Endocrine Actions of Osteocalcin by Aurora Patti, Luigi Gennari, Daniela Merlotti, Francesco Dotta, Ranuccio Nuti

“…Once transcribed, this protein undergoes posttranslational modifications within osteoblastic cells before its secretion, including the carboxylation of three glutamic residues in glutamic acid, which is essential for hydroxyapatite binding and deposition in the extracellular matrix of bone. Recent provocative data from experimental observations in mice showed that the circulating undercarboxylated fraction of osteocalcin increases insulin secretion and sensitivity, lowers blood glucose, and decreases visceral fat in both genders, while it enhances testosterone production by the testes in males. …”
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Matrix Gla Protein Binds to Fibronectin and Enhances Cell Attachment and Spreading on Fibronectin by Satoru Ken Nishimoto, Miyako Nishimoto

“…Matrix Gla protein (MGP) is a vitamin K-dependent, extracellular matrix protein. MGP is a calcification inhibitor of arteries and cartilage. …”
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Contributions of Matrix Metalloproteinases to Neural Plasticity, Habituation, Associative Learning and Drug Addiction by John W. Wright, Joseph W. Harding

“…., neural plasticity) by degrading cell adhesion molecules (CAMs) designed to provide stability to those extracellular matrix (ECM) proteins that form scaffolding supporting neurons and glia. …”
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Vertex model with internal dissipation enables sustained flows by Jan Rozman, KVS Chaithanya, Julia M. Yeomans, Rastko Sknepnek

“…Here we extend an active nematic vertex model by replacing substrate friction with internal viscous dissipation, dominant in epithelia not supported by a substrate or the extracellular matrix, which are found in many early-stage embryos. …”
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Dissolving microneedle patch loaded with adipokines-enriched adipose extract relieves atopic dermatitis in mouse via modulating immune disorders, microbiota imbalance, and skin bar... by Jingyan Guan, Kaiqi Chen, Feng Lu, Yunfan He

“…This research group previously developed a physically extracted adipose-derived extracellular matrix named adipose collagen fragments (ACF), which was determined containing massive adipose matrix-bound adipokines and medicable on AD through intradermal injection. …”
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Nucleus pulposus cell network modelling in the intervertebral disc by Sofia Tseranidou, Maria Segarra-Queralt, Francis Kiptengwer Chemorion, Christine Lyn Le Maitre, Janet Piñero, Jérôme Noailly

“…Abstract Intervertebral disc degeneration (IDD) results from an imbalance between anabolic and catabolic processes in the extracellular matrix (ECM). Due to complex biochemical interactions, a comprehensive understanding is needed. …”
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Recent Advances in Pharmacotherapy Development for Abdominal Aortic Aneurysm by Koichi Yoshimura, Hiroki Aoki

“…Advances in AAA research revealed that activation of inflammatory signaling pathways through proinflammatory mediators shifts the balance of extracellular matrix (ECM) metabolism toward tissue degradation. …”
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Glia detect and transiently protect against dendrite substructure disruption in C. elegans by Katherine C. Varandas, Brianna M. Hodges, Lauren Lubeck, Amelia Farinas, Yupu Liang, Yun Lu, Shai Shaham

“…We demonstrate that disruption of C. elegans sensory neuron dendrite cilia elicits acute glial responses, including increased accumulation of glia-derived extracellular matrix around cilia, changes in gene expression, and alteration of secreted protein repertoire. …”
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Astrocyte-Secreted Matricellular Proteins in CNS Remodelling during Development and Disease by Emma V. Jones, David S. Bouvier

“…Matricellular proteins are secreted, nonstructural proteins that regulate the extracellular matrix (ECM) and interactions between cells through modulation of growth factor signaling, cell adhesion, migration, and proliferation. …”
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Progress on long non-coding RNAs in calcific aortic valve disease by Yan Shen, Jiahui Li, Zehao Zhao, Xiaomin Chen

