Chronic Disease Management in Children Based on the Five Domains of Health by Wing Lung Alvin So

“…Through a case study of a child with cystic fibrosis, the interactions among various domains of health have been discussed—namely, biomedical, physical, psychological/behavioural, and social. …”
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Combined Bile Duct and Pancreatic Duct Injuries during Distal Gastrectomy for Obstructing Peptic Ulcer Disease by Narendra Pandit, Kunal Bikram Deo

“…Anomalous ductal anatomy, distorting duodenal fibrosis, and pancreatic atrophy predispose to this untoward complication during performance of distal gastrectomy for benign peptic stricture. …”
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15-Deoxy-Δ12,14-Prostaglandin J2 Inhibits Homing of Bone Marrow-Derived Mesenchymal Stem Cells Triggered by Chronic Liver Injury via Redox Pathway by Xin Liu, Shuangshuang Jia, Weiyang Li, Le Yang, Lin Yang, Lin Wang, Liying Li

“…In conclusion, our results suggest that 15d-PGJ2 plays a crucial role in homing of BMSCs to the injured liver dependent on ROS production, independently of PPARγ, which may represent a new strategy in the treatment of liver fibrosis.…”
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Caracterización de los pacientes con bradiarritmias atendidos en el servicio de Cardiología de Cienfuegos (2018-2019) by Samuel Sánchez Sánchez, Magdiel Echazabal Leal, Ana Laura Navarro Baldellot, Emmanuel Sánchez Ramos

“…Fueron causas principales de la bradiarritmia no reversible, la fibrosis del sistema excito-conductor y la isquémica.…”
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Synergic Renoprotective Effects of Combined ASC Therapy with RAAS Blockade in Experimental Advanced CKD by Marina P. C. Maires, Krislley R. Pereira, Everidiene K. V. B. Silva, Victor H. R. Souza, Flavio Teles, Paulyana F. Barbosa, Margoth R. Garnica, Felipe M. Ornellas, Irene L. Noronha, Camilla Fanelli

“…Overactivity of the renin-angiotensin-aldosterone system (RAAS), associated to renal inflammation and fibrosis, contributes to its evolution. The treatments currently employed to control CKD progression are limited and mainly based on the pharmacological inhibition of RAAS, associated with diuretics and immunosuppressive drugs. …”
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Fungsi Tiroid Pasca Radioterapi Tumor Ganas Kepala- Leher by Ade Chandra, Sukri Rahman

“…Kelainan pada tiroid pasca radioterapi dihubungkan dengan kerusakan sel dan pembuluh darah kecil kelenjar tiroid serta fibrosis kapsul kelenjar tiroid yang selanjutnya menyebabkan kelenjar tiroid mengecil. …”
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Elastografía por ultrasonido endoscópico en el tumor de recto by Misdrialis Martinez Romero, Raúl Antonio Brizuela Quintanilla, Norberto Alfonso Contino, Jorge Luis García-Menocal Hernández, Maricela Morera Pérez, Dayron Páez Suarez

“…En los tumores tratados con radioterapia disminuye su rentabilidad por la fibrosis que se origina en la pared rectal; indistinguible de los elementos de malignidad. …”
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Serum Interleukin-6, Interleukin-17A, and transforming growth factor beta are raised in systemic sclerosis with interstitial lung disease by Anupam Wakhlu, Rasmi Ranjan Sahoo, Jyoti Ranjan Parida, Mohit K Rai, Durga P Misra, Vinita Agrawal, Vikas Agarwal

“…Higher levels of these cytokines were also observed in patients of diffuse cutaneous SSc, those with lung fibrosis and anti-topoisomerase positivity. Conclusion: Serum IL-6, IL-17A and TGF β1 levels were significantly higher in SSc patients and higher levels were associated with ILD and skin fibrosis.…”
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Distinct Redox Signalling following Macrophage Activation Influences Profibrotic Activity by Caitlin V. Lewis, Antony Vinh, Henry Diep, Chrishan S. Samuel, Grant R. Drummond, Barbara K. Kemp-Harper

“…Thus, M2 macrophage-derived ROS is identified as a potentially important contributor to aortic fibrosis.…”
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A comprehensive analysis of percutaneous liver biopsy characteristics and pathological manifestations in a large patient cohort (2009–2024) by Minling Cao, Jiayi Zeng, Jiayu Wang, Junmin Jiang

“…Patients with hepatitis B complicated by MASLD exhibited disease exacerbation in middle age, with both liver inflammation and fibrosis grading worsening as age advanced. Furthermore, within the same age bracket, the severity of inflammation and the extent of fibrosis were more pronounced in cases where chronic hepatitis B was combined with MASLD compared to those with isolated chronic hepatitis B or MASLD. …”
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Decreased Taurine and Creatine in the Thalamus May Relate to Behavioral Impairments in Ethanol-Fed Mice: A Pilot Study of Proton Magnetic Resonance Spectroscopy by Su Xu PhD, Wenjun Zhu MS, Yamin Wan MD, PhD, JiaBei Wang PhD, Xi Chen PhD, Liya Pi PhD, Mary Kay Lobo PhD, Bin Ren PhD, Zhekang Ying PhD, Michael Morris MD, Qi Cao MD, PhD

