Cell Wall Protein 2 as a Vaccine Candidate Protects Mice Against <i>Clostridioides difficile</i> Infection by Shaohui Wang, Joshua Heuler, Jessica Bullock, Junling Qin, Soumyadeep Chakraborty, Agbendeh Lubem Nathaniel, Shifeng Wang, Xingmin Sun

“…Background/Objectives: <i>Clostridioides difficile</i> is a Gram-positive, spore-forming enteric pathogen that causes intestinal disorders, including inflammation and diarrhea, primarily through toxin production. Standard treatment options for <i>C. difficile</i> infection (CDI) involve a limited selection of antibiotics that are not fully effective, leading to high recurrence rates. …”
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Development of a diagnostic multivariable prediction model of a positive SARS-CoV-2 RT-PCR result in healthcare workers with suspected SARS-CoV-2 infection in hospital settings. by Sandra Liliana Valderrama-Beltrán, Juliana Cuervo-Rojas, Martín Rondón, Juan Sebastián Montealegre-Diaz, Juan David Vera, Samuel Martinez-Vernaza, Alejandra Bonilla, Camilo Molineros, Viviana Fierro, Atilio Moreno, Leidy Villalobos, Beatriz Ariza, Carlos Álvarez-Moreno

“…The selected variables were age, socioeconomic status, occupation, service, symptoms (fever, cough, fatigue/weakness, diarrhea, anosmia or dysgeusia), asthma, history of SARS-CoV-2, vaccination status, and population-level RT-PCR positivity. …”
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Effects of orally administered clioquinol on the fecal microbiome of horses by Mikaila Z. Smith, Mary York, Kile S. Townsend, Lynn M. Martin, Tamara Gull, Lyndon M. Coghill, Aaron C. Ericsson, Philip J. Johnson

“…Abstract Background Whereas restoration of fecal consistency after treatment with clioquinol for chronic diarrhea and free fecal water syndrome has been attributed to its antiprotozoal properties, actions of clioquinol on the colonic bacterial microbiota have not been investigated. …”
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Classification of Nanomaterial Drug Delivery Systems for Inflammatory Bowel Disease by Wang H, Zhou F, Shen M, Ma R, Yu Q

“…Patients with IBD frequently experience recurrent abdominal pain and bloody diarrhea, while severe cases may result in intestinal obstruction, perforation, and cancer. …”
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Effect of Artemisia annua on anticoccidial action, intestinal microbiota and metabolites of Hu lambs by Shuaiqi Liu, Shiheng Li, Shuqi Cheng, Manyu Liu, Jing Li, Senyang Li, Xiaoying Li, Longxian Zhang, Fuchun Jian

“…Abstract Background Coccidia are among the primary pathogens causing diarrhea and even fatalities in lambs. With the increasing use of chemical drugs to treat coccidiosis, the problem of drug resistance is becoming more and more threatening. …”
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TRPV4 modulates inflammatory responses and apoptosis in enteric glial cells triggered by Clostridioides difficile toxins A and B by Dvison de Melo Pacífico, Deiziane Viana da Silva Costa, Maria Lucianny Lima Barbosa, Conceição Silva Martins Rebouças, Simone de Goes Simonato, Cirle Alcantara Warren, Maria Luana Gaudencio dos Santos Morais, Renata Ferreira de Carvalho Leitao, Gerly Anne de Castro Brito

“…Abstract Clostridioides difficile, a spore-forming anaerobic bacterium, is the primary cause of hospital antibiotic-associated diarrhea. Key virulence factors, toxins A (TcdA) and B (TcdB), significantly contribute to C. difficile infection (CDI). …”
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Prevalence, Risk Factors, and Antimicrobial Resistance Profiles of Thermophilic Campylobacter Species in Humans and Animals in Sub-Saharan Africa: A Systematic Review by Noel Gahamanyi, Leonard E. G. Mboera, Mecky I. Matee, Dieudonné Mutangana, Erick V. G. Komba

