Formalin Fixation as Tissue Preprocessing for Multimodal Optical Spectroscopy Using the Example of Human Brain Tumour Cross Sections by Mona Stefanakis, Anita Lorenz, Jörg W. Bartsch, Miriam C. Bassler, Alexandra Wagner, Marc Brecht, Axel Pagenstecher, Jens Schittenhelm, Barbara Boldrini, Sabrina Hakelberg, Susan Noell, Christopher Nimsky, Marcos Tatagiba, Rainer Ritz, Karsten Rebner, Edwin Ostertag

“…As a consequence, spectroscopic methods represent an appropriate additional contrast for chemical and morphological information in neuropathological diagnosis and should be investigated to a greater extent. …”
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践行数智化健康管理理念，提升我国卒中患者管理质量和效率 Implementing the Concept of Digital Intelligent Health Management to Enhance the Quality and Efficiency of Stroke Patient Management in China... by 李星明1，宋西方2，武剑3，4，邱月4，杨宇彤1，过君君1，高雨润1，周立涵1 (LI Xingming1, SONG Xifang2, WU Jian3,4, QIU Yue4, YANG Yutong1, GUO Junjun1, GAO Yurun1, ZHOU Lihan1)

“…This paper analyzes the application progress and existing problems of digital intelligent health management for stroke patients from dimensions such as digital intelligent early diagnosis system, digital intelligent health intervention system, digital intelligent rehabilitation training assistance system, and digital intelligent follow-up management system. …”
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Screening Evaporative Dry Eyes Severity Using an Infrared Image by Qing Zhang, Yi Wu, Yilin Song, Guanghao Qin, Lanting Yang, Sumeet Singh Talwar, Tiezhu Lin, Gagan Deep Singh Talwar, Hongda Zhang, Ling Xu, Jonathan E Moore, Emmanuel Eric Pazo, Wei He

“…Due to the variability in presentation, diagnosis of DED consists of a combination of subjective and objective clinical tests. …”
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Salivary peptidomic profiling of chronic gingivostomatitis in cats by matrix‐assisted laser desorption/ionization‐time‐of‐flight mass spectrometry and nanoscale liquid chromatograp... by Sekkarin Ploypetch, Apisit Pornthummawat, Sittiruk Roytrakul, Janthima Jaresitthikunchai, Narumon Phaonakrop, Sabrina Wahyu Wardhani, Sitthichok Lacharoje, Somporn Techangamsuwan

“…We compared the salivary peptide profiles of diseased and healthy cats. The diagnosis of FCGS was confirmed by histopathology. …”
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RETRACTED ARTICLE: A prospective diagnostic model for breast cancer utilizing machine learning to examine the molecular immune infiltrate in HSPB6 by Lizhe Wang, Yu Wang, Yueyang Li, Li Zhou, Sihan Liu, Yongyi Cao, Yuzhi Li, Shenting Liu, Jiahui Du, Jin Wang, Ting Zhu

“…A machine learning model was developed in this study and specifically trained for breast cancer diagnosis using these genes, achieving high precision. …”
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Brain Age Prediction Using a Lightweight Convolutional Neural Network by Fatma Eltashani, Mario Parreno-Centeno, James H. Cole, Joao Paulo Papa, Fumie Costen

“…Studies based on brain magnetic resonance images showed a strong relationship between the brain ageing process and accelerated brain atrophy, suggesting using brain age prediction models for early diagnosis of neurodegenerative disorders, such as Parkinson’s, Schizophrenia, and Alzheimer’s disease. …”
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Incidence and Predictors of Later Epilepsy in Neonates with Encephalopathy: The Impact of Electrographic Seizures by Carol M. Stephens, Jacopo Proietti, Sean R. Mathieson, Vicki Livingstone, Brian McNamara, Niamh McSweeney, Olivia O'Mahony, Brian H. Walsh, Deirdre M. Murray, Geraldine B. Boylan

