European ILD registry algorithm for self-assessment in interstitial lung diseases (eurILDreg ASA-ILD). by Ekaterina Krauss, Laurenz H Claas, Silke Tello, Jennifer Naumann, Sandra Wobisch, Stefan Kuhn, Raphael W Majeed, Karen Moor, Maria Molina-Molina, Oisin Byrne, Rebecca Borton, Marlies S Wijsenbeek, Nik Hirani, Carlo Vancheri, Bruno Crestani, Andreas Guenther, eurILDreg investigators

“…<h4>Background and aims</h4>Predicting progression and prognosis in Interstitial Lung Diseases (ILD), especially Idiopathic Pulmonary Fibrosis (IPF) and Progressive Pulmonary Fibrosis (PPF), remains a challenge. …”
Get full text

Exploring the Cardioprotective Mechanisms of Ligusticum wallichii in Myocardial Infarction Through Network Pharmacology and Experimental Validation by Yang H, Cao J, Zhou L, Chen J, Tang J, Chen J, Yin L, Xie L, Li J, Luo J

“…In vivo, experiments showed that the active components of Ligusticum wallichii significantly improved myocardial infarction via alleviating myocardial fibrosis and oxidative stress and did not elicit toxic effects in mice.Conclusion: The collective findings suggest that Ligusticum wallichii shows promising potential for myocardial infarction treatment by regulating key target proteins (EGFR, STAT3, and SRC), which play roles in oxidative stress and myocardial fibrosis.Keywords: Ligusticum wallichii, myocardial infarction, Molecular docking, network pharmacology, experimental validation…”
Get full text

Metallothioneins 1 and 2 Modulate Inflammation and Support Remodeling in Ischemic Cardiomyopathy in Mice by Georg D. Duerr, Daniela Dewald, Eva J. Schmitz, Luise Verfuerth, Katharina Keppel, Christine Peigney, Alexander Ghanem, Armin Welz, Oliver Dewald

“…Expression of MT1/2 mRNA was transiently induced during repetitive I/R in WT-mice, accompanied by a transient inflammation, leading to interstitial fibrosis with left ventricular dysfunction without infarction. …”
Get full text

NF-κB-Specific Suppression in Cardiomyocytes Unveils Aging-Associated Responses in Cardiac Tissue by Letícia Aparecida Lopes Morgado, Larissa Maria Zacarias Rodrigues, Daiane Cristina Floriano Silva, Bruno Durante da Silva, Maria Claudia Costa Irigoyen, Ana Paula Cremasco Takano

“…<b>Background/Objectives</b>: Aging is associated with structural and functional changes in the heart, including hypertrophy, fibrosis, and impaired contractility. Cellular mechanisms such as senescence, telomere shortening, and DNA damage contribute to these processes. …”
Get full text

Curcumin and α/β-Adrenergic Antagonists Cotreatment Reverse Liver Cirrhosis in Hamsters: Participation of Nrf-2 and NF-κB by José Roberto Macías-Pérez, Bruno Jesús Vázquez-López, Martin Humberto Muñoz-Ortega, Liseth Rubí Aldaba-Muruato, Sandra Luz Martínez-Hernández, Esperanza Sánchez-Alemán, Javier Ventura-Juárez

“…However, several studies suggest that the toxicity generated by metabolism of these antagonists would hinder its use in cirrhotic patients. In addition, liver fibrosis may be associated with a decrease of the antioxidant response of the nuclear factor erythroid 2-related factor 2 (Nrf-2) and the overregulation of the proinflammatory pathway of nuclear factor kappa B (NF-κB). …”
Get full text

Therapeutic role of miR-26a on cardiorenal injury in a mice model of angiotensin-II induced chronic kidney disease through inhibition of LIMS1/ILK pathway by Weijie Ni, Yajie Zhao, Jinxin Shen, Qing Yin, Yao Wang, Zuolin Li, Taotao Tang, Yi Wen, Yilin Zhang, Wei Jiang, Liangyunzi Jiang, Jinxuan Wei, Weihua Gan, Aiqing Zhang, Xiaoyu Zhou, Bin Wang, Bi-Cheng Liu, Yuanyuan Ji

“…Chronic kidney disease (CKD) is associated with common pathophysiological processes, such as inflammation and fibrosis, in both the heart and the kidney. However, the underlying molecular mechanisms that drive these processes are not yet fully understood. …”
Get full text

Influence of a macrolide antibiotic, roxithromycin, on mast cell growth and activation in vitro by Toshikazu Shimane, Kazuhito Asano, Mayumi Suzuki, Tadashi Hisamitsu, Harumi Suzaki

“…Background: Long-term administration of macrolide antibiotics is recognized to be able to favorably modify the clinical condition of inflammatory diseases, such as diffuse panbronchiolitis and cystic fibrosis. However, the precise mechanisms by which macrolide antibiotics could improve clinical conditions of the patients are not well understood.…”
Get full text

Bullous pemphigoid and morphea: Coexistence or an incidental association by Seema Rani, Sweta Singh, Arvind Ahuja

“…Morphea is considered an autoimmune disease because of reported autoantibody and autoimmune disease associations and is characterized by varying degrees of sclerosis, fibrosis, and atrophy in the skin and subcutaneous tissues and may involve muscle, bone, and brain. …”
Get full text

Autoantibodies and Resident Renal Cells in the Pathogenesis of Lupus Nephritis: Getting to Know the Unknown by Susan Yung, Tak Mao Chan

