Diabetic Mastopathy: An Uncommon Complication of Diabetes Mellitus by R. X. Kirby, D. I. Mitchell, N. P. Williams, D. A. Cornwall, S. O. Cawich

“…Histopathologic evaluation revealed classic features of DMP: parenchymal fibrosis; keloid-like hyalinization of interlobular stroma; adipose tissue entrapment; lobular compression; dense chronic inflammatory cell infiltration; and lymphoid follicle formation. …”
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Immunometabolism of Tregs: mechanisms, adaptability, and therapeutic implications in diseases by Yuming Lu, Yifan Wang, Tiantian Ruan, Yihan Wang, Linling Ju, Mengya Zhou, Luyin Liu, Dengfu Yao, Min Yao

“…The complex mechanisms of Tregs in metabolic diseases are intriguing, particularly in conditions like MASLD, where Tregs are significantly upregulated and contribute to fibrosis, while in diabetes, systemic lupus erythematosus (SLE), and rheumatoid arthritis (RA), they show downregulation and reduced anti-inflammatory capacity. …”
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When the Benign Pneumatosis Intestinalis Becomes No Longer Benign: A Rare Case of Bowel Perforation in a Patient with Systemic Sclerosis by Jian Guan, Alvina Munaf, Alric V. Simmonds, Irteza Inayat

“…Systemic sclerosis is a multisystem disease featured with autoimmunity and organ fibrosis. Although gastrointestinal (GI) tract involvement is common in patients with systemic sclerosis, colonic perforation is extremely rare. …”
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Aldosterone and Its Blockade: A Cardiovascular and Renal Perspective by V. Lahera, V. Cachofeiro, G. Balfagon, J.L. Rodicio

“…A pathophysiological action of aldosterone involves development of extracellular matrix and fibrosis, inflammation, stimulation of reactive oxygen species production, endothelial dysfunction, cell growth and proliferation. …”
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An unexpected and tumultuous diagnosis of a left atrial mass by Catarina Amaral Marques, Carlos Xavier Resende, João Rebelo, Paulo Pinho, Mariana Vasconcelos, Rui André Rodrigues

“…Unexpectedly, the histopathological study revealed the absence of malignancy, identifiable inflammatory and cardiac muscle tissue, and fibrosis. This pattern was compatible with inflammatory myofibroblastic tumor diagnosis, a rare entity with uncertain behavior but a known risk of recurrence and/or potentially fatal complications. …”
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Cellular cross-talk drives mesenchymal transdifferentiation in diabetic kidney disease by Arunita Chatterjee, Jacqueline Tumarin, Sharma Prabhakar

“…Indeed, tubule-interstitial fibrosis may be the most important determinant of progression of DKD as in many forms of chronic glomerulopathies. …”
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Complex application of mathematical methods in diagnostics of diffuse liver diseases by I. Yu. Pirogova, S. A. Pyshkin, A. A. Bolotov

“…The standard of diffuse liver disease (DLD) diagnostics, allowing to determine etiology, stage of liver fibrosis (LF), histological activity index (HAI) is the liver biopsy (LB). …”
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Precision cut lung slices: an integrated ex vivo model for studying lung physiology, pharmacology, disease pathogenesis and drug discovery by Cynthia Koziol-White, Eric Gebski, Gaoyaun Cao, Reynold A. Panettieri

“…Abstract Precision Cut Lung Slices (PCLS) have emerged as a sophisticated and physiologically relevant ex vivo model for studying the intricacies of lung diseases, including fibrosis, injury, repair, and host defense mechanisms. …”
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Solitary Pulmonary Nodule: A Diagnostic Dilemma by Pardeep Masuta, Ioana Amzuta

“…The pathology of the lung showed necrotizing granulomas with giant cells and fibrosis, but lacked active vasculitis or palisading histiocytes, further obscuring the diagnosis. …”
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An Unusual Case of Gastrointestinal Bleeding from Isolated Gallbladder Varices in a Patient with Pancreatic Cancer Complicated by Portal Biliopathy by Mahir Gachabayov, Kubach Kubachev, Elbrus Abdullaev, Nonna Zarkua, Abakar Abdullaev, Artur Fokin

