Aluminium adjuvants versus placebo or no intervention in vaccine randomised clinical trials: a systematic review with meta-analysis and Trial Sequential Analysis by Christian Gluud, Marija Barbateskovic, Sara Russo Krauss, Janus C Jakobsen, Sesilje Bondo Petersen, Sarah Louise Klingenberg, Snezana Djurisic, Mette Kenfelt, De Zhao Kong

“…Objectives To assess the benefits and harms of aluminium adjuvants versus placebo or no intervention in randomised clinical trials in relation to human vaccine development.Design Systematic review with meta-analysis and trial sequential analysis assessing the certainty of evidence with Grading of Recommendations Assessment, Development and Evaluation (GRADE).Data sources We searched CENTRAL, MEDLINE, Embase, LILACS, BIOSIS, Science Citation Index Expanded and Conference Proceedings Citation Index-Science until 29 June 2021, and Chinese databases until September 2021.Eligibility criteria Randomised clinical trials irrespective of type, status and language of publication, with trial participants of any sex, age, ethnicity, diagnosis, comorbidity and country of residence.Data extraction and synthesis Two independent reviewers extracted data and assessed risk of bias with Cochrane’s RoB tool 1. …”
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An exploratory study of serum creatine kinase as a prognostic marker for patients with resectable pancreatic cancer: looking into the relationship with body composition by Cong Chen, Xin Luo, Xianchao Lin, Ronggui Lin, Yuanyuan Yang, Congfei Wang, Haizong Fang, Tianhong Teng, Heguang Huang, Fengchun Lu

“…A low serum CK level showed a significant correlation with the diagnosis of sarcopenia in male patients (P = 0.026). …”
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Longitudinal MRI evaluation of the efficacy of non-enhanced lung cancer brain metastases by Xian Zhang, Jun Yang, Hong Hu, Yong Wang, Zhenfeng Zhang, Jinhao lv, Junping Li

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Healthy dietary patterns and the incidence of chronic kidney disease: results from a prospective cohort study by Yong-Ping Lu, Bin Xia, Xiao-Hua Wang, Qiang-Sheng He, Chang-Bo Qu, Ying-Ying Xie, Tian-Jiao Cui, Si-Qing Wu, Jin-Yu Zhao, Zhi-Hua Zheng, Ting Zhu, Jin-Qiu Yuan, Chun Tang

“…The baseline for analysis was the first 24-hour dietary recall in 2011, with follow-up extending until the earliest occurrence of CKD diagnosis, death, or the end of the study period. Results A total of 207,268 British individuals who completed at least one online 24-hour dietary recall assessment were included in this study. …”
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Modeling a Telemedicine Screening Program for Diabetic Retinopathy in Iran and Implementing a Pilot Project in Tehran Suburb by Sare Safi, Hamid Ahmadieh, Marzieh Katibeh, Mehdi Yaseri, Homayoun Nikkhah, Saeed Karimi, Ramin Nourinia, Ali Tivay, Mohammad Zareinejad, Mohsen Azarmina, Alireza Ramezani, Siamak Moradian, Mohammad Hossein Dehghan, Narsis Daftarian, Davood Abbasi, Afshin Eshghi Fallah, Bahareh Kheiri

“…The sensitivity and specificity for diagnosis of any stage of DR by trained GPs were 82.8% and 86.2%, respectively, in comparison to the gold standard. …”
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Feasibility study to assess the delivery of a lifestyle intervention (TreatWELL) for patients with colorectal cancer undergoing potentially curative treatment by Annie S Anderson, Ronan E O’Carroll, Martine Stead, Robert J C Steele, Mary Wells, Maureen Macleod, Anna Campbell, Jacqui A Sugden, Jackie Rodger, Jennifer McKell

“…Protocol challenges included limited time between diagnosis and surgery and the presence of comorbidities. …”
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Vaccination with Delta-PGM in the control of buffalo (Bubalus bubalis) brucellosis by Alfredo Sánchez-Villalobos, Leandro Salas, Hengelbert Fuenmayor, Omaira Contreras, Enmanuel Machado