“…Chronic long-term alcohol consumption gives rise to advanced liver fibrosis, neurochemical changes in the nuclei, and behavioral changes which may be linked to NDF. …”
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Shionone Inhibits Glomerular Fibirosis by Suppressing NLRP3 Related Inflammasome though SESN2-NRF2/HO-1 Pathway by Tian Xiao, Hanzhen Zhao, Yucong Wang, Mengyin Chen, Cong Wang, Chen Qiao

“…Results The results demonstrated that SH effectively suppressed glomerular fibrosis, induced adenosine monophosphate-activated protein kinase (AMPK) phosphorylation, and inhibited NLR family pyrin domain containing 3 (NLRP3) activation. …”
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Practical Aspects of Clinical Manifestations, Pathogenesis and Therapy of Alcoholic Liver Disease and Non-alcoholic Fatty Liver Disease: Expert Opinion by V. V. Tsukanov, M. F. Osipenko, E. V. Beloborodova, M. A. Livzan, I. B. Khlynov, S. A. Alekseenko, Yu. P. Sivolap, J. L. Tonkikh, A. V. Vasyutin

“…For the diagnosis of liver pathology, it is important to determine the stage of fibrosis and the severity of the exacerbation of the disease. …”
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Challenges in Diagnosing Focal Liver Lesions Using Contrast-Enhanced Ultrasound by Tudor Voicu Moga, Raluca Lupusoru, Mirela Danila, Ana Maria Ghiuchici, Alina Popescu, Bogdan Miutescu, Iulia Ratiu, Calin Burciu, Teofana Bizerea-Moga, Anca Voron, Ioan Sporea, Roxana Sirli

“…Factors such as advanced liver fibrosis, adenomas, and cholangiocarcinoma were significantly associated with higher rates of diagnostic inaccuracies. …”
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Cell therapy for scleroderma: progress in mesenchymal stem cells and CAR-T treatment by Liting Chen, Rongshan Huang, Chaoshuo Huang, Guiming Nong, Yuanyuan Mo, Lvyin Ye, Kunhong Lin, Anping Chen, Anping Chen

“…MSCs possess multiple functions, including immunomodulation, anti-fibrosis, and promotion of vascular regeneration, all of which can improve multiple pathological processes associated with scleroderma. …”
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Ameliorative Impact of Liraglutide on Chronic Intermittent Hypoxia-Induced Atrial Remodeling by Jun Wang, Yongzheng Liu, Changhui Ma, Yue Zhang, Meng Yuan, Guangping Li

“…The CIH group exhibited significant AR, increased atrial fibrosis, and a higher incidence rate of AF compared to the control group. …”
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Targeted Plasma Bile Acid Metabolomic Analysis in Metabolic Dysfunction-Associated Steatohepatitis and Alcoholic Hepatitis by Yuta Hirata, Yasunaru Sakuma, Hideo Ogiso, Ryozo Nagai, Kenichi Aizawa

“…Aspartate aminotransferase (AST) showed strong positive correlations with TCDCA and GCDCA. Child–Pugh score, Fibrosis-4 index, and non-alcoholic fatty liver disease fibrosis score were positively correlated with GCA, whereas the aspartate aminotransferase-to-platelet ratio correlated with TCA, TCDCA, and GCA. …”
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A systematic review and meta-analysis assessing adverse event profile and tolerability of nicergoline by Amit Garg, Jun Xu, Mario Fioravanti, Taku Nakashima

“…None of the studies included in this systematic review reported any incidence of fibrosis or ergotism with nicergoline.…”
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Single-cell RNA-seq reveals immune cell heterogeneity and increased Th17 cells in human fibrotic skin diseases by Cheng-Cheng Deng, Xue-Yan Xu, Yan Zhang, Long-Can Liu, Xuan Wang, Jun-Yi Chen, Liu-Yi Yao, Ding-Heng Zhu, Bin Yang

“…In addition, we explored the function of Th17 cell-fibroblast interaction in skin fibrosis. These findings will help to understand fibrotic skin disease pathogenesis in depth and identify potential targets for fibrotic skin disease treatment.…”
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Small-molecule-induced ERBB4 activation to treat heart failure by Julie M. T. Cools, Bo K. Goovaerts, Eline Feyen, Siel Van den Bogaert, Yile Fu, Céline Civati, Jens Van fraeyenhove, Michiel R. L. Tubeeckx, Jasper Ott, Long Nguyen, Eike M. Wülfers, Benji Van Berlo, Antoine A. F. De Vries, Nele Vandersickel, Daniël A. Pijnappels, Dominique Audenaert, H. Llewelyn Roderick, Hans De Winter, Gilles W. De Keulenaer, Vincent F. M. Segers

“…In wild-type mice, EF-1 inhibits angiotensin-II-induced fibrosis in males and females and reduces heart damage caused by doxorubicin and myocardial infarction in females, but not in Erbb4-null mice. …”
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