“…Several potential predictors for the development of later epilepsy were identified including infants delivered vaginally, low Apgar scores at 1 and 5 min, severe HIE diagnosis, presence of ENS, a severely abnormal EEG background and an abnormal brain MRI. …”
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Comparison study of bioelectrical impedance analyzers for measuring lower limb muscle mass in middle-aged and elderly adults by Ai-Chun Huang, Hsueh-Kuan Lu, Chien-Wei Liang, Kuen-Chang Hsieh, Kuen-Chang Hsieh, Yi-Sung Tsai, Chung-Liang Lai, Chung-Liang Lai

“…Assessing leg muscle mass in middle-aged and elderly individuals is crucial for the prevention and diagnosis of sarcopenia. Current bioelectrical impedance analysis (BIA) devices are capable of measuring LLMM, but validation studies are limited. …”
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Prevalence of Hepatitis C Virus Among Hospitalized Patients in a Tertiary Hospital in Italy: The Basis for a National Screening Assessment Model? by Giulia Morsica, Massimo Locatelli, Gema Hernandez-Ibarburu, Francesca Rusconi, Alba Segovia-Hilara, Davide Di Napoli, Matteo Moro, Salvatore Mazzitelli, Hamid Hasson, Federico Esposti, Roberts Mazzuconi, Antonella Castagna

“…Free-of-charge hepatitis C virus antibody (HCV Ab) screening in some key populations and in 1969–1989 birth cohorts have been funded in Italy as the first step in confirming diagnosis in individuals who may be unaware of their infection. …”
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Video-feedback intervention for promoting social engagement in children with neurodevelopmental disabilities by Rosario Montirosso, Serena Micheletti, Camilla Pisoni, Eleonora Mascheroni, Elisa Scarano, Elisa Scarano, Cecilia Naboni, Elisa Rosa, Annalisa Castagna, Margherita Bonino, Elisa Fazzi, Elisa Fazzi, Simona Orcesi, Simona Orcesi

“…The children, aged between 6 and 24 months, had a diagnosis of ND, including psychomotor delay (n = 26) and cerebral palsy (n = 5). …”
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Markers of Glomerular and Tubular Damage in the Early Stage of Kidney Disease in Type 2 Diabetic Patients by Agnieszka Żyłka, Paulina Dumnicka, Beata Kuśnierz-Cabala, Agnieszka Gala-Błądzińska, Piotr Ceranowicz, Jakub Kucharz, Anna Ząbek-Adamska, Barbara Maziarz, Ryszard Drożdż, Marek Kuźniewski

“…Diabetic kidney disease develops in half of genetically predisposed patients with type 2 diabetes (T2DM). Early diagnosis of kidney damage and nephroprotective treatment are the ways of preventing the disease progression. …”
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Atopic Dermatitis Treatments Before and After Initiation of Ruxolitinib Cream: 6-Month Follow-Up Analysis of a US Payer Claims Database by Liu J, Desai K, Teng CC, Sturm D, Stockbower G, Patadia H, Willey V

“…This analysis describes treatment patterns before and after initiation of ruxolitinib cream among patients with AD.Patients and Methods: This retrospective, observational study used medical and pharmacy claims data from the Healthcare Integrated Research Database (HIRD®) and included adults and adolescents (aged ≥ 12 years) with an AD diagnosis, a first claim for ruxolitinib cream (index date) between October 2021 and July 2022, and continuous enrollment in a commercial or managed Medicare plan for 6 months before and after the index date. …”
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Early Treatment with Empagliflozin and GABA Improves β-Cell Mass and Glucose Tolerance in Streptozotocin-Treated Mice by Caroline Daems, Sophie Welsch, Hasnae Boughaleb, Juliette Vanderroost, Annie Robert, Etienne Sokal, Philippe A. Lysy

