Alpha Mangostin Inhibits the Proliferation and Activation of Acetaldehyde Induced Hepatic Stellate Cells through TGF-β and ERK 1/2 Pathways by Novriantika Lestari, Melva Louisa, Vivian Soetikno, Averina Geffanie Suwana, Putra Andito Ramadhan, Taufiq Akmal, Wawaimuli Arozal

“…Liver fibrosis is characterized by excessive accumulation of extracellular matrix in chronic liver injury. …”
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Interface Hepatitis over Grade 2 May Differentiate Chronic Inflammation Associated with CHB from NAFLD in the Early Stage by Yong-fen Zhu, Jin Wang, Jia-zhui Fang, Qiao Yang, Fang-fang Lv

“…After fibrosis matching, in patients with F0–2 fibrosis, the rate of interface hepatitis over grade 2 in CHB was significantly higher than that in NAFLD (100% vs. 0%; P<0.0001). …”
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Transient Elastography in Alcoholic Liver Disease and Nonalcoholic Fatty Liver Disease: A Systemic Review and Meta-Analysis by Changzhou Cai, Xin Song, Xueyang Chen, Weihua Zhou, Qi Jin, Shenghui Chen, Feng Ji

“…In patients with ALD/NAFLD, CAP was feasible for identifying and screening steatosis, and LSM was accurate for diagnosing fibrosis, especially severe fibrosis and cirrhosis.…”
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Daclatasvir and Sofosbuvir Therapy Enhance Monocyte Phenotypic Changes in Naive Chronic Hepatitis C Patients: A Prospective Cohort Study by Hanan M. Fayed, Ali A. Ghweil, Mona M. AbdelMeguid

“…We aimed to investigate changes in the circulating monocyte phenotypes in response to Daclatasvir-Sofosbuvir (SOF/DCV) therapy in chronic hepatitis C (CHC) and relate findings to the viral kinetics and the fibrosis score. Methods. A longitudinal study involving 100 treatment-naïve patients and 30 healthy controls, tested for liver function, fibrosis scores (AST to platelet ratio index, FIB-4), and blood monocyte subsets based on CD14/CD16 expression by flow cytometer. …”
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Non-alcoholic fatty liver disease: comparative assessment of diagnostic and treatment approaches in the Russian Federation and People’s Republic of China by M. Ch. Semenistaya, Fan Jian-Gao, O. B. Velichenko, Ye. A. Kuznetsova, Ch. S. Pavlov

“…According to the international clinical guidelines, NAFLD screening methods should include elastometry and serological tests to rule out severe liver fibrosis (F> 2). Liver biopsy is carried out at contradictory data of liver elastometry and serological fibrosis markers. …”
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Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) in People Living With HIV Attending Centre of Excellence in HIV Care at a Tertiary Level Teaching Hospital in North... by Ragini Ram, Anuradha Subramanian MD, MSc, FRCP, Rajeshwari K. MD, PhD, FRCPCH

“…While on FIB4 scoring, 4 subjects had scores suggesting stage 0-1 fibrosis while 1 had a score suggestive of stage 4-6 fibrosis as per Ishak Fibrosis staging. …”
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Cardiac Function Remains Impaired Despite Reversible Cardiac Remodeling after Acute Experimental Viral Myocarditis by Peter Moritz Becher, Frauke Gotzhein, Karin Klingel, Felicitas Escher, Stefan Blankenberg, Dirk Westermann, Diana Lindner

“…Interestingly, cardiac fibrosis declined to basal levels as well. Both cardiac inflammation and fibrosis were reversible, whereas the hemodynamic function remains impaired after healed viral myocarditis in C57BL/6J mice.…”
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Diagnostic Value of the 13C Methacetin Breath Test in Various Stages of Chronic Liver Disease by Hamizah Razlan, Nurhayaty Muhamad Marzuki, Mei-Ling Sharon Tai, Azhar-Shah Shamsul, Tze-Zen Ong, Sanjiv Mahadeva

“…Area under curve values for fibrosis was 0.62 (0.39–0.86), whilst that for cirrhosis (all stages) was 0.95 (0.91–0.99). …”
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miR-29c Inhibits Renal Interstitial Fibrotic Proliferative Properties through PI3K-AKT Pathway by Weifeng Feng, Huijun Xie, Jiong Li, Xianxin Yan, Shiping Zhu, Shengyun Sun

