Image inpainting forensics method based on dual branch network by Dengyong ZHANG, Huang WEN, Feng LI, Peng CAO, Lingyun XIANG, Gaobo YANG, Xiangling DING

“…Image inpainting is a technique that uses information from known areas of an image to repair missing or damaged areas of the image.Image editing software based on it has made it easy to edit and modify the content of digital images without any specialized foundation.When image inpainting techniques are used to maliciously remove the content of an image, it will cause confidence crisis on the real image.Current researches in image inpainting forensics can only effectively detect a certain type of image inpainting.To address this problem, a passive forensic method for image inpainting was proposed, which is based on a two-branch network.The high-pass filtered convolutional network in the dual branch first used a set of high-pass filters to attenuate the low-frequency components in the image.Then features were extracted using four residual blocks, and two transposed convolutions were performed with 4x up-sampling to zoom in on the feature map.And thereafter a 5×5 convolution was used to attenuate the tessellation artifacts from the transposed convolutions to generate a discriminative feature map on the high-frequency components of the image.The dual-attention feature fusion branch in the dual branch first added a local binary pattern feature map to the image using a preprocessing block.Then the dual-attention convolution block was used to adaptively integrate the image’s local features and global dependencies to capture the differences in content and texture between the inpainted and pristine regions of the image.Additionally, the features extracted from the dual-attention convolution block were fused, and the feature maps were up-sampled identically to generate the discriminative image content and texture on the feature maps.The extensive experimental results show the proposed method improved the F1 score by 2.05% and the Intersection over Union(IoU) by 3.53% for the exemplar-based method and by 1.06% and 1.22% for the deep-learning-based method in detecting the inpainted region of the removed object.Visualization of the results shows that the edges of the removed objects can be accurately located on the detected inpainted area.…”
Get full text

Toll-like receptors in atopic dermatitis: pathogenesis and therapeutic implications by Ahmad Vafaeian, Fateme Rajabi, Nima Rezaei

“…Future directions include CRISPR-based gene editing to understand TLR functions, development of specific TLR modulators for targeted therapy, and machine learning applications to predict drug responses and identify novel ligands. …”
Get full text

RNA modification writer-based immunological profile and genomic landscape of tumor microenvironment in lung adenocarcinoma by Qiang Xu, Lingyu Kong, Zhezhu Han, Xiuying Jin, Mingyan Ding, Zhengri Piao, Songnan Zhang

“…Methods We assessed the expression properties and genetic alterations of 26 RNA modification writers, including adenosine-to-inosine RNA editing, alternative polyadenylation, m1A, and m6A in 502 lung adenocarcinoma (LUAD) samples from the Cancer Genome Atlas (TCGA) datasets. …”
Get full text

Functional characterization in Chimonobambusa utilis reveals the role of bHLH gene family in bamboo sheath color variation by Long Tong, Long Tong, Long Tong, Qingping Zeng, Yuan Guo, Yanjie Li, Hongyan Li, Lijie Chen, Xia Liu

“…We suggest that these findings will contribute to both scientific research and commercial bamboo cultivation through gene editing technology in the future.…”
Get full text

Teaching Academic English to Russian-speaking Academic Staff: The Case of the Office of Academic Writing by M. A. Chernysheva, A. O. Kozlova, E. V. Donova

“…Upon completion of these programs, authors of scientific papers gain knowledge about the basics of academic writing, the structure of a scientific paper, the English scientific style and its lexical and grammatical features, as well as editing a paper, working with scientific citation databases, and elaborating a publishing strategy. …”
Get full text

Engineering synthetic signaling receptors to enable erythropoietin-free erythropoiesis by Aadit P. Shah, Kiran R. Majeti, Freja K. Ekman, Sridhar Selvaraj, Devesh Sharma, Roshani Sinha, Eric Soupene, Prathamesh Chati, Sofia E. Luna, Carsten T. Charlesworth, Travis McCreary, Benjamin J. Lesch, Tammy Tran, Simon N. Chu, Matthew H. Porteus, M. Kyle Cromer

“…To address this challenge, we develop highly optimized small molecule-inducible synthetic EPO receptors (synEPORs) using design-build-test cycles and genome editing. By integrating synEPOR at the endogenous EPOR locus in O-negative induced pluripotent stem cells, we achieve equivalent erythroid differentiation, transcriptomic changes, and hemoglobin production using small molecules compared to EPO-supplemented cultures. …”
Get full text

Appliances of Generative AI-Powered Language Tools in Academic Writing: A Scoping Review by Lilia Raitskaya, Елена Тихонова

“…The potential of AI language tools embraces many functions (text generation, proofreading, editing, text annotation, paraphrasing and translation) and provides for assistance in research and academic writing, offers strategies for hybrid AI-powered writing of various assignments and genres and improvements in writing quality. …”
Get full text

Application Strategies of Super-Enhancer RNA in Cardiovascular Diseases by Yi He, Yuwei Cai, Yanyan Cao, Yan Wang, Jing Wang, Hu Ding

“…In addition, the use of gene editing techniques to modify relevant eRNA introduces new possibilities for disease treatment. …”
Get full text

Transforming an azaarene into the spine of fusedbicyclics via cycloaddition-induced scaffold hopping of 5-Hydroxypyrazoles by You Zhou, Shuang-Gui Lei, Baihetiguli Abudureheman, Li-Sheng Wang, Zhi-Cheng Yu, Jia-Chen Xiang, An-Xin Wu

