The association between gestational selective serotonin reuptake inhibitor (SSRI) treatment and newborn thyroid screen: a large-scale cohort study by Orian Raviv, Yael Lebenthal, Michal Yackobovitch-Gavan, Eyal Cohen-Sela, Shlomo Almashanu, Ronella Marom, Jacky Herzlich, Liran Hiersch, Avivit Brener

“…Abstract Background The diagnosis of depression or anxiety treated by SSRIs has become relatively common in women of childbearing age. …”
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Path analysis of factors influencing length of stay and hospitalisation expenses for oral cancer patients in tertiary hospitals in southeastern China: a cross-sectional study by Jing Wang, Chen Chen, Xiaoying Hu, Yi Fan, Yaping Wang, Yu Qiu, Qiujiao Yang, Mingming Xu, Yanfeng Weng, Yanni Li, Lisong Lin, Fa Chen, Baochang He, Fengqiong Liu

“…While prevention and early diagnosis remain critical, our findings underscore several modifiable factors, including improving oral hygiene and optimising surgical protocols, such as chemotherapy and lymph node dissection, that present opportunities to reduce costs and enhance cost-effectiveness. …”
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Frequency, demographics, diagnoses and consultation patterns associated with low-acuity attendances in German emergency departments: a retrospective routine healthcare data analysi... by Patrik Dröge, Anna Slagman, Felix Greiner, Martin Möckel, Liane Schenk, Anna Schneider, Thomas Keil, Stephanie Roll, Rainer Röhrig, Felix Walcher, Reinhard Busse, Johannes Drepper, David Legg, Ryan King, Thomas Reinhold, Thomas Ruhnke, Antje Fischer-Rosinský, Yves-Noel Wu, Natalie Baier, Maike Below, Cornelia Henschke, Björn Kreye, Christian Lüpkes, Burgi Riens, Marie-Luise Rosenbusch, Felix Stäps, Kristin Schmieder, Daniel Schreiber, Dominik von Stillfried, Grit Zimmermann

“…This study aimed to estimate the frequency of low-acuity emergency department (ED) attendances and to provide an overview of their demographic, diagnosis and consultation patterns.Design Observational analyses of routine healthcare data.Setting German EDs.Participants Adult patients with statutory health insurance who visited the ED of 16 participating hospitals in 2016.Main outcome measures Frequency, demographics, diagnoses and consultation patterns of low-acuity and high-acuity attendees.Main results Of the 454 747 ED visits, 370 756 visits (50.1% female) were included for analysis. …”
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The Role of Bronchoalveolar Lavage in Therapeutic Antimicrobial Choices for Hematologic Patients with Pulmonary Infiltrates by Filippo Patrucco, Mattia Bellan, Davide Martinotti, Giuseppe Ielo, Paola Rebecca Iovine, Martina Mascheroni, Francesco Todisco, Martina Ubaldi, Nadia Castaldo, Francesco Gavelli, Alberto Fantin

“…<i>Background and Objectives:</i> Lower respiratory tract infections are particularly frequent in hematological patients; their early diagnosis and the timely start of targeted therapy are essential. …”
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The miR-1269a/PCDHGA9/CXCR4/β-catenin pathway promotes colorectal cancer invasion and metastasis by Haitao Mei, Qingshan Luo, Junyong Weng, Jialing Hao, Jinfeng Cai, Runkai Zhou, Ce Bian, Yingzi Ye, Shengzheng Luo, Yugang Wen

“…This research focuses on investigating the impact and underlying molecular mechanisms of protocadherin gamma subfamily A, 9 (PCDHGA9) on the invasion and metastasis of CRC, aiming to identify more precise molecular markers for the diagnosis and prognosis of CRC. Methods PCDHGA9 expression was detected using quantitative real-time quantitative polymerase chain reaction (RT-qPCR) in 63 pairs of colorectal cancer tissues. …”
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Osteoradionecrosis in osseous free flaps after maxillofacial reconstruction: a single-center experience by Jakob Fenske, Philipp Lampert, Eirini Nikolaidou, Claudius Steffen, Marcus Beck, Norbert Neckel, Susanne Nahles, Max Heiland, Friedrich Mrosk, Steffen Koerdt, Carsten Rendenbach

