Capsaicin Modulates Ruminal Fermentation and Bacterial Communities in Beef Cattle with High-Grain Diet-Induced Subacute Ruminal Acidosis by Wei You, Haijian Cheng, Xin Hu, Enliang Song, Fugui Jiang

“…The unique bacterial genera (LDA scores > 4) identified within the SARA group comprised <i>Succinivibrionaceae_UCG-001</i>, <i>Succinivibrio</i>, <i>NK4A214_group</i>, <i>Lachnospiraceae_NK3A20_group</i>, and <i>Ruminococcus</i>, which may serve as potential biomarkers for the diagnosis of SARA. The unique genera associated with the CON group included <i>Rikenellaceae_RC9_gut_group</i>, <i>Prevotellaceae_UCG-003</i>, and <i>U29-B03</i>, while those for the CAP group included <i>Succiniclasticum</i> and <i>Prevotellaceae_UCG-004</i>. …”
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Association between Growth Hormone and Insulin-like Growth Factor-1 (IGF-1) Levels, Liver Function and Short-Term Survival of Paediatric Liver Recipients by R. M. Kurabekova, O. M. Tsiroulnikova, I. E. Pashkova, L. V. Makarova, N. P. Mozheiko, A. R. Monakhov, O. P. Shevchenko

“…Compared to the level of growth hormone, the level of IGF-1 was related to the diagnosis (r = 0.30, p = 0.004). IGF-1 shows lower concentrations in biliary atresia and other cholestatic liver diseases compared to non-cholestatic aetiologies (4.7 (0.0—23.4) and 42.3 (9.0—55.0) ng/mL, respectively, p = 0.03). …”
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Decoding mutational signatures in breast cancer: Insights from a multi-cohort study by Margaux Betz, Andréa Witz, Julie Dardare, Cassandra Michel, Vincent Massard, Romain Boidot, Pauline Gilson, Jean-Louis Merlin, Alexandre Harlé

“…Purpose: Diagnosis and treatment decisions of hormonal breast cancers (BC) are now guided by genomic mutations determination, combined into mutational signatures, and provide insight into the patients’ genomic landscape. …”
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Expression of Sclerostin in Osteoporotic Fracture Patients Is Associated with DNA Methylation in the CpG Island of the SOST Gene by Yanming Cao, Bin Wang, Ding Wang, Dongxiang Zhan, Caiyuan Mai, Peng Wang, Qiushi Wei, Yamei Liu, Haibin Wang, Wei He, Liangliang Xu

“…The aim of this study is to investigate the involvement of CpG methylation in regulation of SOST expression in patients with primary osteoporosis. Methods. The diagnosis of osteoporosis was established on the basis of dual energy X-ray absorptiometry to measure BMD. …”
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Collagenolytic activity of conjunctival fluid in healthy people and patients with aseptic ulcer of the cornea of various etiologies by Brzheskaya I.V., Somov E.E

“…<br> <br> <b>Key words:</b> lacrimal fluid, activity of proteolytic enzymes, dry eye syndrome, Sjorgren’s syndrome, corneal aseptic ulcer, diagnosis of progression.<br> <b>For citation:</b> Brzheskaya I.V., Somov E.E. …”
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The search for a blood-based biomarker for Myalgic Encephalomyelitis/ Chronic Fatigue Syndrome (ME/CFS): from biochemistry to electrophysiology by Krista S. P. Clarke, Caroline C. Kingdon, Michael Pycraft Hughes, Eliana Mattos Lacerda, Rebecca Lewis, Emily J. Kruchek, Robert A. Dorey, Fatima H. Labeed

“…To date there is no complete understanding of the triggering pathomechanisms of disease, and no quantitative biomarker available with sufficient sensitivity, specificity, and adoptability to provide conclusive diagnosis. Clinicians thus eliminate differential diagnoses, and rely on subjective, unspecific, and disputed clinical diagnostic criteria—a process that often takes years with patients being misdiagnosed and receiving inappropriate and sometimes detrimental care. …”
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Diagnostic Evaluation and Management of Chronic Thromboembolic Pulmonary Hypertension: A Clinical Practice Guideline by Sanjay Mehta, Doug Helmersen, Steeve Provencher, Naushad Hirani, Fraser D Rubens, Marc De Perrot, Mark Blostein, Kim Boutet, George Chandy, Carole Dennie, John Granton, Paul Hernandez, Andrew M Hirsch, Karen Laframboise, Robert D Levy, Dale Lien, Simon Martel, Gerard Shoemaker, John Swiston, Justin Weinkauf

