Sestrin2 Signaling Pathway Regulates Podocyte Biology and Protects against Diabetic Nephropathy by Moein Ala

“…Consistently, overexpression of Sestrin2 ameliorated podocyte injury, mesangial proliferation, proteinuria, and renal fibrosis in animal models of diabetic nephropathy. …”
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Autologous Fat Grafting in the Treatment of Facial Scleroderma by Mehdi Gheisari, Arman Ahmadzadeh, Nilofar Nobari, Behzad Iranmanesh, Nikoo Mozafari

“…Systemic sclerosis (SSc) is a rare systemic autoimmune disease, characterized by progressive cutaneous and internal organ fibrosis. Orofacial manifestations of systemic sclerosis are extremely disabling and treatment options are limited. …”
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Ultra-small curcumin-ruthenium coordination polymer nanodots prevent renal ischemia-reperfusion injury and the progression to chronic kidney disease by Xian Liu, Qin Yu, Hai-Bo Mao, Jing-Bo Hu, Wei-Hua Liu

“…Ru/Cur nanodots inhibited renal fibrosis by suppressing epithelial-mesenchymal transition and the secretion of transforming growth factor-β1 in the model of IR-AKI to chronic kidney disease (CKD). …”
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Glycogen Storage Disease Type IX due to a Novel Mutation in PHKA2 Gene by Hamza Hassan Khan, Lauren Parr, Allison Jay, Saleem Raza, Hernando Lyons, Sanjay Kumar

“…Liver and muscle biopsies were obtained: the liver biopsy revealed distended hepatocytes with excessive glycogen accumulation and fine septate fibrosis. Biopsy of the right vastus lateralis muscle showed focal swollen glycogen containing mitochondria. …”
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A Case of Immunoglobulin G4-Related Disease with Extensive Multiorgan Involvements by Kazuhiko Higashioka, Kenji Yoshida, Kensuke Oryoji, Kazuo Kamada, Shinichi Mizuki, Hiroshi Tsukamoto, Eisuke Yokota, Koichi Akashi

“…This case showed many clinical findings, such as bilateral swelling of salivary and lacrimal glands, autoimmune pancreatitis, interstitial nephritis, retroperitoneal fibrosis, periaortitis, systemic swelling of lymph nodes, pulmonary lesions, splenomegaly, and jejunal lesions. …”
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Etoricoxib–NLC Mitigates Radiation-Induced Ovarian Damage in Rats: Insights into Pro-Inflammatory Cytokines, Antioxidant Activity, and Hormonal Responses by Sahar Khateeb

“…These therapeutic effects were achieved through the modulation of oxidative stress, inflammation, augmentation of antioxidant defenses (including <i>Nrf2</i> activation), support for cell survival pathways (via PI3K/Akt signaling), regulation of MAPK, mitigation of fibrosis (<i>TGF-β</i>), and preservation of ovarian reserve (as evidenced by AMH, FSH/LH, and estrogen levels). …”
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Neumomediastino espontáneo y dermatomiositis. Presentación de un caso by Teresa Fonseca Fernández, Yanelka Bouza Jiménez, Yanet Rodríguez Zulueta, Alejandro Muñoz Morales

“…Durante el ingreso se realizaron varios exámenes complementarios dentro de los que se incluyeron creatinphosphokinasa que fue normal, tomografía de tórax con presencia de fibrosis intersticial y biopsia de músculo compatible con los cambios de una miopatía inflamatoria idiopática. …”
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L-Carnitine Alleviates the Myocardial Infarction and Left Ventricular Remodeling through Bax/Bcl-2 Signal Pathway by Hao-Ran Li, Xiao-Ming Zheng, Yan Liu, Jing-Hui Tian, Jie-Jian Kou, Jun-Zhuo Shi, Xiao-Bin Pang, Xin-Mei Xie, Yu Yan

“…H&E staining, TTC staining, and Masson staining were performed for morphological analysis and cardiac fibrosis. ELISA and immunofluorescence were utilized to detect biomarkers and inflammatory mediators. …”
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Therapeutic Benefit in Rheumatoid Cachexia Illustrated Using a Novel Primary Human Triple Cell Coculture Model by Tracey Ollewagen, Gareth S. Tarr, Kathryn H. Myburgh, Helmuth Reuter, Carine Smith

“…Under healthy conditions, BMP-7 exhibited potentially beneficial results in reducing fibrosis-generating TGF-β (p<0.05) and fibronectin (p<0.05). …”
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Chronic glomerulonephritis of the mixed type in patient with HBV-infection (<i>Clinical case</i>) by V. S. Adonyeva, A. B. Botchkarev, O. S. Saurina

“…At ultrasound liver elastometry showed severe fibrosis (METAVIR F3). On a background of glucocorticosteroid treatment elevation of cytolytic enzymes (alanine transaminase of 120 U/L, aspartate aminotransferase of 98 U/L) was registered for the first time. …”
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MAIT cells protect against sterile lung injury by Xiawei Zhang, Shuailin Li, Wojciech Lason, Maria Greco, Paul Klenerman, Timothy S.C. Hinks

