Novel FRET‐Based Biosensors for Real‐Time Monitoring of Estrogen Receptor Dimerization and Translocation Dynamics in Living Cells by Kiseok Han, Jung‐Soo Suh, Gyuho Choi, Yoon‐Kwan Jang, Sanghyun Ahn, Yerim Lee, Tae‐Jin Kim

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Placement of an elastic, biohybrid patch in a model of right heart failure with pulmonary artery banding by Yasunari Hayashi, Yasunari Hayashi, Seungil Kim, Seungil Kim, Seungil Kim, Taro Fujii, Taro Fujii, Drake Dalton Pedersen, Drake Dalton Pedersen, Takahiro Ozeki, Takahiro Ozeki, Hongbin Jiang, Antonio D’Amore, Antonio D’Amore, Antonio D’Amore, Antonio D’Amore, Antonio D’Amore, William R. Wagner, William R. Wagner, William R. Wagner

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Airway MMP-12 and DNA methylation in COPD: an integrative approach by Jonas Eriksson Ström, Simon Kebede Merid, Robert Linder, Jamshid Pourazar, Anne Lindberg, Erik Melén, Annelie F. Behndig

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Mesenchymal stem cell and exosome-based therapy for liver diseases: can it overcome conventional therapeutic inconsistencies? by Zahid Hussain

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A Cellular Potts model simulating cell migration on and in matrix environments by Marco Scianna, Luigi Preziosi, Katarina Wolf

“…Cell migration on and through extracellular matrix is fundamental ina wide variety of physiological and pathological phenomena, and isexploited in scaffold-based tissue engineering. …”
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Phenotypic and Functional Changes of Endothelial and Smooth Muscle Cells in Thoracic Aortic Aneurysms by Anna Malashicheva, Daria Kostina, Aleksandra Kostina, Olga Irtyuga, Irina Voronkina, Larisa Smagina, Elena Ignatieva, Natalia Gavriliuk, Vladimir Uspensky, Olga Moiseeva, Jarle Vaage, Anna Kostareva

“…Cellular proliferation, migration, and synthesis of extracellular matrix proteins are attenuated in the cells of the patients. …”
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Novel Artificial Biofilm Equivalent for Denture Surfaces: A Pilot Study by Jan-Philipp Kunze, Klaus Boening, Heike Meissner, Katarzyna Kresse-Walczak

“…The microbial population of the dental biofilm is embedded in an extracellular matrix that contains organic polymers such as polysaccharides. …”
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The comprehensive assessment of epigenetics changes during skin development by Li Lei, Ling Jiang, Yibo Hu, Menglu Chen, Jinhua Huang, Jing Chen, Qinghai Zeng

“…Epigenetic effectors such as IGF2BP2, GATA2, GATA3, CPA4 and CDK1 were significantly correlated with extracellular matrix organization, and VEGFA, CDK1 and PRKCB with skin immune function. …”
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Engineering a Biocompatible Scaffold with Either Micrometre or Nanometre Scale Surface Topography for Promoting Protein Adsorption and Cellular Response by Xuan Le, Gérrard Eddy Jai Poinern, Nurshahidah Ali, Cassandra M. Berry, Derek Fawcett

“…The nanometre-structured surface features tend to resemble the extracellular matrix, the natural environment in which cells live, communicate, and work together. …”
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The Role of Decorin in Autoimmune and Inflammatory Diseases by Yuanji Dong, Jixin Zhong, Lingli Dong

“…Decorin is an extracellular matrix protein that belongs to the family of small leucine-rich proteoglycans. …”
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Role of Matrix Metalloproteinases in Angiogenesis and Its Implications in Asthma by Khuloud Bajbouj, Rakhee K. Ramakrishnan, Qutayba Hamid

“…In addition to facilitating extracellular matrix turnover, these proteolytic enzymes cleave bioactive molecules, thereby regulating cell signaling. …”
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Novel Nanomaterials Enable Biomimetic Models of the Tumor Microenvironment by Marshall Hunter Joyce, Shane Allen, Laura Suggs, Amy Brock

