Apelin-13 Pretreatment Promotes the Cardioprotective Effect of Mesenchymal Stem Cells against Myocardial Infarction by Improving Their Survival by Guona Chen, Xiaoting Liang, Qian Han, Cong Mai, Linli Shi, Zhuang Shao, Yimei Hong, Fang Lin, Mimi Li, Bei Hu, Xin Li, Yuelin Zhang

“…Moreover, transplantation with Apelin-13-pretreated MSCs improved heart function and increased angiogenesis accompanied by decreased fibrosis compared with MSC transplantation at 28 days following MI. …”
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Autoimmune Hepatitis with Acute Presentation: Clinical, Biochemical, and Histological Features of 126 Patients by Álvaro Urzúa, Carolina Pizarro, Abraham Gajardo, Rafael Poniachik, Claudia Pavez, Máximo Cattaneo, Javier Brahm, Laura Carreño, Jaime Poniachik

“…Rosettes were uncommon (35.6%). Advanced fibrosis was present in 27% of patients. Combined adverse outcomes occurred in 7.9% of cases, all fulminant with histological cholestasis. …”
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Vitamin D Receptor Polymorphisms Predispose to Primary Biliary Cirrhosis and Severity of the Disease in Polish Population by Agnieszka Kempińska-Podhorecka, Ewa Wunsch, Tomasz Jarowicz, Joanna Raszeja-Wyszomirska, Beata Loniewska, Mariusz Kaczmarczyk, Małgorzata Milkiewicz, Piotr Milkiewicz

“…Moreover the BsmI and TaqI polymorphisms were associated with the presence of advanced fibrosis/liver cirrhosis at the diagnosis of PBC. …”
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The Composition of Emissions from Sanding Corian® with Different Sandpapers by Seungkoo Kang, Huayan Liang, Yong Qian, Chaolong Qi

“…The result can help identify the main cause of the pulmonary fibrosis from exposure to aluminum-containing dust while sanding Corian®. …”
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A Normal Range of KL-6/MUC1 Independent of Elevated SP-D Indicates a Better Prognosis in the Patients with Honeycombing on High-Resolution Computed Tomography by Shu Hisata, Yuichiro Kimura, Naoko Shibata, Shuichi Ono, Takao Kobayashi, Shigeki Chiba, Hiromitsu Ohta, Toshihiro Nukiwa, Masahito Ebina

“…Both SP-D and KL-6/MUC1 are established biomarkers of the interstitial pneumonias, including idiopathic pulmonary fibrosis (IPF), but the causes and clinical outcomes based on their independent effects are not known. …”
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Ketamine-associated upper urinary tract dysfunction: What we know from current literature by Zhihuan Zheng, Zhongyi Li, Jiazhe Yuan, Feng Han, Li Huang, Zhao Wang

“…Conclusion: Ketamine abuse can lead to UUT impairment and dysfunction, with symptoms such as bladder dysfunction and contracted bladder with vesicoureteral reflux, direct damage and barrier dysfunction, inflammation, apoptosis, fibrosis and stricture, and papillary necrosis. Oxidative stress, autophagy, and microvascular injury are also potential pathogenic mechanisms. …”
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Usefulness of Low-Dose Splenic Irradiation prior to Reduced-Intensity Conditioning Regimen for Hematopoietic Stem Cell Transplantation in Elderly Patients with Myelofibrosis by Etsuko Matsubara, Jun Yamanouchi, Riko Kitazawa, Taichi Azuma, Hiroshi Fujiwara, Takaaki Hato, Masaki Yasukawa

“…Furthermore, the JAK2 V617F mutation disappeared, and fibrosis in the bone marrow regressed. We suggest that splenic irradiation prior to the RIC regimen for HCT in elderly MF patients with massive splenomegaly is safe. …”
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Experience of entecavir in renal graft recipients with chronic hepatitis B by M. L. Zubkin, Ye. P. Sel'kova, F. K. Kokoyeva, T. A. Semenenko, V. I. Chervinko, A. N. Kolomoyets, E. M. Balakirev, A. V. Frolov, T. P. Nekrasova

“…In all patients stage 1of fibrosis by METAVIR scale was determined. Calculated glomerular filtration rate was over 60 ml/min.Results. …”
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Mice with NOP2/sun RNA methyltransferase 5 deficiency die before reaching puberty due to fatal kidney damage by Hongya Zhang, Xiaohui Li, Jing Bai, Cong Zhang

“…Moreover, we observed glycogen deposition and fibrosis, along with a notable shorting of the primary foot processes of glomeruli in Nsun5-/- kidneys. …”
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Role of sirtuins in epigenetic regulation and aging control by E. M. Samoilova, S. E. Romanov, D.  A. Chudakova, P. P. Laktionov

“…Studies on the functional connection between SIRT and longevity, as well as its effect on pathological processes associated with aging, such as chronic inflammation, fibrosis, and neuroinflammation, have been critically analyzed.…”
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Serum Levels of Mitochondrial Fission- and Fusion-Related Genes of Coal Workers’ Pneumoconiosis and Risk Factor Analysis Based on a Generalized Linear Model by Xiao-Yu Li, Jing-Lin Wei, Yong-Xin Xie, Ji Zhao, Li-Ya Ma, Na Zhang, Hui-Fang Yang