“…The mean time to ORN diagnosis was 19 (7–56) months after surgery. Total flap loss occurred in 7 patients (33%) following flap ORN. …”
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Artificial intelligence-assisted clinical decision support for childhood asthma management: A randomized clinical trial. by Hee Yun Seol, Pragya Shrestha, Joy Fladager Muth, Chung-Il Wi, Sunghwan Sohn, Euijung Ryu, Miguel Park, Kathy Ihrke, Sungrim Moon, Katherine King, Philip Wheeler, Bijan Borah, James Moriarty, Jordan Rosedahl, Hongfang Liu, Deborah B McWilliams, Young J Juhn

“…Study subjects were stratified into three strata (based on asthma severity, asthma care status, and asthma diagnosis) and were blinded to the assigned groups.…”
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Evaluation of treatment for diffuse large B-cell lymphoma using plasma D-dimer levels by Ruonan Shao, Danchen Meng, Beibei Gao, Lu Zhang, Qingqi Meng, Yanqiu Hou, Zhangbiao Long, Jinsong Yan, Xiaofeng Shi

“…Patients who respond well to chemotherapy typically exhibit lower D-dimer levels at the initial diagnosis. Those in the SD or PD groups usually experience a greater increase in D-dimer levels following chemotherapy. …”
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Genetic Landscape and Clinical Manifestations of Multiple Endocrine Neoplasia Type 1 in a Korean Cohort: A Multicenter Retrospective Analysis by Boram Kim, Seung Hun Lee, Chang Ho Ahn, Han Na Jang, Sung Im Cho, Jee-Soo Lee, Yu-Mi Lee, Su-Jin Kim, Tae-Yon Sung, Kyu Eun Lee, Woochang Lee, Jung-Min Koh, Moon-Woo Seong, Jung Hee Kim

“…Results A total of 117 patients were enrolled, including 55 familial cases, with a mean age at diagnosis of 37.4±15.3 years. Primary hyperparathyroidism was identified as the most common presentation (84.6%). …”
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Effects of Electroacupuncture at Fengchi Acupoint on Myosatellite Cells and TLR4/MyD88/NF-κB Signaling Pathway in Chronic Cervical Muscle Injury Rats by HUANG Yuting, CHEN Jiayan, KAN Yu, FANG Yanping, WANG Jinwei, ZHENG Linyao, JING Xianghong, LIAO Jun

“…The protein contents of PCNA, MyoD, TLR4, MyD88 and NF-κBp65 were detected by immunohistochemistry.Results1) Morphological detection: Compared with the blank group, ultrasonic diagnosis results of the model group showed that tissue of posterior cervical muscle of rats was discontinuous and thickness was significantly narrower. …”
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Clinical manifestations of COVID-19 infection and its impact on the outcome in children and adolescents with benign and malignant hematological disease in Egypt: a single-center ex... by Fatma Soliman Elsayed Ebeid, Aya Mostafa, Sondos M. Magdy, Haidy Moahmed Abd El Kader, Amal Abdel Azim Lotfy, Nihal Hussien Aly

“…For all patients, the collected data included the demographic data, diagnosis, cause of hospital visit, cause and duration of admission if needed, presence of symptoms suggestive of COVID-19 infection, and concurrent medications. …”
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Laboratory evaluation of oral fluid for syphilis screening among clinic users from Lima, Peru by Jazmin Qquellon, Silver K. Vargas, Francesca Vasquez, E. Michael Reyes-Diaz, Kelika A. Konda, Carlos F. Caceres, Jeffrey D. Klausner

“…This suggests that oral fluid could be a viable option for syphilis screening, facilitating broader and faster access to diagnosis and treatment. However, further studies are needed to improve the specificity of this method to ensure accurate screening in diverse clinical scenarios.…”
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Identification of Nontuberculous Mycobacteria in Patients with Pulmonary Diseases in Gyeongnam, Korea, Using Multiplex PCR and Multigene Sequence-Based Analysis by Min-Jeong Kim, Kyu-Min Kim, Jeong-Ih Shin, Jong-Hun Ha, Dong-Hae Lee, Jeong-Gyu Choi, Jin-Sik Park, Jung-Hyun Byun, Jung-Wan Yoo, Seokyong Eum, Myunghwan Jung, Seung Chul Baik, Woo Kon Lee, Hyung Lyun Kang, Min-Kyoung Shin

