Inhibition of Endothelial–Mesenchymal Transition Mediated by Activin Receptor Type IIA Attenuates Valvular Injury Induced by Group A Streptococcus in Lewis Rats by Zirong Lu, Yuan Li, Chuanghong Lu, Zhongyuan Meng, Ling Bai, Feng Huang, Zhiyu Zeng

“…After inhibition of ACVR2A, EndMT in valvular tissues was also inhibited, and inflammatory infiltration and fibrosis were reduced. Endothelial cell experiments suggested that mesenchymal transition could be stimulated by activin and that inhibition of ACVR2A attenuated mesenchymal transition. …”
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Non-Alcoholic Fatty Liver Disease in Cardiac Patients with Overweight and Obesity by I. V. Logacheva, T. A. Ryazanova, V. R. Makarova, O. V. Surnina

“…It is demonstrated that the correlation coefficients grow with the progression of fatty infiltration and liver fibrosis signs.Conclusions. The results of the study have revealeda connection between the NAFLD presence and the main markers of visceral fat depots (IAT, EAT, VAI), which is shown to increase the risk of cardio-vascular complications in such patients. …”
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Post-translational histone modifications associated with the development of metabolic dysfunction-associated fatty liver disease. Part 2. Histone methylation by O.E. Abaturov, A.O. Nikulina

“…Histone methy­lation and demethylation, mediating the expression of key genes involved in carbohydrate and lipid metabolism, determine both the occurrence and development of steatosis, inflammation and fibrosis of the liver in patients with metabolic dysfunction-­associated fatty liver disease. …”
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Kanaloplasti pada Atresia Liang Telinga Pasca Trauma by Jacky Munilson, Yan Edward, Surya Azani

“…<p>Abstrak<br />Pendahuluan: Atresia liang telinga didapat adalah suatu kelainan yang jarang terjadi dengan karakteristik pembentukan jaringan fibrosis pada liang telinga. Trauma pada liang telinga pada cedera kepala dapat menyebabkan atresia liang telinga pasca trauma dan menyebabkan tuli konduktif serta terbentuknya kolesteatom di daerah cul de sac sehingga diperlukan tatalaksana dengan pembedahan. …”
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Contrast-Enhanced CT May Be a Diagnostic Alternative for Gastroesophageal Varices in Cirrhosis with and without Previous Endoscopic Variceal Therapy by Qianqian Li, Ran Wang, Xiaozhong Guo, Hongyu Li, Xiaodong Shao, Kexin Zheng, Xiaolong Qi, Yingying Li, Xingshun Qi

“…Background and Aims. Liver fibrosis blood tests, platelet count/spleen diameter ratio (PSR), and contrast-enhanced CT are diagnostic alternatives for gastroesophageal varices, but they have heterogeneous diagnostic performance among different study populations. …”
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The Relationship between Inflammatory Marker Levels and Hepatitis C Virus Severity by Qitian He, Quan He, Xue Qin, Shan Li, Taijie Li, Li Xie, Yan Deng, Yu He, Yongbin Chen, Zhifu Wei

“…The aspartate aminotransferase (AST)/alanine aminotransferase (ALT) ratio (AAR), AST-to-platelet ratio index (APRI), and fibrosis index based on the four factors (FIB-4) scores in HCV-related cirrhosis patients were significantly higher than in chronic HCV patients (all P<0.001). …”
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The Upregulation of COX2 in Human Degenerated Nucleus Pulposus: The Association of Inflammation with Intervertebral Disc Degeneration by Chang Liu, Guoyan Liang, Zhantao Deng, Jing Tan, Qiujian Zheng, Feng-Juan Lyu

“…We previously found upregulated markers of fibrosis, the late stage of chronic inflammation, in degenerated IVD with a small number of clinical specimens. …”
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Genomic insights into a multidrug-resistant pandoraea apista clinical isolate carrying blaOXA-153 from China by Lirong Li, Yawen Zhang, Fang He, Ningjun wu

“…Objectives: Pandoraea apista is notable for its multidrug resistance and is frequently identified in patients with cystic fibrosis or other chronic lung diseases, where it contributes to persistent lung infections. …”
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Hepatocyte Rho-associated kinase signaling is required for mice to survive experimental porphyria-associated liver injury by Jessica M. Herrera, Yun Weng, Tyler J. Lieberthal, Marcus Paoletti, Tammy T. Chang

“…Some studies suggest that ROCK inhibition may serve as a treatment for liver fibrosis. More investigation is needed to understand the role of hepatocyte ROCK signaling in vivo, especially in the context of profibrotic liver injury. …”
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Inflammatory-Driven Angiogenesis in Bone Augmentation with Bovine Hydroxyapatite, B-Tricalcium Phosphate, and Bioglasses: A Comparative Study by Vlad M. Anghelescu, Ioana Neculae, Octavian Dincă, Cristian Vlădan, Claudiu Socoliuc, Mirela Cioplea, Luciana Nichita, Cristiana Popp, Sabina Zurac, Alexandru Bucur

“…Endothelial cell analysis was done by analysing vascularization with PECAM/CD31 and VEGF and fibrosis with collagen IV, laminin, and osteonectin stains. …”
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Burn wound healing using adipose-derived mesenchymal stem cells and manganese nanoparticles in polycaprolactone/gelatin electrospun nanofibers in rats by Azin Shahmohammadi, Hadi Samadian, Saeed Heidari Keshel, Khodabakhsh Rashidi, Amir Kiani, Masoud Soleimani, Farjam Goudarzi

