Erosive Arthritis, Fibromatosis, and Keloids: A Rare Dermatoarthropathy by Fawad Aslam, Jonathan A. Flug, Yousif Yonan, Shelley S. Noland

“…Polyfibromatosis is a rare disease characterized by fibrosis manifesting in different locations. It is commonly characterized by palmar fibromatosis (Dupuytren’s contracture) in variable combinations with plantar fibromatosis (Ledderhose’s disease), penile fibromatosis (Peyronie’s disease), knuckle pads, and keloids. …”
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Role of NKT Cells in the Pathogenesis of NAFLD by Kazuto Tajiri, Yukihiro Shimizu

“…NKT cells may have a protective role at the early stage with simple steatosis through modification of insulin resistance, whereas they act as a progression factor at the advanced stage with fibrosis. Those processes are thought to depend on interaction between NKT cells and CD1d molecule in the liver.…”
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Endothelial-Mesenchymal Transition in Regenerative Medicine by Damian Medici

“…Endothelial-mesenchymal transition (EndMT) is a fundamental cellular mechanism that regulates embryonic development and diseases such as cancer and fibrosis. Recent developments in biomedical research have shown remarkable potential to harness the EndMT process for tissue engineering and regeneration. …”
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A Severe Complication of Crack Cocaine Use by Gokul Vidyasankar, Carolina Souza, Chi Lai, Sunita Mulpuru

“…Serial imaging revealed progressive interstitial fibrosis secondary to recurrent alveolar hemorrhage and inflammation from crack cocaine. …”
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Therapeutic Response to Secukinumab in a 36-Year-Old Woman with Hidradenitis Suppurativa by Astrid-Helene Ravn Jørgensen, Yiqiu Yao, Simon Francis Thomsen

“…It is characterized by recurrent inflamed nodules and abscesses, resulting in fistulae, fibrosis, and scarring. We present a case of HS refractory to local and systemic antibiotic therapy as well as anti-TNF and anti-IL12/23 that was successfully treated with secukinumab (anti-IL17A).…”
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Chemoradiation-Induced Superior Vena Cava Syndrome: A Case Report by Mathieu Castonguay, George Rodrigues, Mark Vincent, Richard A Malthaner, Lin-Ruo Guo

“…A case of a 54-year-old man who developed superior vena cava syndrome secondary to vascular fibrosis, 30 months after radical chemoradiation for stage III non-small cell lung cancer, is presented. …”
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S-NiFe2O4@graphene/cellulose nanofibers/polyvinyl alcohol composite towards high-performance microwave absorption and flame retardancy by Qiang Guo, Yanfei Pan, Shuaiqi Hu, Zhenghua Xue, Sufen Hao, Jintian Huang

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A Review of the Therapeutic Potential of Ginseng and Its Bioactive Components in Nonalcoholic Fatty Liver Disease by Hao L, Li S, Li C, Zhang Z, Hu X, Yan H

“…Additionally, ginseng inhibits oxidative stress by scavenging free radicals and enhancing antioxidant enzyme activities, and it can impede fibrosis by interfering with the fibrotic signaling pathways. …”
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Small Interfering RNA Targeted to ASPP2 Promotes Progression of Experimental Proliferative Vitreoretinopathy by Xiao-Li Chen, Yu-Jing Bai, Qin-Rui Hu, Shan-Shan Li, Lv-Zhen Huang, Xiao-Xin Li

“…EMT markers and related inflammatory and fibrosis cytokines were measured by western blot or flow cytometry. …”
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Tubular MYDGF Slows Progression of Chronic Kidney Disease by Maintaining Mitochondrial Homeostasis by Xiaohan Liu, Yang Zhang, Youzhao Wang, Yujie Yang, Zhe Qiao, Ping Zhan, Huiying Jin, Qianqian Xu, Wei Tang, Yu Sun, Yan Zhang, Fan Yi, Min Liu

“…Tubule‐specific deletion of Mydgf exacerbates kidney injury in mice with CKD; however, Mydgf overexpression attenuates kidney fibrosis by remodeling mitochondrial homeostasis in tubular epithelial cells. …”
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Liver HLA-E Expression Is Associated with Severity of Liver Disease in Chronic Hepatitis C by Roberta C. Araújo, Fabricio C. Dias, Bruna C. Bertol, Deisy M. Silva, Patrícia H. Almeida, Andreza C. Teixeira, Fernanda F. Souza, Marcia G. Villanova, Leandra N. Z. Ramalho, Eduardo A. Donadi, Ana L. C. Martinelli

“…The liver samples classified as severe fibrosis and necroinflammatory activity presented greater expression of HLA-E on Kupffer cells and hepatocytes, with a significant linear association. …”
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Supporting self-management for patients with Interstitial Lung Diseases: Utility and acceptability of digital devices. by Malik A Althobiani, Rebecca Shuttleworth, John Conway, Jonathan Dainton, Anna Duckworth, Ana Jorge Da Ponte, Jessica Mandizha, Joseph W Lanario, Michael A Gibbons, Sarah Lines, Chris J Scotton, John R Hurst, Joanna C Porter, Anne-Marie Russell