“…Many care gaps exist in the diagnosis and management of CTEPH patients including lack of awareness, incomplete diagnostic assessment, and inconsistent use of surgical and medical therapies.…”
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Clinical analysis and case series report on autoimmune glial fibrillary acidic protein astrocytopathy presenting with autonomic dysfunction by Xiao Ke Wu, Guojie Zhai, Jin Ru Zhang, Hua Ping Du, Lan Hu, Shu Ye Yu, Hai Lun Hang, Sirui Han, Yanlin Zhang, Yuan Xu

“…These findings aim to establish a foundation for personalized diagnosis and treatment strategies in such patients.MethodWe performed a retrospective data analysis from three cases of GFAP-A involvement in autonomic nerves from the Ninth People’s Hospital of Suzhou and the Second Affiliated Hospital of Soochow University from 2020 to 2023. …”
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Exploring ketogenic diet resistance in glucose transporter type 1 deficiency syndrome: A comprehensive review and critical appraisal by Raffaele Falsaperla, Vincenzo Sortino, Gerhard Josef Kluger, Thomas Herberhold, Andrea Rüegger, Pasquale Striano, Martino Ruggieri, Joerg Klepper, Georgia Ramantani

“…We identified five cases of KDT failure in female GLUT1DS patients, aged 10 days to 13 years at diagnosis. Predominant seizure types were absence seizures, with a few cases of clonic, tonic, or myoclonic seizures. …”
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The serum hepcidin and the hepcidin/ferritin ratio in NAFLD: a systematic review and meta-analysis by Jingmin Song, Heqing Wang, Xiaolian Gao, Fen Yang, Xinhong Zhu, Guiyuan Qiao, Ting Gan, Junxiu Tao

“…Further investigations are needed to fully elucidate the role of these variables in iron metabolism and their potential impact on the diagnosis, prevention, and management of NAFLD.…”
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Multi-Modal Fusion of Routine Care Electronic Health Records (EHR): A Scoping Review by Zina Ben-Miled, Jacob A. Shebesh, Jing Su, Paul R. Dexter, Randall W. Grout, Malaz A. Boustani

“…In particular, routine care EHR data are collected for a large number of patients.These data span multiple heterogeneous elements (i.e., demographics, diagnosis, medications, clinical notes, vital signs, and laboratory results) which contain semantic, concept, and temporal information. …”
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Genomic analysis of the SMN1 gene region in patients with clinically diagnosed spinal muscular atrophy: a retrospective observational study by Tamaki Kato, Mamoru Yokomura, Yutaka Osawa, Kensuke Matsuo, Yuji Kubo, Taihei Homma, Kayoko Saito

“…With current genetic testing, SMN1 copy number is determined; a diagnosis is reached when the copy number is zero. …”
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A qualitative study to explore healthcare providers' perspectives on barriers and enablers to early detection of breast and cervical cancers among women attending primary healthcar... by Gugulethu Tshabalala, Charmaine Blanchard, Keletso Mmoledi, Desiree Malope, Daniel S O'Neil, Shane A Norris, Maureen Joffe, Janan Janine Dietrich

“…Sub-Saharan African (SSA) countries, including South Africa (SA), bear some of the world's highest cancer case fatality rates, largely attributed to late diagnosis. We explored contextual enablers and barriers for early detection of breast and cervical cancers according to facility managers and clinical staff at primary healthcare clinics in the Soweto neighbourhood of Johannesburg, South Africa. …”
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Association between demographic, clinical characteristics and severe complications by SARS-CoV-2 infection in a community-based healthcare network in Chile. by Javiera Leniz, Sam Hernández-Jaña, Mauricio Soto, Eduardo Arenas, Paula Margozzini, Francisco Suarez, Daniel Capurro, María Paulina Rojas, Claudia Bambs