“…Electronic databases, namely, PubMed, Google Scholar, Research4life-HINARI Health, and Researchgate.net, were searched using the following search terms “thermophilic Campylobacter,” “Campylobacter jejuni,” “Campylobacter coli,” “diarrhea/diarrhoea,” “antimicrobial resistance,” “antibiotic resistance,” “humans,” “animals,” “Sub-Saharan Africa,” and “a specific country name.” …”
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In Vitro Antibacterial and Antioxidant Activities, Pharmacokinetics, and In Silico Molecular Docking Study of Phytochemicals from the Roots of Ziziphus spina-christi by Hadush Gebrehiwot, Urgessa Ensermu, Aman Dekebo, Milkyas Endale, Tariku Nefo Duke

“…Ziziphus spina-christi (Rhamnaceae family) is a medicinal plant traditionally used to treat dandruff, wounds, hair loss, diarrhea, mastitis, abdominal pain, and gastrointestinal complications. …”
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Predictive Model for the Risk of Severe Acute Malnutrition in Children by Olivier Mukuku, Augustin Mulangu Mutombo, Lewis Kipili Kamona, Toni Kasole Lubala, Paul Makan Mawaw, Michel Ntetani Aloni, Stanislas Okitotsho Wembonyama, Oscar Numbi Luboya

“…Low birth weight, history of recurrent or chronic diarrhea, daily meal’s number less than 3, age of breastfeeding’s cessation less than 6 months, age of introduction of complementary diets less than 6 months, maternal age below 25 years, parity less than 5, family history of malnutrition, and number of children under 5 over 2 were predictive factors of SAM. …”
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Suggestive Diagnostic Process in a Case of Multiple Myeloma with Gastrointestinal Immunoglobulin Light-Chain Amyloidosis Accompanied by Protein-Losing Enteropathy by Katsuya Endo, Takehito Ito, Jun Nomura, Keigo Murakami, Shiho Kondo, Tomonori Satoh, Daisuke Fukushi, Yuki Yoshino, Yoshiteru Sasaki, Atsuko Takasu, Takayuki Kogure, Morihisa Hirota, Takayoshi Meguro, Kazuhiro Murakami, Junichi Kameoka, Kennichi Satoh

“…The diagnostic process was suggestive, in that diarrhea and refractory leg edema related to protein-losing enteropathy were the primary symptoms and the trigger for making a sequential diagnosis of gastrointestinal AL amyloidosis and underlying multiple myeloma. …”
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Mirvetuximab Soravtansine in solid tumors: A systematic review and meta-analysis. by Shamsnur Rehim, Shuang Yuan, Hongjing Wang

“…The most common adverse effects were blurred vision (45.20%), nausea (40.13%), diarrhea (39.52%), fatigue (33.84%) and keratopathy (31.20%).…”
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Ten-year trends in clinical characteristics and outcome of children hospitalized with severe wasting or nutritional edema in Malawi (2011-2021): Declining admissions but worsened c... by Mphatso Nancy Chisala, Celine Bourdon, Emmanuel Chimwezi, Allison I Daniel, Chikondi Makwinja, Dominic Wang, Linnea Weise, Isabel Potani, Emmie Mbale, Robert J H Bandsma, Wieger P Voskuijl

“…Age, wasting, having both dehydration and diarrhea, or having vomiting, cough, or difficulty breathing were associated with mortality but these associations did not show any interaction over time.…”
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Gross and Histopathology of Goats Feeding on Opuntia stricta in Laikipia County, Kenya by Jackson M. Ncebere, Paul G. Mbuthia, Robert M. Waruiru, Peter K. Gathumbi

“…Clinically, goats affected by O. stricta had poor body condition, wounds on various body parts, and diarrhea. Variable numbers of O. stricta spines occurred externally on the skin throughout the body and elicited pain, swelling, and ulcerative wounds on affected parts. …”
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Seroprevalence of bovine Herpesvirus-1, bovine viral diarrhoea virus, Neospora caninum and Coxiella burnetii in dairy cows in Ethiopia by Gebrerufael Girmay, Bezina Arega Emeru, Desiye Tesfaye Tegegne, Shelema Kelbesa Bora, Workitu Firomsa Gudeta, Betelhem Seyoum Dersso, Beksisa Urge Hurrisa, Gebremeskel Mamu Werid, Shimels Tikuye Yalew, Yohannes Equar Messele

