The safety of cyclosporine and tacrolimus in pediatric nephrotic syndrome patients: a disproportionate analysis based on the FAERS database by Yu Liu, Chong Yan, Yaowang Zhao, Sui Deng, Jiancheng Zu

“…TAC was associated with an increased risk of dystonia (ROR = 67.93, 95% CI: 8.63–534.86), kidney fibrosis (ROR = 22.65, 95% CI: 8.16–62.87), and diabetic ketoacidosis (ROR = 46.51, 95% CI: 5.68–380.97). …”
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The potential of aloe vera gel utilization for skin wound healing in rats based on GC–MS and HPLC chemical profile by Nadia Mohamed Said Arafa, Huda Mohammad Ahmad Hummadi, Gehan Moustafa Badr

“…Skin showed moderate epidermal acanthosis, and dermis had fibrosis, hemorrhage and loss of sebaceous glands and hair follicles. …”
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Cytokines and Liver Diseases by Herbert Tilg

“…There is increasing evidence that several cytokines mediate hepatic inflammation, apoptosis and necrosis of liver cells, cholestasis and fibrosis. Interestingly, the same mediators also mediate the regeneration of liver tissue after injury. …”
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Updates in the management of connective tissue disease-associated interstitial lung disease by Chengappa Kavadichanda, G S R S N K Naidu

“…Most of the evidence in treating these cases is limited to a few trials in scleroderma and idiopathic pulmonary fibrosis along with several observational studies in other CTDs. …”
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Systemic sclerosis and the gastrointestinal tract by Irena Walecka

“…It is characterised by vascular and immunological abnormalities leading to fibrosis of the skin and internal organs. It is a rather rare disease with a prevalence of around 20 per 100,000. …”
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Hepatic Actinomycosis with Infiltration of the Diaphragm and Right Lung: A Case Report by Tasbirul Islam, Muhammad Nauman Athar, Muhammad Kamran Athar, Mohammed Haris Umer Usman, Baqir Misbah

“…Classic features include purulent foci surrounded by dense fibrosis that, over time, cross natural boundaries into contiguous structures, with the formation of fistulas and sinus tracts in some cases. …”
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Association between Leptin, Metabolic Factors and Liver Histology in Patients with Chronic Hepatitis C by Robert P Myers, Djamila Messous, Thierry Poynard, Francoise Imbert-Bismut

“…BACKGROUND: Steatosis is common in hepatitis C virus (HCV)-infected patients and likely accelerates fibrosis progression. Leptin, the peptide product of the obesity gene (ob), has been implicated in hepatic fibrogenesis; circulating levels of leptin correlate with body fat mass. …”
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Lymphoid Tissue Mesenchymal Stromal Cells in Development and Tissue Remodeling by Luca Genovese, Andrea Brendolan

“…However, chronic inflammatory conditions can promote uncontrolled stromal cell activation and aberrant tissue remodeling including fibrosis, thus leading to tissue damage. Despite recent advancements, the origin and role of mesenchymal stromal cells involved in SLO development and remodeling remain unclear.…”
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Inherited Causes of Exocrine Pancreatic Dysfunction by Peter R Durie

“…Most inherited causes of pancreatic dysfunction are due to a generalized disorder. Cystic fibrosis is, by far, the most common inherited cause of disturbed pancreatic function among Caucasian children. …”
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Pleuroparenchymal Fibroelastosis as a Late-Onset Pulmonary Toxicity after Treatment with Anticancer Chemotherapy for High-Risk Neuroblastoma by Satoshi Yokoyama, Risa Kanai, Daisuke Fukao, Keigo Hamahata

“…It is characterized by pleural thickening, fibrosis, subpleural elastosis, and intraalveolar collagen deposits. …”
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Spontaneous Rupture of the Urinary Bladder 10 Years after Curative Radiotherapy by Apostolos P. Labanaris, Vahudin Zugor, Reinhold Nützel, Reinhard Kühn

“…Such complications include hematuria, fibrosis, and cystitis. An extremely rare, but dangerous, medical complication following curative radiotherapy that can also be noted is spontaneous bladder perforation. …”
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IgG4 Inflammatory Pseudotumor of the Kidney by Ahmed N. Alkhasawneh, Robert W. Allan

“…It is characterized by elevated serum IgG4 levels and infiltration of organs by IgG4 positive plasma cells associated with fibrosis. Patients usually present with mass or masses in the involved organ that mimic neoplasia. …”
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Oxidative Stress and Inflammation in Heart Disease: Do Antioxidants Have a Role in Treatment and/or Prevention? by Fredric J. Pashkow