“…The aortic valve, influenced by factors such as endothelial dysfunction, inflammation, oxidative stress, lipid metabolism disorders, calcium deposition, and extracellular matrix remodeling, undergoes fibrosis and calcification, ultimately leading to stenosis. …”
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Biological Events in Periodontal Ligament and Alveolar Bone Associated with Application of Orthodontic Forces by L. Feller, R. A. G. Khammissa, I. Schechter, G. Thomadakis, J. Fourie, J. Lemmer

“…Orthodontic force-induced stresses cause dynamic alterations within the extracellular matrix and within the cytoskeleton of cells in the periodontal ligament and alveolar bone, mediating bone remodelling, ultimately enabling orthodontic tooth movement. …”
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A mathematical model of mechanotransduction by Bradley J. Roth

“… This article reviews the mechanical bidomain model, a mathematical description of how the extracellular matrix and intracellular cytoskeleton of cardiac tissue are coupled by integrin membrane proteins. …”
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An Analysis of the Mechanical Properties of the Ponseti Method in Clubfoot Treatment by Murtaza Kadhum, Mu-Huan Lee, Jan Czernuszka, Chris Lavy

“…This triggers extracellular matrix remodeling and tissue growth, but due to the viscoelastic properties of tendons and ligaments, the initial strain size, rate, and loading history will affect the relaxation behavior and mechanical strength of the tissue. …”
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Homocysteine and Hypertension in Diabetes: Does PPARγ Have a Regulatory Role? by Utpal Sen, Suresh C. Tyagi

“…Homocysteine induces oxidative injury of vascular endothelial cells, involved in matrix remodeling through modulation of the matrix metalloproteinase (MMP)/tissue inhibitor of metalloproteinase (TIMP) axis, and increased formation and accumulation of extracellular matrix protein, such as collagen. In heart this leads to increased endothelial-myocyte uncoupling resulting in diastolic dysfunction and hypertension. …”
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Endothelial Dysfunction and Diabetes: Effects on Angiogenesis, Vascular Remodeling, and Wound Healing by Gopi Krishna Kolluru, Shyamal C. Bir, Christopher G. Kevil

“…It is well known that type 2 DM causes amplification of the atherosclerotic process, endothelial cell dysfunction, glycosylation of extracellular matrix proteins, and vascular denervation. …”
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Using Platelet-Rich Fibrin to Remove Graphite Tattoos May Yield Excellent Long-Term Result by Young Joon Cho, Yong Tak Jeong, Tae Hee Lee, Hyun Woo Cho

“…The entire pigmented gingiva was surgically removed and covered with two layers of PRF membrane to protect the exposed bone surface and provide an extracellular matrix for migration of gingival fibroblasts. …”
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Regulation of the G1/S Transition in Hepatocytes: Involvement of the Cyclin-Dependent Kinase Cdk1 in the DNA Replication by Anne Corlu, Pascal Loyer

“…Finally, we provided strong evidences that Cdk1 expression and activation is correlated to extracellular matrix degradation upon stimulation by the pro-inflammatory cytokine TNFα leading to the identification of a new signaling pathway regulating Cdk1 expression at the G1/S transition. …”
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PPARγ as a Novel Therapeutic Target in Lung Cancer by Aravind T. Reddy, Sowmya P. Lakshmi, Raju C. Reddy

“…Angiogenesis and secretion of certain matrix metalloproteinases and extracellular matrix proteins within the tumor microenvironment are also regulated by PPARγ. …”
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A polysaccharide-based hydrogel platform for tumor spheroid production and anticancer drug screening by Elliot Lopez-Vince, Teresa Simon-Yarza, Claire Wilhelm

“…Abstract Extracellular matrix mimics are still needed to grow cancer cells in 3D environments and study their evolution in vitro while precisely controlling relevant features. …”
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The Role of Glucose, Serum, and Three-Dimensional Cell Culture on the Metabolism of Bone Marrow-Derived Mesenchymal Stem Cells by Byron Deorosan, Eric A. Nauman

“…The results indicate that glucose and extracellular matrix were significant factors in the metabolic response of the cells. …”
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