Management of the Kidney Transplant Patient with Chronic Hepatitis C Infection by Ignatius Y. S. Tang, Natasha Walzer, Nidhi Aggarwal, Ivo Tzvetanov, Scott Cotler, Enrico Benedetti

“…Renal transplant candidates with serologic evidence of HCV infection should undergo a liver biopsy to assess for fibrosis and cirrhosis. Patients with Metavir fibrosis score ≤3 and compensated cirrhosis should be evaluated for interferon-based therapy. …”
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Associations between Extracellular Matrix Protein 1 Gene Polymorphism and Progression of Liver Disease by Xiuting He, Ting Liu, Rui Zhang, Xu Li

“…ECM1 gene polymorphism in rs3834087 and rs3754217 loci is associated with a reduced risk of chronic HBV infection but not with liver fibrosis development and the occurrence of HCC.…”
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Follistatin like-1 aggravates silica-induced mouse lung injury by Yinshan Fang, Si Zhang, Xiaohe Li, Fangxin Jiang, Qiao Ye, Wen Ning

“…Meanwhile, Fstl1 promoted fibrosis via positive regulation of TGF-β1 signaling. …”
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Immunoglobulin G4 Sclerosing Cholangitis: An Unusual Cause of Obstructive Jaundice—Case Report and Literature Review by Pragya Shrestha, Brian Le, Brent Wagner, William Pompella, Paras Karmacharya

“…The presence of extra-biliary clinical manifestations of IgG4-RD, such as parotid and lacrimal swelling, lymphadenopathy, autoimmune pancreatitis, and retroperitoneal fibrosis, if present could provide important clues to diagnosis. …”
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A Cytokine That Is Involved in Immune Responses in Chronic Hepatitis B Virus Patients by Noor R. Abady, Zeana Shakir Al-Al Hindi

“…Conclusion: The investigation comes to the conclusion that IL-17 levels increase as liver disease severity increases, suggesting that it is involved in the development of fibrosis and the progression of the disease. Gaining insight into the function of IL-17 may help develop more effective therapies for CHB and LC patients. …”
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Clinical Evaluation of Specific Oral Manifestations in Pediatric Patients with Ascertained versus Potential Coeliac Disease: A Cross-Sectional Study by Ennio Bramanti, Marco Cicciù, Giada Matacena, Stefano Costa, Giuseppe Magazzù

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Major Histocompatibility Class II Pathway Is Not Required for the Development of Nonalcoholic Fatty Liver Disease in Mice by Gilles Willemin, Catherine Roger, Armelle Bauduret, Kaori Minehira

“…The CCl4 treatment significantly induced genes related to the fibrosis formation in wild-type mice, whereas this was lower in MHCIIΔ/Δ mice. …”
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Choice of Allograft in Patients Requiring Intestinal Transplantation: A Critical Review by Genevieve Huard, Thomas Schiano, Jang Moon, Kishore Iyer

“…Thus, patients with cirrhosis or advanced fibrosis should receive a combined allograft, while patients with lower grades of liver fibrosis can usually safely undergo ITx. …”
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Assessment and follow-up of interstitial lung disease by Devarasetti Phani Kumar

“…Screening guidelines based on expert opinion are available for idiopathic pulmonary fibrosis (IPF) and non-IPF ILDs (sarcoidosis, hypersensitivity pneumonitis, and systemic sclerosis). …”
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Type 2 Diabetes Mellitus, a Sequel of Untreated Childhood Onset Growth Hormone Deficiency Developing in a 17-Year-Old Patient by Rohan K. Henry, Ram K. Menon

“…We present a 17-year-old nonobese female with untreated childhood onset growth hormone deficiency (CO-GHD) who developed type 2 diabetes mellitus (T2DM) and steatohepatitis with bridging fibrosis. Based on height z-score of – 3.1 and a history of radiation therapy as treatment for a medulloblastoma at 7 years of age, GHD was quite likely. …”
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Corrosive induced esophageal and gastric injury: Histopathological evaluation of surgically resected specimens over a decade in a tertiary care center by Jimil Shah, Anuraag Jena, Shweta Shweta, Kim Vaiphei, Vikas Gupta, Naveen Kumar, Anupam K Singh, Rakesh Kochhar

“…Conclusion: Caustic ingestion leads to mucosal ulceration, transmural inflammation, and transmural fibrosis which might be the reason for refractory stricture in such patients.…”
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Non-Invasive Biomarkers and Breath Tests for Diagnosis and Monitoring of Chronic Liver Diseases by Pasawat Boon-yasidhi, Wikrom Karnsakul