“…Portal biliopathy is the complex of abnormalities of extrahepatic and intrahepatic bile ducts, cystic duct, and gallbladder, arising as a result of extrahepatic portal vein obstruction and noncirrhotic portal fibrosis, which can be caused by coagulopathies, tumors, inflammation, postoperative complications, dehydration, and neonatal umbilical vein catheterization. …”
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Extensive Mycobacterium abscessus Pneumonia in an Immunocompetent Infant with No Underlying Lung Pathology by Morouge M. Alramadhan, James R. Murphy, Michael L. Chang

“…Pulmonary infection due to Mycobacterium abscessus occurs in patients with cystic fibrosis, but rarely in immunocompetent children without underlying lung pathology. …”
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Valvular Cardiomyopathy: The Value of Cardiovascular Magnetic Resonance Imaging by Vasiliki Tsampasian, Sandeep S. Hothi, Thuwarahan Ravindrarajah, Andrew J. Swift, Pankaj Garg, Vassilios S. Vassiliou

“…T1 mapping and late gadolinium enhancement (LGE) imaging provide deep myocardial tissue characterisation that is changing the approach towards risk stratification of patients as an increasing body of evidence suggests that the presence of fibrosis is related to adverse events and prognosis. …”
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Mitochondrial Dysfunction as a Therapeutic Target in Diabetic Cardiomyopathy: Progress and Prospects by Feng Zhang, Zhuqing Li, Yanxin Wang, Chao Li, Chengzhi Lu

“…DCM causes microvascular disease, myocardial metabolic disorder, and myocardial fibrosis, thereby leading to left ventricular remodeling, diastolic and/or systolic dysfunction, and eventually progressing to congestive heart failure. …”
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A Curious Case of Iron-Deficiency Anemia by Seth Shaffer, Mayur Brahmania, Hemant Shah

“…His past history was significant for cirrhosis based on a previous variceal bleed but a workup for chronic liver disease was negative and a liver biopsy did not show steatosis, fibrosis, or cirrhosis. A gastroscopy in this admission showed large esophageal varices without high-risk stigmata and no overt bleeding was seen. …”
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Progress on long non-coding RNAs in calcific aortic valve disease by Yan Shen, Jiahui Li, Zehao Zhao, Xiaomin Chen

“…The aortic valve, influenced by factors such as endothelial dysfunction, inflammation, oxidative stress, lipid metabolism disorders, calcium deposition, and extracellular matrix remodeling, undergoes fibrosis and calcification, ultimately leading to stenosis. …”
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Cardiac regeneration: 20 years of development and update in zebrafish and mouse by Lekun Gui, Lijun Jin, Huangjun Liu

“…Zebrafish are extremely sensitive to cardiac injury and, within a short period, stimulate the proliferation of cardiomyocytes in numbers that fully regenerate to pre-injury levels; meanwhile, the initial scarring is gradually absorbed until there is little or no visible sign of fibrosis in the regenerating myocardium. The newborn mouse heart has the same remarkable regenerative potential before birth as one week after cardiac injury. …”
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A case report of idiopathic hypertrophic pachymeningitis by G. Makarevičius, J. Grigaitė, M. Jokubaitis, A. Klimašauskienė

“… Idiopathic hypertrophic pachymeningitis (IHP) is a condition characterised by diffuse or local thickening and fibrosis of dura matter caused by inflammation of unknown origin. …”
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Silent enemy of the hand: The Viking disease by Stoiljković Vera

“…Dupuytren's contracture (DK) is the most common progressive idiopathic fibrosis of the superficial palmar fascia, often asymptomatic at its onset, caused by changes in the palmar aponeurosis, resulting in flexion contractures in the fingers of the hand. …”
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Airway Remodelling in Asthma: From Benchside to Clinical Practice by Céline Bergeron, Meri K Tulic, Qutayba Hamid

“…In asthma, airway structural changes include subepithelial fibrosis, increased smooth muscle mass, gland enlargement, neovascularization and epithelial alterations. …”
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Complete Recovery from COVID-19 Bilateral Pneumonia in an Immunosuppressed Man with Immune-Mediated Necrotizing Myopathy by Thomas C. Bolig, Nada Abdulaziz, Elena Schiopu

“…The 14-week follow-up computed tomography (CT) was negative for residual pneumonitis or fibrosis. More data are needed regarding management and prognosis of patients with connective tissue diseases who become infected with SARS-CoV-2.…”
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