“…The incidence of NTM-related infections is steadily increasing. As the diagnosis and treatment of NTM infection should be distinguished from tuberculosis, and the treatment should be specific to the species of NTM acquired, accurate species identification is required. …”
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Comparison of the Impact of tNGS with mNGS on Antimicrobial Management in Patients with LRTIs: A Multicenter Retrospective Cohort Study by Li D, Li Q, Huang Z, Wu W, Fan X, Liu J, Li R, Zhang Q, Su X

“…Then, the diagnostic efficacy of tNGS and mNGS was compared, along with their impact on antimicrobial management and clinical outcomes.Results: 548 patients with an initial diagnosis of LRTIs who underwent tNGS or mNGS were evaluated. …”
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A Systematic Review of Research on Guided Access Cavity Preparation Endodontic Treatment: Dentin Preservation Perspectives by Muryani A, Aripin D, Dharsono HDA, Rajion ZA, Wicaksono S

“…Anna Muryani,1,2 Dudi Aripin,2 Hendra Dian Adhita Dharsono,2 Zainul Ahmad Rajion,3 Satrio Wicaksono4 1Doctoral Programme Faculty of Medicine, Universitas Padjadjaran, Bandung, West Java, Indonesia; 2Conservative Dentistry Department Faculty of Dentistry, Universitas Padjadjaran, Bandung, West Java, Indonesia; 3Department Oral Maxillofacial Surgery and Oral Diagnosis Kulliyyah of Dentistry International Islamic University Malaysia, Kuantan, Malaysia; 4Faculty of Mechanical and Aerospace Engineering, Institut Teknologi Bandung, Bandung, West Java, IndonesiaCorrespondence: Anna Muryani, Gedung Pamitran Unpad, lantai 4 Wing Utara Jl. …”
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A Comprehensive Analysis of <i>Echinococcus granulosus</i> Infections in Children and Adolescents: Results of a 7-Year Retrospective Study and Literature Review by Cristina Maria Mihai, Ancuta Lupu, Tatiana Chisnoiu, Adriana Luminita Balasa, Ginel Baciu, Vasile Valeriu Lupu, Violeta Popovici, Felicia Suciu, Florin-Daniel Enache, Simona Claudia Cambrea, Ramona Mihaela Stoicescu

“…According to the medical files, the diagnosis was established using imaging techniques and serological tests for CE. …”
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Effect of Lingnan Painless Apitherapy combined with McKenzie Therapy on Patients with Lumbar Disc Herniation by Hongbo WU, Xinghua CHEN, Ruike ZHANG, Qinglu LUO, Yongming CHENG