“…This study aimed to determine the seroprevalence to Bovine Herpesvirus-1 (BHV1), Bovine Viral Diarrhea Virus (BVDV), Neospora caninum (N. caninum) and C. burnetii (C. burnetii) exposures in dairy cows with reproductive disorders in selected areas of Ethiopia. …”
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Genotyping <em> Escherichia coli </em> O157:H7 strains isolated from cattle and small ruminants in Fars province (Iran) using Enterobacterial Repetitive Intergenic Consensus PCR A... by Sedigheh Mokhtari, Yahya Tahamtan, Mohammad Kargar, Keyvan Tadayon, Elham Moazamian

“…The strain E. coli O157:H7 diarrhea, hemorrhagic colitis, and hemolytic-uremic syndrome in humans. …”
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Independent Heath Facility Meets Cancer Care Ontario and Canadian Association of Gastroenterology Guidelines for Endoscopic Procedure Wait Times While Meeting Quality Indicators: A... by Fraser Kegel, Niv Sne, Timothy Rice, Eric Joy, Shayan Shahsavar, Celeste A. Collins, Maria Gagarine, Alexandra Allard-Coutu, Lisa Klotz, Angela Coates, Kamyar Kahnamoui, Marko Simunovic

“…Median wait times from referral to colonoscopy met the recommendations set out by the Canadian Association of Gastroenterology and Cancer Care Ontario for all indications: chronic abdominal pain: 43 days; new onset change in bowel habits: 36 days; bright red rectal bleeding: 42 days; documented iron-deficiency anemia: 43 days; fecal occult blood test positive: 38 days; cancer likely based on imaging or physical exam: 23 days; chronic diarrhea and chronic constipation: 42 days; and screening colonoscopies: 55 days. …”
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Effect of Fusion to the LTB Carrier Protein on Coronavirus Spike Protein Vaccine Candidates Produced in Maize by Erin Egelkrout, Magdalena Maj, Rodrigo Manjarin, Gina Fake, Muneaki Watanabe, Jenna Williams, Nate Blanchard, John Walker, Celine Hayden, John Howard

“…Coronaviruses continue to disrupt health and economic productivity worldwide. Porcine epidemic diarrhea virus (PEDV) is a devastating swine disease and SARS-CoV-2 is the latest coronavirus to infect the human population. …”
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Characteristics of Pediatric Crohn’s Disease in Saudi Children: A Multicenter National Study by Omar I. Saadah, Mohammad El Mouzan, Mohammad Al Mofarreh, Ali Al Mehaidib, Mohammad Al Edreesi, Mohammed Hasosah, Abdulrahman Al-Hussaini, Khalid AlSaleem

“…The most common symptoms were abdominal pain (84.2%), weight loss (75.2%), and diarrhea (71.8%). The main disease location was ileocolonic (42.1%) and the main disease behavior was nonstricturing and nonpenetrating (63.6%). …”
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Clinical and Hematological Manifestation of Dengue Patients in 2022 Outbreak: A Tertiary Care Hospital‐Based Cross‐Sectional Study by Md. Jubayer Hossain, Manisha Das, Muhibullah Shahjahan, Md. Wahidul Islam, Syeda Tasneem Towhid

“…Symptoms included headache (84%), retroorbital pain (51%), joint pain (75%), myalgia (72%), vomiting (75%), abdominal pain (69%), diarrhea (39%), and shock (48%). Thrombocytopenia was present in 61% of patients, with 79% showing elevated hematocrit (HCT) levels. …”
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Effect of probiotics on the growth, blood profile, and nutritional-metabolic profile of feedlot cattle by Flavia I. Mansilla, María C. Aristimuño Ficoseco, María H. Miranda, Marcela D’Urso Villar, Graciela M. Vignolo, María E. F. Nader-Macías

“…Isolated nasal discharges and the absence of diarrhea were observed at 105 days in the group administered with multistrain and Lim. fermentum CRL2085 probiotics. …”
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