“…Renal fibrosis, in particular tubulointerstitial fibrosis, which is characterized by an increased extracellular matrix (ECM) formation and development in the interstitium, is the common end pathway for nearly all progressive kidney disorders. …”
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Establishment and Mechanism Study of a Primary Ovarian Insufficiency Mouse Model Using Lipopolysaccharide by Si-Ji Lv, Shu-Hui Hou, Lei Gan, Jing Sun

“…Histopathological examination was performed to examine ovarian fibrosis. TUNEL assay was carried out to evaluate granulosa cell apoptosis. …”
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Syndecan-1: A Review on Its Role in Heart Failure and Chronic Liver Disease Patients’ Assessment by Radu-Stefan Miftode, Ionela-Lăcrămioara Şerban, Amalia-Stefana Timpau, Ionela-Larisa Miftode, Adriana Ion, Ana-Maria Buburuz, Alexandru-Dan Costache, Irina-Iuliana Costache

“…Syndecan-1—a transmembrane proteoglycan that exerts its functions mainly via its heparane sulfate chains—is a very promising biomarker, correlated not only with the degree of cardiac fibrosis but also with the severity of liver fibrosis. …”
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A Fibromatosis Case Mimicking Abdominal Aorta Aneurysm by Arzu Tasdemir, Cemal Kahraman, Kutay Tasdemir, Ertugrul Mavili

“…Retroperitoneal fibrosis is a rare fibrosing reactive process that may be confused with mesenteric fibromatosis. …”
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Correlation of severity of alcohol dependence with liver dysfunction (by transient elastography) in freshly diagnosed cases of alcohol dependence syndrome by Guggilla Madhusudhan, Kartikeya R Singh, Om Panda, Priyadarshee Patra

“…According to Alcohol Use Disorders Identification Test, 38% had a medium-to-severe risk of harmful alcohol consumption. Liver fibrosis assessment showed that 63.8% had no or mild fibrosis on day 1, increasing to 81.0% by day 28. …”
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A New Hope for the Patients of Non‐Alcoholic Steatohepatitis: FDA Gives Green Signal for Resmetirom Use by Abdul Haseeb Hasan, Muhammad Ali Abid, Muhammad Hafi Abid, Laiba Suhail, Abubakar Nazir

“…Results Resmetirom demonstrated efficacy in resolving NASH without fibrosis progression and improving fibrosis scores in patients with biopsy‐confirmed NASH. …”
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Inflammation and ER Stress Downregulate BDH2 Expression and Dysregulate Intracellular Iron in Macrophages by Susu M. Zughaier, Brandon B. Stauffer, Nael A. McCarty

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Reconstructing skeletal homeostasis through allogeneic hematopoietic stem cell transplantation in myelofibrosis by Mathias Schäfersküpper, Alexander Simon, Timur A. Yorgan, Felix N. von Brackel, Maximilian M. Delsmann, Anke Baranowsky, Nico Gagelmann, Francis Ayuk, Thorsten Schinke, Michael Amling, Nicolaus Kröger, Tim Rolvien

“…Abstract Myeloproliferative neoplasm-associated myelofibrosis is a clonal stem cell process characterized by pronounced bone marrow fibrosis associated with extramedullary hematopoiesis and splenomegaly. …”
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Resveratrol Inhibits Hepatic Stellate Cell Activation via the Hippo Pathway by Chunxue Li, Rongrong Zhang, Yating Zhan, Jianjian Zheng

“…In recent years, Res has been found to inhibit liver fibrosis. Enhanced Hippo pathway activation has also been reported to inhibit tumor progression and liver fibrosis. …”
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Emphysema Then and Now by William M Thurlbeck

“…The presence of fibrosis should not preclude emphysema by definition. …”
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Animal Models of Chronic Pancreatitis by Makoto Otsuki, Mitsuyoshi Yamamoto, Taizo Yamaguchi

“…However, the damaged tissue was replaced by fatty tissue without fibrosis. Continuous pancreatic ductal hypertension (PDH) caused diffuse interlobular and intralobular fibrosis closely resembling human CP.…”
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The Extracellular Matrix Contributes to Mechanotransduction in Uterine Fibroids by Phyllis C. Leppert, Friederike L. Jayes, James H. Segars

“…Fibrosis affects cell growth by mechanotransduction, the dynamic signaling system whereby mechanical forces initiate chemical signaling in cells. …”
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