“…<h4>Results</h4>104 patients accessed the survey and 89/104 (86%) reported a diagnosis of lung fibrosis, including 46/89 (52%) idiopathic pulmonary fibrosis (IPF) with 57/89 (64%) of participants diagnosed >3 years and 59/89 (66%) female. 52/65(80%) were in the UK; 33/65 (51%) reported severe breathlessness medical research council MRC grade 3-4 and 32/65 (49%) disclosed co-morbid arthritis or joint problems. …”
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Cholinergic Elicitation Prevents Ventricular Remodeling via Alleviations of Myocardial Mitochondrial Injury Linked to Inflammation in Ischemia-Induced Chronic Heart Failure Rats by Yang Zhao, Huaxin Sun, Kai Li, Luxiang Shang, Xiaoyan Liang, Hang Yang, Zhenyu Dong, Jiasuoer Xiaokereti, Shuai Shang, Qina Zhou, Xianhui Zhou, Ling Zhang, Yanmei Lu, Baopeng Tang

“…CAP induction alleviates macrophage infiltration and cardiac fibrosis, of which the effect is counteracted by vagotomy. …”
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Global Gene Expression Profiling in PPAR-γ Agonist-Treated Kidneys in an Orthologous Rat Model of Human Autosomal Recessive Polycystic Kidney Disease by Daisuke Yoshihara, Masanori Kugita, Tamio Yamaguchi, Harold M. Aukema, Hiroki Kurahashi, Miwa Morita, Yoshiyuki Hiki, James P. Calvet, Darren P. Wallace, Takafumi Toyohara, Takaaki Abe, Shizuko Nagao

“…Kidneys are enlarged by aberrant proliferation of tubule epithelial cells leading to the formation of numerous cysts, nephron loss, and interstitial fibrosis in polycystic kidney disease (PKD). Pioglitazone (PIO), a PPAR-γ agonist, decreased cell proliferation, interstitial fibrosis, and inflammation, and ameliorated PKD progression in PCK rats (Am. …”
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Natural History of Metabolic Dysfunction-Associated Steatotic Liver Disease: From Metabolic Syndrome to Hepatocellular Carcinoma by Melchor Alpízar Salazar, Samantha Estefanía Olguín Reyes, Andrea Medina Estévez, Julieta Alejandra Saturno Lobos, Jesús Manuel De Aldecoa Castillo, Juan Carlos Carrera Aguas, Samary Alaniz Monreal, José Antonio Navarro Rodríguez, Dulce María Fernanda Alpízar Sánchez

“…These methods detect liver steatosis and fibrosis with reasonable accuracy, offering alternatives to biopsy despite varying sensitivity and specificity. …”
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Karyopherin Alpha 2-Expressing Pancreatic Duct Glands and Intra-Islet Ducts in Aged Diabetic C414A-Mutant-CRY1 Transgenic Mice by Satoshi Okano, Akira Yasui, Shin-ichiro Kanno, Kennichi Satoh, Masahiko Igarashi, Osamu Nakajima

“…Additionally, the formation of mucin-producing intra-islet ducts, islet fibrosis, and massive T cell recruitment to the islet occurred in aged Tg mice. …”
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Combination of rapamycin and adipose-derived mesenchymal stromal cells enhances therapeutic potential for osteoarthritis by Damien Veret, Gautier Tejedor, Esther Perez, Alison Chomette, Maylis Farno, Rosanna Ferreira-Lopez, Louis Dagneaux, Yves-Marie Pers, Christian Jorgsensen, Claire Gondeau, Jean-Marc Brondello

“…First, rapamycin effects on senescence and fibrosis markers were investigated in freshly isolated OA chondrocytes by immunostaining. …”
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N6-methyladenosine regulates metabolic remodeling in kidney aging through transcriptional regulator GLIS1 by Li Xu, Shuo Chen, Qiuling Fan, Yonghong Zhu, Hang Mei, Jiao Wang, Hongyuan Yu, Ying Chen, Fan Liu

“…Abstract Background Age-related kidney impairment, characterized by tubular epithelial cell senescence and renal fibrosis, poses a significant global public health threat. …”
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Bone Marrow-Derived Multipotent Stromal Cells Attenuate Inflammation in Obliterative Airway Disease in Mouse Tracheal Allografts by Alicia Casey, Fabian Dirks, Olin D. Liang, Hakima Harrach, Katharina Schuette-Nuetgen, Kristen Leeman, Carla F. Kim, Craig Gerard, Meera Subramaniam

“…Treatment of recipient mice with MSCs suppressed neutrophil, macrophage, and T-cell infiltration and reduced fibrosis. These beneficial effects were observed despite lack of significant MSC epithelial engraftment or new epithelial cell generation. …”
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Decrease in HBsAg After TAF Switching from Entecavir During Long-Term Treatment of Chronic Hepatitis B Virus Infection by Kazuto Tajiri, Yuka Hayashi, Aiko Murayama, Nozomu Muraishi, Masami Minemura, Ichiro Yasuda

“…This finding suggests patients with mild to moderate fibrosis may respond better to TAF in terms of HBsAg reduction.…”
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