“…The mean age was 44.30 (sd 17.31), 55.6% were female, 15.9% had a type of healthcare insurance for people from the lowest category of income, 11.6% and 9.4% had a record of hypertension or diabetes mellitus diagnosis. Among the 44,674 people, 455 (1.02%) had a hospital admission due to a COVID-19 infection and 216(0.48%) of them also had an ICU admission. …”
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Pharmacist-led DE-eSCALation of opioids post-surgical dischargE (DESCALE) – A multi-centre, non-randomised, feasibility study protocol [version 2; peer review: 1 approved, 2 approv... by Ellie Santer, Julie H Hedayioglu, Vanessa J Short, Sabina Hulbert, Emma L Veale, Melanie Rees-Roberts, Johanna Theron

“…Participants aged ≥18 years who have undergone a surgical procedure at a single NHS trust in Southeast England and discharged with opioids and without a history of long-term opioid use, cancer diagnosis or study contraindications will be offered a Medicines Use Review (MUR) within 7-10 days of discharge. …”
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Threats of zoonotic pathogens in food chain: Current status and gaps in IndiaKey public health Message: by Madhuchhanda Das, Anup Kumar Ojha, Venencia Albert, Saradi Borah, Thandavarayan Ramamurthy, Samaresh Das, Tapan Kumar Dutta, Hosterson Kylla, Rajkumari Mandakini, Sarangthem Indira Devi

“…Result: SWOT analysis showed that different national and international programs supporting One Health initiative are the strengths, whereas poor awareness related to animal health issues, insufficient number of veterinary hospitals and excellence centers for diagnosis, and research are the weaknesses. International and National funding opportunities, and policy support for one health initiative remains a long-term vision. …”
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Comparison of Survival Outcomes of Lymphovascular Space Invasion-Negative and Lymphovascular Space Invasion - Positive Women with Stage IIIC Endometrioid Endometrial Cancer: A Case... by Zeliha Firat Cuylan, Mehmet Mutlu Meydanli, Murat Öz, Ahmet Taner Turan, Ozgur Akbayir, Murat Dede, Ali Ayhan

“…Cases and controls were matched in terms of age at diagnosis, grade of tumor, depth of myometrial invasion, sub-stage and adjuvant treatment. …”
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Tick-borne encephalitis vaccination in persons with a recent history of Lyme borreliosis: Insights from a Knowledge, Attitudes and Behaviour survey in Bavaria, Germany by Stefanie Böhm, Andreas Beyerlein, Volker Fingerle, Merle M. Böhmer, Manfred Wildner

“…Our study aimed to identify the reasons for and against TBE vaccination among persons at high risk for tick-borne diseases (TBD) based on recent diagnosis of Lyme borreliosis (LB) to inform future preventive measures.We invited persons with a recent course of LB notified between June and August 2019 to complete a self-reported questionnaire about their knowledge, attitudes and behaviours regarding TBD-related themes. …”
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Genomic and virulent characterization of a duck-associated Salmonella serovar Potsdam from China by Hongli An, Xiamei Kang, Chenhu Huang, Chenghao Jia, Jiaqi Chen, Yingying Huang, Qianzhe Cao, Yan Li, Biao Tang, Min Yue

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Comparing 1-L and 2-L Polyethylene Glycol with Ascorbic Acid for Small Bowel Capsule Endoscopy: A Randomized Controlled Trial by Chang Kyo Oh, Sang Pyo Lee, Jae Gon Lee, Young Joo Yang, Seung In Seo, Chang Seok Bang, Yu Jin Kim, Woon Geon Shin, Jin Bae Kim, Hyun Joo Jang, Sea Hyub Kae, Gwang Ho Baik, Hallym Gastrointestinal Study Group

“…Background/Aims: Small bowel capsule endoscopy (SBCE) has become the standard for initial evaluation in the diagnosis of small bowel lesions. Although optimal visualization of the mucosa is important, patients experience difficulty in consuming a large volume of bowel preparation agents. …”
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