“…Objective:To observe the clinical efficacy of Lingnan painless apitherapy combined with McKenzie therapy on patients with lumbar disc herniation(LDH).Methods:A total of 80 patients with LDH who were treated in the department of rehabilitation medicine of the fifth affiliated hospital of Guangzhou medical university from February 2019 to June 2020 were randomly divided into the control group and the observation group according to the random number table method, with 40 cases in each group.The control group received magnetic thermal-vibration therapy and McKenzie therapy.The Japanese magnetic thermal-vibration therapy instrument(TM-3200)was used in the magnetic thermotherapy, the appropriate intensity(high, hot, warm and low temperature)was selected according to the patient's feeling and symptoms, 20 minutes each time, once a day, seven times a week, continuous treatment for two weeks.In addition, the patients with LDH received McKenzie therapy, which was assisted by the therapist or the patient actively completed the flowing training, such as prone position stretching, prone position stretching combined with compression, standing position lateral movement and so on.Each step rested for one minute, once every two days, continuous treatment for two weeks.The observation group received Lingnan painless apitherapy on the basis of treatment in the control group after half an hour's rest.Before treatment, the patients were given apitherapy tolerance test, performing apitherapy with one bee on each Zusanli acupoints on both sides.After apitherapy for 15 minutes, if there was no adverse reaction, the patients were given painless apitherapy with a quiet and comfortable environment, every other day.In this treatment, both sides of Huatuo Jiaji acupoints on the lumbar spinous processes were selected, and Huatuo Jiaji acupoints on both sides of the 5th lumbar spinous process were selected in the first treatment, one acupoint on the left and one on the right.After that, two acupoints were added each time, and each acupoint was treated by one bee.According to the order of Jiaji points on the 4th, 3rd, 2nd and 1st lumbar vertebrae, the number of bee needles increased to 10 bees.Before treatment and two weeks after treatment, visual analogue scales(VAS)was used to evaluate the pain degree, Oswestry disability index(ODI)was used to assess the lumbar spine dysfunction, and TCM syndrome score was used to evaluate the therapeutic effect, and the clinical efficacy was evaluated by <italic>the diagnosis and curative effect standards of TCM diseases</italic>.Results:Before treatment, there was no significant difference in the VAS score, ODI score and TCM syndrome score between the observation group and the control group(<italic>P</italic>&gt;0.05).Compared with treatment before, the VAS score, ODI score and TCM syndrome score after treatment for two weeks of the two groups were significantly reduced, with a statistically significant difference(<italic>P</italic>&lt;0.05).Compared with the control group, the VAS score and TCM syndrome score of the observation group were lower than those of the control group, with a statistically significant difference(<italic>P</italic>&lt;0.05), but there was no considerable difference in ODI score between the two groups(<italic>P</italic>&gt;0.05), and the clinical efficacy of the observation group(95%)was significantly higher than that of the control group(80%)(<italic>P</italic>&lt;0.05).Conclusion:Lingnan painless apitherapy combined with McKenzie therapy can significantly improve the pain degree and lumbar spine dysfunction of patients with LDH, which have a good effect and it is worthy of clinical promotion.However, it's necessary to develop large-sample randomized controlled trials and follow-up, to provide more reliable basis for clinical treatment of LDH.…”
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Real-world survival outcomes with immune checkpoint inhibitors in large-cell neuroendocrine tumors of lung by Samuel Kareff, Jair Bar, Amir Onn, Alona Zer, Chul Kim, Stephen V Liu, Elizabeth Dudnik, Mor Moskovitz, Anastasiya Lobachov, Teodor Gottfried, Damien Urban, Ofer Rotem, Mira Wollner

“…Overall survival since advanced disease diagnosis (OS DX) and OS since ICI initiation (OS ICI) were captured.Results With a median follow-up of 11.8 months (mo) (IQR 7.5–17.9) and 6.0mo (IQR 3.1–10.9), 66% and 76% of patients died in groups A and B, respectively. …”
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Comparing multi-texture fibrosis analysis versus binary opacity-based abnormality detection for quantitative assessment of idiopathic pulmonary fibrosis by Sebastian Nowak, Dominik Creuzberg, Maike Theis, Carmen Pizarro, Alexander Isaak, Claus C. Pieper, Julian A. Luetkens, Dirk Skowasch, Alois M. Sprinkart, Daniel Kütting

“…In this retrospective study, two automated tools were compared in 45 patients with biopsy proven (12/45) and imaging-based (33/45) IPF diagnosis (mean age 74 ± 9 years, 37 male) for quantification of pulmonary fibrosis in CT. …”
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E_N_T_R_O_P_Y: Monocentric analysis of rectal cancer radio-chemotherapy treatment in patients of young age by E. Meldolesi, A. Nicolì, N. Dinapoli, G. Chiloiro, A. Romano, R. Menghi, R. Persiani, F. Pacelli, C. Coco, C. Ratto, S. Manfrida, L. Boldrini, B. Corvari, M.A. Gambacorta

“…Results: All patients were classified in different risk groups, according to the ESMO 2017 rectal cancer clinical practice guidelines. 88 % of patients under 55 years old at the diagnosis belonged to the bad or advanced risk groups with an equal division. …”
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