Viral Mimetic Bacterial Outer Membrane Vesicles for Targeting Angiotensin-Converting Enzyme 2 by Ahn G, Yoon HW, Jeong JH, Kim YH, Shin WR, Song MS, Ahn JY

“…Experiments in mice, Ag43β 700_RBD OMVs was successfully proven to be safe and effective; they produced a detectable level of nAbs with 39– 58% neutralisation and reduced viral titres in the lungs and brain without weight loss.Conclusion: The developed viral mimetic Ag43β 700_RBD OMVs may therefore be applied as a nanovesicle-theranostic platform for further emerging infectious disease-related diagnosis, vaccination, and treatment. Keywords: outer membrane vesicle, antigen 43 autotransporters, targeted delivery vehicle, theranostics, angiotensin-converting enzyme 2…”
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Evaluation of Metabolic Characteristics of Brain Tumours Utilising 31-Phosphorus MR Spectroscopy in 3T MRI: A Cross-sectional Study by Nivetha Kannan, Babu Peter Sathyanathan

“…Aim: To metabolically characterise brain tumours and compare them with normal brain parenchyma using 31-Phosphorus spectroscopy by obtaining applicable parameters for evaluation, diagnosis and grading of brain tumours. Materials and Methods: This cross-sectional study was conducted at the Barnard Institute of Radiology, Madras Medical College, Chennai, Tamil Nadu, India, from December 2019 to December 2021. …”
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FGF23-related hypophosphatemia in a patient with small cell lung cancer: a case report and literature review by Hajime Kato, Soichiro Kimura, Maho Taguchi, Takashi Sunouchi, Yoshitomo Hoshino, Naoko Hidaka, Nadia Edvige Foligno, Minae Koga, Katsunori Manaka, Hiroyuki Tamiya, Masanori Kawakami, Hidenori Kage, Yoichi Yasunaga, Masaomi Nangaku, Noriko Makita, Nobuaki Ito

“…A reduced level of the tubular reabsorption of phosphate concomitant with an inappropriately elevated level of fibroblast growth factor (FGF) 23 (48.4 pg/mL) was noted, leading to the diagnosis of FGF23-related hypophosphatemia. Laboratory data also showed hypercortisolemia with an elevated ACTH level and hyponatremia with an inappropriately unsuppressed level of antidiuretic hormone (ADH). …”
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Cost savings of reducing opioid prescribing for the treatment of people with low back pain in general practice: a modelling studyResearch in context by Anagha Killedar, Romi Haas, Alexandra Gorelik, Sean Docking, Rachelle Buchbinder, Chris G. Maher, Chung-Wei Christine Lin, Alison Hayes

“…Methods: Two decision tree models were developed: the healthcare actions model, which tracked post-diagnosis care pathways, and the opioid overdose model, which modelled overdoses and consequent healthcare costs and deaths, following opioid prescribing. …”
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MAZ-mediated tumor progression and immune evasion in hormone receptor-positive breast cancer: Targeting tumor microenvironment and PCLAF+ subtype-specific therapy by Gaofeng Ni, Yuwei Sun, Hongling Jia, Zhikai Xiahou, Yumeng Li, Fu Zhao, Hongyan Zang

“…The findings underscored the importance of overcoming drug resistance, recognizing novel treatment targets, and crafting tailored diagnosis regimens.…”
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Plasma phospho-tau217 as a predictive biomarker for Alzheimer’s disease in a large south American cohort by Neetesh Pandey, Zikun Yang, Basilio Cieza, Dolly Reyes-Dumeyer, Min Suk Kang, Rosa Montesinos, Marcio Soto-Añari, Nilton Custodio, Lawrence S. Honig, Giuseppe Tosto

“…We tested plasma levels of p-tau using the Quanterix Simoa ALZpathp-tau217 assay in 525 samples and tested the association between p-tau217 and clinical diagnosis (healthy controls n = 234 vs. AD n = 113) using generalized mixed regression models, adjusting for sex, age, education, APOE-e4 allele (fixed effects) and study site (random effect). …”
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Comparative Analysis of 95 Patients with Different Severity in the Early Outbreak of COVID-19 in Wuhan, China by Fang He, Xue-feng Ding, Meng Cao, Hai-ying Gong, Xiang-zhen Fu, Jie Luo, Kui Liu, Zhou-zhou Tian, Lin Luo, Yu-yuan Fan, Ting Li, Qian-Jing Yao, Xiao-ju Chen, Xiang-lin Duan, Li Chen, Li Jiang

