Evaluation of Protocol Biopsy Utility 12 Months after Renal Transplantation: A Multicenter Observational Analysis by Bruno Moulin, Pierre Merville, Karine Renaudin, David Buob, Sophie Ferlicot, Michel Delahousse, Jacques Dantal, Laetitia Albano, Christelle Barbet, Georges Mourad, Laure-Hélène Noel

“…In the SB group, slight nonspecific changes were observed in 51 cases, rejection (acute or chronic) in 6 cases, CNI-related toxicity in 15 cases, recurrence of initial disease in two cases, and interstitial fibrosis/tubular atrophy (IF/TA) in 83 cases (71.6%), of which 35 cases (30.2%) were grade II/III lesions. eGFR <50 mL/min/1.73 m² at month 6 predicted IF/TA grade II or III (OR 3.85, 95% CI 1.64, 9.05, 𝑃<0.002). …”
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Dietary Choline Deprivation Exacerbates Kidney Injury in Streptozotocin-Induced Diabetes in Adult Rats by Ahmed W. Al-Humadi, Carel W. le Roux, Neil G. Docherty, Werd Al-Najim, Martin Tze Wah Kueh, Andreas C. Lazaris, Charis Liapi

“…Kidney histopathology revealed that renal tubular necrosis, mesangial matrix expansion, and renal fibrosis substantially increased in the DM + CD group compared to all other groups, and KIM-1 and VEGF-A expressions were most pronounced in the DM + CD and DM groups, respectively. …”
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Features and predictive value of 6-min walk test outcomes in interstitial lung disease: an observation study using wearable monitors by Jiaying Li, Xiaobing Wu, Xiaoyan Li, Miaozhen Deng, Xinyin Liang, Huiqun Wei

“…Objectives To describe 6-min walk test (6MWT) outcomes, and to investigate their correlations with cardiopulmonary and lung function among patients with interstitial lung disease (ILD) which was not limited to idiopathic pulmonary fibrosis.Methods We collected patients’ demographic data and obtained minute-by-minute 6MWT outcomes. …”
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Bioinformatics-Based Exploration of the Ability of Ginkgetin to Alleviate the Senescence of Cardiomyocytes After Myocardial Infarction and Its Cardioprotective Effects by Li H, Wei D, Cao H, Han Y, Li L, Liu Y, Qi J, Wu X, Zhang Z

“…In vitro studies revealed that ginkgetin attenuated elevated OGD-induced cytotoxicity, increased cell viability, and alleviated OGD-induced senescent apoptosis, thus protecting cardiomyocytes.Conclusion: Ginkgetin inhibits postinfarction myocardial fibrosis and cardiomyocyte hypertrophy, scavenges oxygen free radicals, decreases postinfarction limbic cell inflammatory infiltration, suppresses activation of the inflammatory-immune pathway, and delays postinfarction peripheral cells from undergoing senescent apoptosis, thus protecting the heart. …”
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Spatial proteomics identifies a CRTC-dependent viral signaling pathway that stimulates production of interleukin-11 by Benjamin J. Ravenhill, Marisa Oliveira, George Wood, Ying Di, Joanne Kite, Xinyue Wang, Colin T.R. Davies, Yongxu Lu, Robin Antrobus, Gill Elliott, Nerea Irigoyen, David J. Hughes, Paul A. Lyons, Betty Chung, Georg H.H. Borner, Michael P. Weekes

“…This may be important clinically in viral infections associated with fibrosis, including SARS-CoV-2. Nuclear translocation of CRTC2/3 is, therefore, identified as an important pathway in the context of viral infection.…”
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Adverse drug events (ADEs) risk signal mining related to eculizumab based on the FARES database by Xi-Feng Wang, Lu-Ri Bao, Ta-La Hu, Rui-Feng Xu, Wu-Niri Gao, Jing-Yuan Wang, Jian-Rong Zhao, Zhen-Li Fu, Shu-Fang Wang, Yan Meng