“…In the complex tumor microenvironment, chemical and mechanical signals from tumor cells, stromal cells, and the surrounding extracellular matrix influence all aspects of disease progression and response to treatment. …”
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Fibronectin and Cyclic Strain Improve Cardiac Progenitor Cell Regenerative Potential In Vitro by Kristin M. French, Joshua T. Maxwell, Srishti Bhutani, Shohini Ghosh-Choudhary, Marcos J. Fierro, Todd D. Johnson, Karen L. Christman, W. Robert Taylor, Michael E. Davis

“…This work aims to assess the influence of two distinct signaling moieties on CPCs: cyclic biaxial strain and extracellular matrix. We evaluate four endpoints for improving CPC therapy: paracrine signaling, proliferation, connexin43 expression, and alignment. …”
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Alpha Lipoic Acid Modulated High Glucose-Induced Rat Mesangial Cell Dysfunction via mTOR/p70S6K/4E-BP1 Pathway by Chuan Lv, Can Wu, Yue-hong Zhou, Ying Shao, Guan Wang, Qiu-yue Wang

“…The aim of this study was to investigate whether alpha lipoic acid (LA) regulates high glucose-induced mesangial cell proliferation and extracellular matrix production via mTOR/p70S6K/4E-BP1 signaling. …”
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Cellular Origins of Regenerating Nodules and Malignancy in the FAH Model of Liver Injury after Bone Marrow Cell Transplantation by Pei-Rong Wang, Yi Li

“…There was higher expression of extracellular matrix proteins and more inflammatory cells in liver tumor nodules than in regenerating normal liver nodules. …”
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Functional Live-Cell Imaging Demonstrates that β-Integrin Promotes Type IV Collagen Degradation by Breast and Prostate Cancer Cells by Mansoureh Sameni, Julie Dosescu, Kenneth M. Yamada, Bonnie F. Sloane, Dora Cavallo-Medved

“…Here we conducted functional live-cell imaging in real time to investigate the effects of modulating β 1 -integrin expression and function on proteolytic remodeling of the extracellular matrix. Human breast and prostate cancer cells were grown on reconstituted basement membrane containing a quenched fluorescent form of collagen IV. …”
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Timp2 loss-of-function mutation and TIMP2 treatment in a murine model of NSCLC: Modulation of immunosuppression and oncogenic signaling by David Peeney, Sarvesh Kumar, Tej Pratap Singh, Yueqin Liu, Sandra M. Jensen, Ananda Chowdhury, Sasha Coates-Park, Joshua Rich, Sadeechya Gurung, Yu Fan, Daoud Meerzaman, William G. Stetler-Stevenson

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Electrospun Nanostructured Fibers of Collagen-Biomimetic Apatite on Titanium Alloy by Michele Iafisco, Ismaela Foltran, Simona Sabbatini, Giorgio Tosi, Norberto Roveri

“…., bone implant contact) can be obtained by the application of a material that mimics the bone extracellular matrix. To this aim, this work describes a new method to produce nanostructured collagen-apatite composites on titanium alloy substrate, by combining electrospinning and biomimetic mineralization. …”
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Is hyaluronan deposition in the stroma of pancreatic ductal adenocarcinoma of prognostic significance? by Florian Gebauer, Marius Kemper, Guido Sauter, Peter Prehm, Udo Schumacher

“…In contrast, HABP staining was generally confined to the extracellular matrix and was completely abolished by hyaluronidase pretreatment. …”
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Fibrin and Collagen Differentially but Synergistically Regulate Sprout Angiogenesis of Human Dermal Microvascular Endothelial Cells in 3-Dimensional Matrix by Xiaodong Feng, Marcia G. Tonnesen, Shaker A. Mousa, Richard A. F. Clark

“…Angiogenesis is a highly regulated event involving complex, dynamic interactions between microvascular endothelial cells and extracellular matrix (ECM) proteins. Alteration of ECM composition and architecture is a hallmark feature of wound clot and tumor stroma. …”
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