“…To explore the clinical characteristics of patients with different severity in the early outbreak of COVID-19, hoping to provide reference for clinical diagnosis and treatment. Methods. We retrospectively analyzed the clinical data of 95 COVID-19 patients in Wuhan Red Cross Hospital of China from January 17 to February 13, 2020. …”
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Association between weight-adjusted-waist index and long-term prognostic outcomes in cardiovascular disease patients: results from the NHANES 1999–2018 study by Hanbin Li, Wen Zhong, Hongxin Cheng, Shiqi Wang, Ran Li, Lu Wang, Chengqi He, Quan Wei

“…Abstract Background As cardiovascular disease (CVD) morbidity and mortality increase yearly, this study aimed to explore the potential of the weight-adjusted-waist index (WWI) and its relation to long-term mortality in patients with CVD. Methods The diagnosis of CVD was based on standardized medical condition questionnaires that incorporated participants’ self-reported physician diagnoses. …”
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The Utility of Neutrophil CD64 and Presepsin as Diagnostic, Prognostic, and Monitoring Biomarkers in Neonatal Sepsis by Heba E. Hashem, Rania M. Abdel Halim, Sherin A. El Masry, Amira M. Mokhtar, Noureldin M. Abdelaal

“…Laboratory sepsis evaluation included highly sensitive CRP (hs-CRP), CBC, in addition to nCD64 (flow cytometry technique), and presepsin measurement (CLEIA technique combined with Magtration® technology); the diagnosis was confirmed thereafter by positive blood culture results (BacT/Alert system). …”
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A Phase II Trial of Melphalan Based Reduced-Intensity Conditioning for Transplantation of T-Replete HLA-Haploidentical Peripheral Blood Stem Cells with Posttransplant Cyclophospham... by Melhem M. Solh, Gabriel Hinojosa, Justin Laporte, Scott R. Solomon, Lawrence E. Morris, Xu Zhang, H. Kent Holland, Asad Bashey

“…Median age was 57 years (range from 35 to 68). Transplantation diagnosis included AML (n = 11), ALL (n = 4), MDS/MPD (n = 6), NHL/CLL (n = 3), and MM (n = 1). …”
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Benefits of Liver Volume and Serum Zinc Level Assessment for the Screening of Covert Hepatic Encephalopathy in Patients with Child–Pugh Class A Cirrhosis by Masanori Fukushima, Hisamitsu Miyaaki, Ryu Sasaki, Yasuhiko Nakao, Masafumi Haraguchi, Kosuke Takahashi, Eisuke Ozawa, Satoshi Miuma, Kazuhiko Nakao

“…Detection of Child–Pugh class A is necessary for its early diagnosis. This study aimed to establish a simple diagnostic method of CHE in patients with Child–Pugh class A. …”
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Exploring changes in metabolites and fecal microbiota of advanced gastric cancer based on plasma metabolomics and 16S rDNA sequencing by Xinyi Feng, Yu Zhang, Jun Feng, Zhongjun Li, Zhi Zhang, Lin Zhu, Ruoyu Zhou, Haibo Wang, Xiaojun Dai, Yanqing Liu

“…This deepens our understanding of the physiological and pathological mechanisms of advanced gastric cancer and helps to improve the diagnosis and treatment of advanced gastric cancer.…”
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Impact of porcelain aorta on outcomes in transfemoral aortic valve implantation (TAVI) with balloon-expandable valves by Bernhard Schieffer, Thomas Kuntze, Tamer Owais, Philipp Lauten, Julian Kreutz, Lisa C Costello-Boerrigter, Mathias Schreiber, Guido Boerrigter, Christian Albert, Mohammad El Garhy, Björn Göbel, Harald Lapp, Birgit Markus

“…For this single-centre (Zentralklinik Bad Berka, Germany), retrospective analysis, we only selected patients who received BEV. PA diagnosis was made when non-contrast axial CT images fulfilled Valve Academic Research Consortium-2 criteria for PA. …”
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Evaluation of three-dose fosfomycin tromethamine in the treatment of patients with urinary tract infections: an uncontrolled, open-label, multicentre study by Shan Chen, Yong Yang, Bo Yang, Ming Chen, Kai Zhang, Yi Wang, Lu-Dong Qiao, Bo Zheng, Hong-Feng Guo, Yuan-Jie Niu, Ben-Kang Shi, Wei-Min Yang, Xiao-Kun Zhao, Xiao-Feng Gao