“…Accumulating evidence shows that anti-dsDNA antibodies play a critical role in the pathogenesis of lupus nephritis through their binding to cell surface proteins of resident kidney cells, thereby triggering the downstream activation of signaling pathways and the release of mediators of inflammation and fibrosis. This paper describes the mechanisms through which autoantibodies interact with resident renal cells and how this interaction plays a part in disease pathogenesis that ultimately leads to structural and functional alterations in lupus nephritis.…”
Get full text

Research Progress on the Mechanism of Acupuncture Treatment for Nonalcoholic Fatty Liver Disease by Bai Li, Li Fang

“…Nonalcoholic fatty liver disease (NAFLD) represents the most common chronic liver disease worldwide, ranging from simple steatosis and nonalcoholic steatohepatitis to fibrosis, cirrhosis, and hepatocellular carcinoma. …”
Get full text

Dual role of pyroptosis in liver diseases: mechanisms, implications, and therapeutic perspectives by Siyuan Yang, Yunyi Zou, Chunhua Zhong, Zuoqiong Zhou, Xiyang Peng, Changfa Tang

“…Conversely, excessive pyroptosis intensifies inflammatory responses, exacerbates hepatocyte damage and promotes the activation and proliferation of hepatic stellate cells, accelerating liver fibrosis. Furthermore, by sustaining an inflammatory state, impacts the survival and proliferation of cancer cells. …”
Get full text

Rasmussen’s aneurysm: A rare fatal complication in a patient of post-COVID-19 pneumonia with invasive aspergillosis by Jyoti Bajpai, Shubhajeet Roy, Anmary Royson, Akshyaya Pradhan, Surya Kant

“…Pulmonary manifestations post-COVID-19 are varied, including lung fibrosis, vascular diseases, and secondary infections. …”
Get full text

Matrix Metalloproteinases in Inflammatory Bowel Disease: An Update by Shane O’Sullivan, John F. Gilmer, Carlos Medina

“…Through digestion of the extracellular matrix and cleavage of bioactive proteins, a huge diversity of roles have been revealed for the MMPs in IBD, where they have been shown to regulate epithelial barrier function, immune response, angiogenesis, fibrosis, and wound healing. For this reason, MMPs have been recognised as potential biomarkers for disease activity in IBD and inhibition remains a huge area of interest. …”
Get full text

Unlocking the Potential of Chest MRI: Strategies for Establishing a Successful Practice by Kyubin Kim, Kun-Il Kim, Ji Won Lee, Yeon Joo Jeong

“…Its applications span various clinical scenarios, including the differentiation of non-tumorous and tumorous conditions in the mediastinum or pleura, planning of surgical interventions and treatments for such tumors, evaluation of post-treatment recurrence, staging of lung cancer, and diagnosis of progressive massive fibrosis. Despite the technical hurdles posed by cardiac and respiratory motion, advancements in sequence and scan techniques have enabled high-quality chest MRI examinations to be conducted across diverse clinical settings. …”
Get full text

Ultrasound Guided Percutaneous Nephrolithotomy in Mesh-Repaired Incisional Hernia by Seyed Hassan Inanloo, Mohammad Reza Nikoobakht, Hamed Akhavizadegan, Mojgan Karbakhsh

“…Polypropylene mesh which is used for fascia strengthening in hernia repair elicits intense inflammatory reaction and the consequent fibrosis alters the characteristics of abdominal wall. …”
Get full text

A LARGE MASS IN THE MANDIBLE IN AN EIGHT YEAR OLD CHILD by Gökhan Gürler, Serdar Yılmaz, Çağrı Delilbaşı, Merva Soluk Tekkesin

“…Fibro-osseous lesions are a group of lesions characterized by fibrosis and contain varying amounts of calcified tissue resembling bone, cement or both. …”
Get full text

Methods of risk prediction and monitoring of treatment response rate of bleedings from esophageal varices in patients with liver cirrhosis by D. V. Garbuzenko

“…Their inherent disadvantages promoted studying of sensitivity and specificity of other predictors of this complication, as well as technologies estimating severity of portal hypertension, such as capsule endoscopy, Doppler ultrasound, multispiral computer tomography, non-invasive methods of liver fibrosis diagnostics and of some others.Conclusion. …”
Get full text

Penile Rehabilitation Therapy with PDE-V Inhibitors Following Radical Prostatectomy: Proceed with Caution by M. Eric Brewer, Edward D. Kim

“…Secondary smooth muscle changes in the penis have been identified as the underlying causes of penile atrophy, veno-occlusive dysfunction, and fibrosis. Initial observations that intracavernous injection therapies used on a regular basis postoperatively resulted in improvements in the return of spontaneous erectile function led to the development of penile rehabilitation protocols. …”
Get full text

Newborn Screening Saves Lives but Cannot Replace the Need for Clinical Vigilance by F. Neemuchwala, M. Taki, E. Secord, S. Z. Nasr

“…Newborn screening for cystic fibrosis (CF) enables early diagnosis and treatment leading to improved health outcomes for patients with CF. …”
Get full text

A Gentleman with Anemia and Cholestasis by Siu-Tong Law, Wai-Ki Lee, Michael Kin-Kong Li, Ka-Ho Lok

“…Primary sclerosing cholangitis is a rare cause of cholestasis caused by progressive inflammation and fibrosis of both intrahepatic and extrahepatic bile ducts leading to multifocal ductal strictures. …”
Get full text