“…Traditionally, liver biopsy has been the gold standard for evaluating liver fibrosis and other chronic liver conditions. However, biopsy’s invasiveness, associated risks, and sampling variability indicate the need for reliable, noninvasive alternatives. …”
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A combination of ursodeoxycholic acid and Allium sativum prevents liver cirrhosis in cholestatic rats by Pratama Nurmalik Adhuri, Neni Susilaningsih, Sigit Adi Prasetyo, Nani Maharani, Trilaksana Nugroho

“…Cholestasis causes liver cirrhosis due to chronic total obstruction, in which accumulated bile acids induce liver inflammation and fibrosis. Inflammatory conditions are associated with hypoalbuminemia, and changes in albumin levels indicate the patient's clinical condition. …”
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Combined Effects of PPARγ Agonists and Epidermal Growth Factor Receptor Inhibitors in Human Proximal Tubule Cells by Katherine Pegg, Jie Zhang, Carol Pollock, Sonia Saad

“…Our data suggests that combination of an EGFR inhibitor and a PPARγ agonist mitigates high-glucose-induced fibrosis and inflammation and reverses the upregulation of transporters and channels involved in sodium and water retention in human proximal tubule cells. …”
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The histopathological and functional consequences of microplastic exposure by Yujeong Lee, Minkyoung Sung, Soo-Eun Sung, Joo-Hee Choi, Kyung-Ku Kang, Jae Woo Park, Ye-jin Kim, Sijoon Lee

“…Except in the nervous system, the main morphological changes involve degenerative changes throughout the body, such as apoptosis, inflammation, and fibrosis. Most changes were induced by inflammatory responses to microplastics, leading to fibrosis and subsequent functional impairments. …”
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Post Covid-19 Syndromes, The Time line of Covid by Nadia Shams, Zaid Umar, Lubna Meraj, Neelam Ayub, Muhammad Waseem, Kazim Abbas Virk

“…Persistent post-Covid syndrome (PPCS), Myocarditis. Lung Fibrosis.   …”
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Validation of the Chronic Liver Disease Questionnaire for MASH (CLDQ-MASH) by Zobair M. Younossi, Maria Stepanova, Issah Younossi, Andrei Racila

“…In a subsample of subjects with 1-year follow-up, the instrument was responsive to changes in Enhanced Liver Fibrosis® scores and liver stiffness measurements (p <0.05 for four to six domains). …”
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Liver sinusoidal endothelial cells regulate the balance between hepatic immunosuppression and immunosurveillance by Kimberly N. Kremer, Hadeel A. Khammash, Anjelica M. Miranda, Lauren N. Rutt, Shannon M. Twardy, Paige E. Anton, Margaret L. Campbell, Christian Garza-Ortiz, David J. Orlicky, Roberta Pelanda, Rebecca L. McCullough, Raul M. Torres

“…Repair of liver injury is initiated by interactions between injured hepatocytes and liver sinusoidal endothelial cells (LSEC), however, chronic injury can lead to fibrosis. Here, using a diethylnitrosamine/carbon tetrachloride (DEN/CCl4) mouse model of early HCC development, we demonstrate that chronic liver injury and fibrosis are sufficient to induce a CD8 T cell exhaustion signature with a corresponding increase in expression of immunosuppressive molecules on LSEC. …”
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Spironolactone Protects against Diabetic Cardiomyopathy in Streptozotocin-Induced Diabetic Rats by Wenjuan Liu, Wei Gong, Min He, Yemei Liu, Yeping Yang, Meng Wang, Meng Wu, Shizhe Guo, Yifei Yu, Xuanchun Wang, Fei Sun, Yiming Li, Linuo Zhou, Shengmei Qin, Zhaoyun Zhang

“…Compared to the STZ + NS group, cardiac oxidative stress, fibrosis, inflammation, and mitochondrial dysfunction were improved by SPR treatment. …”
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miRNAs and Hematological Markers in Non-Alcoholic Fatty Liver Disease—A New Diagnostic Path? by Agata Michalak, Małgorzata Guz, Joanna Kozicka, Marek Cybulski, Witold Jeleniewicz, Ilona Telejko, Karolina Szczygieł, Ewa Tywanek, Halina Cichoż-Lach

“…Therefore, we decided to explore relationships between selected types of microRNAs (miRNAs), serological markers of liver fibrosis and hematological parameters in the course of non-alcoholic fatty liver disease (NAFLD). …”
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