Bourcier, Jean Piero Margaria, Valentin Jin, Audrey Varin, Agnès Hivonnait, Françoise Mercier‐Nomé, Delphine Mika, Alessandra Ghigo, Flavien Charpentier, Vincent Algalarrondo, Emilio Hirsch, Rodolphe Fischmeister, Grégoire Vandecasteele, Jérôme Leroy

“…In mice injected with serotype 9 adeno‐associated viruses encoding for LUC (luciferase), isoproterenol or isoproterenol+phenylephrine infusion induced left ventricular hypertrophy, decreased ejection fraction unveiled by echocardiography, and promoted fibrosis and apoptosis assessed by Masson's trichrome and Tunel, respectively. …”
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The modern options of chronic hepatitis C antiviral therapy with daclatasvir: results of named patient program by V. T. Ivashkin, M. V. Mayevskaya, D. T. Abdurakhmanov, I. G. Bakulin, N. I. Geyvandova, M. L. Zubkin, S. N. Kizhlo, A. V. Kuznetsova, I. B. Latysheva, N. A. Mamonova, V. G. Morozov, O. I. Sagalova, Ye. V. Esaulenko, Ye. O. Lyusina

“…The options of antiviral therapy (AVT) in the stages of severe liver fibrosis and cirrhosis (LC) as well as in the patients with comorbidities for the long time were limited to the standard therapy by pegilated interferon (peg-IFN) in combination to ribavirin (RBV). …”
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LIX1L aggravates MASH-HCC progression by reprogramming of hepatic metabolism and microenvironment via CD36 by Yingrong Leng, Yanqiu Zhang, Yang Cheng, Shengtao Ye, Ying Zheng, Mengmeng He, Enyi Wu, Lingyi Kong, Hao Zhang

“…Lix1l deletion inhibits hepatic lipid accumulation, inflammation, and fibrosis as well as adipocyte differentiation by downregulating CD36, alleviating MASH and associated HCC progression in mice. …”
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Anti-PL-7/PL-12 antisynthetase syndrome associated with interstitial lung disease following SARS-COV-2 infection and vaccination: A case study review by Laura García-Bravo, Ángela Villegas, Bárbara López Uceda, Anaís Mariscal, Cristina Vadillo, M Asunción Nieto Barbero, Juan Luis Rodríguez-Hermosa, Beatriz Mediero Valeros, José Carlos Plaza-Hernández, Miguel Fernández-Arquero, María Guzmán-Fulgencio, Gloria Candelas-Rodríguez, Silvia Sánchez-Ramón, Juliana Ochoa-Grullón

“…The study highlights the clinical and pathogenic overlap between ASS-ILD and SARS-CoV-2-related lung involvement.Both conditions share similar high-resolution computed tomography (HRCT) patterns, including inflammation and pulmonary fibrosis (PF), driven by IFN-γ signaling, which complicates accurate diagnosis. …”
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Ligadura de fugas venosas dorsales en pacientes con disfunción eréctil. Reporte de 50 pacientes con seguimiento a 6 meses by Juan F. Uribe-Arcila, John J. Zuleta-Tobón

“…El diagn&oacute;stico de fugas venosas se hizo mediante ecograf&iacute;a Doppler peneana con vasoactivo, registrando fugas venosas, grado de fibrosis peneana y presencia de glande blando. El protocolo del estudio fue aprobado por el Comit&eacute; de Investigaci&oacute;n del Hospital Pablo Tob&oacute;n Uribe, de Medell&iacute;n. …”
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Hepatocyte-derived liver progenitor-like cells attenuate liver cirrhosis via induction of apoptosis in hepatic stellate cells by Xu Zhou, Wen-Ming Liu, Han-Yong Sun, Yuan Peng, Ren-Jie Huang, Cai-Yang Chen, Hong-Dan Zhang, Shen-Ao Zhou, Hong-Ping Wu, Dan Tang, Wei-Jian Huang, Han Wu, Qi-Gen Li, Bo Zhai, Qiang Xia, Wei-Feng Yu, He-Xin Yan

“…Transplantation of HepLPCs resulted in decreased active fibrogenesis and net fibrosis in cirrhosis models. Apoptosis of HSCs was observed in vivo after HepLPC treatment. …”
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Cardiac Abnormalities in Acromegaly Patients: A Cardiac Magnetic Resonance Study by Xiaopeng Guo, Jian Cao, Peijun Liu, Yihan Cao, Xiao Li, Lu Gao, Zihao Wang, Ligang Fang, Zhengyu Jin, Yining Wang, Bing Xing

“…We aimed to evaluate the frequencies of left ventricular hypertrophy (LVH), interventricular septum hypertrophy (IVSH), LV systolic dysfunction (LVSD), right ventricular systolic dysfunction (RVSD), and myocardial fibrosis (MCF) and detailed quantitative parameters in acromegaly patients using CMR and analyze their correlations with clinical features. …”
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Differentiating Liver Metastases from Primary Liver Cancer: A Retrospective Study of Imaging and Pathological Features in Patients with Histopathological Confirmation by Laura Andreea Ghenciu, Mirela Loredana Grigoras, Luminioara Maria Rosu, Sorin Lucian Bolintineanu, Laurentiu Sima, Octavian Cretu