“…The program focused on: vaccination with Delta-PGM (Agropharma Laboratories, Buenos Aires, Argentina), 2ml subcutaneous injection in 3- to- 8- month females, aiming to secure two dosages before the service (2nd dosage seven months after the first), and detection/elimination of the infected through serial diagnosis with buffered plate antigen test (BPA, Agropharma Laboratories, Buenos Aires, Argentina) and fluorescence polarization assay (FPA, Biotehnika Laboratories, Serbia). …”
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October 7th Mass Casualty Attack in Israel: Injury Profiles of Hospitalized Casualties by Sharon Goldman, MPH, Ari M. Lipsky, MD, Irina Radimislensky, BSc, Adi Givon, BSc, Ofer Almog, MD, Avi Benov, MD, Israel Trauma Group, Eldad Katorza, MD, MSC, MBA, H. Bahouth, A. Bar, A. Braslavsky, D. Czeiger, D. Fadeev, A. L. Goldstein, I. Grevtsev, G. Hirschhorn, I. Jeroukhimov, A. Kedar, Y. Klein, A. Korin, B. Levit, I. Schrier, A. D. Schwarz, W. Shomar, D. Soffer, M. Weiss, O. Yaslowitz, I. Zoarets

“…Israel’s hospitals faced many challenges following the mega mass casualty incident, including the absorption, diagnosis, treatment, and rehabilitation of a massive number of casualties. …”
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Impact of Comorbidities on Prognosis and Treatment Outcomes in Elderly Patients with Hodgkin Lymphoma by Dávid Tóthfalusi, Boglárka Dobó, Fanni Borics, László Imre Pinczés, Árpád Illés, Zsófia Miltényi

“…The most common subtype was nodular sclerosis, and 72% of patients were in advanced stages at diagnosis. Treatment varied by age, with younger patients receiving ABVD and older patients (80–89) receiving brentuximab vedotin with dacarbazine. …”
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Rare and syndromic tumours in South African children: A novel report from Sub-Saharan Africa by Alessia Pisapia, Guy Shemesh, Derek Harrison

“…Overall, there was a 66 % survival rate. Conclusion: The diagnosis of rare tumours in the paediatric population is rising but are rarely associated with a syndrome. …”
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Diagnosing glaucoma in optometry practice by A.V. Korneeva, I.N. Isakov, A.V. Kuroyedov, O.N. Onufriichuk

“…It elucidates the findings of domestic and international studies focused on the early glaucoma diagnosis in optometry. The evolving role of optometry personnel in the public health system is underpinned by the increasing number of patients with eye diseases and the growing demand for primary ophthalmic care due to a higher life expectancy of the population. …”
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Computer analysis of regulation of hepatocarcinoma marker genes hypermethylated by HCV proteins by E. A. Antropova, T. M. Khlebodarova, P. S. Demenkov, A. S. Venzel, N. V. Ivanisenko, A.  D.  Gavrilenko, T.  V. Ivanisenko, A. V. Adamovskaya, P. M. Revva, I. N. Lavrik, V. A. Ivanisenko

“…Aber rant DNA methylation is a mediator of epigenetic changes that are closely associated with the HCC pathogenesis and considered a biomarker for its early diagnosis. The ANDSystem software package was used to reconstruct and evaluate the statistical significance of the pathways HCV could potentially use to regulate 32 hypermethylated genes in HCC, including both oncosuppressor and protumorigenic ones identified by genome-wide analysis of DNA methylation. …”
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Demographic and Clinical Characteristics of Patients with Corneal Ectasia at Multiple Medical Centers in Saudi Arabia: A Hospital-based Study by Waleed Alghamdi, Sulaiman Aldakhil, Saif Hassan Alrasheed, Kareem Allinjawi, Mustafa Abdu, Raghda F. Mutwaly, Khaled Al Rashah, Hani M. Ghazal, Ghassan H. Radwan, Naveen Kumar Challa