“…Objective To evaluate the clinical and microbiological efficacy and safety of three doses of 3 g fosfomycin tromethamine administered orally to treat lower urinary tract infections.Design and participants This prospective, uncontrolled, open-label study was conducted in 12 medical centres in China, between January and December 2011. According to the diagnosis criteria of Chinese Guidelines on Urological Infections, patients (18–70 years) with acute uncomplicated cystitis, recurrent lower urinary tract infection or complicated lower urinary tract infection received three doses of 3 g fosfomycin tromethamine orally, at days 1, 3 and 5.Primary and secondary outcome measures Efficacy endpoints (clinical efficacy, microbiological efficacy and overall efficacy) were evaluated on day 15. …”
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Ginsenoside Rg1: A bioactive therapeutic agent for diverse liver diseases by Mingyu Wu, Ke Li, Jiabin Wu, Xianyi Ding, Xiaotong Ma, Wenhong Wang, Weihua Xiao

“…Diverse liver diseases are characterised by late diagnosis and rapid progression and have become one of the major threats to human health. …”
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External beam radiation therapy versus radical prostatectomy for high-risk prostate cancer: protocol of the RECOVER study by Caroline M. van der Starre, Chris H. Bangma, Maarten J. Bijlsma, Alfons C.M. van den Bergh, Lambertus A.L.M. Kiemeney, Wietske Kievit, Kees Vos, Diederik M. Somford, Sally M. Wildeman, Katja K.H. Aben, Igle J. de Jong, Floris J. Pos, Berdine L. Heesterman

“…Clinical data regarding patient-, tumor- and treatment characteristics and oncological outcomes are collected up to 5 years after diagnosis. For sufficient power, patient reported outcomes of 471 patients must be collected 36 months after treatment initiation. …”
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A perspective on the current state of smartphone-based mobile applications for scar assessment by Peter Moortgat, Jill Meirte, Mieke Anthonissen, Koen Maertens, Thibau Demarbaix, Ulrike Van Daele

“…Scars can have a significant impact on the physical and psychosocial well-being, so the assessment of scars is crucial for accurate diagnosis, monitoring, and treatment. Traditionally, these assessments required specialized, bulky equipment that needed a wired connection to computers, making these assessment tools less accessible and efficient. …”
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Dual-Stage AI Model for Enhanced CT Imaging: Precision Segmentation of Kidney and Tumors by Nalan Karunanayake, Lin Lu, Hao Yang, Pengfei Geng, Oguz Akin, Helena Furberg, Lawrence H. Schwartz, Binsheng Zhao

“…Objectives: Accurate kidney and tumor segmentation of computed tomography (CT) scans is vital for diagnosis and treatment, but manual methods are time-consuming and inconsistent, highlighting the value of AI automation. …”
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Surgical and Non-surgical Treatments in Pleural Empyema by Sami DENİZ, Nimet AKSEL, Özer ÖZDEMİR, Görkem VAYISOĞLU ŞAHİN, Ezgi ÇİMEN ÇELİK, Mutlu Onur GÜÇSAV, Filiz GÜLDAVAL, Ahmet Emin ERBAYCU, Ahmet ÜÇVET

“…Methods: Patients those had been diagnosed and treated for empyema were assessed in a retrospective design. For the definitive diagnosis of empyema, thoracentesis was made. We categorized the patients in two groups as therapeutic drainage (group 1) and open surgery (group 2). …”
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Secondary vs. primary pituitary xanthogranulomas: which yellow is more mellow? by Dragana Miljic, Sandra Pekic, Mirjana Doknic, Marko Stojanovic, Sasa Ilic, Marina Nikolic Djurovic, Zvezdana Jemuovic, Toplica Milojevic, Mihailo Milicevic, Marija Jovanovic, Milica Medic Stojanoska, Bojana Carić, Nevena Radic, Sanja Medenica, Emilija Manojlovic Gacic, Milan Petakov

“…In a retrospective review of 714 patients operated for sellar masses, at tertiary center, we identified 16 (2.24%) with histologically confirmed diagnosis of pituitary XG over the period of 7 years (2015–2021). …”
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