“…Pathological features recorded included tumor differentiation, vascular invasion, necrosis, and fibrosis. Statistical analyses were performed using chi-squared tests, <i>t</i>-tests, and logistic regression, with a significance level of <i>p</i> < 0.05. …”
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Very low urinary marinobufagenin excretion reflects a high risk of disease progression in non-advanced CKD by Davide Bolignano, Davide Bolignano, Marta Greco, Marta Greco, Loredana Tripodi, Mario D’Agostino, Paola Cianfrone, Roberta Misiti, Roberta Misiti, Sara Pugliese, Mariateresa Zicarelli, Michela Musolino, Michela Musolino, Daniela Patrizia Foti, Daniela Patrizia Foti, Michele Andreucci, Michele Andreucci, Giuseppe Coppolino, Giuseppe Coppolino

“…BackgroundChronic kidney disease (CKD) has now reached pandemic proportions but risk prediction towards end-stage kidney disease (ESKD) remains challenging. Kidney fibrosis is a key determinant in the transition from CKD to ESKD. …”
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Antioxidant Properties of Tonsil-Derived Mesenchymal Stem Cells on Human Vocal Fold Fibroblast Exposed to Oxidative Stress by Sung-Chan Shin, Hyung-Sik Kim, Yoojin Seo, Cho Hee Kim, Ji Min Kim, Hyun-Keun Kwon, Jin-Choon Lee, Eui-Suk Sung, Byung-Joo Lee

“…However, few studies have examined the direct correlation between oxidative damage and reconstitution of extracellular matrix (ECM) in the vocal fold fibrosis. We, therefore, sought to investigate the impact of oxidative stress on cell survival and ECM production of human vocal fibroblasts (hVFFs) and the protective effects elicited by TMSCs against oxidative damages in hVFFs. hVFFs were exposed to different concentrations of tert-butyl hydroperoxide in the presence or absence of TMSCs. …”
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Long-term outcome in people who use drugs successfully treated for hepatitis C infection with glecaprevir/pibrentasvir by Shana Yi, David Truong, Brian Conway

“…We note a median age of 47 (22–75) years, 28 % female, 21.3 % identifying as indigenous, the majority with mild fibrosis (90.8 % F0–F2), slightly more than half with unstable housing. …”
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α-methyltryptophan-mediated protection against diabetic nephropathy in db/db mice as studied with a metabolomics approach by Aimin Cai, Dingchao Shen, Qiushuang Xiong, Jie Ding, Yang Ding, Xinlu Lin, Lijia Chen, Qing Yao, Qing Yao, Guangyong Lin, Ruijie Chen, Vadivel Ganapathy, Vadivel Ganapathy, Longfa Kou

“…SLC6A14 and also an inhibitor of indoleamine 2,3-dioxygenase-1 (IDO1).MethodsIn this study, we employed a nuclear magnetic resonance-based metabolomic approach to investigate the therapeutic effects of α-MT in a db/db mouse model of DN and explore the underlying molecular mechanisms.ResultsThe results of the study demonstrated that α-MT significantly reduced the urinary excretion of albumin and creatinine, improved kidney function, and decreased renal fibrosis in db/db mice. Metabolomic analyses of kidney tissues and urine samples indicated that db/db mice displayed increased activity of the enzyme IDO1, and alongside pronounced metabolic disturbances. …”
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Role of glucocorticoid receptor expression in Chronic Chagas Cardiomyopathy: implications for inflammation and cardiac hypertrophy by Florencia B. González, Florencia B. González, Antonella Pacini, Araceli Castro, Susana Lioi, Silvina R. Villar, Silvina R. Villar, Luciano D’Attilio, Luciano D’Attilio, Rodolfo D. Leiva, Rodolfo D. Leiva, Liliana Favaloro, Oscar A. Bottasso, Oscar A. Bottasso, Carlos A. Vigliano, Carlos A. Vigliano, Ana Rosa Pérez, Ana Rosa Pérez

“…The presence of inflammatory infiltrates and fibrosis were also recorded.ResultsGR-α was expressed similarly in the PBMCs from Co and CCC individuals, but 11β-HSD1 expression was increased only in CCC, conjointly with enhanced ratios of IL-6/TTP and IFN-γ/TTP. …”
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Ziziphus jujube promotes fertility and pregnancy outcomes in Rat model of uterine adhesions by Fereshteh Asgharzadeh, Fereshteh Asgharzadeh, Mahsa Attarian, Majid Khazaei, Majid Khazaei, Abdulridha Mohammed Al-Asady, Abdulridha Mohammed Al-Asady, Abdulridha Mohammed Al-Asady, Saeide Mansoori, Hamideh Naimi, Moein Eskandari, Azar Khorrami, Seyedeh Elnaz Nazari, Akram Aminian, Marjaneh Farazastanian, Elaheh Eshtad, Amir Avan, Amir Avan, Mikhail Ryzhikov, Malihe Hasanzadeh, Seyed Mahdi Hassanian, Seyed Mahdi Hassanian

“…Fibrotic changes were examined through histological Trichrome staining and analysis of pro-fibrotic factors.ResultsTreatment with Z. jujube resulted in a significant reduction in uterine tissue fibrosis, as evidenced by histological evaluation and reduced expression of fibrotic markers. …”
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