“…We evaluated the potential of empagliflozin (EMPA) and GABA (gamma-aminobutyric acid) to protect β-cell mass against glucotoxicity and to increase β-cell mass after diagnosis of T1D. Empagliflozin is a SGLT2 (sodium-dependent glucose cotransporter) inhibitor which thereby blocks glucose recapture by the kidney and promotes glucose excretion in urine. …”
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Uncovering somatic mosaic variants of PIK3CA-related overgrowth disorders – three cases with different clinical presentations by M. Tooming, M. Tooming, P. Mertsina, T. Kahre, T. Kahre, R. Teek, I. Vainumäe, I. Vainumäe, S. Lilles, S. Lilles, M. H. Wojcik, M. H. Wojcik, M. H. Wojcik, P. Ilves, P. Ilves, K. Õunap, K. Õunap

“…This approach can enhance patient care by providing a more accurate diagnosis and better understanding of the genetic underpinnings of PRD.…”
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Investigation of the Mechanism of Complement System in Diabetic Nephropathy via Bioinformatics Analysis by Bojun Xu, Lei Wang, Huakui Zhan, Liangbin Zhao, Yuehan Wang, Meng Shen, Keyang Xu, Li Li, Xu Luo, Shasha Zhou, Anqi Tang, Gang Liu, Lu Song, Yan Li

“…We confirmed that the complement cascade-related hub genes may be the novel biomarkers for DN early diagnosis and targeted treatment.…”
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Lower Urinary Tract and Gastrointestinal Dysfunction Are Common in Early Parkinson’s Disease by Daniel Martinez-Ramirez, Edna Sophia Velazquez-Avila, Alejandro Almaraz-Espinoza, Arnulfo Gonzalez-Cantú, Genaro Vazquez-Elizondo, Daniel Overa-Posada, Amin Cervantes-Arriaga, Mayela Rodriguez-Violante, Mirna Gonzalez-Gonzalez

“…Results. 414 PD patients had a mean age of 61.1 (SD 9.7) years at diagnosis and mean disease duration of 6.7 (SD 6.6) months. …”
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Outcomes, Healthcare Resource Utilization, and Costs of Overall, Community-Acquired, and Hospital-Acquired Acute Kidney Injury in COVID-19 Patients by Jay L. Koyner, Rachel H. Mackey, Ning A. Rosenthal, Leslie A. Carabuena, J. Patrick Kampf, Paul McPherson, Toni Rodriguez, Aarti Sanghani, Julien Textoris

“…**Methods:** This retrospective cohort study included inpatients with COVID-19 discharged from US hospitals in the Premier PINC AI™ Healthcare Database April 1–October 31, 2020, categorized as AKI, CA-AKI, HA-AKI, or no AKI by ICD-10-CM diagnosis codes. Outcomes were assessed during index (initial) hospitalization and 30 days postdischarge. …”
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Significance of Early Postoperative Arterial Lactic Acid, Inferior Vena Cava Variability, and Central Venous Pressure in Hypovolemic Shock by Wei Lin, Xingsheng Lin, Yingfeng Zhuang, Xiaobin Pan, Chao Wu, Shujuan Zhang, Lihui Zhang, Jian Lin, Songjing Shi, Songchang Shi

“…We use the ROC (receiver-operating characteristic) curve to evaluate the significance of each indicator in the diagnosis. For correlation analysis between groups, we first use linear regression for processing and then analysis with correlation. …”
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Risk of residual/recurrent cervical diseases in HPV-positive women post-conization depends on HPV integration status by Wenyu Lin, Yuxuan Huang, Yan Zhang, Lixiang Huang, Hongning Cai, Guanxiang Huang, Ye Li, Qiaoyu Zhang, Huifeng Xue, Binhua Dong, Pengming Sun

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Pleural metastases from differentiated thyroid cancer: clinical features and long-term outcomes by Mengyue Liu, Juan Tang, Nan Sun, Chuang Xi, Chentian Shen, Song Hongjun, Quanyong Luo, Xianzhao Deng, Zhongling Qiu

“…The median age at the time of initial diagnosis of PM was 59 years (range: 34–79). At the end of follow-up, eight patients (29.63%) had disease progression (PD), four (14.81%) had a partial response, and the remainder had stable disease; no patient achieved complete response. …”
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