“…In addition to the formation of atherosclerosis, it involves lipid metabolism, plaque rupture, thrombosis, myocardial injury, apoptosis, fibrosis and failure. The recognition of the critical importance of oxidative stress has led to the enthusiastic use of antioxidants in the treatment and prevention of heart disease, but the results of prospective, randomized clinical trials have been overall disappointing. …”
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Coronary Atherosclerotic Plaque Vulnerability Rather than Stenosis Predisposes to Non-ST Elevation Acute Coronary Syndromes by Mohamed Laimoud, Farouk Faris, Helmy Elghawaby

“…The vulnerability is related to the lesion characteristics especially lipidic core and calcification while lesion fibrosis favours lesion stability.…”
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Intrapericardial injection of hydrogels with ASC and their secretome to treat dilated cardiomyopathies by Tácia Tavares Aquinas Liguori, Gabriel Romero Liguori, Viktor Sinkunas, Cristiano Jesus Correia, Raphael dos Santos Coutinho e Silva, Fernando Luiz Zanoni, Vera Demarchi Aiello, Martin Conrad Harmsen, Luiz Felipe Pinho Moreira

“…Interstitial myocardial fibrosis was assessed by PicroSirius Red staining and hemodynamics parameters in pressure-volume loops. …”
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Targeting ASK1 by CS17919 alleviates kidney‐ and liver‐related diseases in murine models by Guoqiang Liao, Qianjiao Yang, Xuhua Mao, Yiru Zhao, Beizhong Chen, Kun Zhang, Yu Zhang, Ping Zhang, Zhengli Chen, Shengjian Huang

“…In the unilateral ureteral obstruction model (UUO), CS17919 and GS‐4997 preserved kidney function and showed a non‐significant tendency to alleviate kidney fibrosis. In the diabetic kidney disease (DKD) model, CS17919 significantly improved serum creatinine and glomerular sclerosis. …”
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Elastografía cualitativa por ultrasonido endoscópico en la reestadificación del tumor de recto irradiado by Misdrialis Martinez Romero, Raúl Antonio Brizuela Quintanilla, Norberto Alfonso Contino, Pablo Miguel Raventós Vaquer, Jorge Luis Garcia-Menocal Hernández, Ana Mercedes Mendoza Romero

“…Introducción: En la reestadificación del paciente con tumor de recto irradiado, la elastografía cualitativa por ultrasonido endoscópico puede identificar la fibrosis y diferenciarla del tumor residual. Objetivo: Determinar la utilidad de la elastografía cualitativa por ultrasonido endoscópico en la reestadificación del tumor de recto irradiado. …”
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Unusual hypertrophic cardiomyopathy: case report of an early onset wild-type ATTR amyloidosis accompanied by a chromosomal duplication involving the MYH6 and MYH7 gene by Jassin Hamidi, Yvonne Hanel, Sven Dittmann, Wanda Maria Gerding, Huu Phuc Nguyen, Karin Klingel, Eric Schulze-Bahr

“…Functionally, enhanced tissue stiffness and reduced elasticity, combined with diastolic dysfunction and myocardial fibrosis, can eventually lead to life-threatening arrhythmias and impaired blood flow through the heart chamber. …”
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Metallothionein 1B attenuates inflammation and hepatic steatosis in MASH by inhibiting the AKT/PI3K pathway by Canghai Guan, Xinlei Zou, Wujiang Shi, Jianjun Gao, Chengru Yang, Yifei Ge, Zhaoqiang Xu, Shaowu Bi, Xiangyu Zhong

“…In vivo experiments demonstrate that specific downregulation of hepatic MT1B expression via AAV8-shMT1B injection significantly increases triglyceride and total cholesterol levels, exacerbates lipid accumulation, and markedly elevates liver fibrosis and inflammatory factor expression. RNA-seq and bioinformatics analyses show that the AKT/PI3K pathway is significantly suppressed in MT1B-overexpressing cells. …”
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The construction of large-aperture Schottky heterostructures and the study of the reduction properties of heavy metal ions under natural light by FengQi Qiu, Yanfei Pan, Yuan Tian, Huiming Shi, Shuaiqi Hu, Qiang Guo, Yuan Wang, Qinglun Liang, Mayin Dai, Zhenhua Xue

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