“…Some PTs, such as aplastic anemia, gene mutation, mastication disorder, kidney fibrosis, BK virus infection, abnormal neutrophil count, C3 glomerulopathy, neuroblastoma, and glomerulonephritis membranoproliferative, were also detected outside the instructions. …”
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Natural history of non-neovascular pigment epithelial detachments (PEDs): Comparison between serous and drusenoid PEDs by Mathilde M. Goudot, Eric H. Souied, Donato Colantuono, Camille Jung, Carl-Joe Mehanna, Benjamin Memmi, Giuseppe Querques, Salomon-Yves Cohen, Alexandra Miere

“…Ten eyes (50 %) with SPEDs and 11 eyes (41 %) with DPEDs (p = 0.46) progressed toward geographic atrophy, and 4 eyes (20 %) with SPEDs and 3 eyes (11 %) with DPEDs (p = 0.68) progressed toward fibrosis. Conclusion: This analysis of large nnPEDs revealed that large PEDs pose a high risk of complications regardless of their nature.…”
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Inhibition of complement system-related gene ITGB2 attenuates epithelial–mesenchymal transition and inflammation in diabetic nephropathy by Jun Peng, Wenqi Zhao, Lu Zhou, Kun Ding

“…Then the cell viability, inflammatory factors, and the expression of epithelial–mesenchymal transition (EMT) and fibrosis markers were determined by using Cell Counting Kit-8 (CCK-8) assay, enzyme linked immunosorbent assay (ELISA), western blotting assays, respectively. …”
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The Role of Intravitreal Anti-VEGF Agents in Rabbit Eye Model of Open-Globe Injury by Xiao Zhao, Han Han, Yinting Song, Mei Du, Mengyu Liao, Xue Dong, Xiaohong Wang, Ferenc Kuhn, Annette Hoskin, Heping Xu, Hua Yan

“…On day 28 after OGI, B scan examination and histological examination were performed to evaluate intravitreal proliferation and formation of epiretinal fibrosis. Results. Vitreous levels of vascular endothelial growth factor (VEGF), platelet-derived growth factor (PDGF), transforming growth factor-beta (TGF-β), and plasminogen activator inhibitor-1 (PAI-1) were significantly increased in rabbit eyes after OGI. …”
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Gastrointestinal Bleeding and Diffuse Skin Thickening as Kaposi Sarcoma Clinical Presentation by Sara Querido, Henrique Silva Sousa, Tiago Assis Pereira, Rita Birne, Patrícia Matias, Cristina Jorge, André Weigert, Teresa Adragão, Margarida Bruges, Domingos Machado

“…A renal allograft biopsy revealed interstitial fibrosis and tubular atrophy grade II. Toxicity of calcineurin inhibitor was assumed and, after a switch for everolimus, renal function improved. …”
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IgG4 as a Biomarker in Graves’ Orbitopathy by Michał Olejarz, Ewelina Szczepanek-Parulska, Daniela Dadej, Nadia Sawicka-Gutaj, Remigiusz Domin, Marek Ruchała

“…Immunoglobulin G4-related disease (IgG4-RD) is a chronic inflammatory disorder associated with fibrosis and abundant tissue lymphoplasmacytic infiltrations. …”
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Circulating Galectin-3 and Aldosterone for Predicting Atrial Fibrillation Recurrence after Radiofrequency Catheter Ablation by Zhong-bao Ruan, Run-feng Gao, Fei Wang, Ge-cai Chen, Jun-guo Zhu, Yin Ren, Li Zhu

“…Circulating galectin-3 (Gal-3) and aldosterone (ALD) are involved in fibrosis and inflammation. However, their potential value as predictors of atrial fibrillation (AF) recurrence after radiofrequency catheter ablation (RFCA) is unknown or controversial. …”
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Distinct Murine Pancreatic Transcriptomic Signatures during Chronic Pancreatitis Recovery by Yinjie Zhang, Baibing Yang, Joy M. Davis, Madeline M. Drake, Mamoun Younes, Qiang Shen, Zhongming Zhao, Yanna Cao, Tien C. Ko