“…This high rate of bilaterality of diseases during diagnosis may be due to misdiagnosis in the initial stages, which highlights the importance of community and eye care professionals’ awareness of comprehensive eye examinations and regular follow-up, including corneal topography assessments of both eyes.…”
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Oxidative alterations in exfoliated oral mucosa cells of patients with major depressive disorder by Lukas Mendes de Abreu, Cintia Rodrigues da Silva, Ana Laura Ferreira Bortoleto, Giovana Barros Nunes, Matheus Martins Gracia, Rafael Akira Tzanno Murayama, Daniel Galera Bernabé, Gisele Zoccal Mingoti

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Unraveling the pathogenesis of Barrett’s esophagus and esophageal adenocarcinoma: the “omics” era by Alberto Barchi, Giuseppe Dell’Anna, Giuseppe Dell’Anna, Luca Massimino, Luca Massimino, Francesco Vito Mandarino, Edoardo Vespa, Edi Viale, Sandro Passaretti, Vito Annese, Vito Annese, Alberto Malesci, Alberto Malesci, Silvio Danese, Silvio Danese, Federica Ungaro

“…Omics technologies, thanks to the potentiality of managing huge amounts of genetic and epigenetic data, sequencing the whole genome, have revolutionized the understanding of BE carcinogenesis, paving the way for biomarker development helpful in early diagnosis and risk progression assessment. Genomics and transcriptomics studies, implemented with the most advanced bioinformatics technologies, have brought to light many new risk loci and genomic alterations connected to BE and its progression to EAC, further exploring the complex pathogenesis of the disease. …”
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Prognostic value of neutrophil-to-lymphocyte ratio dynamics in patients with septic acute kidney injury: a cohort study by Wei Wei, Caihong Liu, Guojiao Song, Letian Yang, Jian Li, Bo Wang, Ting Yin, Yingying Yang, Liang Ma, Ling Zhang, Ping Fu, Yuliang Zhao

“…ΔNLR was defined as the difference between the NLR at septic AKI diagnosis and at hospital admission. The relationship between the ΔNLR and mortality was evaluated by Kaplan–Meier curves, Cox proportional hazards, and cubic spline analyses. …”
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Pseudodominant Nanophthalmos in a Roma Family Caused by a Novel PRSS56 Variant by Lubica Dudakova, Pavlina Skalicka, Olga Ulmanová, Martin Hlozanek, Viktor Stranecky, Frantisek Malinka, Andrea L. Vincent, Petra Liskova

“…A known pathogenic founder CTDP1 variant c.863+389C>T in a homozygous state was identified in the other family member confirming the suspected diagnosis of congenital cataracts, facial dysmorphism, and demyelinating neuropathy syndrome. …”
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Association between Air Pollution and Risk of Hospital Admission for Pediatric Pneumonia in a Tropical City, Kaohsiung, Taiwan by Peng-Huei Liu, Kuo-Chen Huang, Yu-Lun Tseng, I-Min Chiu, Hsiu-Yung Pan, Fu-Jen Cheng

“…The medical records of non-traumatic patients under 17 years of age who had visited the ED between 2008 to 2013, with a principal diagnosis of pneumonia were extracted. We evaluated the relationship between air pollutant exposure and the risk of admission and length of hospital stay (LOS). …”
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Identification and characterization of Serratia nematophila and Acinetobacter guillouiae from putrid-skin disease lesions in farmed Chinese spiny frog (Quasipaa spinosa) by Ling Guo, Xiyu Jin, Dan Yang, Li Wei, Jie Chen, Zhihua Lin, Li Ma

“…Our findings offer a scientific foundation for the accurate diagnosis and control of putrid-skin disease in frogs, contributing to the preservation of Q. spinosa genetic resources.…”
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The International Vitreoretinal B-Cell Lymphoma Registry: a protocol paper by David J Wilson, Valérie Touitou, Justine R Smith, Manabu Mochizuki, Hiroshi Takase, Steven Yeh, Alexandra L Farrall, H Nida Sen, Daniel V Vasconcelos-Santos, Joke H de Boer, Ninette H ten Dam-van Loon, Janet L Davis, Anthony J Hall, Mark H B Radford

“…Introduction Vitreoretinal lymphoma is a rare ocular cancer with high morbidity and mortality despite treatment. Diagnosis by cytopathology is often delayed, and various molecular and image-based investigations have been developed. …”
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