“…Abstract Skeleton editing for heteroarenes, especially pyrazoles, is challenging and remains scarce because these non-strained aromatics exhibit inert reactivities, making them relatively inactive for performing a dearomatization/cleavage sequence. …”
Get full text

GENEALOGI PEMIKIRAN ANGELIKA NEUWIRTH TENTANG TARTIB NUZULI SEBAGAI METODE PENAFSIRAN AL-QUR’AN by Asyrifah Luthfiana Azmi, Nurun Nisaa Baihaqi, Aidah Mega Kumalasari

“…Pemikiran Neuwirth tentang marginalisasi yakni kritiknya terhadap riset akademis yang berfokus pada teks- teks pasca- editing daripada menyampaikan aspek- aspek pra- kanonisasinya.. …”
Get full text

Allelic differences in the key genes of betalain biosynthesis in table beet accessions with contrasting root color from the VIR collection by A. S. Mikhailova, D. V. Sokolova, N. A. Shvachko, V. S. Popov, E. K. Khlestkina

“…It is possible to identify the best table beet accessions for further genome editing among a previously selected high-betanin group. …”
Get full text

Optimization of determination and application of complexly distributed loads on a double curvature cable-stayed covering by V. A. Dagaev, G. M. Purvin, F. S. Shkoliar

“…This direction allows to get away from more labour-intensive and time-consuming processes of manual editing of graphic materials. This approach to architectural design is called parametric modelling. …”
Get full text

APOBEC3C‐mediated NF‐κB activation enhances clear cell renal cell carcinoma progression by Nora Hase, Danny Misiak, Helge Taubert, Stefan Hüttelmaier, Michael Gekle, Marcel Köhn

“…Here, we unveil that the enhanced expression of the RNA‐binding protein DNA dC → dU‐editing enzyme APOBEC‐3C (APOBEC3C; also known as A3C) in ccRCC tissue and ccRCC‐derived cell lines serves as a catalyst for tumor growth by amplifying nuclear factor‐kappa B (NF‐κB) activity. …”
Get full text

Shared rare genetic variants in multiplex autism families suggest a social memory gene under selection by Kang Seon Lee, Taeyeop Lee, Mujun Kim, Elizaveta Ignatova, Hyo-Jeong Ban, Min Kyung Sung, Younghoon Kim, Youn-Jae Kim, Jin-Hee Han, Jung Kyoon Choi

“…The results of our population genetic and evolutionary analyses, behavior experiments, and genome editing propose a molecular mechanism that may confer a selective advantage through social memory enhancement and may cause autism-related social impairment when disrupted in humans. …”
Get full text

Loss of protein C vs protein S results in discrepant thrombotic phenotypes by Chia-Jui Ku, Xinge Yu, Queena Y. Zhao, Steven J. Grzegorski, Jeffrey G. Daniel, Allison C. Ferguson, Jordan A. Shavit

“…Here, we generate proc (zebrafish PROC ortholog) and pros1 knockouts through genome editing in zebrafish and uncover partially discordant phenotypes. proc−/− mutants exhibited ∼70% lethality at 1 year of age, whereas pros1−/− survival was unaffected. …”
Get full text

Exploratory analysis of a Novel RACK1 mutation and its potential role in epileptic seizures via Microglia activation by Sai Zhang, Zhaofei Dong, Jing Guo, Ze Li, Hong Wu, Linming Zhang, Fuli Min, Tao Zeng

“…These effects were further validated in a mouse model using CRISPR/Cas9 gene editing technology. Mutant microglia exhibited increased activation and induced apoptosis in hippocampal neurons, leading to higher action potential frequency and excitatory synaptic marker expression. …”
Get full text

Generation and characterization of the LINC01405 knockout human embryonic stem cell line by Yaping Xu, Hongchun Wu, Jingxiu Jiang, Lingqun Ye, Kaili Hao, Kunjun Han, Shijun Hu, Wei Lei, Zhikun Guo

“…By utilizing the CRISPR/Cas9 gene editing system, we generated a LINC01405 knockout human embryonic stem cell (hESC) line. …”
Get full text

Resistance to viruses of potato: current status and prospects by S. S. Makarova, V. V. Makarov, M. E. Taliansky, N. O. Kalinina

“…Recently developed new genome editing technologies with the potential to be a powerful tool for gene design open up broad opportunities for development of next-generation resistance genes. …”
Get full text

Alkaloids of narrow-leaved lupine as a factor determining alternative ways of the crop’s utilization and breeding by M. A. Vishnyakova, A. V. Kushnareva, T. V. Shelenga, G. P. Egorova

“…Information is briefly presented about the genomic resources of the species and the prospects for their use in marker-assistant selection and genome editing.…”
Get full text

All Roads Lead to Rome: Pathways to Engineering Disease Resistance in Plants by Aziz Ul Ikram, Muhammad Saad Shoaib Khan, Faisal Islam, Sulaiman Ahmed, Tengfang Ling, Feng Feng, Zongtao Sun, Huan Chen, Jian Chen

“…Recent developments in genetic engineering, including efficient gene manipulation and transformation methods, gene editing and synthetic biology, coupled with the understanding of microbial pathogenicity and plant immunity, both at molecular and genomic levels, have enhanced the capabilities to develop disease resistance in plants. …”
Get full text