“…With the aggravation of CWP, the degree of fibrosis and inflammation increased oxidative damage, increased mitochondrion division, and decreased fusion, which were more sensitive in the second and third stages of CWP. …”
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FGF21 ameliorates diabetic nephropathy through CDK1-dependently regulating the cell cycle by Yudie Zhang, Yudie Zhang, Yudie Zhang, Yudie Zhang, Yudie Zhang, Fan Wang, Fan Wang, Fan Wang, Fan Wang, Chongyang Zhang, Chongyang Zhang, Chongyang Zhang, Chongyang Zhang, Fan Yao, Fan Yao, Fan Yao, Fan Yao, Bin Zhang, Bin Zhang, Bin Zhang, Bin Zhang, Yongping Zhang, Xiaobo Sun, Xiaobo Sun, Xiaobo Sun, Xiaobo Sun

“…After 8 weeks of FGF21 treatment, glomerular glycogen deposition, fibrosis, and renin expression decreased in db/db mice. …”
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Pirfenidone Inhibits Hypoxic Pulmonary Hypertension through the NADPH/ROS/p38 Pathway in Adventitial Fibroblasts in the Pulmonary Artery by Song Zhang, ZongXiu Yin, WeiDong Qin, XiaoLi Ma, Yao Zhang, EnXiu Liu, YanBiao Chu

“…These findings demonstrate that PFD is a novel therapeutic agent to prevent cell proliferation, migration, and fibrosis, which might be useful in inhibiting vascular remodeling in patients with HPH.…”
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Do We Need Exercise Tests to Detect Gas Exchange Impairment in Fibrotic Idiopathic Interstitial Pneumonias? by Benoit Wallaert, Lidwine Wemeau-Stervinou, Julia Salleron, Isabelle Tillie-Leblond, Thierry Perez

“…Results were obtained in 121 patients with idiopathic pulmonary fibrosis (IPF, n=88) and fibrotic nonspecific interstitial pneumonias (NSIP, n=33). …”
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Clinical Examination and Self-Reported Upper Extremity Impairments in Patients with Long-Standing Type 1 Diabetes Mellitus by Kerstin Gutefeldt, Simon Lundstedt, Ingrid S. M. Thyberg, Margareta Bachrach-Lindström, Hans J. Arnqvist, Anna Spångeus

“…Self-reported reduced hand strength was associated to lower grip force, Prayer’s sign, trigger finger, fibrosis string structures, and reduced thenar strength as well as reduced shoulder mobility. …”
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Assessment of the Vanillin Anti-Inflammatory and Regenerative Potentials in Inflamed Primary Human Gingival Fibroblast by Erica Costantini, Bruna Sinjari, Katia Falasca, Marcella Reale, Sergio Caputi, Srinivas Jagarlapodii, Giovanna Murmura

“…The protracted inflammatory phase may delay wound healing and probably support tissue fibrosis and reduce tissue regeneration. Vanillin is a well-known natural compound with potential anti-inflammatory capacity. …”
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Metabolic Profiles of the Gut Microbiota in Patients with Different Stages of Metabolism Dysfunction-Associated Fatty Liver Disease by X. Cao, O. Yu. Zolnikova, R. V. Maslennikov, E. A. Poluektova, E. L. Bueverova, M. S. Reshetova, M. S. Zharkova, V. T. Ivashkin

“…The study included 85 patients with MAFLD (27 patients with steatosis without steatohepatitis and fibrosis, 42 patients with steatohepatitis, 16 patients with cirrhosis as an outcome of MAFLD, Child — Pugh class A–B) and 20 healthy people who formed the control group. …”
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An Egyptian child with Wolman disease presenting with hemophagocytic lymphohistiocytosis by Rabab El Hawary, Safa Meshaal, Alia S. Eldash, Sohilla Lotfy, Dalia Abd Elaziz, Radwa Alkady, Rania Darwish, Aya Erfan, Mai Saad, Engy Chohayeb, Nermeen Galal, Aisha M. Elmarsafy

“…CESD has lower mortality and presents by hyperlipidemia, atherosclerosis, and hepatic fibrosis, while WD classic presentations include hepatosplenomegaly, malabsorption, failure to thrive, and organ-specific symptoms such as hepatic damage or adrenal calcification. …”
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Validity of serum autotaxin and Doppler ultrasound as noninvasive markers of esophageal varices in patients with liver cirrhosis by Doaa El Wazzan, Ayman F. El-Shayeb, Soraya Hamouda, Mohamed El Shafei, Akram A. Degheidy, Basma Salem, Mohamed Adel

“…Child–Pugh classification, fibrosis-4 (FIB-4), age to platelet index (API), model for end-stage liver disease (MELD), platelet/splenic diameter, portal vein velocity, flow volume, and serum autotaxin were entered in stepwise logistic regression model for prediction of esophageal varices, and serum autotaxin, portal vein velocity, and flow volume were significant in multivariate regression analysis with sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) of 96.25%, 75%, 93.9%, and 83.33%, respectively. …”
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Treatment with Lobeglitazone Attenuates Hepatic Steatosis in Diet-Induced Obese Mice by Sorim Choung, Kyong Hye Joung, Bo Ram You, Sang Ki Park, Hyun Jin Kim, Bon Jeong Ku

“…However, TZDs are a controversial treatment for NAFLD because of conflicting results regarding hepatic steatosis and fibrosis. To evaluate a possible effective drug for treatment of NAFLD, we investigated the effects of a newly developed TZD, lobeglitazone, with an emphasis on hepatic lipid metabolism. …”
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