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The growth of eel fed with different protein level and protein-energy ratio
Published 2015-10-01Get full text
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Brucella osteoarthritis: recent progress and future directions
Published 2025-02-01Get full text
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Needs for rehabilitation in China: Estimates based on the Global Burden of Disease Study 1990–2019
Published 2025-01-01Get full text
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Protein kinase inhibitors as targeted therapy for glioblastoma: a meta-analysis of randomized controlled clinical trials
Published 2025-02-01“…For instance, when comparing PKI treatment with other treatments, median OS and PFS showed no significant difference (-0.78 months, 95 % CI, −2.12–0.55, p = 0.25; −0.23 months, 95 % CI, −0.79–0.34, p = 0.43, respectively), and similar non-significant results were observed in the pooled analyses (OS: HR = 0.89, 95 % CI, 0.59–1.32, p = 0.55; PFS: HR = 0.83, 95 % CI, 0.63–1.11, p = 0.21).Despite these overall negative findings, some data indicate improved clinical outcomes in a subset of GBM patients treated with certain PKIs (i.e., regorafenib) and encourage further research to identify PKIs with better blood-brain barrier penetration and lower risk for resistance development.…”
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A rare haplotype of the GJD3 gene segregating in familial Meniere’s disease interferes with connexin assembly
Published 2025-01-01“…Results We found an enrichment of rare missense variants in the GJD3 gene when comparing allelic frequencies in FMD (N = 94) with the Spanish reference population (OR = 3.9[1.92–7.91], FDR = 2.36E-03). In the GJD3 sequence, we identified a rare haplotype (TGAGT) composed of two missense, two synonymous, and one downstream variant. …”
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