“…A number of selected pancreatic fibrosis-relevant DEGs were validated by qPCR. The top 20 gene sets enriched from DEGs shared between CP and CPR are relevant to extracellular matrix and cancer biology, whereas the top 10 gene sets enriched from DEGs specific to CPR are pertinent to DNA methylation and specific signaling pathways. …”
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Effects of Renal Denervation via Renal Artery Adventitial Cryoablation on Atrial Fibrillation and Cardiac Neural Remodeling by Wei Wang, Zhaolei Jiang, Rongxin Lu, Hao Liu, Nan Ma, Jie Cai, Min Tang, Ju Mei

“…Compared with the Sham group, left stellate ganglion (LSG) tissue fibrosis was increased in the LRDN group. LRDN significantly increased the percentage of TH-negative ganglionic cells and decreased the density of TH-positive nerves in the LSG (P<0.001). …”
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The immunoregulatory effects of scoparone on immune-mediated inflammatory diseases by Feifei Qiu, Jingru Lin, Xiaofei Huang, Bin Yang, Weihui Lu, Weihui Lu, Zhenhua Dai, Zhenhua Dai

“…., but also provides a comprehensive summary of its therapeutic effects on hepatic diseases, including non-alcoholic steatohepatitis, fulminant hepatic failure and hepatic fibrosis. In this review, we also include the broad impacts of SCO on intracellular signaling pathways, such as TLR4/Myd88/NFκB, TGFβR/Smad3, Nrf2/P38, JAK2/STAT3 and JNK/Sab/SHP-1 etc. …”
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Cathepsin G promotes arteriovenous fistula maturation by positively regulating the MMP2/MMP9 pathway by Lemei Hu, Changqing Zheng, Ying Kong, Zhiqing Luo, Fengzhang Huang, Zhigang Zhu, Quhuan Li, Ming Liang

“…Furthermore, CTSG was found to inhibit VSMC migration.Conclusions CTSG may promote AVF maturation by stimulating the secretion of MMP2 and MMP9 from VSMCs and reducing the extent of medial fibrosis in AVF veins by inhibiting the secretion of collagen I and collagen III.…”
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Merck Open Global Health Library in vitro screening against Schistosoma mansoni identified two new substances with antischistosomal activities for further development by Monique Evelyn Ueberall, Martina Berchthold, Cécile Häberli, Sven Lindemann, Thomas Spangenberg, Jennifer Keiser, Christoph G. Grevelding

“…Abstract Background Schistosomiasis, which is caused by the parasite Schistosoma mansoni as well as other species of the trematode genus Schistosoma, leads to chronic inflammation and finally to liver fibrosis. If untreated, the disease can cause life-threatening complications. …”
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The therapeutic potential of PX-478 in a murine model of pelvic organ prolapse by Wei-Min Fan, Yu-Qi Yang, Li-Wen Zhang, Xiao-Hui Mei, Ke Sun, Duan-Qing Wu, Ying Yang, Chun-Fang Duan, Jun Ye, Ru-Jun Chen

“…It reduces vaginal length, attenuates fibrosis, and modulates collagen synthesis. Its immunomodulation is evident through reduced M1 and M2 macrophages and suppressed IL-18 secretion.…”
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Comparative Efficacy of NAFLD Therapies and Biomarker Associations: A Meta-Analysis Based on Liver Fat Content by Haoxiang Zhu, Ling Xu, Yinhua Lv, Juan Yang, Jihan Huang, Qingshan Zheng, Guang Ji, Lujin Li

“…Drugs such as fibroblast growth factor agonists, and those targeting adipocytes, inflammation, or fibrosis, showed greater efficacy in reducing LFC compared to Resmetirom, which has an efficacy of reducing LFC by 5.2%. …”
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The Effect of St. John’s Wort Oil on Urethral Stricture: An Experimental Study in Rat Model by Kazım Yelsel, Ergün Alma, Ömer Yüceer, Zeynel Abidin Taş, Berna Totan Ateş, Murat Kobaner, Halil Esimek, Adem Altunkol, Umut Ünal, Ali Ayyıldız

“…JW) oil on inflammation and urethral fibrosis development in a rat urethral trauma model. …”
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