“…Human scRNA-seq data revealed that MAIT cells were activated, with increased cDC populations in idiopathic pulmonary fibrosis patients. Thus, MAIT cells enhance defense against sterile lung injury by fostering cDC1-driven anti-fibrotic pathways.…”
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A Rare Cause of Persistent Blood Loss after Continuous Ambulatory Peritoneal Dialysis Catheter Placement by T. Natroshvili, T. Elling, S. A. Dam, M. vd Berg, R. R. H. Nap, R. J. Hissink

“…We report a case of a 68-year-old female patient with a previous history of diabetes mellitus, myelodysplastic syndrome, extensive collateral varices, anaemia, and ESRD due to obstructive uropathy caused by retroperitoneal fibrosis, who presented with persistent blood loss after the laparoscopic placement of a CAPD catheter. …”
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Nanocrystal Agglomerates of Curcumin Prepared by Electrospray Drying as an Excipient-Free Dry Powder for Inhalation by Shahram Emami, Zahra Hemmati, Shadi Yaqoubi, Hamed Hamishehkar, Amin Alvani

“…Curcumin has shown beneficial effects on pulmonary diseases with chronic inflammation or abnormal inflammatory responses, including chronic obstructive pulmonary disease, asthma, and pulmonary fibrosis. Clinical applications of curcumin are limited due to its chemical instability in solution, low water solubility, poor oral bioavailability, and intestinal and liver first-pass metabolism. …”
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Qualitative study exploring the views and perceptions of parents/carers of young children with CF regarding the introduction of CFTR modulator therapy (The REVEAL study; PaRents pE... by Kevin W Southern, Sioned Haf Davies, Faye Wade, Heather Fogg, Adam Walsh

“…Background Cystic fibrosis (CF) is associated with a historically high treatment burden which causes anxiety and exhaustion for parents of children with CF, especially in the early years of a child’s life. …”
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Widespread mutagenesis and chromosomal instability shape somatic genomes in systemic sclerosis by Sriram Vijayraghavan, Thomas Blouin, James McCollum, Latarsha Porcher, François Virard, Jiri Zavadil, Carol Feghali-Bostwick, Natalie Saini

“…Abstract Systemic sclerosis is a connective tissue disorder characterized by excessive fibrosis that primarily affects women, and can present as a multisystem pathology. …”
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The Impact of Epigenetics on the Pathophysiology of Type 2 Diabetes and Associated Nephropathic Complications by Amit Mukherjee, Tanusree Debbarman, Basu D. Banerjee, Sheelu S. Siddiqi

“…Various epigenetic mechanisms, including DNA methylation, histone modifications, chromatin remodeling, and non-coding RNA regulation, drive cell dysfunction, inflammation, and fibrosis, aggravating diabetes and its complications. …”
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Systemic Sclerosis in Males—Deciphering the Enigma of Erasmus Syndrome by Reena K. Sharma, Mudita Gupta

“…Background: Systemic sclerosis is an autoimmune connective tissue disease characterized by fibrosis in skin and internal organs. Chronic exposure to silica may not only lead to silicosis of lungs but also systemic sclerosis. …”
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Inhibition of CFTR-mediated intestinal chloride secretion by nornidulin: Cellular mechanisms and anti-secretory efficacy in human intestinal epithelial cells and human colonoids. by Chamnan Yibcharoenporn, Thidarat Kongkaew, Nichakorn Worakajit, Rungtiwa Khumjiang, Praphatsorn Saetang, Saravut Satitsri, Vatcharin Rukachaisirikul, Chatchai Muanprasat

“…Secretory diarrhea, a major global health concern, particularly among young children, is often characterized by excessive chloride secretion through the cystic fibrosis transmembrane conductance regulator (CFTR) channel. …”
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Constitutional Nephrin Deficiency in Conditionally Immortalized Human Podocytes Induced Epithelial-Mesenchymal Transition, Supported by β-Catenin/NF-kappa B Activation: A Consequen... by Gian Marco Ghiggeri, Maddalena Gigante, Armando Di Donato

“…Recent findings showed that murine podocytes could undergo epithelial-mesenchymal transformation (EMT), suggesting new hypotheses about the pathogenesis of glomerular fibrosis. Here, we show that also human podocytes can undergo EMT, but more importantly nephrin ablation itself can trigger this phenotypic transformation. …”
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A Case of Disseminated Cryptococcal Infection and Concurrent Lung Tuberculosis in a Patient under Steroid Therapy for Interstitial Pneumonia by Aoi Kuroda, Sadatomo Tasaka, Kazuma Yagi, Takao Mochimaru, Tetsuo Tani, Ho Namkoong, Kyuto Tanaka, Yusuke Suzuki, Mami Hatano, Naoki Hasegawa, Yasunori Okada, Tomoko Betsuyaku

“…Based on the patient’s clinical course, serial computed tomography images, and autopsy results, we believe that the preceding several months of corticosteroid treatment might have contributed to these coinfections in the lungs already vulnerable due to underlying fibrosis.…”
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