“…Also, the lowest amount of α-SMA was observed in these two groups, demonstrating stem cells' role in reducing α-SMA levels and thus preventing fibrosis. Moreover, the amount of α-SMA in the Mn+S group is lower than in the N+S group and, is closer to healthy skin. …”
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Screening and Early Diagnosis of Hepatocellular Cancer and Optimization of Diagnostic Imaging Techniques: A Review and Conclusion of the Expert Panel by V. V. Breder, R. B. Alikhanov, S. S. Bagnenko, E. N. Bessonova, V. A. Isakov, N. E. Kudashkin, B. M. Medvedeva, A. V. Mishchenko, M. S. Novruzbekov, V. S.  Rudakov

“…Screening for HCC in high-risk groups (cirrhosis of any etiology, patients with chronic viral hepatitis B and patients with F3 liver fibrosis) should be organized as regular (every 6 months) liver ultrasound in combination with determination of the serum alpha-fetoprotein (AFP) level. …”
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Skeletal muscle stem cells modulate niche function in Duchenne muscular dystrophy mouse through YY1-CCL5 axis by Yang Li, Chuhan Li, Qiang Sun, Xingyuan Liu, Fengyuan Chen, Yeelo Cheung, Yu Zhao, Ting Xie, Bénédicte Chazaud, Hao Sun, Huating Wang

“…Deregulated MuSC/MP/FAP interactions and the ensuing inflammation and fibrosis are hallmarks of dystrophic muscle. Here we demonstrate intrinsic deletion of transcription factor Yin Yang 1 (YY1) in MuSCs exacerbates dystrophic pathologies by altering composition and heterogeneity of MPs and FAPs. …”
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Reactivation of Denervated Schwann Cells by Embryonic Spinal Cord Neurons to Promote Axon Regeneration and Remyelination by Xinyu Fang, Chaofan Zhang, Chongjing Zhang, Yuanqing Cai, Zibo Yu, Zida Huang, Wenbo Li, Wenming Zhang

“…Thus, the neurons play the role of proximal axons to prevent chronic degeneration and fibrosis of SCs. After excision of the transplanted cells, the SCs returned to their dedifferentiated phenotype and upregulated growth-associated gene expression. …”
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GPX4 expression changes in proximal tubule cells highlight the role of ferroptosis in IgAN by Jianbo Qing, Lijuan Zhang, Ru Fan, Huiwen Zhi, Changqun Li, Yaheng Li, Junnan Wu, Chongyang Han, Yafeng Li

“…Abstract As an important mechanism of renal injury, oxidative stress (OS) is inseparable from the occurrence of renal fibrosis and the rapid progression of renal failure. …”
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Infarct‐like myocarditis with coronary vasculitis and aneurysm formation caused by Epstein–Barr virus infection by Cristina Chimenti, Romina Verardo, Claudia Grande, Marco Francone, Andrea Frustaci

“…Cardiac magnetic resonance revealed the presence of a micro‐aneurism in the inferior LV wall, a diffuse oedematous imbibition of LV myocardium suggested by hyper‐intensity of T2 mapping, and increased fibrosis as suggested by areas of late gadolinium enhancement signals. …”
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Baseline FIB‐4 May Be a Risk Factor of Recurrence After SBRT in Patients With HBV‐Related Small HCC by Zhan Zeng, Yifan Han, Wengang Li, Hongyu Chen, Ning Lin, Yanyan Yu, Xiaoyuan Xu

“…ABSTRACT Aims Exploring fibrosis index‐4 (FIB‐4)'s predictive value for HBV‐related hepatocellular carcinoma (HCC) in assessing recurrence following stereotactic body radiation therapy (SBRT) in patients with HBV‐related HCC. …”
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Effective treatment of severe acute pancreatitis and COVID-19 pneumonia with tocilizumab by Piotr Zielecki, Magdalena Kaniewska, Mariusz Furmanek, Tomasz Bulski, Grażyna Rydzewska

“…It has been reported that a systemic inflammatory syndrome called cytokine release syndrome (CRS) is responsible for the development of ARDS in SARS-CoV-2 infection, which leads to pulmonary fibrosis and organ failure. In this pathophysiological process interleukin-6 (IL-6), and B and T cells play key roles [11]. …”
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Left ventricular hypertrophy in young hypertensives: the possible crosstalk of mTOR and angiotensin-II -a case-control study by Busayo Onafowoke Oguntola, Stephen Olawale Oguntola, Opeyemi Ezekiel Ojo, Pauleen Ayomide Ukpabio, Adams Olalekan Omoaghe, Kehinde Samuel Olaniyi

“…In addition, it shows that LVH is associated with dyslipidemia, inflammation, and fibrosis.…”
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Telaprevir: options of application in separate patient groups by M. V. Mayevskaya, I. N. Tikhonov, V. T. Ivashkin

“…According to data of original studies, inclusion of telaprevir in treatment mode of patients with 1-st genotype of chronic hepatitis C increases treatment response rate in group of patients with unsuccessful AVT experience, severe fibrosis or liver cirrhosis, and unseals new options of treatment of patients from the liver transplantation waiting list, after transplantation and in group of chronic renal disease.…”
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